LOCUS       NM_014441               1692 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens sialic acid binding Ig like lectin 9 (SIGLEC9),
            transcript variant 2, mRNA.
ACCESSION   NM_014441
VERSION     NM_014441.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1692)
  AUTHORS   Ge,L., Wang,N., Chen,Z., Xu,S. and Zhou,L.
  TITLE     Expression of Siglec-9 in peripheral blood neutrophils was
            increased and associated with disease severity in patients with
            AECOPD
  JOURNAL   Cytokine 177, 156558 (2024)
   PUBMED   38412768
  REMARK    GeneRIF: Expression of Siglec-9 in peripheral blood neutrophils was
            increased and associated with disease severity in patients with
            AECOPD.
REFERENCE   2  (bases 1 to 1692)
  AUTHORS   He,X., Zhang,X., Wu,B., Deng,J., Zhang,Y., Zhu,A., Yuan,Y., Lin,Y.,
            Chen,A., Feng,J., Wang,X., Wu,S., Liu,Y., Liu,J., Wang,Y., Li,R.,
            Liang,C., Yuan,Q., Liang,Y., Fang,Q., Xi,Z., Li,W., Liang,L.,
            Zhang,Z., Tang,H., Peng,Y., Ke,C., Ma,X., Cai,W., Pan,T., Liu,B.,
            Deng,K., Chen,J., Zhao,J., Wei,X., Chen,R., Zhang,Y. and Zhang,H.
  TITLE     The receptor binding domain of SARS-CoV-2 Omicron subvariants
            targets Siglec-9 to decrease its immunogenicity by preventing
            macrophage phagocytosis
  JOURNAL   Nat Immunol 25 (4), 622-632 (2024)
   PUBMED   38454157
  REMARK    GeneRIF: The receptor binding domain of SARS-CoV-2 Omicron
            subvariants targets Siglec-9 to decrease its immunogenicity by
            preventing macrophage phagocytosis.
REFERENCE   3  (bases 1 to 1692)
  AUTHORS   Zhang,Y., Jin,K., Dai,Y., Hu,N., Zhou,T., Yang,Z., Ding,N.,
            Zhang,R., Xu,R., Zhao,J., Han,Y., Zhu,C., Zhu,J. and Li,J.
  TITLE     The change of Siglec-9 expression in peripheral blood NK cells of
            SFTS patients can affect the function of NK cells
  JOURNAL   Immunol Lett 263, 97-104 (2023)
   PUBMED   37865296
  REMARK    GeneRIF: The change of Siglec-9 expression in peripheral blood NK
            cells of SFTS patients can affect the function of NK cells.
REFERENCE   4  (bases 1 to 1692)
  AUTHORS   Mei,Y., Wang,X., Zhang,J., Liu,D., He,J., Huang,C., Liao,J.,
            Wang,Y., Feng,Y., Li,H., Liu,X., Chen,L., Yi,W., Chen,X., Bai,H.M.,
            Wang,X., Li,Y., Wang,L., Liang,Z., Ren,X., Qiu,L., Hui,Y.,
            Zhang,Q., Leng,Q., Chen,J. and Jia,G.
  TITLE     Siglec-9 acts as an immune-checkpoint molecule on macrophages in
            glioblastoma, restricting T-cell priming and immunotherapy response
  JOURNAL   Nat Cancer 4 (9), 1273-1291 (2023)
   PUBMED   37460871
  REMARK    GeneRIF: Siglec-9 acts as an immune-checkpoint molecule on
            macrophages in glioblastoma, restricting T-cell priming and
            immunotherapy response.
REFERENCE   5  (bases 1 to 1692)
  AUTHORS   Avril,T., Floyd,H., Lopez,F., Vivier,E. and Crocker,P.R.
  TITLE     The membrane-proximal immunoreceptor tyrosine-based inhibitory
            motif is critical for the inhibitory signaling mediated by
            Siglecs-7 and -9, CD33-related Siglecs expressed on human monocytes
            and NK cells
  JOURNAL   J Immunol 173 (11), 6841-6849 (2004)
   PUBMED   15557178
  REMARK    GeneRIF: Siglec-9 can inhibit Fc epsilon receptor I-mediated
            serotonin release from rat basophilic leukemia cells and recruit
            the tyrosine phosphatases SHP-1 and SHP-2.
REFERENCE   6  (bases 1 to 1692)
  AUTHORS   Ikehara,Y., Ikehara,S.K. and Paulson,J.C.
  TITLE     Negative regulation of T cell receptor signaling by Siglec-7
            (p70/AIRM) and Siglec-9
  JOURNAL   J Biol Chem 279 (41), 43117-43125 (2004)
   PUBMED   15292262
  REMARK    GeneRIF: Siglec-7 and Siglec-9 are capable of negative regulation
            of TCR signaling and ligand binding is required for optimal
            activity
REFERENCE   7  (bases 1 to 1692)
  AUTHORS   Sonnenburg,J.L., Altheide,T.K. and Varki,A.
  TITLE     A uniquely human consequence of domain-specific functional
            adaptation in a sialic acid-binding receptor
  JOURNAL   Glycobiology 14 (4), 339-346 (2004)
   PUBMED   14693915
  REMARK    GeneRIF: Binding studies on recombinant human Siglec-9 show
            recognition of both Neu5Ac and Neu5Gc; in striking contrast,
            chimpanzee and gorilla Siglec-9 strongly prefer binding Neu5Gc.
REFERENCE   8  (bases 1 to 1692)
  AUTHORS   Zhang,J.Q., Nicoll,G., Jones,C. and Crocker,P.R.
  TITLE     Siglec-9, a novel sialic acid binding member of the immunoglobulin
            superfamily expressed broadly on human blood leukocytes
  JOURNAL   J Biol Chem 275 (29), 22121-22126 (2000)
   PUBMED   10801862
REFERENCE   9  (bases 1 to 1692)
  AUTHORS   Angata,T. and Varki,A.
  TITLE     Cloning, characterization, and phylogenetic analysis of siglec-9, a
            new member of the CD33-related group of siglecs. Evidence for
            co-evolution with sialic acid synthesis pathways
  JOURNAL   J Biol Chem 275 (29), 22127-22135 (2000)
   PUBMED   10801860
REFERENCE   10 (bases 1 to 1692)
  AUTHORS   Foussias,G., Yousef,G.M. and Diamandis,E.P.
  TITLE     Identification and molecular characterization of a novel member of
            the siglec family (SIGLEC9)
  JOURNAL   Genomics 67 (2), 171-178 (2000)
   PUBMED   10903842
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011473.4.
            
            On Jul 1, 2020 this sequence version replaced NM_014441.2.
            
            Transcript Variant: This variant (2) includes an alternate 3'
            terminal coding exon, compared to variant 1. The resulting protein
            (isoform 2) is shorter and has a distinct C-terminus, compared to
            isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF227924.1, AY358913.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000250360.8/ ENSP00000250360.2
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-490               AC011473.4         124988-125477
            491-769             AC011473.4         125679-125957
            770-817             AC011473.4         126163-126210
            818-1084            AC011473.4         127112-127378
            1085-1175           AC011473.4         128031-128121
            1176-1272           AC011473.4         128496-128592
            1273-1692           AC011473.4         129973-130392
FEATURES             Location/Qualifiers
     source          1..1692
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..1692
                     /gene="SIGLEC9"
                     /gene_synonym="CD329; CDw329; FOAP-9; OBBP-LIKE; siglec-9"
                     /note="sialic acid binding Ig like lectin 9"
                     /db_xref="GeneID:27180"
                     /db_xref="HGNC:HGNC:10878"
                     /db_xref="MIM:605640"
     exon            1..490
                     /gene="SIGLEC9"
                     /gene_synonym="CD329; CDw329; FOAP-9; OBBP-LIKE; siglec-9"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1461
                     /gene="SIGLEC9"
                     /gene_synonym="CD329; CDw329; FOAP-9; OBBP-LIKE; siglec-9"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; protein FOAP-9"
                     /codon_start=1
                     /product="sialic acid-binding Ig-like lectin 9 isoform 2
                     precursor"
                     /protein_id="NP_055256.1"
                     /db_xref="CCDS:CCDS12825.1"
                     /db_xref="GeneID:27180"
                     /db_xref="HGNC:HGNC:10878"
                     /db_xref="MIM:605640"
                     /translation="MLLLLLPLLWGRERAEGQTSKLLTMQSSVTVQEGLCVHVPCSFS
                     YPSHGWIYPGPVVHGYWFREGANTDQDAPVATNNPARAVWEETRDRFHLLGDPHTKNC
                     TLSIRDARRSDAGRYFFRMEKGSIKWNYKHHRLSVNVTALTHRPNILIPGTLESGCPQ
                     NLTCSVPWACEQGTPPMISWIGTSVSPLDPSTTRSSVLTLIPQPQDHGTSLTCQVTFP
                     GASVTTNKTVHLNVSYPPQNLTMTVFQGDGTVSTVLGNGSSLSLPEGQSLRLVCAVDA
                     VDSNPPARLSLSWRGLTLCPSQPSNPGVLELPWVHLRDAAEFTCRAQNPLGSQQVYLN
                     VSLQSKATSGVTQGVVGGAGATALVFLSFCVIFVVVRSCRKKSARPAAGVGDTGIEDA
                     NAVRGSASQGPLTEPWAEDSPPDQPPPASARSSVGEGELQYASLSFQMVKPWDSRGQE
                     ATDTEYSEIKIHR"
     exon            491..769
                     /gene="SIGLEC9"
                     /gene_synonym="CD329; CDw329; FOAP-9; OBBP-LIKE; siglec-9"
                     /inference="alignment:Splign:2.1.0"
     exon            770..817
                     /gene="SIGLEC9"
                     /gene_synonym="CD329; CDw329; FOAP-9; OBBP-LIKE; siglec-9"
                     /inference="alignment:Splign:2.1.0"
     exon            818..1084
                     /gene="SIGLEC9"
                     /gene_synonym="CD329; CDw329; FOAP-9; OBBP-LIKE; siglec-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1175
                     /gene="SIGLEC9"
                     /gene_synonym="CD329; CDw329; FOAP-9; OBBP-LIKE; siglec-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1272
                     /gene="SIGLEC9"
                     /gene_synonym="CD329; CDw329; FOAP-9; OBBP-LIKE; siglec-9"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1692
                     /gene="SIGLEC9"
                     /gene_synonym="CD329; CDw329; FOAP-9; OBBP-LIKE; siglec-9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1670..1675
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIGLEC9"
                     /gene_synonym="CD329; CDw329; FOAP-9; OBBP-LIKE; siglec-9"
                     /note="hexamer: ACTAAA"
     polyA_site      1692
                     /gene="SIGLEC9"
                     /gene_synonym="CD329; CDw329; FOAP-9; OBBP-LIKE; siglec-9"
                     /note="major polyA site"
ORIGIN      
        1 gcagttcctg agagaagaac cctgaggaac agacgttccc tcgcggccct ggcacctcta
       61 accccagaca tgctgctgct gctgctgccc ctgctctggg ggagggagag ggcggaagga
      121 cagacaagta aactgctgac gatgcagagt tccgtgacgg tgcaggaagg cctgtgtgtc
      181 catgtgccct gctccttctc ctacccctcg catggctgga tttaccctgg cccagtagtt
      241 catggctact ggttccggga aggggccaat acagaccagg atgctccagt ggccacaaac
      301 aacccagctc gggcagtgtg ggaggagact cgggaccgat tccacctcct tggggaccca
      361 cataccaaga attgcaccct gagcatcaga gatgccagaa gaagtgatgc ggggagatac
      421 ttctttcgta tggagaaagg aagtataaaa tggaattata aacatcaccg gctctctgtg
      481 aatgtgacag ccttgaccca caggcccaac atcctcatcc caggcaccct ggagtccggc
      541 tgcccccaga atctgacctg ctctgtgccc tgggcctgtg agcaggggac accccctatg
      601 atctcctgga tagggacctc cgtgtccccc ctggacccct ccaccacccg ctcctcggtg
      661 ctcaccctca tcccacagcc ccaggaccat ggcaccagcc tcacctgtca ggtgaccttc
      721 cctggggcca gcgtgaccac gaacaagacc gtccatctca acgtgtccta cccgcctcag
      781 aacttgacca tgactgtctt ccaaggagac ggcacagtat ccacagtctt gggaaatggc
      841 tcatctctgt cactcccaga gggccagtct ctgcgcctgg tctgtgcagt tgatgcagtt
      901 gacagcaatc cccctgccag gctgagcctg agctggagag gcctgaccct gtgcccctca
      961 cagccctcaa acccgggggt gctggagctg ccttgggtgc acctgaggga tgcagctgaa
     1021 ttcacctgca gagctcagaa ccctctcggc tctcagcagg tctacctgaa cgtctccctg
     1081 cagagcaaag ccacatcagg agtgactcag ggggtggtcg ggggagctgg agccacagcc
     1141 ctggtcttcc tgtccttctg cgtcatcttc gttgtagtga ggtcctgcag gaagaaatcg
     1201 gcaaggccag cagcgggcgt gggagatacg ggcatagagg atgcaaacgc tgtcaggggt
     1261 tcagcctctc aggggcccct gactgaacct tgggcagaag acagtccccc agaccagcct
     1321 cccccagctt ctgcccgctc ctcagtgggg gaaggagagc tccagtatgc atccctcagc
     1381 ttccagatgg tgaagccttg ggactcgcgg ggacaggagg ccactgacac cgagtactcg
     1441 gagatcaaga tccacagatg agaaactgca gagactcacc ctgattgagg gatcacagcc
     1501 cctccaggca agggagaagt cagaggctga ttcttgtaga attaacagcc ctcaacgtga
     1561 tgagctatga taacactatg aattatgtgc agagtgaaaa gcacacaggc tttagagtca
     1621 aagtatctca aacctgaatc cacactgtgc cctccctttt atttttttaa ctaaaagaca
     1681 gacaaattcc ta
//
