LOCUS       NM_001245               3647 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens sialic acid binding Ig like lectin 6 (SIGLEC6),
            transcript variant 1, mRNA.
ACCESSION   NM_001245
VERSION     NM_001245.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3647)
  AUTHORS   Schmidt,E.N., Lamprinaki,D., McCord,K.A., Joe,M., Sojitra,M.,
            Waldow,A., Nguyen,J., Monyror,J., Kitova,E.N., Mozaneh,F.,
            Guo,X.Y., Jung,J., Enterina,J.R., Daskhan,G.C., Han,L.,
            Krysler,A.R., Cromwell,C.R., Hubbard,B.P., West,L.J., Kulka,M.,
            Sipione,S., Klassen,J.S., Derda,R., Lowary,T.L., Mahal,L.K.,
            Riddell,M.R. and Macauley,M.S.
  TITLE     Siglec-6 mediates the uptake of extracellular vesicles through a
            noncanonical glycolipid binding pocket
  JOURNAL   Nat Commun 14 (1), 2327 (2023)
   PUBMED   37087495
  REMARK    GeneRIF: Siglec-6 mediates the uptake of extracellular vesicles
            through a noncanonical glycolipid binding pocket.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3647)
  AUTHORS   Smiljkovic,D., Herrmann,H., Sadovnik,I., Gamperl,S., Berger,D.,
            Stefanzl,G., Eisenwort,G., Hoermann,G., Kopanja,S., Dorofeeva,Y.,
            Focke-Tejkl,M., Jaksch,P., Hoetzenecker,K., Szepfalusi,Z.,
            Valenta,R., Arock,M. and Valent,P.
  TITLE     Expression and regulation of Siglec-6 (CD327) on human mast cells
            and basophils
  JOURNAL   J Allergy Clin Immunol 151 (1), 202-211 (2023)
   PUBMED   35953001
  REMARK    GeneRIF: Expression and regulation of Siglec-6 (CD327) on human
            mast cells and basophils.
REFERENCE   3  (bases 1 to 3647)
  AUTHORS   Guan,X., Yu,M., Wu,L., Chen,J., Tong,J., Wu,X., Yin,A., Xiao,T.,
            Wang,B., Zhang,J.V. and Niu,J.
  TITLE     Elevated trophoblastic Siglec6 contributes to the impairment of
            vascular endothelial cell functions by downregulating
            Wnt6/beta-catenin signaling in preeclampsia
  JOURNAL   Arch Biochem Biophys 730, 109396 (2022)
   PUBMED   36113626
  REMARK    GeneRIF: Elevated trophoblastic Siglec6 contributes to the
            impairment of vascular endothelial cell functions by downregulating
            Wnt6/beta-catenin signaling in preeclampsia.
REFERENCE   4  (bases 1 to 3647)
  AUTHORS   Stefanski,A.L., Renecle,M.D., Kramer,A., Sehgal,S., Narasimhan,P.,
            Rumer,K.K. and Winn,V.D.
  TITLE     Siglec-6 Signaling Uses Src Kinase Tyrosine Phosphorylation and
            SHP-2 Recruitment
  JOURNAL   Cells 11 (21), 3427 (2022)
   PUBMED   36359823
  REMARK    GeneRIF: Siglec-6 Signaling Uses Src Kinase Tyrosine
            Phosphorylation and SHP-2 Recruitment.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3647)
  AUTHORS   Robida,P.A., Rische,C.H., Morgenstern,N.B., Janarthanam,R., Cao,Y.,
            Krier-Burris,R.A., Korver,W., Xu,A., Luu,T., Schanin,J., Leung,J.,
            Rothenberg,M.E., Wechsler,J.B., Youngblood,B.A., Bochner,B.S. and
            O'Sullivan,J.A.
  TITLE     Functional and Phenotypic Characterization of Siglec-6 on Human
            Mast Cells
  JOURNAL   Cells 11 (7), 1138 (2022)
   PUBMED   35406705
  REMARK    GeneRIF: Functional and Phenotypic Characterization of Siglec-6 on
            Human Mast Cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3647)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 3647)
  AUTHORS   Winn,V.D., Gormley,M., Paquet,A.C., Kjaer-Sorensen,K., Kramer,A.,
            Rumer,K.K., Haimov-Kochman,R., Yeh,R.F., Overgaard,M.T., Varki,A.,
            Oxvig,C. and Fisher,S.J.
  TITLE     Severe preeclampsia-related changes in gene expression at the
            maternal-fetal interface include sialic acid-binding
            immunoglobulin-like lectin-6 and pappalysin-2
  JOURNAL   Endocrinology 150 (1), 452-462 (2009)
   PUBMED   18818296
  REMARK    GeneRIF: Preeclampsia involves changes in the gene expression of
            SIGLEC6 in placental cytotrophoblasts.
            Review article
REFERENCE   8  (bases 1 to 3647)
  AUTHORS   Brinkman-Van der Linden,E.C., Hurtado-Ziola,N., Hayakawa,T.,
            Wiggleton,L., Benirschke,K., Varki,A. and Varki,N.
  TITLE     Human-specific expression of Siglec-6 in the placenta
  JOURNAL   Glycobiology 17 (9), 922-931 (2007)
   PUBMED   17580316
  REMARK    GeneRIF: the negative signaling potential of Siglec-6 may have a
            role in human-specific placental expression, to slow the tempo of
            the human birth process
REFERENCE   9  (bases 1 to 3647)
  AUTHORS   Patel,N., Brinkman-Van der Linden,E.C., Altmann,S.W., Gish,K.,
            Balasubramanian,S., Timans,J.C., Peterson,D., Bell,M.P.,
            Bazan,J.F., Varki,A. and Kastelein,R.A.
  TITLE     OB-BP1/Siglec-6. a leptin- and sialic acid-binding protein of the
            immunoglobulin superfamily
  JOURNAL   J Biol Chem 274 (32), 22729-22738 (1999)
   PUBMED   10428856
  REMARK    Erratum:[J Biol Chem 1999 Sep 24;274(39):28058]
REFERENCE   10 (bases 1 to 3647)
  AUTHORS   Takei,Y., Sasaki,S., Fujiwara,T., Takahashi,E., Muto,T. and
            Nakamura,Y.
  TITLE     Molecular cloning of a novel gene similar to myeloid antigen CD33
            and its specific expression in placenta
  JOURNAL   Cytogenet Cell Genet 78 (3-4), 295-300 (1997)
   PUBMED   9465907
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC020914.9 and BC035359.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001245.6.
            
            Summary: This gene encodes a member of the SIGLEC (sialic acid
            binding immunoglobulin-like lectin) family of proteins. The encoded
            transmembrane receptor binds sialyl-TN glycans and leptin.
            Placental expression of the encoded protein is upregulated in
            preeclampsia. [provided by RefSeq, Jul 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U71382.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142853 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000425629.8/ ENSP00000401502.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                AC020914.9         99813-99901         c
            90-449              AC020914.9         99391-99750         c
            450-728             AC020914.9         98912-99190         c
            729-776             AC020914.9         98668-98715         c
            777-1034            AC020914.9         97955-98212         c
            1035-1128           AC020914.9         96391-96484         c
            1129-1210           AC020914.9         95978-96059         c
            1211-1719           AC020914.9         87978-88486         c
            1720-1936           BC035359.1         1719-1935
            1937-3076           AC020914.9         86621-87760         c
            3077-3647           BC035359.1         1936-2506
FEATURES             Location/Qualifiers
     source          1..3647
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..3647
                     /gene="SIGLEC6"
                     /gene_synonym="CD327; CD33L; CD33L1; CD33L2; CDW327;
                     OBBP1"
                     /note="sialic acid binding Ig like lectin 6"
                     /db_xref="GeneID:946"
                     /db_xref="HGNC:HGNC:10875"
                     /db_xref="MIM:604405"
     exon            1..89
                     /gene="SIGLEC6"
                     /gene_synonym="CD327; CD33L; CD33L1; CD33L2; CDW327;
                     OBBP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..1384
                     /gene="SIGLEC6"
                     /gene_synonym="CD327; CD33L; CD33L1; CD33L2; CDW327;
                     OBBP1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; CD33 antigen-like 1; obesity-binding protein 1"
                     /codon_start=1
                     /product="sialic acid-binding Ig-like lectin 6 isoform 1
                     precursor"
                     /protein_id="NP_001236.4"
                     /db_xref="CCDS:CCDS12834.3"
                     /db_xref="GeneID:946"
                     /db_xref="HGNC:HGNC:10875"
                     /db_xref="MIM:604405"
                     /translation="MQGAQEASASEMLPLLLPLLWAGALAQERRFQLEGPESLTVQEG
                     LCVLVPCRLPTTLPASYYGYGYWFLEGADVPVATNDPDEEVQEETRGRFHLLWDPRRK
                     NCSLSIRDARRRDNAAYFFRLKSKWMKYGYTSSKLSVRVMALTHRPNISIPGTLESGH
                     PSNLTCSVPWVCEQGTPPIFSWMSAAPTSLGPRTTQSSVLTITPRPQDHSTNLTCQVT
                     FPGAGVTMERTIQLNVSYAPQKVAISIFQGNSAAFKILQNTSSLPVLEGQALRLLCDA
                     DGNPPAHLSWFQGFPALNATPISNTGVLELPQVGSAEEGDFTCRAQHPLGSLQISLSL
                     FVHWKPEGRAGGVLGAVWGASITTLVFLCVCFIFRVKTRRKKAAQPVQNTDDVNPVMV
                     SGSRGHQHQFQTGIVSDHPAEAGPISEDEQELHYAVLHFHKVQPQEPKVTDTEYSEIK
                     IHK"
     exon            90..449
                     /gene="SIGLEC6"
                     /gene_synonym="CD327; CD33L; CD33L1; CD33L2; CDW327;
                     OBBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            450..728
                     /gene="SIGLEC6"
                     /gene_synonym="CD327; CD33L; CD33L1; CD33L2; CDW327;
                     OBBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            729..776
                     /gene="SIGLEC6"
                     /gene_synonym="CD327; CD33L; CD33L1; CD33L2; CDW327;
                     OBBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            777..1034
                     /gene="SIGLEC6"
                     /gene_synonym="CD327; CD33L; CD33L1; CD33L2; CDW327;
                     OBBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1128
                     /gene="SIGLEC6"
                     /gene_synonym="CD327; CD33L; CD33L1; CD33L2; CDW327;
                     OBBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1210
                     /gene="SIGLEC6"
                     /gene_synonym="CD327; CD33L; CD33L1; CD33L2; CDW327;
                     OBBP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..3647
                     /gene="SIGLEC6"
                     /gene_synonym="CD327; CD33L; CD33L1; CD33L2; CDW327;
                     OBBP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1484..1489
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIGLEC6"
                     /gene_synonym="CD327; CD33L; CD33L1; CD33L2; CDW327;
                     OBBP1"
                     /note="hexamer: CATAAA"
     polyA_site      1501
                     /gene="SIGLEC6"
                     /gene_synonym="CD327; CD33L; CD33L1; CD33L2; CDW327;
                     OBBP1"
                     /note="major polyA site"
     regulatory      1710..1715
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIGLEC6"
                     /gene_synonym="CD327; CD33L; CD33L1; CD33L2; CDW327;
                     OBBP1"
                     /note="hexamer: AATAAA"
     polyA_site      1739
                     /gene="SIGLEC6"
                     /gene_synonym="CD327; CD33L; CD33L1; CD33L2; CDW327;
                     OBBP1"
                     /note="major polyA site"
     regulatory      3625..3630
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIGLEC6"
                     /gene_synonym="CD327; CD33L; CD33L1; CD33L2; CDW327;
                     OBBP1"
                     /note="hexamer: ATTAAA"
     polyA_site      3647
                     /gene="SIGLEC6"
                     /gene_synonym="CD327; CD33L; CD33L1; CD33L2; CDW327;
                     OBBP1"
ORIGIN      
        1 actcccttcc ccttctctgc tcatgcaggg agcccaggaa gcctccgcct cagagatgct
       61 accgctgctg ctgcccctgc tgtgggcagg ggccctggct caggagcgga gattccagct
      121 ggaggggcca gagtcactga cggtgcagga gggtctgtgc gtcctcgtac cctgcagatt
      181 gcccactacc cttccagcct cgtactatgg ttatggctac tggttcctgg aaggggctga
      241 tgttccagtg gccacaaacg acccagacga agaagtgcag gaggagaccc ggggccgatt
      301 ccacctcctc tgggatccca gaaggaagaa ctgctccctg agcatcagag atgcccggag
      361 gagggacaat gctgcatact tctttcggtt gaagtccaaa tggatgaaat acggttatac
      421 atcttccaag ctctctgtgc gtgtgatggc cctgacccac aggcccaaca tctccatccc
      481 agggaccctg gagtctggcc atcccagcaa tctgacctgc tctgtgccct gggtctgtga
      541 gcaggggacg ccccccatct tctcctggat gtcagctgcc cccacctccc tgggccccag
      601 gaccacccag tcctcggtgc tcacaatcac cccacggccc caggaccaca gcaccaacct
      661 cacctgtcag gtgacgttcc ctggagccgg tgtgaccatg gagagaacca tccagctcaa
      721 tgtctcctat gctccacaga aagtggccat cagcatcttc caaggaaaca gcgcagcctt
      781 caaaatcctg caaaacacct cgtccctccc tgtcctggag ggccaggctc tgcggctgct
      841 ctgtgatgct gacggcaacc cccctgcaca cctgagctgg ttccagggct tccccgccct
      901 gaacgccacc cccatctcca ataccggggt cctggagctg cctcaagtag ggtctgcaga
      961 agaaggagat ttcacctgcc gtgctcagca tcctctgggc tccctgcaaa tctctctgag
     1021 tctctttgtg cattggaaac cagaaggcag ggctggtggt gtcctgggag cagtctgggg
     1081 agctagcatc acaaccctgg ttttcctctg tgtttgcttc atcttcagag tgaagactag
     1141 aaggaagaaa gcagcccagc cagtgcaaaa cacggatgat gtgaaccccg tcatggtctc
     1201 aggctccagg ggtcatcagc accagttcca gacaggcata gtttcagacc accctgctga
     1261 ggctggcccc atctcagaag atgagcagga gctccactac gctgtcctac acttccacaa
     1321 ggtgcaacct caggaaccaa aggtcaccga cactgagtac tcagaaatca agatacacaa
     1381 gtgaggaatt gtccaaagcc ataaccttga ttggagagaa catggtacct ctcagtgtat
     1441 tggttactag ggctgccaca gcaatgtacc acaaaccgag tgacataaac acagaacttt
     1501 attttcgtat agtttcagat gttagaggtc tgagaacaag gtgttatcag ggttggtccc
     1561 ttctaaggcc tctcttgttg gcttgtagat ggctgtctcc tccttgtgtc ttcacatggt
     1621 ctttcctctg agtgtgtttg tgtcctaatc ttctcttctt ataaagacac tagtcatatt
     1681 ggattagggc ctccccatga cctaatttaa ataaattaac tatttaaaga ccctccaaat
     1741 acagtaacct tctgagatat tgagatttag gacttccaac atatgaattt tagaagggaa
     1801 caatttagcc cataacactg tgtccaattc ttttaaaatt aatgtttttg ttgtaaatgg
     1861 actatataaa taccttcgta tatatggcag accacaggac ttctgtccaa gagaactgag
     1921 ttcaactcca tctatgccag ctattgagca agtcgcttta tgtccctgct ctgtaaggca
     1981 gggaaataat ttccatctaa ccagattatt gtgaaaggtc aaagaaagca tacagctaac
     2041 atacagcttt gttagctgta aaacagctaa caaaggccct gacacaaagg ttttcataaa
     2101 gtctgtatat ttttgtaaat gaatgccttg tatctggctt tggctagctt tttttttttt
     2161 tttttttttc tgagatggag tcttgctgta tctcccaggc tggagtgcag tggtgcgatc
     2221 ttggctcagt gcaagcttcg ccccctgggt tcacaccatt ctcctgcctc agcctcccaa
     2281 gtagctggga ctacaggcac ccaccaccac acccggctaa ttttttgtat ttttagtaga
     2341 gacggggttt caccgtgtta gccaggatgg tcttgatctc ctgacctcgt gatctgccct
     2401 cctcggcctc ccaaagtgct gagattacag gcatgagcca ccgcacccgg ctttgattag
     2461 ctgttttaac agacggtttc tgctggcaat ttcttctaag gctgaaaagg agtaggccca
     2521 gaggccacag caccaggtgt ctgtgtcacc ccctgttcag aactcttcac gactccccaa
     2581 aataaggttt ccatccatca tctttctgct caaggctctc tacatgatct tgtccatcca
     2641 gatttcccca gatcaattcc tcaccagtca ccaatacccc atgtccattt ccacagcttc
     2701 ctcttacaaa tcccagtctc cactattcca gtgaaattga agaaagcatt taatgaagac
     2761 caactattaa ggaaaattct taagagtagc catgaaaaat aaaaagatag attacactta
     2821 aaagaccaca gttagcagtg gctcacgcct gtaatcccag cactttggga ggctgaggtg
     2881 ggtggatcac tggaggtcag gagttcgaga ctggtctggc caacatggtg aaaccccatc
     2941 tctactaaaa tacaaaaatt agctcggtgt ggtggcactt gcctgtaatc ccaggtactt
     3001 ctgcaggttg aagcaggaga attgcttgaa cctgggaggt ggaggttgaa gtgagctgag
     3061 attgcatcac tgcactccag cctgggcaac agagcgagac tccaactcag aaaaagcaaa
     3121 acaaaacaaa caaacaagca aaaaaccaca attagactga cagctgactt ttttaggagc
     3181 aatattggaa ggctaaatgc aatagaaaga tgtctttgat ggcttaagag aaataaatgt
     3241 tgttttagaa agcctactca atgaaaacac attttaagac tgaaagtgaa atatagatat
     3301 tttaaggaaa accaaaatat gtgagtgtta ataaagaaaa gatttctcaa ataaattcta
     3361 aaacatataa ttcaggtatt aggaaagtga tcccagatta gatttttgag atccaaaaaa
     3421 aatgaaaacc taggaaagta gcaaatatgt gagcaaaatg aaacaaatac ttgttgtaaa
     3481 aatgatggtt tgtagagggg tcaaacatca aatgtaatat tgaaatacca atattatata
     3541 gcccagaaac tataataaca taaagttcag aagagtgtaa atagaattta tattacataa
     3601 agtctttata tttttccaga gaaaattaaa tgttatgatg aatgtta
//
