LOCUS       NP_056006                926 aa            linear   PRI 15-MAR-2025
DEFINITION  serine/threonine-protein kinase SIK2 [Homo sapiens].
ACCESSION   NP_056006 XP_370655
VERSION     NP_056006.1
DBSOURCE    REFSEQ: accession NM_015191.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 926)
  AUTHORS   Proteau,S., Krossa,I., Husser,C., Gueguinou,M., Sella,F., Bille,K.,
            Irondelle,M., Dalmasso,M., Barouillet,T., Cheli,Y., Pisibon,C.,
            Arrighi,N., Nahon-Esteve,S., Martel,A., Gastaud,L., Lassalle,S.,
            Mignen,O., Brest,P., Mazure,N.M., Bost,F., Baillif,S.,
            Landreville,S., Turcotte,S., Hasson,D., Carcamo,S., Vandier,C.,
            Bernstein,E., Yvan-Charvet,L., Levesque,M.P., Ballotti,R.,
            Bertolotto,C. and Strub,T.
  TITLE     LKB1-SIK2 loss drives uveal melanoma proliferation and
            hypersensitivity to SLC8A1 and ROS inhibition
  JOURNAL   EMBO Mol Med 15 (12), e17719 (2023)
   PUBMED   37966164
  REMARK    GeneRIF: LKB1-SIK2 loss drives uveal melanoma proliferation and
            hypersensitivity to SLC8A1 and ROS inhibition.
            Erratum:[EMBO Mol Med. 2024 Sep;16(9):2262-2267. doi:
            10.1038/s44321-024-00114-1. PMID: 39164473]
REFERENCE   2  (residues 1 to 926)
  AUTHORS   Sall,J., Lindahl,M., Fritzen,A.M., Fryklund,C., Kopietz,F.,
            Nyberg,E., Warvsten,A., Moren,B., Foretz,M., Kiens,B.,
            Stenkula,K.G. and Goransson,O.
  TITLE     Salt-inducible kinases are required for glucose uptake and insulin
            signaling in human adipocytes
  JOURNAL   Obesity (Silver Spring) 31 (10), 2515-2529 (2023)
   PUBMED   37608474
  REMARK    GeneRIF: Salt-inducible kinases are required for glucose uptake and
            insulin signaling in human adipocytes.
REFERENCE   3  (residues 1 to 926)
  AUTHORS   Lee,G.K., Kim,H.Y. and Park,J.H.
  TITLE     Inhibiting eukaryotic initiation factor 5A (eIF5A) hypusination
            attenuated activation of the SIK2 (salt-inducible kinase 2)-p4E-BP1
            pathway involved in ovarian cancer cell proliferation and migration
  JOURNAL   Mol Biol Rep 50 (7), 5807-5816 (2023)
   PUBMED   37219665
  REMARK    GeneRIF: Inhibiting eukaryotic initiation factor 5A (eIF5A)
            hypusination attenuated activation of the SIK2 (salt-inducible
            kinase 2)-p4E-BP1 pathway involved in ovarian cancer cell
            proliferation and migration.
REFERENCE   4  (residues 1 to 926)
  AUTHORS   Liu,B., Zhang,L., Yang,H., Chen,X., Zheng,H. and Liao,X.
  TITLE     SIK2 protects against renal tubular injury and the progression of
            diabetic kidney disease
  JOURNAL   Transl Res 253, 16-30 (2023)
   PUBMED   36075517
  REMARK    GeneRIF: SIK2 protects against renal tubular injury and the
            progression of diabetic kidney disease.
REFERENCE   5  (residues 1 to 926)
  AUTHORS   Shi,X., Yu,X., Wang,J., Bian,S., Li,Q., Fu,F., Zou,X., Zhang,L.,
            Bast,R.C. Jr., Lu,Z., Guo,L., Chen,Y. and Zhou,J.
  TITLE     SIK2 promotes ovarian cancer cell motility and metastasis by
            phosphorylating MYLK
  JOURNAL   Mol Oncol 16 (13), 2558-2574 (2022)
   PUBMED   35278271
  REMARK    GeneRIF: SIK2 promotes ovarian cancer cell motility and metastasis
            by phosphorylating MYLK.
REFERENCE   6  (residues 1 to 926)
  AUTHORS   Screaton,R.A., Conkright,M.D., Katoh,Y., Best,J.L., Canettieri,G.,
            Jeffries,S., Guzman,E., Niessen,S., Yates,J.R. 3rd, Takemori,H.,
            Okamoto,M. and Montminy,M.
  TITLE     The CREB coactivator TORC2 functions as a calcium- and
            cAMP-sensitive coincidence detector
  JOURNAL   Cell 119 (1), 61-74 (2004)
   PUBMED   15454081
REFERENCE   7  (residues 1 to 926)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human FOXN5 and rat Foxn5
            genes in silico
  JOURNAL   Int J Oncol 24 (5), 1339-1344 (2004)
   PUBMED   15067358
REFERENCE   8  (residues 1 to 926)
  AUTHORS   Lizcano,J.M., Goransson,O., Toth,R., Deak,M., Morrice,N.A.,
            Boudeau,J., Hawley,S.A., Udd,L., Makela,T.P., Hardie,D.G. and
            Alessi,D.R.
  TITLE     LKB1 is a master kinase that activates 13 kinases of the AMPK
            subfamily, including MARK/PAR-1
  JOURNAL   EMBO J 23 (4), 833-843 (2004)
   PUBMED   14976552
REFERENCE   9  (residues 1 to 926)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human KIAA1391 and mouse
            Kiaa1391 genes encoding novel RhoGAP family proteins with RA domain
            and ANXL repeats
  JOURNAL   Int J Oncol 23 (5), 1471-1476 (2003)
   PUBMED   14532992
REFERENCE   10 (residues 1 to 926)
  AUTHORS   Horike,N., Takemori,H., Katoh,Y., Doi,J., Min,L., Asano,T.,
            Sun,X.J., Yamamoto,H., Kasayama,S., Muraoka,M., Nonaka,Y. and
            Okamoto,M.
  TITLE     Adipose-specific expression, phosphorylation of Ser794 in insulin
            receptor substrate-1, and activation in diabetic animals of
            salt-inducible kinase-2
  JOURNAL   J Biol Chem 278 (20), 18440-18447 (2003)
   PUBMED   12624099
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP000925.6.
            
            On Jan 27, 2004 this sequence version replaced XP_370655.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB096248.1, AL136764.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304987.4/ ENSP00000305976.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..926
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.1"
     Protein         1..926
                     /product="serine/threonine-protein kinase SIK2"
                     /EC_number="2.7.11.1"
                     /note="salt-inducible serine/threonine kinase 2; SNF1-like
                     kinase 2; serine/threonine-protein kinase SNF1-like kinase
                     2; qin-induced kinase; salt-inducible protein kinase 2"
                     /calculated_mol_wt=103785
     Region          19..271
                     /region_name="STKc_SIK"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     Salt-Inducible kinases; cd14071"
                     /db_xref="CDD:270973"
     Site            25
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:19369195; propagated from
                     UniProtKB/Swiss-Prot (Q9H0K1.1)"
     Site            order(26..30,34,47,49,80,96..99,103,105..106,108,141..142,
                     144,146..147,149,159..160,163,176..181,183,213..216,218)
                     /site_type="active"
                     /db_xref="CDD:270973"
     Site            order(26..29,34,47,49,80,96..99,103,146..147,149,159..160)
                     /site_type="other"
                     /note="ATP binding site [chemical binding]"
                     /db_xref="CDD:270973"
     Site            53
                     /site_type="acetylation"
                     /note="N6-acetyllysine, by EP300.
                     /evidence=ECO:0000269|PubMed:23322770; propagated from
                     UniProtKB/Swiss-Prot (Q9H0K1.1)"
     Site            order(103,105..106,108,142,144,146,163,176..181,183,
                     213..216,218)
                     /site_type="other"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]"
                     /db_xref="CDD:270973"
     Site            159..181
                     /site_type="other"
                     /note="activation loop (A-loop)"
                     /db_xref="CDD:270973"
     Site            175
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by LKB1.
                     /evidence=ECO:0000269|PubMed:14976552; propagated from
                     UniProtKB/Swiss-Prot (Q9H0K1.1)"
     Region          297..341
                     /region_name="UBA_SIK2"
                     /note="UBA domain found in salt-inducible kinase 2 (SIK2);
                     cd14409"
                     /db_xref="CDD:270592"
     Site            484
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000269|PubMed:30586628; propagated from
                     UniProtKB/Swiss-Prot (Q9H0K1.1)"
     Site            534
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8CFH6; propagated from
                     UniProtKB/Swiss-Prot (Q9H0K1.1)"
     Site            587
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:18669648,
                     ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163,
                     ECO:0007744|PubMed:24275569; propagated from
                     UniProtKB/Swiss-Prot (Q9H0K1.1)"
     Region          644..666
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H0K1.1)"
     Region          742..776
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H0K1.1)"
     Region          801..896
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9H0K1.1)"
     CDS             1..926
                     /gene="SIK2"
                     /gene_synonym="LOH11CR1I; QIK; SIK-2; SNF1LK2"
                     /coded_by="NM_015191.3:116..2896"
                     /db_xref="CCDS:CCDS8347.1"
                     /db_xref="GeneID:23235"
                     /db_xref="HGNC:HGNC:21680"
                     /db_xref="MIM:608973"
ORIGIN      
        1 mvmadgprhl qrgpvrvgfy diegtlgkgn favvklgrhr itktevaiki idksqldavn
       61 lekiyrevqi mkmldhphii klyqvmetks mlylvteyak ngeifdylan hgrlnesear
      121 rkfwqilsav dychgrkivh rdlkaenlll dnnmnikiad fgfgnffksg ellatwcgsp
      181 pyaapevfeg qqyegpqldi wsmgvvlyvl vcgalpfdgp tlpilrqrvl egrfripyfm
      241 sedcehlirr mlvldpskrl tiaqikehkw mlievpvqrp vlypqeqene psigefneqv
      301 lrlmhslgid qqktieslqn ksynhfaaiy fllverlksh rssfpveqrl dgrqrrpsti
      361 aeqtvakaqt vglpvtmhsp nmrllrsall pqasnveafs fpasgcqaea afmeeecvdt
      421 pkvngclldp vppvlvrkgc qslpsnmmet sidegleteg eaeedpahaf eafqstrsgq
      481 rrhtlsevtn qlvvmpgagk ifsmndspsl dsvdseydmg svqrdlnfle dnpslkdiml
      541 anqpsprmts pfislrptnp amqalssqkr evhnrspvsf regrrasdts ltqgivafrq
      601 hlqnlartkg ilelnkvqll yeqigpeadp nlapaapqlq dlasscpqee vsqqqesvst
      661 lpasvhpqls prqsletqyl qhrlqkpsll skaqntcqly ckepprsleq qlqehrlqqk
      721 rlflqkqsql qayfnqmqia essypqpsqq lplprqetpp psqqappfsl tqplspvlep
      781 sseqmqyspf lsqyqemqlq plpstsgpra applptqlqq qqpppppppp pprqpgaapa
      841 plqfsyqtce lpsaaspapd yptpcqypvd gaqqsdltgp dcprspglqe apssydplal
      901 selpglfdce mldavdpqhn gyvlvn
//
