LOCUS       NM_005866               1672 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens sigma non-opioid intracellular receptor 1 (SIGMAR1),
            transcript variant 1, mRNA.
ACCESSION   NM_005866
VERSION     NM_005866.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1672)
  AUTHORS   Kong,M., Chen,Z., Lin,Z., Yin,P. and Zhao,Q.
  TITLE     SIGMAR1 targets AMPK/ULK1 pathway to inhibit SH-SY5Y cell apoptosis
            by regulating endoplasmic reticulum stress and autophagy
  JOURNAL   Funct Integr Genomics 24 (4), 134 (2024)
   PUBMED   39107544
  REMARK    GeneRIF: SIGMAR1 targets AMPK/ULK1 pathway to inhibit SH-SY5Y cell
            apoptosis by regulating endoplasmic reticulum stress and autophagy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1672)
  AUTHORS   D'Atri,I., Martin,E.R., Yang,L., Sears,E., Baple,E., Crosby,A.H.,
            Chilton,J.K. and Oguro-Ando,A.
  TITLE     Unraveling the CLCC1 interactome: Impact of the Asp25Glu variant
            and its interaction with SigmaR1 at the Mitochondrial-Associated ER
            Membrane (MAM)
  JOURNAL   Neurosci Lett 830, 137778 (2024)
   PUBMED   38621504
  REMARK    GeneRIF: Unraveling the CLCC1 interactome: Impact of the Asp25Glu
            variant and its interaction with SigmaR1 at the
            Mitochondrial-Associated ER Membrane (MAM).
REFERENCE   3  (bases 1 to 1672)
  AUTHORS   Hosszu,A., Toth,A.R., Lakat,T., Stepanova,G., Antal,Z.,
            Wagner,L.J., Szabo,A.J. and Fekete,A.
  TITLE     The Sigma-1 Receptor Is a Novel Target for Improving Cold
            Preservation in Rodent Kidney Transplants
  JOURNAL   Int J Mol Sci 24 (14), 11630 (2023)
   PUBMED   37511389
  REMARK    GeneRIF: The Sigma-1 Receptor Is a Novel Target for Improving Cold
            Preservation in Rodent Kidney Transplants.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1672)
  AUTHORS   Zhao,F., Yang,T., Zhou,L., Li,R., Liu,J., Zhao,J. and Jia,R.
  TITLE     Sig1R activates extracellular matrix-induced bladder cancer cell
            proliferation and angiogenesis by combing beta-integrin
  JOURNAL   Aging (Albany NY) 15 (10), 4182-4201 (2023)
   PUBMED   37199665
  REMARK    GeneRIF: Sig1R activates extracellular matrix-induced bladder
            cancer cell proliferation and angiogenesis by combing
            beta-integrin.
REFERENCE   5  (bases 1 to 1672)
  AUTHORS   Couly,S., Yasui,Y. and Su,T.P.
  TITLE     SIGMAR1 Confers Innate Resilience against Neurodegeneration
  JOURNAL   Int J Mol Sci 24 (9), 7767 (2023)
   PUBMED   37175473
  REMARK    GeneRIF: SIGMAR1 Confers Innate Resilience against
            Neurodegeneration.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1672)
  AUTHORS   Dussossoy,D., Carayon,P., Belugou,S., Feraut,D., Bord,A.,
            Goubet,C., Roque,C., Vidal,H., Combes,T., Loison,G. and Casellas,P.
  TITLE     Colocalization of sterol isomerase and sigma(1) receptor at
            endoplasmic reticulum and nuclear envelope level
  JOURNAL   Eur J Biochem 263 (2), 377-386 (1999)
   PUBMED   10406945
REFERENCE   7  (bases 1 to 1672)
  AUTHORS   Ganapathy,M.E., Prasad,P.D., Huang,W., Seth,P., Leibach,F.H. and
            Ganapathy,V.
  TITLE     Molecular and ligand-binding characterization of the sigma-receptor
            in the Jurkat human T lymphocyte cell line
  JOURNAL   J Pharmacol Exp Ther 289 (1), 251-260 (1999)
   PUBMED   10087012
REFERENCE   8  (bases 1 to 1672)
  AUTHORS   Prasad,P.D., Li,H.W., Fei,Y.J., Ganapathy,M.E., Fujita,T.,
            Plumley,L.H., Yang-Feng,T.L., Leibach,F.H. and Ganapathy,V.
  TITLE     Exon-intron structure, analysis of promoter region, and chromosomal
            localization of the human type 1 sigma receptor gene
  JOURNAL   J Neurochem 70 (2), 443-451 (1998)
   PUBMED   9453537
REFERENCE   9  (bases 1 to 1672)
  AUTHORS   Jbilo,O., Vidal,H., Paul,R., De Nys,N., Bensaid,M., Silve,S.,
            Carayon,P., Davi,D., Galiegue,S., Bourrie,B., Guillemot,J.C.,
            Ferrara,P., Loison,G., Maffrand,J.P., Le Fur,G. and Casellas,P.
  TITLE     Purification and characterization of the human SR 31747A-binding
            protein. A nuclear membrane protein related to yeast sterol
            isomerase
  JOURNAL   J Biol Chem 272 (43), 27107-27115 (1997)
   PUBMED   9341151
REFERENCE   10 (bases 1 to 1672)
  AUTHORS   Kekuda,R., Prasad,P.D., Fei,Y.J., Leibach,F.H. and Ganapathy,V.
  TITLE     Cloning and functional expression of the human type 1 sigma
            receptor (hSigmaR1)
  JOURNAL   Biochem Biophys Res Commun 229 (2), 553-558 (1996)
   PUBMED   8954936
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK130502.1, AL450283.16 and
            BC007839.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005866.3.
            
            Summary: This gene encodes a receptor protein that interacts with a
            variety of psychotomimetic drugs, including cocaine and
            amphetamines. The receptor is believed to play an important role in
            the cellular functions of various tissues associated with the
            endocrine, immune, and nervous systems. As indicated by its
            previous name, opioid receptor sigma 1 (OPRS1), the product of this
            gene was erroneously thought to function as an opioid receptor; it
            is now thought to be a non-opioid receptor. Mutations in this gene
            has been associated with juvenile amyotrophic lateral sclerosis 16.
            Alternative splicing of this gene results in transcript variants
            encoding distinct isoforms. [provided by RefSeq, Aug 2013].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK130502.1, SRR3476690.394732.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000277010.9/ ENSP00000277010.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-792               AK130502.1         23-814
            793-793             AL450283.16        23139-23139         c
            794-1672            BC007839.2         703-1581
FEATURES             Location/Qualifiers
     source          1..1672
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.3"
     gene            1..1672
                     /gene="SIGMAR1"
                     /gene_synonym="ALS16; DSMA2; HMNR2; hSigmaR1; OPRS1;
                     SIG-1R; sigma1R; SR-BP; SR-BP1; SRBP"
                     /note="sigma non-opioid intracellular receptor 1"
                     /db_xref="GeneID:10280"
                     /db_xref="HGNC:HGNC:8157"
                     /db_xref="MIM:601978"
     exon            1..241
                     /gene="SIGMAR1"
                     /gene_synonym="ALS16; DSMA2; HMNR2; hSigmaR1; OPRS1;
                     SIG-1R; sigma1R; SR-BP; SR-BP1; SRBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..762
                     /gene="SIGMAR1"
                     /gene_synonym="ALS16; DSMA2; HMNR2; hSigmaR1; OPRS1;
                     SIG-1R; sigma1R; SR-BP; SR-BP1; SRBP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     SR31747 binding protein 1; sigma 1-type opioid receptor;
                     aging-associated gene 8 protein"
                     /codon_start=1
                     /product="sigma non-opioid intracellular receptor 1
                     isoform 1"
                     /protein_id="NP_005857.1"
                     /db_xref="CCDS:CCDS6562.1"
                     /db_xref="GeneID:10280"
                     /db_xref="HGNC:HGNC:8157"
                     /db_xref="MIM:601978"
                     /translation="MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQ
                     LARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSE
                     YVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEAT
                     AVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYL
                     FGQDP"
     exon            242..442
                     /gene="SIGMAR1"
                     /gene_synonym="ALS16; DSMA2; HMNR2; hSigmaR1; OPRS1;
                     SIG-1R; sigma1R; SR-BP; SR-BP1; SRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            443..535
                     /gene="SIGMAR1"
                     /gene_synonym="ALS16; DSMA2; HMNR2; hSigmaR1; OPRS1;
                     SIG-1R; sigma1R; SR-BP; SR-BP1; SRBP"
                     /inference="alignment:Splign:2.1.0"
     exon            536..1672
                     /gene="SIGMAR1"
                     /gene_synonym="ALS16; DSMA2; HMNR2; hSigmaR1; OPRS1;
                     SIG-1R; sigma1R; SR-BP; SR-BP1; SRBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1648..1653
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIGMAR1"
                     /gene_synonym="ALS16; DSMA2; HMNR2; hSigmaR1; OPRS1;
                     SIG-1R; sigma1R; SR-BP; SR-BP1; SRBP"
                     /note="hexamer: AATAAA"
     polyA_site      1672
                     /gene="SIGMAR1"
                     /gene_synonym="ALS16; DSMA2; HMNR2; hSigmaR1; OPRS1;
                     SIG-1R; sigma1R; SR-BP; SR-BP1; SRBP"
                     /note="major polyA site"
ORIGIN      
        1 gtgggcagcc ggcgggctcc gaggccgtga gcgcaaagcc tcaggccccg gctccctcct
       61 gagctgcgcc gtgccaggcc gcccgccggg atgcagtggg ccgtgggccg gcggtgggcg
      121 tgggccgcgc tgctcctggc tgtcgcagcg gtgctgaccc aggtcgtctg gctctggctg
      181 ggtacgcaga gcttcgtctt ccagcgcgaa gagatagcgc agttggcgcg gcagtacgct
      241 gggctggacc acgagctggc cttctctcgt ctgatcgtgg agctgcggcg gctgcaccca
      301 ggccacgtgc tgcccgacga ggagctgcag tgggtgttcg tgaatgcggg tggctggatg
      361 ggcgccatgt gccttctgca cgcctcgctg tccgagtatg tgctgctctt cggcaccgcc
      421 ttgggctccc gcggccactc ggggcgctac tgggctgaga tctcggatac catcatctct
      481 ggcaccttcc accagtggag agagggcacc accaaaagtg aggtcttcta cccaggggag
      541 acggtagtac acgggcctgg tgaggcaaca gctgtggagt gggggccaaa cacatggatg
      601 gtggagtacg gccggggcgt catcccatcc accctggcct tcgcgctggc cgacactgtc
      661 ttcagcaccc aggacttcct caccctcttc tatactcttc gctcctatgc tcggggcctc
      721 cggcttgagc tcaccaccta cctctttggc caggaccctt gaccagccag gcctgaagga
      781 agacctgcgg atagacagga gcgggcaggc ccgcacatat ccacttgctg gagcccatgt
      841 ttacagacag ggacatacac catgcagatc ctgagttcct gctgtatgag cagggatatc
      901 catgcttatg tatccaaaca cagagaccca tgggaacaaa tgagacacat atagatactg
      961 agacctgtgt gtacagtagg accatgcact cacacccatc tggagaggga gcccccggta
     1021 taccaaggga gccagttgtg ttcagacaca cacatcacag cttgactcac taactgaggc
     1081 ctttccatag ctccacagct tcccacctcc tccccaccaa accggggttc tagagttaag
     1141 gatgggggag ggtattatac tgcctcagtc tgactcctca acccagcagc aatttgaggg
     1201 gatgaggggg aagaggagct gccttttgga ggcccccttc acctgcagct atgatgccct
     1261 tccccttctc ccctgtcctc accatatgcc ttatccccat tctactcccc tgctatgcaa
     1321 gtgcccctgt ggcttgtccc caaccccctc agcaacaaag ctcagctggg gaacgagagt
     1381 aatttgaaga atgcttgaag tcagcgtctt ccattccaga aagaccccca ttcttccttt
     1441 gggggtatga tgtggaagct ggtttcagcc caggacccac cactgaggag aggatctaga
     1501 caggtgggcc taattccaag gggcccttcc tggcctggag aaggcctttt acacacacac
     1561 aacacataca cacacacaca cacacacaca tatcacagtt ttcacacagc ccctgctgca
     1621 ttctctgtcc atctgtctgt ttctattaat aaagatttgt tgatctgttc ca
//
