LOCUS       NM_015191               9622 bp    mRNA    linear   PRI 15-MAR-2025
DEFINITION  Homo sapiens salt inducible kinase 2 (SIK2), mRNA.
ACCESSION   NM_015191 XM_370655
VERSION     NM_015191.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9622)
  AUTHORS   Proteau,S., Krossa,I., Husser,C., Gueguinou,M., Sella,F., Bille,K.,
            Irondelle,M., Dalmasso,M., Barouillet,T., Cheli,Y., Pisibon,C.,
            Arrighi,N., Nahon-Esteve,S., Martel,A., Gastaud,L., Lassalle,S.,
            Mignen,O., Brest,P., Mazure,N.M., Bost,F., Baillif,S.,
            Landreville,S., Turcotte,S., Hasson,D., Carcamo,S., Vandier,C.,
            Bernstein,E., Yvan-Charvet,L., Levesque,M.P., Ballotti,R.,
            Bertolotto,C. and Strub,T.
  TITLE     LKB1-SIK2 loss drives uveal melanoma proliferation and
            hypersensitivity to SLC8A1 and ROS inhibition
  JOURNAL   EMBO Mol Med 15 (12), e17719 (2023)
   PUBMED   37966164
  REMARK    GeneRIF: LKB1-SIK2 loss drives uveal melanoma proliferation and
            hypersensitivity to SLC8A1 and ROS inhibition.
            Erratum:[EMBO Mol Med. 2024 Sep;16(9):2262-2267. doi:
            10.1038/s44321-024-00114-1. PMID: 39164473]
REFERENCE   2  (bases 1 to 9622)
  AUTHORS   Sall,J., Lindahl,M., Fritzen,A.M., Fryklund,C., Kopietz,F.,
            Nyberg,E., Warvsten,A., Moren,B., Foretz,M., Kiens,B.,
            Stenkula,K.G. and Goransson,O.
  TITLE     Salt-inducible kinases are required for glucose uptake and insulin
            signaling in human adipocytes
  JOURNAL   Obesity (Silver Spring) 31 (10), 2515-2529 (2023)
   PUBMED   37608474
  REMARK    GeneRIF: Salt-inducible kinases are required for glucose uptake and
            insulin signaling in human adipocytes.
REFERENCE   3  (bases 1 to 9622)
  AUTHORS   Lee,G.K., Kim,H.Y. and Park,J.H.
  TITLE     Inhibiting eukaryotic initiation factor 5A (eIF5A) hypusination
            attenuated activation of the SIK2 (salt-inducible kinase 2)-p4E-BP1
            pathway involved in ovarian cancer cell proliferation and migration
  JOURNAL   Mol Biol Rep 50 (7), 5807-5816 (2023)
   PUBMED   37219665
  REMARK    GeneRIF: Inhibiting eukaryotic initiation factor 5A (eIF5A)
            hypusination attenuated activation of the SIK2 (salt-inducible
            kinase 2)-p4E-BP1 pathway involved in ovarian cancer cell
            proliferation and migration.
REFERENCE   4  (bases 1 to 9622)
  AUTHORS   Liu,B., Zhang,L., Yang,H., Chen,X., Zheng,H. and Liao,X.
  TITLE     SIK2 protects against renal tubular injury and the progression of
            diabetic kidney disease
  JOURNAL   Transl Res 253, 16-30 (2023)
   PUBMED   36075517
  REMARK    GeneRIF: SIK2 protects against renal tubular injury and the
            progression of diabetic kidney disease.
REFERENCE   5  (bases 1 to 9622)
  AUTHORS   Shi,X., Yu,X., Wang,J., Bian,S., Li,Q., Fu,F., Zou,X., Zhang,L.,
            Bast,R.C. Jr., Lu,Z., Guo,L., Chen,Y. and Zhou,J.
  TITLE     SIK2 promotes ovarian cancer cell motility and metastasis by
            phosphorylating MYLK
  JOURNAL   Mol Oncol 16 (13), 2558-2574 (2022)
   PUBMED   35278271
  REMARK    GeneRIF: SIK2 promotes ovarian cancer cell motility and metastasis
            by phosphorylating MYLK.
REFERENCE   6  (bases 1 to 9622)
  AUTHORS   Screaton,R.A., Conkright,M.D., Katoh,Y., Best,J.L., Canettieri,G.,
            Jeffries,S., Guzman,E., Niessen,S., Yates,J.R. 3rd, Takemori,H.,
            Okamoto,M. and Montminy,M.
  TITLE     The CREB coactivator TORC2 functions as a calcium- and
            cAMP-sensitive coincidence detector
  JOURNAL   Cell 119 (1), 61-74 (2004)
   PUBMED   15454081
REFERENCE   7  (bases 1 to 9622)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human FOXN5 and rat Foxn5
            genes in silico
  JOURNAL   Int J Oncol 24 (5), 1339-1344 (2004)
   PUBMED   15067358
REFERENCE   8  (bases 1 to 9622)
  AUTHORS   Lizcano,J.M., Goransson,O., Toth,R., Deak,M., Morrice,N.A.,
            Boudeau,J., Hawley,S.A., Udd,L., Makela,T.P., Hardie,D.G. and
            Alessi,D.R.
  TITLE     LKB1 is a master kinase that activates 13 kinases of the AMPK
            subfamily, including MARK/PAR-1
  JOURNAL   EMBO J 23 (4), 833-843 (2004)
   PUBMED   14976552
REFERENCE   9  (bases 1 to 9622)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human KIAA1391 and mouse
            Kiaa1391 genes encoding novel RhoGAP family proteins with RA domain
            and ANXL repeats
  JOURNAL   Int J Oncol 23 (5), 1471-1476 (2003)
   PUBMED   14532992
REFERENCE   10 (bases 1 to 9622)
  AUTHORS   Horike,N., Takemori,H., Katoh,Y., Doi,J., Min,L., Asano,T.,
            Sun,X.J., Yamamoto,H., Kasayama,S., Muraoka,M., Nonaka,Y. and
            Okamoto,M.
  TITLE     Adipose-specific expression, phosphorylation of Ser794 in insulin
            receptor substrate-1, and activation in diabetic animals of
            salt-inducible kinase-2
  JOURNAL   J Biol Chem 278 (20), 18440-18447 (2003)
   PUBMED   12624099
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP000925.6.
            
            On Nov 23, 2018 this sequence version replaced NM_015191.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB096248.1, AL136764.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304987.4/ ENSP00000305976.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-250               AP000925.6         32272-32521
            251-367             AP000925.6         46066-46182
            368-431             AP000925.6         50162-50225
            432-593             AP000925.6         117824-117985
            594-718             AP000925.6         130709-130833
            719-842             AP000925.6         131275-131398
            843-1063            AP000925.6         133026-133246
            1064-1216           AP000925.6         134810-134962
            1217-1381           AP000925.6         142034-142198
            1382-1610           AP000925.6         149598-149826
            1611-1895           AP000925.6         150301-150585
            1896-2059           AP000925.6         150722-150885
            2060-2170           AP000925.6         151653-151763
            2171-2262           AP000925.6         152488-152579
            2263-9622           AP000925.6         153319-160678
FEATURES             Location/Qualifiers
     source          1..9622
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.1"
     gene            1..9622
                     /gene="SIK2"
                     /gene_synonym="LOH11CR1I; QIK; SIK-2; SNF1LK2"
                     /note="salt inducible kinase 2"
                     /db_xref="GeneID:23235"
                     /db_xref="HGNC:HGNC:21680"
                     /db_xref="MIM:608973"
     exon            1..250
                     /gene="SIK2"
                     /gene_synonym="LOH11CR1I; QIK; SIK-2; SNF1LK2"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..2896
                     /gene="SIK2"
                     /gene_synonym="LOH11CR1I; QIK; SIK-2; SNF1LK2"
                     /EC_number="2.7.11.1"
                     /note="salt-inducible serine/threonine kinase 2; SNF1-like
                     kinase 2; serine/threonine-protein kinase SNF1-like kinase
                     2; qin-induced kinase; salt-inducible protein kinase 2"
                     /codon_start=1
                     /product="serine/threonine-protein kinase SIK2"
                     /protein_id="NP_056006.1"
                     /db_xref="CCDS:CCDS8347.1"
                     /db_xref="GeneID:23235"
                     /db_xref="HGNC:HGNC:21680"
                     /db_xref="MIM:608973"
                     /translation="MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKT
                     EVAIKIIDKSQLDAVNLEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNG
                     EIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIAD
                     FGFGNFFKSGELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFD
                     GPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEVP
                     VQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLV
                     ERLKSHRSSFPVEQRLDGRQRRPSTIAEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQ
                     ASNVEAFSFPASGCQAEAAFMEEECVDTPKVNGCLLDPVPPVLVRKGCQSLPSNMMET
                     SIDEGLETEGEAEEDPAHAFEAFQSTRSGQRRHTLSEVTNQLVVMPGAGKIFSMNDSP
                     SLDSVDSEYDMGSVQRDLNFLEDNPSLKDIMLANQPSPRMTSPFISLRPTNPAMQALS
                     SQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQHLQNLARTKGILELNKVQLLYEQI
                     GPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVSTLPASVHPQLSPRQSLETQYLQH
                     RLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQKRLFLQKQSQLQAYFNQMQIA
                     ESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEPSSEQMQYSPFLSQYQEMQ
                     LQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPAPLQFSYQTCELPSAAS
                     PAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLALSELPGLFDCEMLDA
                     VDPQHNGYVLVN"
     exon            251..367
                     /gene="SIK2"
                     /gene_synonym="LOH11CR1I; QIK; SIK-2; SNF1LK2"
                     /inference="alignment:Splign:2.1.0"
     exon            368..431
                     /gene="SIK2"
                     /gene_synonym="LOH11CR1I; QIK; SIK-2; SNF1LK2"
                     /inference="alignment:Splign:2.1.0"
     exon            432..593
                     /gene="SIK2"
                     /gene_synonym="LOH11CR1I; QIK; SIK-2; SNF1LK2"
                     /inference="alignment:Splign:2.1.0"
     exon            594..718
                     /gene="SIK2"
                     /gene_synonym="LOH11CR1I; QIK; SIK-2; SNF1LK2"
                     /inference="alignment:Splign:2.1.0"
     exon            719..842
                     /gene="SIK2"
                     /gene_synonym="LOH11CR1I; QIK; SIK-2; SNF1LK2"
                     /inference="alignment:Splign:2.1.0"
     exon            843..1063
                     /gene="SIK2"
                     /gene_synonym="LOH11CR1I; QIK; SIK-2; SNF1LK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1216
                     /gene="SIK2"
                     /gene_synonym="LOH11CR1I; QIK; SIK-2; SNF1LK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1381
                     /gene="SIK2"
                     /gene_synonym="LOH11CR1I; QIK; SIK-2; SNF1LK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1610
                     /gene="SIK2"
                     /gene_synonym="LOH11CR1I; QIK; SIK-2; SNF1LK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1895
                     /gene="SIK2"
                     /gene_synonym="LOH11CR1I; QIK; SIK-2; SNF1LK2"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..2059
                     /gene="SIK2"
                     /gene_synonym="LOH11CR1I; QIK; SIK-2; SNF1LK2"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2170
                     /gene="SIK2"
                     /gene_synonym="LOH11CR1I; QIK; SIK-2; SNF1LK2"
                     /inference="alignment:Splign:2.1.0"
     exon            2171..2262
                     /gene="SIK2"
                     /gene_synonym="LOH11CR1I; QIK; SIK-2; SNF1LK2"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..9622
                     /gene="SIK2"
                     /gene_synonym="LOH11CR1I; QIK; SIK-2; SNF1LK2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4796..4801
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIK2"
                     /gene_synonym="LOH11CR1I; QIK; SIK-2; SNF1LK2"
                     /note="hexamer: AATAAA"
     polyA_site      4823
                     /gene="SIK2"
                     /gene_synonym="LOH11CR1I; QIK; SIK-2; SNF1LK2"
     regulatory      9598..9603
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIK2"
                     /gene_synonym="LOH11CR1I; QIK; SIK-2; SNF1LK2"
                     /note="hexamer: AATAAA"
     polyA_site      9622
                     /gene="SIK2"
                     /gene_synonym="LOH11CR1I; QIK; SIK-2; SNF1LK2"
                     /note="major polyA site"
ORIGIN      
        1 aaggagcgaa ggagcgaagg agcaagcgga gcggccgtcg cccaagccaa gccgcgctgc
       61 caaccctccc gcccgcccgc gctcctgtcc gccgtgtcta gcagcggggc ccagcatggt
      121 catggcggat ggcccgaggc acttgcagcg cgggccggtc cgggtggggt tctacgacat
      181 cgagggcacg ctgggcaagg gcaacttcgc tgtggtgaag ctggggcggc accggatcac
      241 caagacggag gtggcaataa aaataatcga taagtctcag ctggatgcag tgaaccttga
      301 gaaaatctac cgagaagtac aaataatgaa aatgttagac caccctcaca taatcaaact
      361 ttatcaggta atggagacca aaagtatgtt gtaccttgtg acagaatatg ccaaaaatgg
      421 agaaattttt gactatcttg ctaatcatgg ccggttaaat gagtctgaag ccaggcgaaa
      481 attctggcaa atcctgtctg ctgttgatta ttgtcatggt cggaagattg tgcaccgtga
      541 cctcaaagct gaaaatctcc tgctggataa caacatgaat atcaaaatag cagatttcgg
      601 ttttggaaat ttctttaaaa gtggtgaact gctggcaaca tggtgtggca gcccccctta
      661 tgcagcccca gaagtctttg aagggcagca gtatgaagga ccacagctgg acatctggag
      721 tatgggagtt gttctttatg tccttgtctg tggagctctg ccctttgatg gaccgactct
      781 tccaattttg aggcagaggg ttctggaagg aagattccgg attccgtatt tcatgtcaga
      841 agattgcgag caccttatcc gaaggatgtt ggtcctagac ccatccaaac ggctaaccat
      901 agcccaaatc aaggagcata aatggatgct catagaagtt cctgtccaga gacctgttct
      961 ctatccacaa gagcaagaaa atgagccatc catcggggag tttaatgagc aggttctgcg
     1021 actgatgcac agccttggaa tagatcagca gaaaaccatt gagtctttgc agaacaagag
     1081 ctataaccac tttgctgcca tttatttctt gttggtggag cgcctgaaat cacatcggag
     1141 cagtttccca gtggagcaga gacttgatgg ccgccagcgt cggcctagca ccattgctga
     1201 gcaaacagtt gccaaggcac agactgtggg gctcccagtg accatgcatt caccgaacat
     1261 gaggctgctg cgatctgccc tcctccccca ggcatccaac gtggaggcct tttcatttcc
     1321 agcatctggc tgtcaggcgg aagctgcatt catggaagaa gagtgtgtgg acactccaaa
     1381 ggtcaatggc tgtctgcttg accctgtgcc tcctgtcctg gtgcggaagg gatgccagtc
     1441 actgcccagc aacatgatgg agacctccat tgacgaaggg ctggagacag aaggagaggc
     1501 cgaggaagac cccgctcatg cctttgaggc atttcagtcc acacgcagcg ggcagagacg
     1561 gcacactctg tcagaagtga ccaatcaact ggtcgtgatg cctggggcag ggaaaatttt
     1621 ctccatgaat gacagcccct cccttgacag tgtggactct gagtatgata tggggtctgt
     1681 tcagagggac ctgaactttc tggaagacaa cccttccctt aaggacatca tgttagccaa
     1741 tcagccttca ccccgcatga catctccctt cataagcctg agacctacca acccagccat
     1801 gcaggctctg agctcccaga aacgagaggt ccacaacagg tctccagtga gcttcagaga
     1861 gggccgcaga gcatcagata cctccctcac ccagggaatt gtagcattta gacaacatct
     1921 tcagaatctg gctagaacca aaggaattct agagttgaac aaagtgcagt tgttgtatga
     1981 acaaatagga ccggaggcag accctaacct ggcgccggcg gctcctcagc tccaggacct
     2041 tgctagcagc tgccctcagg aagaagtttc tcagcagcag gaaagcgtct ccactctccc
     2101 tgccagcgtg catccccagc tgtccccacg gcagagcctg gagacccagt acctgcagca
     2161 cagactccag aagcccagcc ttctgtcaaa ggcccagaac acctgtcagc tttattgcaa
     2221 agaaccaccg cggagccttg agcagcagct gcaggaacat aggctccagc agaagcgact
     2281 ctttcttcag aagcagtctc aactgcaggc ctattttaat cagatgcaga tagcagagag
     2341 ctcctaccca cagccaagtc agcagctgcc ccttccccgc caggagactc caccgccttc
     2401 tcagcaggcc ccaccgttca gcctgaccca gcccctgagc cccgtcctgg agccttcctc
     2461 cgagcagatg caatacagcc ctttcctcag ccagtaccaa gagatgcagc ttcagcccct
     2521 gccctccact tccggtcccc gggctgctcc tcctctgccc acgcagctac agcagcagca
     2581 gccgccaccg ccaccacccc ctccaccacc acgacagcca ggagctgccc cagccccctt
     2641 acagttctcc tatcagactt gtgagctgcc aagcgctgct tcccctgcgc cagactatcc
     2701 cactccctgt cagtatcctg tggatggagc ccagcagagc gacctaacgg ggccagactg
     2761 tcccagaagc ccaggactgc aagaggcccc ctccagctac gacccactag ccctctctga
     2821 gctacctgga ctctttgatt gtgaaatgct agacgctgtg gatccacaac acaacgggta
     2881 tgtcctggtg aattagtctc agcacaggaa ttgaggtggg tcaggtgaag gaagagtgta
     2941 tgttcctatt tttattccag ccttttaaat ttaaagctta ttttcttgcc ctctccctaa
     3001 cggggagaaa tcgagccacc caactggaat cagagggtct ggctggggtg gatgttgctt
     3061 cctcctggtt ctgccccacc acaaagtttt ctgtggcaag tgctggaaca tagttgtagg
     3121 ctgaggctcc tgcccttcgg tcgagtggag caagctctcg agggcagcac tgacaaatgt
     3181 gttcctaaga agacattcag acccaggtgt tatgcaggat tacatccgtt tattatcaag
     3241 ggcaaccttg gtgaaagcag aaagggtgtg tgctattgca tatatatggg ggaaaaggca
     3301 atatattttt cactgaagct gagcaaccac atattgctac aaggcaaatc aagaagacat
     3361 caggaaatca gatgcacagg aaataaagga aagctgtgct ttgtcattga atcctaagtt
     3421 cttagctgct gatgcaagtt gtcccccaag gccatcacaa agcagtgggg catgagctgt
     3481 gtttcagggg ccactaaata acagctggta ctgaccccag aaaccgcctt catctccatt
     3541 cggaagcagg tgacacaccc cttcagaagg tgccctgggt tgccgagtgt cagaatatac
     3601 tcaggactcc agaggtgtca cacgtggaac tgacaggaga cccgccaccg tggaggcagg
     3661 gggcaagaaa ctcaagaacg catcaagagc accagccctg ggccagggaa gacaggctct
     3721 tcctgcagtt tctcgtggac actgctggct tgcgggcagt cggtctccag ggtacctgtt
     3781 gtctcttttc cgatgtaata actactttga ccttacacta tatgttgcta gtagtttatt
     3841 gagctttgta tatttggaca gtttcatata gggcttagag attttaagga catgataaat
     3901 gaacttttct gtcccatgtg aagtggtagt gcggtgcctt tcccccagat catgctttaa
     3961 ttctttcttt tctgtagaaa ccaacagttt ccatttatgt caatgctaaa tccaaagtca
     4021 cttcagagtt tgttttccac catgtgggaa tcagcattct taatttcgtt aaagttttga
     4081 cttgtaatga aatgttcaag tattacagca atattcaaag aaagaaccac agatgtgtta
     4141 accatttaag cagatcatct gccaaacatt atattactaa taaaacttaa ccaacactta
     4201 caattcagtc atcaaagtaa gtaaaaatta gatgctacag ctagctaact gtatccctag
     4261 aaatgatgaa taatttgcca tttggacagt taacatccag gtgttacaaa gtcagtgtta
     4321 attctaaaga tgatcatttc tgccctttag aatggcttgt cccatcagca gatgaatgtg
     4381 ttaagcacaa agcatcttcc ttaaagcaca aagagaggga ctaactgatg ctgcatctag
     4441 aaaacacctt taagttgcct ttcctctttg tagttagcgt tcaggcaggt gacgtgtgga
     4501 aagtctaggg ggttccattc tggccatgcg agcccagctc ctaccaacgt cggtaacttg
     4561 agcagtccct gttgctggcc agagactgcc tggtcgccag cgctcaccat gggtgccagg
     4621 atgcttcgca gaggcactgt gctcacggtt ggacttggtg tcagtgggaa agggcagtgt
     4681 ggggactgtc atttttgtga tttaataaca cacagtgaaa atccaggaag aatgaattaa
     4741 gcttcttctg ggagttgttt attcctgctc gtgcttaaga ttgatgattt cgtgaaataa
     4801 agaacatcat ttcatttaag agatcatttc attaagatct ctaatctgtt ttgagtcttt
     4861 acaaaatagc cagttataaa atggggcttg atttgtttag actgaaggaa gacgttttcc
     4921 caaaatatac tacagaagtg ctacaatatt tgcgatatta aaatgcctgc agattgaaaa
     4981 tgggggccac tcatttcaga actgcaggaa tggtgtagtt acagatcgac ataaactcct
     5041 gccccccaac aatgccatga gctgcttagc ccaggagacc tgggagctat ggcaggacgg
     5101 ttaggccagc cgatgaggga ctgcagagag gctactggaa ggttaaggac ccagagagaa
     5161 atcgagaggt gccctacagc agccaggcct atcaggatcc gtcacacacg gcagcggcgt
     5221 ggacaccggc ctgatgcaga gcgtgacccc tcctgctggg acctgtgttg taagctccta
     5281 tttgcttatc ttgtttattt caagcagaaa tcaataaatt ccataaccct ctgtattgac
     5341 tgcaatgtaa gctgctgagg agactggttc tgttggtcag tcaggtgttt gctcagccct
     5401 gtctgatcac ctgtgctgct ctgtccctaa ctagtgaccc atggaagctt ccaagcagtt
     5461 ttctcttcat cactactaac aaacaaaaca ctaagaaggc ttagtatcgc tctttttctg
     5521 cggggctact ctgaagtact gacttgcttt ccagtctgat tcacgttagc agtgtgtaca
     5581 ctactgtatc atcatcagct tcatcaccct gtaaaccagg ctcctctgaa gagactttgg
     5641 tgagatgaac gtgaggtaaa aatttcgttc ggcaaaaagt gcaatatgtg tggtacttta
     5701 ttttttatgt tcttttttta aatctggggt attagtctgt gctttgggag aaatgcacta
     5761 gctctgcaat tcccagctgg gcaagtgtgt ctctagtatc tccacgcaac tgatacactg
     5821 gtccctgtaa ggcaaacagc atgttagccc gacaggaaga gggggcccac tttcacattc
     5881 ccggtgacac tgaccgtccc cagctgcccc ctcgccacct ctgcctgcac tgccttctgt
     5941 caccgtggga aaaggaggct gatggttctc tacaccatcc accttgagaa tccctgcgtg
     6001 ggagagcatc agggcccacc aggggagtgg ggatggggct caggggctgt tcatgcccat
     6061 ctgagcaaac cccttctctc ttccatccac ttttgcctcc taggaaagaa aaagtcagtg
     6121 gccctttctt cctcagatat caagaactcc caagtgttta aaccgtatgc tggagtcagt
     6181 ggttgggaca gacaggagcc caagactgaa gccagccctt gcctcttgtg tcccttccca
     6241 actctggtgc tggagtaatg gggtgctctg cattttgatg gggagcaagg ggggaccccc
     6301 cctgtaggag tatcggcctc tcccctgccc cctaccctct ctcgtggacc aaagtctcca
     6361 gcagaagaga ctcatcataa gactgacgac tcccccacct ccacccacac accgagtgtc
     6421 atcagtccta aaggcaggga aacgctcaca gaattctgcc cacgggttag atgtggggag
     6481 aaggatattc tcagctccag agtgattagg tgatcagcca gaaactaagg caaggtgaca
     6541 agcagcagcc tggagtcaca gttggtccca ggcgtgtggg cactaagcag cctctggaga
     6601 catgcgggca gttgaggatg caaggacaca gtgagtgagt ggcgctcctt tttggggtcc
     6661 tccagcctct agtcaagccc caggttcgta aatatgtttg tattacattt taaaacctgt
     6721 atcaacagtc acatttaagc tccctattgg tttaaagaaa attcatactc caggtaactt
     6781 tttcccattc gacctcctat agagacaata tgcagtgtgt catttcacag tctcagtccc
     6841 tgtgaacagt ggctgacacc ggtgccaggg ctgacctgct acactcaaac tcctaaactg
     6901 ggctgcctct aactgcctcc tgggaagcca cccgagccac tcggtctctt tgtgcctaaa
     6961 catgaaaggt gaaaattgga gaacagggaa gctcgtaagt tggagtcatt gtacaggcag
     7021 ggatctttga tcattttgtt gcttctggaa tttatttaat tttttttttt tttgagacag
     7081 agtctcgctc tgtcacccag gctggaatgc agtggcgtga tttcagctca ctgcaacctc
     7141 cacctcctgg gttcaagcca ttctcctgcc tcagcctccc aagtagctgg gactacaggt
     7201 gtgtgctacc gcatccagct agtttgtata tttttagtag agatggggtt tcaccatgtt
     7261 gtccaggctg atcttgaact cctgacctca ggtgacccac ccaccttggc ctcccaaagt
     7321 actgggatta caggtgtgag ccaccacacc cgacctggaa tttttttata gaacttatct
     7381 tcagagcaat gtatgaaaga caagagcagt atcagccggg cgcggtggct cacgcctgta
     7441 atcccaacac tttgggaggc caaggcaggc ggatcacgag gtcaggagat tgagaccatc
     7501 ctaacacagt gaaacgccgt ctctactaaa aatacaaaaa attagccggg cgtggtggtg
     7561 ggcgcctgta gttccagcta ctcgggaggc tgaggcagga gaatggcgtg aacccgggag
     7621 gtggagcttg cagtgagcca agatcgtgcc actgcactcc agcctgggcg acagagcaag
     7681 actccacctc aaaaaaaaaa aaaaagacaa gagcagtatc atctgcctct gtttctaaac
     7741 tggacaaaga gattttctta aagtttctat catctccctt ctgacaggtt ctacagtgtg
     7801 gtctgaagca cctgtaatgt cagagccctt gtctggccct tggtggcagg tgaacgaaag
     7861 cagtggagcc tctcaccttc cagtagcctc tcacattctt attttaccat ttttgtccta
     7921 attaaggtag cctagctgat tctagaagac agccatccta cgtgcacccc caccttgtgt
     7981 ccacatcttc tccaggcagg tttcaaccta tcagcagact caggcacaca ctggggcaca
     8041 gatagagaac caggcggcag cagtgctcgc agacccaccc agggagagct gtgatgggtt
     8101 ctgcccagat actctgctcg cccacccaca agggagcaat agcttatatt tgtacattag
     8161 ttttaccaag cactttctct tctaaccctc acaacaattc tatgaaatta gctggggaga
     8221 tactgtcctt atttttcaca gctgaagaaa ccaaagcttt gggaagtttg tgacttctct
     8281 gagatcacag ctggtgatag aaggagctgg gacacgcgct tgggttgact ggcttctggt
     8341 tttggttctc tggcttctag tgctggaaga agccctctct ttcccttctc tttcctcagt
     8401 agcatctgac tcttttcata agcaaacagc tgtataaaca aagcccccat tttggtcaag
     8461 cacagggtga atgtgatatt gttcccacaa ccttattctc cactcaacag ccgcctggct
     8521 ttggggaaga ggccgccttc aggtgacagt gcagctgtcc aggtggccgt gcactgaacc
     8581 aggctgaggg agacaaaaac cccgcagacc cgcctgcctt tcagcgtcca gttaactgca
     8641 gaagtttagg ctcacctcaa agatgtctag tttttccaag ttacaataca gcagtttcct
     8701 acagaacacc cccttcctca attgccaagg ggccgcatcg cacggcatca ggccaccact
     8761 gcaggccagc agattccacc ccaggaacgg tcatgaactc agcctttgtc tcaacgaggg
     8821 gcgtaacatt tccttacagt caagccccat caactagaag tgcttattac ttttaggatt
     8881 aaaaaagtaa taacagactt tgacttaata ctctgtcttt tcagaggcaa agtgggtggg
     8941 tagaggggag ctttaaaaat agaagtacaa aacaacatcc tggaaacata tgaccccaga
     9001 tggaataatg tcacattccc cagtgcagat aatgggctgc tgctggctct gtggtgtctg
     9061 tctgcagaag atttgctcag tcaaggaaat tcaagtggtg agacctttcc accatgggtg
     9121 gtaagagaaa cctgccttca ccaaaatctc tgaaggggaa agaagtggag agaaaggttt
     9181 gcttcacttc ggggactgca gtttgagaaa taaaagggat acagagatat ctgcactttg
     9241 tagaaagggc aagattattt gcttatatct gaagggaggt gggtggtttt gctggatgtt
     9301 tggtctgaaa gagttacttt tgataaagtt aatctaactg tagttatatt ttctgtgtgc
     9361 ttttttttaa ttactaagaa aaaaattggt gagttcagta gctttggtat tatgagtgca
     9421 aatcataata gctccaatgt gaaaaaaaaa atcaaaagta taacttgtca cttaatgtta
     9481 gaaaattgcc taaaatgcag tgtaataaat aatctctgta ccaaatagta atttaaatgg
     9541 ggtaattttc tgcaaggaaa atgtactgtt tttatgtttc caaccctctt gaattaaaat
     9601 aaaaacaact tcttttctaa ga
//
