LOCUS       NM_003830               2993 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens sialic acid binding Ig like lectin 5 (SIGLEC5),
            transcript variant 1, mRNA.
ACCESSION   NM_003830
VERSION     NM_003830.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2993)
  AUTHORS   Lozano-Rodriguez,R., Avendano-Ortiz,J., Montalban-Hernandez,K.,
            Ruiz-Rodriguez,J.C., Ferrer,R., Martin-Quiros,A., Maroun-Eid,C.,
            Gonzalez-Lopez,J.J., Fabrega,A., Terron-Arcos,V.,
            Gutierrez-Fernandez,M., Alonso-Lopez,E., Cubillos-Zapata,C.,
            Fernandez-Velasco,M., Perez de Diego,R., Pelegrin,P.,
            Garcia-Palenciano,C., Cueto,F.J., Del Fresno,C. and
            Lopez-Collazo,E.
  TITLE     The prognostic impact of SIGLEC5-induced impairment of CD8+ T cell
            activation in sepsis
  JOURNAL   EBioMedicine 97, 104841 (2023)
   PUBMED   37890368
  REMARK    GeneRIF: The prognostic impact of SIGLEC5-induced impairment of
            CD8[+] T cell activation in sepsis.
REFERENCE   2  (bases 1 to 2993)
  AUTHORS   Diaz-Garcia,E., Garcia-Sanchez,A., Alfaro,E., Lopez-Fernandez,C.,
            Manas,E., Cano-Pumarega,I., Lopez-Collazo,E., Garcia-Rio,F. and
            Cubillos-Zapata,C.
  TITLE     PSGL-1: a novel immune checkpoint driving T-cell dysfunction in
            obstructive sleep apnea
  JOURNAL   Front Immunol 14, 1277551 (2023)
   PUBMED   37854605
  REMARK    GeneRIF: PSGL-1: a novel immune checkpoint driving T-cell
            dysfunction in obstructive sleep apnea.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2993)
  AUTHORS   Muller,R., Freitag-Wolf,S., Weiner,J. 3rd, Chopra,A., Top,T.,
            Dommisch,H. and Schaefer,A.S.
  TITLE     Case-only design identifies interactions of genetic risk variants
            at SIGLEC5 and PLG with the lncRNA CTD-2353F22.1 implying the
            importance of periodontal wound healing for disease aetiology
  JOURNAL   J Clin Periodontol 50 (1), 90-101 (2023)
   PUBMED   36129033
  REMARK    GeneRIF: Case-only design identifies interactions of genetic risk
            variants at SIGLEC5 and PLG with the lncRNA CTD-2353F22.1 implying
            the importance of periodontal wound healing for disease aetiology.
REFERENCE   4  (bases 1 to 2993)
  AUTHORS   Akiyama,M., Eura,Y. and Kokame,K.
  TITLE     Siglec-5 and Siglec-14 mediate the endocytosis of ADAMTS13
  JOURNAL   Thromb Res 219, 49-59 (2022)
   PUBMED   36116391
  REMARK    GeneRIF: Siglec-5 and Siglec-14 mediate the endocytosis of
            ADAMTS13.
REFERENCE   5  (bases 1 to 2993)
  AUTHORS   Carlin,A.F., Chang,Y.C., Areschoug,T., Lindahl,G.,
            Hurtado-Ziola,N., King,C.C., Varki,A. and Nizet,V.
  TITLE     Group B Streptococcus suppression of phagocyte functions by
            protein-mediated engagement of human Siglec-5
  JOURNAL   J Exp Med 206 (8), 1691-1699 (2009)
   PUBMED   19596804
  REMARK    GeneRIF: Group B Streptococcus beta protein binding to Siglec-5
            functions to impair leukocyte phagocytosis, oxidative burst, and
            extracellular trap production, promoting bacterial survival.
REFERENCE   6  (bases 1 to 2993)
  AUTHORS   Erickson-Miller,C.L., Freeman,S.D., Hopson,C.B., D'Alessio,K.J.,
            Fischer,E.I., Kikly,K.K., Abrahamson,J.A., Holmes,S.D. and
            King,A.G.
  TITLE     Characterization of Siglec-5 (CD170) expression and functional
            activity of anti-Siglec-5 antibodies on human phagocytes
  JOURNAL   Exp Hematol 31 (5), 382-388 (2003)
   PUBMED   12763136
  REMARK    GeneRIF: expression of Siglec-5 on cells of the myelomonocytic
            lineage and alteration of its expression by inflammatory stimuli
            suggest a role for this protein in cell/cell interactions following
            microbial exposure.
REFERENCE   7  (bases 1 to 2993)
  AUTHORS   Yousef,G.M., Ordon,M.H., Foussias,G. and Diamandis,E.P.
  TITLE     Genomic organization of the siglec gene locus on chromosome 19q13.4
            and cloning of two new siglec pseudogenes
  JOURNAL   Gene 286 (2), 259-270 (2002)
   PUBMED   11943481
REFERENCE   8  (bases 1 to 2993)
  AUTHORS   Patel,N., Brinkman-Van der Linden,E.C., Altmann,S.W., Gish,K.,
            Balasubramanian,S., Timans,J.C., Peterson,D., Bell,M.P.,
            Bazan,J.F., Varki,A. and Kastelein,R.A.
  TITLE     OB-BP1/Siglec-6. a leptin- and sialic acid-binding protein of the
            immunoglobulin superfamily
  JOURNAL   J Biol Chem 274 (32), 22729-22738 (1999)
   PUBMED   10428856
  REMARK    Erratum:[J Biol Chem 1999 Sep 24;274(39):28058]
REFERENCE   9  (bases 1 to 2993)
  AUTHORS   Kim,H.S.
  TITLE     Assignment of the human OB binding protein-2 gene (CD33L2) to
            chromosome 19q13.3 by radiation hybrid mapping
  JOURNAL   Cytogenet Cell Genet 84 (1-2), 96 (1999)
   PUBMED   10343116
REFERENCE   10 (bases 1 to 2993)
  AUTHORS   Cornish,A.L., Freeman,S., Forbes,G., Ni,J., Zhang,M., Cepeda,M.,
            Gentz,R., Augustus,M., Carter,K.C. and Crocker,P.R.
  TITLE     Characterization of siglec-5, a novel glycoprotein expressed on
            myeloid cells related to CD33
  JOURNAL   Blood 92 (6), 2123-2132 (1998)
   PUBMED   9731071
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U71383.1 and AC018755.3.
            
            On Jun 26, 2020 this sequence version replaced NM_003830.3.
            
            Summary: This gene encodes a member of the sialic acid-binding
            immunoglobulin-like lectin (Siglec) family. These cell surface
            lectins are characterized by structural motifs in the
            immunoglobulin (Ig)-like domains and sialic acid recognition sites
            in the first Ig V set domain. The encoded protein is a member of
            the CD33-related subset of Siglecs and inhibits the activation of
            several cell types including monocytes, macrophages and
            neutrophils. Binding of group B Streptococcus (GBS) to the encoded
            protein plays a role in GBS immune evasion. [provided by RefSeq,
            Feb 2012].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.1250673.1,
                                           SRR14038191.2919493.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000683636.1/ ENSP00000507738.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1862              U71383.1           77-1938
            1863-2993           AC018755.3         38109-39239         c
FEATURES             Location/Qualifiers
     source          1..2993
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..2993
                     /gene="SIGLEC5"
                     /gene_synonym="CD170; CD33L2; OB-BP2; OBBP2; SIGLEC-5"
                     /note="sialic acid binding Ig like lectin 5"
                     /db_xref="GeneID:8778"
                     /db_xref="HGNC:HGNC:10874"
                     /db_xref="MIM:604200"
     exon            1..103
                     /gene="SIGLEC5"
                     /gene_synonym="CD170; CD33L2; OB-BP2; OBBP2; SIGLEC-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1722
                     /gene="SIGLEC5"
                     /gene_synonym="CD170; CD33L2; OB-BP2; OBBP2; SIGLEC-5"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; CD33 antigen-like 2; sialic acid-binding
                     immunoglobulin-like lectin 5; OB-binding protein 2;
                     obesity-binding protein 2"
                     /codon_start=1
                     /product="sialic acid-binding Ig-like lectin 5 isoform 1
                     precursor"
                     /protein_id="NP_003821.1"
                     /db_xref="CCDS:CCDS33088.1"
                     /db_xref="GeneID:8778"
                     /db_xref="HGNC:HGNC:10874"
                     /db_xref="MIM:604200"
                     /translation="MLPLLLLPLLWGGSLQEKPVYELQVQKSVTVQEGLCVLVPCSFS
                     YPWRSWYSSPPLYVYWFRDGEIPYYAEVVATNNPDRRVKPETQGRFRLLGDVQKKNCS
                     LSIGDARMEDTGSYFFRVERGRDVKYSYQQNKLNLEVTALIEKPDIHFLEPLESGRPT
                     RLSCSLPGSCEAGPPLTFSWTGNALSPLDPETTRSSELTLTPRPEDHGTNLTCQMKRQ
                     GAQVTTERTVQLNVSYAPQTITIFRNGIALEILQNTSYLPVLEGQALRLLCDAPSNPP
                     AHLSWFQGSPALNATPISNTGILELRRVRSAEEGGFTCRAQHPLGFLQIFLNLSVYSL
                     PQLLGPSCSWEAEGLHCRCSFRARPAPSLCWRLEEKPLEGNSSQGSFKVNSSSAGPWA
                     NSSLILHGGLSSDLKVSCKAWNIYGSQSGSVLLLQGRSNLGTGVVPAALGGAGVMALL
                     CICLCLIFFLIVKARRKQAAGRPEKMDDEDPIMGTITSGSRKKPWPDSPGDQASPPGD
                     APPLEEQKELHYASLSFSEMKSREPKDQEAPSTTEYSEIKTSK"
     exon            104..487
                     /gene="SIGLEC5"
                     /gene_synonym="CD170; CD33L2; OB-BP2; OBBP2; SIGLEC-5"
                     /inference="alignment:Splign:2.1.0"
     exon            488..766
                     /gene="SIGLEC5"
                     /gene_synonym="CD170; CD33L2; OB-BP2; OBBP2; SIGLEC-5"
                     /inference="alignment:Splign:2.1.0"
     exon            767..805
                     /gene="SIGLEC5"
                     /gene_synonym="CD170; CD33L2; OB-BP2; OBBP2; SIGLEC-5"
                     /inference="alignment:Splign:2.1.0"
     exon            806..1063
                     /gene="SIGLEC5"
                     /gene_synonym="CD170; CD33L2; OB-BP2; OBBP2; SIGLEC-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1348
                     /gene="SIGLEC5"
                     /gene_synonym="CD170; CD33L2; OB-BP2; OBBP2; SIGLEC-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1448
                     /gene="SIGLEC5"
                     /gene_synonym="CD170; CD33L2; OB-BP2; OBBP2; SIGLEC-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1530
                     /gene="SIGLEC5"
                     /gene_synonym="CD170; CD33L2; OB-BP2; OBBP2; SIGLEC-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..2993
                     /gene="SIGLEC5"
                     /gene_synonym="CD170; CD33L2; OB-BP2; OBBP2; SIGLEC-5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1999..2004
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIGLEC5"
                     /gene_synonym="CD170; CD33L2; OB-BP2; OBBP2; SIGLEC-5"
                     /note="hexamer: AAGAAA"
     polyA_site      2022
                     /gene="SIGLEC5"
                     /gene_synonym="CD170; CD33L2; OB-BP2; OBBP2; SIGLEC-5"
                     /note="major polyA site"
     regulatory      2971..2976
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIGLEC5"
                     /gene_synonym="CD170; CD33L2; OB-BP2; OBBP2; SIGLEC-5"
                     /note="hexamer: AATAAA"
     polyA_site      2993
                     /gene="SIGLEC5"
                     /gene_synonym="CD170; CD33L2; OB-BP2; OBBP2; SIGLEC-5"
                     /note="major polyA site"
ORIGIN      
        1 atttggagca tttccttccc tgacagccgg acctgggact gggctggggc cctggcggat
       61 ggagacatgc tgcccctgct gctgctgccc ctgctgtggg gggggtccct gcaggagaag
      121 ccagtgtacg agctgcaagt gcagaagtcg gtgacggtgc aggagggcct gtgcgtcctt
      181 gtgccctgct ccttctctta cccctggaga tcctggtatt cctctccccc actctacgtc
      241 tactggttcc gggacgggga gatcccatac tacgctgagg ttgtggccac aaacaaccca
      301 gacagaagag tgaagccaga gacccagggc cgattccgcc tccttgggga tgtccagaag
      361 aagaactgct ccctgagcat cggagatgcc agaatggagg acacgggaag ctatttcttc
      421 cgcgtggaga gaggaaggga tgtaaaatat agctaccaac agaataagct gaacttggag
      481 gtgacagccc tgatagagaa acccgacatc cactttctgg agcctctgga gtccggccgc
      541 cccacaaggc tgagctgcag ccttccagga tcctgtgaag cgggaccacc tctcacattc
      601 tcctggacgg ggaatgccct cagccccctg gaccccgaga ccacccgctc ctcggagctc
      661 accctcaccc ccaggcccga ggaccatggc accaacctca cctgtcagat gaaacgccaa
      721 ggagctcagg tgaccacgga gagaactgtc cagctcaatg tctcctatgc tccacagacc
      781 atcaccatct tcaggaacgg catagcccta gagatcctgc aaaacacctc ataccttccg
      841 gtcctggagg gccaggctct gcggctgctc tgtgatgctc ccagcaaccc ccctgcacac
      901 ctgagctggt tccagggctc ccctgccctg aacgccaccc ccatctccaa taccgggatc
      961 ttggagcttc gtcgagtaag gtctgcagaa gaaggaggct tcacctgccg cgctcagcac
     1021 ccgctgggct tcctgcaaat ttttctgaat ctctcagttt actccctccc acagttgctg
     1081 ggcccctcct gctcctggga ggctgagggt ctgcactgca gatgctcctt tcgagcccgg
     1141 ccggccccct ccctgtgctg gcggcttgag gagaagccgc tggaggggaa cagcagccag
     1201 ggctcattca aggtcaactc cagctcagct gggccctggg ccaacagctc cctgatcctc
     1261 cacggggggc tcagctccga cctcaaagtc agctgcaagg cctggaacat ctatgggtcc
     1321 cagagcggct ctgtcctgct gctgcaaggg agatcgaacc tcgggacagg agtggttcct
     1381 gcagcccttg gtggtgctgg tgtcatggcc ctgctctgta tctgtctgtg cctcatcttc
     1441 tttttaatag tgaaagcccg caggaagcaa gcagctggga gaccagagaa aatggatgat
     1501 gaagacccca ttatgggtac catcacctcg ggttccagga agaagccctg gccagacagc
     1561 cccggagatc aagcatctcc tcctggggat gcccctccct tggaagaaca aaaggagctc
     1621 cattatgcct cccttagttt ttctgagatg aagtcgaggg agcctaagga ccaggaggcc
     1681 ccaagcacca cggagtactc ggagatcaag acaagcaagt gaggatttgc ccagagttca
     1741 gtcctggctg gaggagccac agcctgtctg ggggaaagga caagtcaggg accacttgct
     1801 gaagcacgaa gagcccttgt ggcaatgtta acattaactg atgtttaagt gctccaagca
     1861 gatggaatta gagaggtggg ctcaaatcta ggccctggca ctgtcatcaa gcaattcact
     1921 gcatccctct gtgcctcagt ttcccattct gtaaatcaga gatcatgcat gctacctcaa
     1981 aggttgttgt gaacattaaa gaaatcaaca catggaaatc aaccaacatg ggtcctggaa
     2041 cagggcgttg tgctcagtgc tttctggtct ctcttccttg aatagaaagg tcctgctggc
     2101 aagttctctc aaggctgggg atgaccaggc acaaaaaaca gggcagcaat atgttggtgt
     2161 cactcccctt cccaaaactc ttcgaagact ccctaggaaa gaccagcccc tcagcctggc
     2221 acttggttca tgatgtggga tcttatatcc ttgccagagt catatctttg cccactttta
     2281 cctgcaatcc ttgcatcata ttcctttggc tccagtcctt catttatgag acccatagga
     2341 atccttccaa cagccaaaga gttgagtcta actctttcct gcccaaaccc attcacggcc
     2401 ccctggcctt agacaatata tcacaagcat ctcccctgac acataaagtc cttcatgatc
     2461 tccctgctat ctattcattt atactttcct cttgcctaac ccttccttaa gcctttcatg
     2521 ctggttcata ccacactgtc tttgcaattt gagattcctc ctcctggaag ccatgcctcc
     2581 ttgctttcat ctggcttaca ctatcttttc ctccaaacat gagttaatgg gtggtcttga
     2641 gttggaagag tggactgaag aaagaactta tactctccct cctctaaaat tgaactaatt
     2701 tattttttaa aatgctaaac caaaagcagc taaaaattct ccagttactt atctagggta
     2761 tctccaaacc cagataaatg acaatgttag aaacttcagc aagtggtcat gaggaaatga
     2821 gtggataatt ccagtggagt actgggagga cattgattct caatatctac cacccaaact
     2881 tcattttcat cactgtaaag aaggtgaatt gtgactactg ttttggttat gacaggttag
     2941 ataattttga tcaagccttg tgttgaaaat aataaaatct tttggggaaa aaa
//
