LOCUS       NM_173354               4747 bp    mRNA    linear   PRI 24-FEB-2025
DEFINITION  Homo sapiens salt inducible kinase 1 (SIK1), mRNA.
ACCESSION   NM_173354
VERSION     NM_173354.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4747)
  AUTHORS   Zhang,X., Liu,J., Zuo,C., Peng,X., Xie,J., Shu,Y., Ao,D., Zhang,Y.,
            Ye,Q. and Cai,J.
  TITLE     Role of SIK1 in tumors: Emerging players and therapeutic potentials
            (Review)
  JOURNAL   Oncol Rep 52 (6) (2024)
   PUBMED   39422046
  REMARK    GeneRIF: Role of SIK1 in tumors: Emerging players and therapeutic
            potentials (Review).
            Review article
REFERENCE   2  (bases 1 to 4747)
  AUTHORS   Durrani,I.A., Bhatti,A. and John,P.
  TITLE     Integrated bioinformatics analyses identifying potential biomarkers
            for type 2 diabetes mellitus and breast cancer: In SIK1-ness and
            health
  JOURNAL   PLoS One 18 (8), e0289839 (2023)
   PUBMED   37556419
  REMARK    GeneRIF: Integrated bioinformatics analyses identifying potential
            biomarkers for type 2 diabetes mellitus and breast cancer: In
            SIK1-ness and health.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4747)
  AUTHORS   Anvarnia,A., Panahizadeh,R., Zarredar,H., Asadi,M., Hashemzadeh,S.,
            Vatankhah,M.A., Valizadeh,H. and Raeisi,M.
  TITLE     Down-regulation and Clinic-pathological Correlation of SIK-1 and
            SIK-1-LNC in Non-small Cell Lung Cancer Patients
  JOURNAL   Asian Pac J Cancer Prev 24 (4), 1407-1411 (2023)
   PUBMED   37116165
  REMARK    GeneRIF: Down-Regulation and Clinic-Pathological Correlation of
            SIK-1 and SIL-1-LNC in Non-Small Cell Lung Cancer Patients.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4747)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   5  (bases 1 to 4747)
  AUTHORS   Jin,Y. and Wang,H.
  TITLE     Circ_0078607 inhibits the progression of ovarian cancer via
            regulating the miR-32-5p/SIK1 network
  JOURNAL   J Ovarian Res 15 (1), 3 (2022)
   PUBMED   34983607
  REMARK    GeneRIF: Circ_0078607 inhibits the progression of ovarian cancer
            via regulating the miR-32-5p/SIK1 network.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4747)
  AUTHORS   Hansen,J., Snow,C., Tuttle,E., Ghoneim,D.H., Yang,C.S., Spencer,A.,
            Gunter,S.A., Smyser,C.D., Gurnett,C.A., Shinawi,M., Dobyns,W.B.,
            Wheless,J., Halterman,M.W., Jansen,L.A., Paschal,B.M. and
            Paciorkowski,A.R.
  TITLE     De novo mutations in SIK1 cause a spectrum of developmental
            epilepsies
  JOURNAL   Am J Hum Genet 96 (4), 682-690 (2015)
   PUBMED   25839329
  REMARK    GeneRIF: De novo mutations in SIK1 cause a spectrum of
            developmental epilepsies.
            Erratum:[Am J Hum Genet. 2015 Jun 4;96(6):1009]
REFERENCE   7  (bases 1 to 4747)
  AUTHORS   Al-Hakim,A.K., Goransson,O., Deak,M., Toth,R., Campbell,D.G.,
            Morrice,N.A., Prescott,A.R. and Alessi,D.R.
  TITLE     14-3-3 cooperates with LKB1 to regulate the activity and
            localization of QSK and SIK
  JOURNAL   J Cell Sci 118 (Pt 23), 5661-5673 (2005)
   PUBMED   16306228
REFERENCE   8  (bases 1 to 4747)
  AUTHORS   Lizcano,J.M., Goransson,O., Toth,R., Deak,M., Morrice,N.A.,
            Boudeau,J., Hawley,S.A., Udd,L., Makela,T.P., Hardie,D.G. and
            Alessi,D.R.
  TITLE     LKB1 is a master kinase that activates 13 kinases of the AMPK
            subfamily, including MARK/PAR-1
  JOURNAL   EMBO J 23 (4), 833-843 (2004)
   PUBMED   14976552
REFERENCE   9  (bases 1 to 4747)
  AUTHORS   Nishimura,Y., Hayashi,M., Inada,H. and Tanaka,T.
  TITLE     Molecular cloning and characterization of mammalian homologues of
            vesicle-associated membrane protein-associated (VAMP-associated)
            proteins
  JOURNAL   Biochem Biophys Res Commun 254 (1), 21-26 (1999)
   PUBMED   9920726
REFERENCE   10 (bases 1 to 4747)
  AUTHORS   Ruiz,J.C., Conlon,F.L. and Robertson,E.J.
  TITLE     Identification of novel protein kinases expressed in the myocardium
            of the developing mouse heart
  JOURNAL   Mech Dev 48 (3), 153-164 (1994)
   PUBMED   7893599
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY008464.1, AB047786.1 and
            AP001046.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_173354.4.
            
            Summary: This gene encodes a serine/threonine protein kinase that
            contains a ubiquitin-associated (UBA) domain. The encoded protein
            is a member of the adenosine monophosphate-activated kinase (AMPK)
            subfamily of kinases that play a role in conserved signal
            transduction pathways. A mutation in this gene is associated with
            early infantile epileptic encephalopathy 30. [provided by RefSeq,
            Nov 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB047786.1, SRR7346977.2153149.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000270162.8/ ENSP00000270162.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 HY008464.1         3-11
            10-4715             AB047786.1         1-4706
            4716-4747           AP001046.1         147101-147132       c
FEATURES             Location/Qualifiers
     source          1..4747
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.3"
     gene            1..4747
                     /gene="SIK1"
                     /gene_synonym="DEE30; MSK; SIK; SIK-1; SIK1B; SNF1LK"
                     /note="salt inducible kinase 1"
                     /db_xref="GeneID:150094"
                     /db_xref="HGNC:HGNC:11142"
                     /db_xref="MIM:605705"
     exon            1..122
                     /gene="SIK1"
                     /gene_synonym="DEE30; MSK; SIK; SIK-1; SIK1B; SNF1LK"
                     /inference="alignment:Splign:2.1.0"
     exon            123..292
                     /gene="SIK1"
                     /gene_synonym="DEE30; MSK; SIK; SIK-1; SIK1B; SNF1LK"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..2488
                     /gene="SIK1"
                     /gene_synonym="DEE30; MSK; SIK; SIK-1; SIK1B; SNF1LK"
                     /EC_number="2.7.11.1"
                     /EC_number="2.7.11.1"
                     /note="myocardial SNF1-like kinase; salt-inducible protein
                     kinase 1; serine/threonine-protein kinase SNF1LK;
                     serine/threonine-protein kinase SNF1-like kinase 1;
                     Probable serine/threonine-protein kinase SIK1B;
                     Salt-inducible kinase 1B; Putative
                     serine/threonine-protein kinase SIK1B"
                     /codon_start=1
                     /product="serine/threonine-protein kinase SIK1"
                     /protein_id="NP_775490.2"
                     /db_xref="CCDS:CCDS33575.1"
                     /db_xref="GeneID:150094"
                     /db_xref="HGNC:HGNC:11142"
                     /db_xref="MIM:605705"
                     /translation="MVIMSEFSADPAGQGQGQQKPLRVGFYDIERTLGKGNFAVVKLA
                     RHRVTKTQVAIKIIDKTRLDSSNLEKIYREVQLMKLLNHPHIIKLYQVMETKDMLYIV
                     TEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDGN
                     MDIKLADFGFGNFYKSGEPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLV
                     CGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIAQIRQHR
                     WMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGIMQTLGVDRQRTVESLQNSSYNHF
                     AAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEVPQEGLSTDPFRPALLCPQ
                     PQTLVQSVLQAEMDCELQSSLQWPLFFPVDASCSGVFRPRPVSPSSLLDTAISEEARQ
                     GPGLEEEQDTQESLPSSTGRRHTLAEVSTRLSPLTAPCIVVSPSTTASPAEGTSSDSC
                     LTFSASKSPAGLSGTPATQGLLGACSPVRLASPFLGSQSATPVLQAQGGLGGAVLLPV
                     SFQEGRRASDTSLTQGLKAFRQQLRKTTRTKGFLGLNKIKGLARQVCQAPASRASRGG
                     LSPFHAPAQSPGLHGGAAGSREGWSLLEEVLEQQRLLQLQHHPAAAPGCSQAPQPAPA
                     PFVIAPCDGPGAAPLPSTLLTSGLPLLPPPLLQTGASPVASAAQLLDTHLHIGTGPTA
                     LPAVPPPRLARLAPGCEPLGLLQGDCEMEDLMPCSLGTFVLVQ"
     exon            293..409
                     /gene="SIK1"
                     /gene_synonym="DEE30; MSK; SIK; SIK-1; SIK1B; SNF1LK"
                     /inference="alignment:Splign:2.1.0"
     exon            410..473
                     /gene="SIK1"
                     /gene_synonym="DEE30; MSK; SIK; SIK-1; SIK1B; SNF1LK"
                     /inference="alignment:Splign:2.1.0"
     exon            474..635
                     /gene="SIK1"
                     /gene_synonym="DEE30; MSK; SIK; SIK-1; SIK1B; SNF1LK"
                     /inference="alignment:Splign:2.1.0"
     exon            636..760
                     /gene="SIK1"
                     /gene_synonym="DEE30; MSK; SIK; SIK-1; SIK1B; SNF1LK"
                     /inference="alignment:Splign:2.1.0"
     exon            761..884
                     /gene="SIK1"
                     /gene_synonym="DEE30; MSK; SIK; SIK-1; SIK1B; SNF1LK"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1108
                     /gene="SIK1"
                     /gene_synonym="DEE30; MSK; SIK; SIK-1; SIK1B; SNF1LK"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1255
                     /gene="SIK1"
                     /gene_synonym="DEE30; MSK; SIK; SIK-1; SIK1B; SNF1LK"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1381
                     /gene="SIK1"
                     /gene_synonym="DEE30; MSK; SIK; SIK-1; SIK1B; SNF1LK"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1598
                     /gene="SIK1"
                     /gene_synonym="DEE30; MSK; SIK; SIK-1; SIK1B; SNF1LK"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1880
                     /gene="SIK1"
                     /gene_synonym="DEE30; MSK; SIK; SIK-1; SIK1B; SNF1LK"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..2112
                     /gene="SIK1"
                     /gene_synonym="DEE30; MSK; SIK; SIK-1; SIK1B; SNF1LK"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..4747
                     /gene="SIK1"
                     /gene_synonym="DEE30; MSK; SIK; SIK-1; SIK1B; SNF1LK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4692..4697
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIK1"
                     /gene_synonym="DEE30; MSK; SIK; SIK-1; SIK1B; SNF1LK"
                     /note="hexamer: AATAAA"
     polyA_site      4715
                     /gene="SIK1"
                     /gene_synonym="DEE30; MSK; SIK; SIK-1; SIK1B; SNF1LK"
                     /note="major polyA site"
ORIGIN      
        1 gacatgcggc gcggccccgg aggcagcagc agcggcggcg gcagccggag cagtaggcac
       61 ccgagcagcg ccagcggccg agcgggcggc ttcctggcct gggcgctccg gtggcggcgg
      121 aggtgcgcgc ggagccatgg ttatcatgtc ggagttcagc gcggaccccg cgggccaggg
      181 tcagggccag cagaagcccc tccgggtggg tttttacgac atcgagcgga ccctgggcaa
      241 aggcaacttc gcggtggtga agctggcgcg gcatcgagtc accaaaacgc aggttgcaat
      301 aaaaataatt gataaaacac gattagattc aagcaatttg gagaaaatct atcgtgaggt
      361 tcagctgatg aagcttctga accatccaca catcataaag ctttaccagg ttatggaaac
      421 aaaggacatg ctttacatcg tcactgaatt tgctaaaaat ggagaaatgt ttgattattt
      481 gacttccaac gggcacctga gtgagaacga ggcgcggaag aagttctggc aaatcctgtc
      541 ggccgtggag tactgtcacg accatcacat cgtccaccgg gacctcaaga ccgagaacct
      601 cctgctggat ggcaacatgg acatcaagct ggcagatttt ggatttggga atttctacaa
      661 gtcaggagag cctctgtcca cgtggtgtgg gagccccccg tatgccgccc cggaagtctt
      721 tgaggggaag gagtatgaag gcccccagct ggacatctgg agcctgggcg tggtgctgta
      781 cgtcctggtc tgcggttctc tccccttcga tgggcctaac ctgccgacgc tgagacagcg
      841 ggtgctggag ggccgcttcc gcatcccctt cttcatgtct caagactgtg agagcctgat
      901 ccgccgcatg ctggtggtgg accccgccag gcgcatcacc atcgcccaga tccggcagca
      961 ccggtggatg cgggctgagc cctgcttgcc gggacccgcc tgccccgcct tctccgcaca
     1021 cagctacacc tccaacctgg gcgactacga tgagcaggcg ctgggtatca tgcagaccct
     1081 gggcgtggac cggcagagga cggtggagtc actgcaaaac agcagctata accactttgc
     1141 tgccatttat tacctcctcc ttgagcggct caaggagtat cggaatgccc agtgcgcccg
     1201 ccccgggcct gccaggcagc cgcggcctcg gagctcggac ctcagtggtt tggaggtgcc
     1261 tcaggaaggt ctttccaccg accctttccg acctgccttg ctgtgcccgc agccgcagac
     1321 cttggtgcag tccgtcctcc aggccgagat ggactgtgag ctccagagct cgctgcagtg
     1381 gcccttgttc ttcccggtgg atgccagctg cagcggagtg ttccggcccc ggcccgtgtc
     1441 cccaagcagc ctgctggaca cagccatcag tgaggaggcc aggcaggggc cgggcctaga
     1501 ggaggagcag gacacgcagg agtccctgcc cagcagcacg ggccggaggc acaccctggc
     1561 cgaggtctcc acccgcctct ccccactcac cgcgccatgt atagtcgtct ccccctccac
     1621 cacggcaagt cctgcagagg gaaccagctc tgacagttgt ctgaccttct ctgcgagcaa
     1681 aagccccgcg gggctcagtg gcaccccggc cactcagggg ctgctgggcg cctgctcccc
     1741 ggtcaggctg gcctcgccct tcctggggtc gcagtccgcc accccagtgc tgcaggctca
     1801 ggggggcttg ggaggagctg ttctgctccc tgtcagcttc caggagggac ggcgggcgtc
     1861 ggacacctca ctgactcaag ggctgaaggc ctttcggcag cagctgagga agaccacgcg
     1921 gaccaaaggg tttctgggac tgaacaaaat caaggggctg gctcgccagg tgtgccaggc
     1981 ccccgccagc cgggccagca ggggcggcct gagccccttc cacgcccctg cacagagccc
     2041 aggcctgcac ggcggcgcag ccggcagccg ggagggctgg agcctgctgg aggaggtgct
     2101 agagcagcag aggctgctcc agttacagca ccacccggcc gctgcacccg gctgctccca
     2161 ggccccccag ccggcccctg ccccgtttgt gatcgccccc tgtgatggcc ctggggctgc
     2221 cccgctcccc agcaccctcc tcacgtcggg gctcccgctg ctgccgcccc cactcctgca
     2281 gaccggcgcg tccccggtgg cctcagcggc gcagctcctg gacacacacc tgcacattgg
     2341 caccggcccc accgccctcc ccgctgtgcc cccaccacgc ctggccaggc tggccccagg
     2401 ttgtgagccc ctggggctgc tgcaggggga ctgtgagatg gaggacctga tgccctgctc
     2461 cctaggcacg tttgtcctgg tgcagtgagg gcagccctgc atcctggcac ggacactgac
     2521 tcttacagca ataacttcag aggaggtgaa gacatctggc ctcaaagcca agaactttct
     2581 agaagcgaaa taagcaatac gttaggtgtt ttggcttttt agtttatttt tgttttattt
     2641 ttttcttgca ctgagtgacc tcaactttga gtagggactg gaaactttag gaagaaagat
     2701 aattgagggg cgtgtctggg ggcgggggca ggaggggagc ggggtggagg gaacacgtgc
     2761 agtgccgtgg tgtggggatc tcggcccctc tctctgggtt cgtcgtggtt gagatgatta
     2821 cctcggacgt ctacggaaac gagcgggcgc attgttgtcc gcttgtgtgt gtgtgtgtgt
     2881 gtgtgtgtgt gcgcgtgcat tgattactat ccatttcttt agtcaacgct ctccacttcc
     2941 tgatttctgc tttaaggaaa actgtgaact ttctgcttca tgtatcagtt ttaaagcagc
     3001 ccaggcaaag atcatctaca gattctagga attctctccc ctgaaatcaa aacctggaag
     3061 actttttttt cttattttag ttgagaagtt tcataaactg ctcaaggatt agttttccag
     3121 gactctgcgg aggaacggca ggaagaacct cagagagggc agaggtgact tcaaagtgct
     3181 ggggactccg tcctgagggt cacttggccc tgagcccctg cgtgcccttg cggaagccca
     3241 gaagcttctt cctgctgcac ctcccgtttc cgctgctgct gacgtttatg catttcatga
     3301 tggggtccaa caagaacacc tgacttgggt gaagttgtgc aatattggag gctgactgta
     3361 gggctgggca gctgggagac aggctcatgg ctcatggctc atggctcagg gcggtgcctg
     3421 ccctgggccg ggacccccct ccccaccccc cacctaggct ttttgggttt tgttcaagga
     3481 aggtaaagtg agaggtttag gtcagtgttt ttaagttttt gttttttttt taaagcaaat
     3541 cctgtatatg tatctacatg ggagacaggt agacactact tatttgttac attttgtact
     3601 atacgtttgt gttccaggtt tcagcttccc tcgctcctgt tgttaagaag cgtccctgtc
     3661 agcacaggtg tgcattgagg aaggggcccc agggccttcg ctccctcagc actggggtgg
     3721 aggcggcagg aaggggcggc ccttacctgg caggtctggg cgcaccttta gcaggtggac
     3781 tccgtggggc tccaccagcc agaagcctct ggaaggcaac gaaggcaatg ctgctccctg
     3841 agtccagtcc ccgcccccaa acccagccca ggtgccttca gctacttcgg cttcttaaac
     3901 cctgcagtgt taaacagagg cattgagaaa ggggaaaggc gggtattttt aaaagccaaa
     3961 gattgaccca gttacttgag ggtagggagg cgggcccagt gcaggaggct gcatccctgg
     4021 cctgctggtg cccaccgggg gctgtgcctg tgccgggccg cagggaagct ggctgccccc
     4081 attcctgctg ctgctgctgc tgctgctctg tggctgtttc aaagactggg cgaaaggctg
     4141 tccggagggc agaccaggtg ccttgccgca gagaaaacac caaagtctcc tgttcgctca
     4201 taaagaagtt tttgggatgg gagagaatcc agaccatctt ggggcagcca ggcccttgcc
     4261 ttcattttta cagaggtagc acaactgatt ccaacacaaa accccttccc ctttttaaaa
     4321 tgatttctgt tctaatgcca tagatcaaag gcctcagaaa ccattgtgtg tttcctcttt
     4381 gaagcaatga caagcacttt actttcacgg tggtttttgt tttttcttat tgctgtggaa
     4441 cctcttttgg aggacgttaa aggcgtgttt tacttgtttt tttaagagtg tgtgatgtgt
     4501 gttttgtaga tttcttgaca gtgctgtaat acagacggca atgcaatagc ctatttaaag
     4561 acactacgtg atctgattga gatgtacata gttttttttt ttaccataac tgaattattt
     4621 tatctcttat gttaacatga gaaatgtatg ccaaatgatt agttgatgta tgttttttaa
     4681 tttaatattt aaataaaata tttggaagga aaaaaccttg actttttccc ttcctctctc
     4741 tctcatc
//
