LOCUS       NM_001385465            1983 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens SIGLEC family like 1 (SIGLECL1), transcript variant 4,
            mRNA.
ACCESSION   NM_001385465 XM_005258799
VERSION     NM_001385465.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1983)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1983)
  AUTHORS   Rendina,A., Drongitis,D., Donizetti,A., Fucci,L., Milan,G.,
            Tripodi,F., Giustezza,F., Postiglione,A., Pappata,S., Ferrari,R.,
            Bossu,P., Angiolillo,A., di Costanzo,A., Caiazzo,M. and Vitale,E.
  TITLE     CD33 and SIGLECL1 Immunoglobulin Superfamily Involved in Dementia
  JOURNAL   J Neuropathol Exp Neurol 79 (8), 891-901 (2020)
   PUBMED   32647856
  REMARK    GeneRIF: CD33 and SIGLECL1 Immunoglobulin Superfamily Involved in
            Dementia.
REFERENCE   3  (bases 1 to 1983)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1983)
  AUTHORS   Wu,J.H., Lemaitre,R.N., Manichaikul,A., Guan,W., Tanaka,T., Foy,M.,
            Kabagambe,E.K., Djousse,L., Siscovick,D., Fretts,A.M., Johnson,C.,
            King,I.B., Psaty,B.M., McKnight,B., Rich,S.S., Chen,Y.D.,
            Nettleton,J.A., Tang,W., Bandinelli,S., Jacobs,D.R. Jr.,
            Browning,B.L., Laurie,C.C., Gu,X., Tsai,M.Y., Steffen,L.M.,
            Ferrucci,L., Fornage,M. and Mozaffarian,D.
  TITLE     Genome-wide association study identifies novel loci associated with
            concentrations of four plasma phospholipid fatty acids in the de
            novo lipogenesis pathway: results from the Cohorts for Heart and
            Aging Research in Genomic Epidemiology (CHARGE) consortium
  JOURNAL   Circ Cardiovasc Genet 6 (2), 171-183 (2013)
   PUBMED   23362303
REFERENCE   5  (bases 1 to 1983)
  AUTHORS   Angata,T., Varki,N.M. and Varki,A.
  TITLE     A second uniquely human mutation affecting sialic acid biology
  JOURNAL   J Biol Chem 276 (43), 40282-40287 (2001)
   PUBMED   11546777
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC063977.6.
            
            On Jul 17, 2020 this sequence version replaced XM_005258799.5.
            
            Transcript Variant: This variant (4) represents the longest
            transcript and encodes the longer isoform (1). Variants 1, 4, and 5
            all encode the same isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.331479.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000601727.6/ ENSP00000469601.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-466               AC063977.6         130241-130706
            467-678             AC063977.6         143044-143255
            679-960             AC063977.6         144529-144810
            961-1066            AC063977.6         144938-145043
            1067-1223           AC063977.6         146534-146690
            1224-1983           AC063977.6         147732-148491
FEATURES             Location/Qualifiers
     source          1..1983
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..1983
                     /gene="SIGLECL1"
                     /gene_synonym="C19orf75; SIGLEC23P; SIGLECP7"
                     /note="SIGLEC family like 1"
                     /db_xref="GeneID:284369"
                     /db_xref="HGNC:HGNC:26856"
     exon            1..466
                     /gene="SIGLECL1"
                     /gene_synonym="C19orf75; SIGLEC23P; SIGLECP7"
                     /inference="alignment:Splign:2.1.0"
     exon            467..678
                     /gene="SIGLECL1"
                     /gene_synonym="C19orf75; SIGLEC23P; SIGLECP7"
                     /inference="alignment:Splign:2.1.0"
     CDS             657..1250
                     /gene="SIGLECL1"
                     /gene_synonym="C19orf75; SIGLEC23P; SIGLECP7"
                     /note="isoform 1 is encoded by transcript variant 4;
                     SIGLEC family-like protein 1; sialic acid binding Ig-like
                     lectin, pseudogene 7"
                     /codon_start=1
                     /product="SIGLEC family-like protein 1 isoform 1"
                     /protein_id="NP_001372394.1"
                     /db_xref="CCDS:CCDS12827.1"
                     /db_xref="GeneID:284369"
                     /db_xref="HGNC:HGNC:26856"
                     /translation="MLPLLQLVPAKLLNSSCSLEKTLQCSCSFHGIPTPSVQWWMGGV
                     PVGVDGMDGSLQVTSTMLGPWANSTISLTEEPEMGMRLLCEGKNQNGTHALSILLMSR
                     KSSLAAQAFVKGLIQGAIYAGIVIALLFLCLLPLIVKHIRKKQAKKAAAIRAKKSSKV
                     RASQELEMSLKPEEPGKPVVATFSESRILEKQDKRAS"
     exon            679..960
                     /gene="SIGLECL1"
                     /gene_synonym="C19orf75; SIGLEC23P; SIGLECP7"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1066
                     /gene="SIGLECL1"
                     /gene_synonym="C19orf75; SIGLEC23P; SIGLECP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1223
                     /gene="SIGLECL1"
                     /gene_synonym="C19orf75; SIGLEC23P; SIGLECP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1983
                     /gene="SIGLECL1"
                     /gene_synonym="C19orf75; SIGLEC23P; SIGLECP7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1296..1301
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIGLECL1"
                     /gene_synonym="C19orf75; SIGLEC23P; SIGLECP7"
                     /note="hexamer: ATTACA"
     polyA_site      1314
                     /gene="SIGLECL1"
                     /gene_synonym="C19orf75; SIGLEC23P; SIGLECP7"
     regulatory      1963..1968
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIGLECL1"
                     /gene_synonym="C19orf75; SIGLEC23P; SIGLECP7"
                     /note="hexamer: AATACA"
     polyA_site      1983
                     /gene="SIGLECL1"
                     /gene_synonym="C19orf75; SIGLEC23P; SIGLECP7"
                     /note="major polyA site"
ORIGIN      
        1 gcactcacct aaggatgcga gctagcaggt cttgcagcgg ctatcacgcc cctcacgccg
       61 ctatctctgt gcagccgact gaggatccct agtcgcataa ggctgtgcct ggcctgttgg
      121 cgtccctggc agttgttggg ttctggcggt tgttgggtcc ctggcagttg ttggcggttg
      181 ttgggttcct tcattgaaac tgcactaact gggcttccag tcagcgtcag tcagcggatc
      241 cttgggccgt ggggcagccg caggtcggtt aggccaccag ggcggctctc gtgccagtga
      301 ggcccctgag agccctttgg tcagacagag gctaaatctg aacagtcagg cggtgagatt
      361 aagcatagtc agggagttcg ccaggagcca gcgttcctca gcctccacca cgtcagtcac
      421 ctggtcagcc agagggcagc tggggcgaca tccatctacc aagaaggtga acaggccttc
      481 acgatgacca gagacagaag cccctgactt ggctaaagat acttctgctc tccccatccc
      541 cacatcctct ttcagttacg catcacctca ctccttctga accatatggt tctgatgtca
      601 gagccagtgt agtaaagagc ttctgctgtt cctgagaact gttgctgctg gaagtgatgc
      661 ttccactgct acagctggta cctgctaagc tgctcaactc ctcttgctcc ttggagaaga
      721 cactgcagtg cagctgttcc ttccatggga ttcccacacc ctctgtgcag tggtggatgg
      781 gaggagtccc cgtgggtgtg gatggcatgg atggcagcct ccaagtgact tccaccatgc
      841 ttggcccctg ggctaacagc accatcagcc taactgaaga gccagaaatg ggcatgagac
      901 ttctctgtga ggggaagaac caaaacggaa cccatgcttt gagcatccta ctgatgtcaa
      961 gaaagagttc tttggctgcc caggccttcg tgaaagggct gatccagggt gctatctatg
     1021 cgggaattgt aattgcgctg ctcttcctct gcctcctccc tctcatagtg aaacatatca
     1081 gaaagaagca ggcgaagaaa gctgcagcga tcagagcaaa aaagagctct aaagtcagag
     1141 caagccaaga acttgagatg tctctgaagc ctgaggaacc aggaaaaccc gtagtcgcca
     1201 cattttctga gagccggata ttggaaaagc aagataaacg agccagctaa gcctgtggaa
     1261 catgcctcat acctggagtc gccattatcc ctggaattac aaagatctgc aaaatttata
     1321 gcgctcacag aaaccctgga ggctgtaata aacctggagc cccctggact ctcctcagct
     1381 cacaaaaccc tctcaattcc tacacatccc ttaacactca ttctccattg aataggtggt
     1441 tactcttaga cctagtctta gaacctctga agacacactt tgtaatttgt tgtttggcta
     1501 aatgagaaga aatctgtgcc accctgggaa ggtgtcaaaa gaaggaaaaa tacatgtgac
     1561 aatatgaatc aagtccatca gcaagttact tttgagcgcc tactgtgtgt cagtgcctga
     1621 gatacaccta caagagcgcc aggctttcaa gccttcatat ctggatagaa tcccaacttc
     1681 agtgcttggt ggctgtctat ctttggacaa gatctttcat tccccatcct ttgaacatca
     1741 catgacccat atctgggtgg agaatgggtg aaaagtactg ttcagagatg caggtgagaa
     1801 aaaacatgac gatgggccct gaatgccaag attcattgga gctttggagc tttatcttgt
     1861 aggaccttat cctgactccc ttagaatgta agttccaaga gaacagggac tttgtctgcc
     1921 ttgttttcta cttttatcac cagcacccag aatgatgcct aaaatacaat aagatctcaa
     1981 gaa
//
