LOCUS       NM_014385               1754 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens sialic acid binding Ig like lectin 7 (SIGLEC7),
            transcript variant 1, mRNA.
ACCESSION   NM_014385
VERSION     NM_014385.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1754)
  AUTHORS   An,W., Ren,C., Yuan,L., Qiu,Z., Wang,P., Cheng,Y., He,Z., Han,X.,
            Li,S. and An,Y.
  TITLE     High expression of SIGLEC7 may promote M2-type macrophage
            polarization leading to adverse prognosis in glioma patients
  JOURNAL   Front Immunol 15, 1411072 (2024)
   PUBMED   39211050
  REMARK    GeneRIF: High expression of SIGLEC7 may promote M2-type macrophage
            polarization leading to adverse prognosis in glioma patients.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1754)
  AUTHORS   Stewart,N., Daly,J., Drummond-Guy,O., Krishnamoorthy,V.,
            Stark,J.C., Riley,N.M., Williams,K.C., Bertozzi,C.R. and
            Wisnovsky,S.
  TITLE     The glycoimmune checkpoint receptor Siglec-7 interacts with T-cell
            ligands and regulates T-cell activation
  JOURNAL   J Biol Chem 300 (2), 105579 (2024)
   PUBMED   38141764
  REMARK    GeneRIF: The glycoimmune checkpoint receptor Siglec-7 interacts
            with T-cell ligands and regulates T-cell activation.
REFERENCE   3  (bases 1 to 1754)
  AUTHORS   Huang,Y.F., Su,S.C., Chuang,H.Y., Chen,H.H. and Twu,Y.C.
  TITLE     Histone deacetylation-regulated cell surface Siglec-7 expression
            promoted megakaryocytic maturation and enhanced platelet-like
            particle release
  JOURNAL   J Thromb Haemost 21 (2), 329-343 (2023)
   PUBMED   36700509
  REMARK    GeneRIF: Histone deacetylation-regulated cell surface Siglec-7
            expression promoted megakaryocytic maturation and enhanced
            platelet-like particle release.
REFERENCE   4  (bases 1 to 1754)
  AUTHORS   Haas,Q., Markov,N., Muerner,L., Rubino,V., Benjak,A., Haubitz,M.,
            Baerlocher,G.M., Ng,C.K.Y., Munz,C., Riether,C., Ochsenbein,A.F.,
            Simon,H.U. and von Gunten,S.
  TITLE     Siglec-7 represents a glyco-immune checkpoint for non-exhausted
            effector memory CD8+ T cells with high functional and metabolic
            capacities
  JOURNAL   Front Immunol 13, 996746 (2022)
   PUBMED   36211376
  REMARK    GeneRIF: Siglec-7 represents a glyco-immune checkpoint for
            non-exhausted effector memory CD8+ T cells with high functional and
            metabolic capacities.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1754)
  AUTHORS   Suenaga,T., Mori,Y., Suzutani,T. and Arase,H.
  TITLE     Regulation of Siglec-7-mediated varicella-zoster virus infection of
            primary monocytes by cis-ligands
  JOURNAL   Biochem Biophys Res Commun 613, 41-46 (2022)
   PUBMED   35526487
  REMARK    GeneRIF: Regulation of Siglec-7-mediated varicella-zoster virus
            infection of primary monocytes by cis-ligands.
REFERENCE   6  (bases 1 to 1754)
  AUTHORS   Vitale,C., Romagnani,C., Falco,M., Ponte,M., Vitale,M., Moretta,A.,
            Bacigalupo,A., Moretta,L. and Mingari,M.C.
  TITLE     Engagement of p75/AIRM1 or CD33 inhibits the proliferation of
            normal or leukemic myeloid cells
  JOURNAL   Proc Natl Acad Sci U S A 96 (26), 15091-15096 (1999)
   PUBMED   10611343
REFERENCE   7  (bases 1 to 1754)
  AUTHORS   Nicoll,G., Ni,J., Liu,D., Klenerman,P., Munday,J., Dubock,S.,
            Mattei,M.G. and Crocker,P.R.
  TITLE     Identification and characterization of a novel siglec, siglec-7,
            expressed by human natural killer cells and monocytes
  JOURNAL   J Biol Chem 274 (48), 34089-34095 (1999)
   PUBMED   10567377
REFERENCE   8  (bases 1 to 1754)
  AUTHORS   Ye,X., Mehlen,P., Rabizadeh,S., VanArsdale,T., Zhang,H., Shin,H.,
            Wang,J.J., Leo,E., Zapata,J., Hauser,C.A., Reed,J.C. and
            Bredesen,D.E.
  TITLE     TRAF family proteins interact with the common neurotrophin receptor
            and modulate apoptosis induction
  JOURNAL   J Biol Chem 274 (42), 30202-30208 (1999)
   PUBMED   10514511
REFERENCE   9  (bases 1 to 1754)
  AUTHORS   Falco,M., Biassoni,R., Bottino,C., Vitale,M., Sivori,S.,
            Augugliaro,R., Moretta,L. and Moretta,A.
  TITLE     Identification and molecular cloning of p75/AIRM1, a novel member
            of the sialoadhesin family that functions as an inhibitory receptor
            in human natural killer cells
  JOURNAL   J Exp Med 190 (6), 793-802 (1999)
   PUBMED   10499918
REFERENCE   10 (bases 1 to 1754)
  AUTHORS   Reif,K., Buday,L., Downward,J. and Cantrell,D.A.
  TITLE     SH3 domains of the adapter molecule Grb2 complex with two proteins
            in T cells: the guanine nucleotide exchange protein Sos and a
            75-kDa protein that is a substrate for T cell antigen
            receptor-activated tyrosine kinases
  JOURNAL   J Biol Chem 269 (19), 14081-14087 (1994)
   PUBMED   8188688
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC063977.6.
            
            On Jul 1, 2020 this sequence version replaced NM_014385.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028150.1, AF170485.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000317643.10/ ENSP00000323328.6
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-502               AC063977.6         21465-21966
            503-781             AC063977.6         23570-23848
            782-829             AC063977.6         24076-24123
            830-1096            AC063977.6         25019-25285
            1097-1193           AC063977.6         25918-26014
            1194-1290           AC063977.6         26385-26481
            1291-1754           AC063977.6         32227-32690
FEATURES             Location/Qualifiers
     source          1..1754
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..1754
                     /gene="SIGLEC7"
                     /gene_synonym="AIRM-1; AIRM1; CD328; CDw328; D-siglec;
                     p75; p75/AIRM1; QA79; SIGLEC-7; SIGLEC19P; SIGLECP2"
                     /note="sialic acid binding Ig like lectin 7"
                     /db_xref="GeneID:27036"
                     /db_xref="HGNC:HGNC:10876"
                     /db_xref="MIM:604410"
     exon            1..502
                     /gene="SIGLEC7"
                     /gene_synonym="AIRM-1; AIRM1; CD328; CDw328; D-siglec;
                     p75; p75/AIRM1; QA79; SIGLEC-7; SIGLEC19P; SIGLECP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1473
                     /gene="SIGLEC7"
                     /gene_synonym="AIRM-1; AIRM1; CD328; CDw328; D-siglec;
                     p75; p75/AIRM1; QA79; SIGLEC-7; SIGLEC19P; SIGLECP2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; adhesion inhibitory receptor molecule 1,
                     siglec-7; sialic acid binding immunoglobulin-like lectin
                     7; QA79 membrane protein"
                     /codon_start=1
                     /product="sialic acid-binding Ig-like lectin 7 isoform 1
                     precursor"
                     /protein_id="NP_055200.1"
                     /db_xref="CCDS:CCDS12826.1"
                     /db_xref="GeneID:27036"
                     /db_xref="HGNC:HGNC:10876"
                     /db_xref="MIM:604410"
                     /translation="MLLLLLLPLLWGRERVEGQKSNRKDYSLTMQSSVTVQEGMCVHV
                     RCSFSYPVDSQTDSDPVHGYWFRAGNDISWKAPVATNNPAWAVQEETRDRFHLLGDPQ
                     TKNCTLSIRDARMSDAGRYFFRMEKGNIKWNYKYDQLSVNVTALTHRPNILIPGTLES
                     GCFQNLTCSVPWACEQGTPPMISWMGTSVSPLHPSTTRSSVLTLIPQPQHHGTSLTCQ
                     VTLPGAGVTTNRTIQLNVSYPPQNLTVTVFQGEGTASTALGNSSSLSVLEGQSLRLVC
                     AVDSNPPARLSWTWRSLTLYPSQPSNPLVLELQVHLGDEGEFTCRAQNSLGSQHVSLN
                     LSLQQEYTGKMRPVSGVLLGAVGGAGATALVFLSFCVIFIVVRSCRKKSARPAADVGD
                     IGMKDANTIRGSASQGNLTESWADDNPRHHGLAAHSSGEEREIQYAPLSFHKGEPQDL
                     SGQEATNNEYSEIKIPK"
     exon            503..781
                     /gene="SIGLEC7"
                     /gene_synonym="AIRM-1; AIRM1; CD328; CDw328; D-siglec;
                     p75; p75/AIRM1; QA79; SIGLEC-7; SIGLEC19P; SIGLECP2"
                     /inference="alignment:Splign:2.1.0"
     exon            782..829
                     /gene="SIGLEC7"
                     /gene_synonym="AIRM-1; AIRM1; CD328; CDw328; D-siglec;
                     p75; p75/AIRM1; QA79; SIGLEC-7; SIGLEC19P; SIGLECP2"
                     /inference="alignment:Splign:2.1.0"
     exon            830..1096
                     /gene="SIGLEC7"
                     /gene_synonym="AIRM-1; AIRM1; CD328; CDw328; D-siglec;
                     p75; p75/AIRM1; QA79; SIGLEC-7; SIGLEC19P; SIGLECP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1193
                     /gene="SIGLEC7"
                     /gene_synonym="AIRM-1; AIRM1; CD328; CDw328; D-siglec;
                     p75; p75/AIRM1; QA79; SIGLEC-7; SIGLEC19P; SIGLECP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1290
                     /gene="SIGLEC7"
                     /gene_synonym="AIRM-1; AIRM1; CD328; CDw328; D-siglec;
                     p75; p75/AIRM1; QA79; SIGLEC-7; SIGLEC19P; SIGLECP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1754
                     /gene="SIGLEC7"
                     /gene_synonym="AIRM-1; AIRM1; CD328; CDw328; D-siglec;
                     p75; p75/AIRM1; QA79; SIGLEC-7; SIGLEC19P; SIGLECP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1733..1738
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIGLEC7"
                     /gene_synonym="AIRM-1; AIRM1; CD328; CDw328; D-siglec;
                     p75; p75/AIRM1; QA79; SIGLEC-7; SIGLEC19P; SIGLECP2"
                     /note="hexamer: AATATA"
     polyA_site      1754
                     /gene="SIGLEC7"
                     /gene_synonym="AIRM-1; AIRM1; CD328; CDw328; D-siglec;
                     p75; p75/AIRM1; QA79; SIGLEC-7; SIGLEC19P; SIGLECP2"
                     /note="major polyA site"
ORIGIN      
        1 gcagttcctg agagaagaac cctgaggaac agacgttccc tcgcggccct ggcacctcca
       61 accccagata tgctgctgct gctgctgctg cccctgctct gggggaggga gagggtggaa
      121 ggacagaaga gtaaccggaa ggattactcg ctgacgatgc agagttccgt gaccgtgcaa
      181 gagggcatgt gtgtccatgt gcgctgctcc ttctcctacc cagtggacag ccagactgac
      241 tctgacccag ttcatggcta ctggttccgg gcagggaatg atataagctg gaaggctcca
      301 gtggccacaa acaacccagc ttgggcagtg caggaggaaa ctcgggaccg attccacctc
      361 cttggggacc cacagaccaa aaattgcacc ctgagcatca gagatgccag aatgagtgat
      421 gcggggagat acttctttcg tatggagaaa ggaaatataa aatggaatta taaatatgac
      481 cagctctctg tgaacgtgac agccttgacc cacaggccca acatccttat ccccggtacc
      541 ctggagtctg gctgcttcca gaatctgacc tgctctgtgc cctgggcctg tgagcagggg
      601 acgcccccta tgatctcctg gatggggacc tctgtgtccc ccctgcaccc ctccaccacc
      661 cgctcctcag tgctcaccct catcccacag ccccagcacc acggcaccag cctcacctgt
      721 caggtgacct tgcctggggc cggcgtgacc acgaacagga ccatccaact caatgtgtcc
      781 taccctcctc agaacttgac tgtgactgtc ttccaaggag aaggcacagc atccacagct
      841 ctggggaaca gctcatctct ttcagtccta gagggccagt ctctgcgctt ggtctgtgct
      901 gttgacagca atccccctgc caggctgagc tggacctgga ggagtctgac cctgtacccc
      961 tcacagccct caaaccctct ggtactggag ctgcaagtgc acctggggga tgaaggggaa
     1021 ttcacctgtc gagctcagaa ctctctgggt tcccagcacg tttccctgaa cctctccctg
     1081 caacaggagt acacaggcaa aatgaggcct gtatcaggag tgttgctggg ggcggtcggg
     1141 ggagctggag ccacagccct ggtcttcctc tccttctgtg tcatcttcat tgtagtgagg
     1201 tcctgcagga agaaatcggc aaggccagca gcggacgtgg gagacatagg catgaaggat
     1261 gcaaacacca tcaggggctc agcctctcag ggtaacctga ctgagtcctg ggcagatgat
     1321 aacccccgac accatggcct ggctgcccac tcctcagggg aggaaagaga gatccagtat
     1381 gcacccctca gctttcataa gggggagcct caggacctat caggacaaga agccaccaac
     1441 aatgagtact cagagatcaa gatccccaag taagaaaatg cagaggctcg ggcttgtttg
     1501 agggttcacg acccctccag caaaggagtc tgaggctgat tccagtagaa ttagcagccc
     1561 tcaatgctgt gcaacaagac atcagaactt attcctcttg tctaactgaa aatgcatgcc
     1621 tgatgaccaa actctccctt tccccatcca atcggtccac actccccgcc ctggcctctg
     1681 gtacccacca ttctcctctg tacttctcta aggatgacta ctttagattc cgaatatagt
     1741 gagattgtaa cgtg
//
