LOCUS       NM_213602               2948 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens sialic acid binding Ig like lectin 15 (SIGLEC15),
            mRNA.
ACCESSION   NM_213602
VERSION     NM_213602.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2948)
  AUTHORS   Chen,Z., Yu,M., Zhang,B., Jin,L., Yu,Q., Liu,S., Zhou,B., Yan,J.,
            Zhang,W., Li,X., Xu,Y., Xiao,Y., Zhou,J., Fan,J., Hung,M.C., Ye,Q.,
            Li,H. and Guo,L.
  TITLE     SIGLEC15, negatively correlated with PD-L1 in HCC, could induce
            CD8+ T cell apoptosis to promote immune evasion
  JOURNAL   Oncoimmunology 13 (1), 2376264 (2024)
   PUBMED   38988824
  REMARK    GeneRIF: SIGLEC15, negatively correlated with PD-L1 in HCC, could
            induce CD8+ T cell apoptosis to promote immune evasion.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2948)
  AUTHORS   Gao,H.Y., Liu,G.J. and Qiu,Y.R.
  TITLE     Siglec-15 regulates cell proliferation, migration and invasion in
            bladder cancer
  JOURNAL   Asian J Surg 47 (4), 1892-1894 (2024)
   PUBMED   38169162
  REMARK    GeneRIF: Siglec-15 regulates cell proliferation, migration and
            invasion in bladder cancer.
REFERENCE   3  (bases 1 to 2948)
  AUTHORS   Huang,Z., Guo,Y., Li,B., Shen,M., Yi,Y., Li,L., Zhao,X. and Yang,L.
  TITLE     Siglec-15 on macrophages suppress the immune microenvironment in
            patients with PD-L1 negative non-metastasis lung adenocarcinoma
  JOURNAL   Cancer Gene Ther 31 (3), 427-438 (2024)
   PUBMED   38072971
  REMARK    GeneRIF: Siglec-15 on macrophages suppress the immune
            microenvironment in patients with PD-L1 negative non-metastasis
            lung adenocarcinoma.
REFERENCE   4  (bases 1 to 2948)
  AUTHORS   Moreira,R.S., da Silva,M.M., de Melo Vasconcelos,C.F., da
            Silva,T.D., Cordeiro,G.G., Mattos-Jr,L.A.R., da Rocha Pitta,M.G.,
            de Melo Rego,M.J.B. and Pereira,M.C.
  TITLE     Siglec 15 as a biomarker or a druggable molecule for non-small cell
            lung cancer
  JOURNAL   J Cancer Res Clin Oncol 149 (19), 17651-17661 (2023)
   PUBMED   37843557
  REMARK    GeneRIF: Siglec 15 as a biomarker or a druggable molecule for
            non-small cell lung cancer.
            Review article
REFERENCE   5  (bases 1 to 2948)
  AUTHORS   Li,B., Guo,Y., Yi,Y., Huang,Z., Ren,Y., Wang,H. and Yang,L.
  TITLE     Non-spatial and spatial heterogeneity revealed a suppressive immune
            feature of Siglec-15 in lung adenocarcinomas
  JOURNAL   J Transl Med 21 (1), 599 (2023)
   PUBMED   37674198
  REMARK    GeneRIF: Non-spatial and spatial heterogeneity revealed a
            suppressive immune feature of Siglec-15 in lung adenocarcinomas.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2948)
  AUTHORS   Kang,F.B., Chen,W., Wang,L. and Zhang,Y.Z.
  TITLE     The diverse functions of Siglec-15 in bone remodeling and antitumor
            responses
  JOURNAL   Pharmacol Res 155, 104728 (2020)
   PUBMED   32112821
  REMARK    GeneRIF: The diverse functions of Siglec-15 in bone remodeling and
            antitumor responses.
            Review article
REFERENCE   7  (bases 1 to 2948)
  AUTHORS   Angata,T.
  TITLE     Siglec-15: a potential regulator of osteoporosis, cancer, and
            infectious diseases
  JOURNAL   J Biomed Sci 27 (1), 10 (2020)
   PUBMED   31900164
  REMARK    GeneRIF: hemical biology has advanced our understanding of the
            nature of Siglec-15 ligands, but the exact nature of Siglec-15
            ligand depends on the biological context, leaving plenty of room
            for further exploration
            Review article
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2948)
  AUTHORS   Wang,J., Sun,J., Liu,L.N., Flies,D.B., Nie,X., Toki,M., Zhang,J.,
            Song,C., Zarr,M., Zhou,X., Han,X., Archer,K.A., O'Neill,T.,
            Herbst,R.S., Boto,A.N., Sanmamed,M.F., Langermann,S., Rimm,D.L. and
            Chen,L.
  TITLE     Siglec-15 as an immune suppressor and potential target for
            normalization cancer immunotherapy
  JOURNAL   Nat Med 25 (4), 656-666 (2019)
   PUBMED   30833750
  REMARK    GeneRIF: Siglec-15 is a potential target for normalization cancer
            immunotherapy.
REFERENCE   9  (bases 1 to 2948)
  AUTHORS   Takamiya,R., Ohtsubo,K., Takamatsu,S., Taniguchi,N. and Angata,T.
  TITLE     The interaction between Siglec-15 and tumor-associated sialyl-Tn
            antigen enhances TGF-beta secretion from monocytes/macrophages
            through the DAP12-Syk pathway
  JOURNAL   Glycobiology 23 (2), 178-187 (2013)
   PUBMED   23035012
  REMARK    GeneRIF: Siglec-15 recognizes the tumoral sTn antigen and
            transduces a signal for enhanced TGF-beta secretion in TAMs
REFERENCE   10 (bases 1 to 2948)
  AUTHORS   Angata,T., Tabuchi,Y., Nakamura,K. and Nakamura,M.
  TITLE     Siglec-15: an immune system Siglec conserved throughout vertebrate
            evolution
  JOURNAL   Glycobiology 17 (8), 838-846 (2007)
   PUBMED   17483134
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC299128.1, AK172835.1 and AC087685.9.
            
            On May 17, 2019 this sequence version replaced NM_213602.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK172835.1, AY971516.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2146236, SAMEA2155751
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000389474.8/ ENSP00000374125.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                DC299128.1         164-183
            21-1410             AK172835.1         116-1505
            1411-2948           AC087685.9         43254-44791         c
FEATURES             Location/Qualifiers
     source          1..2948
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q12.3"
     gene            1..2948
                     /gene="SIGLEC15"
                     /gene_synonym="CD33L3; HsT1361; SIGLEC-15"
                     /note="sialic acid binding Ig like lectin 15"
                     /db_xref="GeneID:284266"
                     /db_xref="HGNC:HGNC:27596"
                     /db_xref="MIM:618105"
     exon            1..106
                     /gene="SIGLEC15"
                     /gene_synonym="CD33L3; HsT1361; SIGLEC-15"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1041
                     /gene="SIGLEC15"
                     /gene_synonym="CD33L3; HsT1361; SIGLEC-15"
                     /note="CD33 antigen-like 3; CD33 molecule-like 3"
                     /codon_start=1
                     /product="sialic acid-binding Ig-like lectin 15 precursor"
                     /protein_id="NP_998767.1"
                     /db_xref="CCDS:CCDS32819.1"
                     /db_xref="GeneID:284266"
                     /db_xref="HGNC:HGNC:27596"
                     /db_xref="MIM:618105"
                     /translation="MEKSIWLLACLAWVLPTGSFVRTKIDTTENLLNTEVHSSPAQRW
                     SMQVPPEVSAEAGDAAVLPCTFTHPHRHYDGPLTAIWRAGEPYAGPQVFRCAAARGSE
                     LCQTALSLHGRFRLLGNPRRNDLSLRVERLALADDRRYFCRVEFAGDVHDRYESRHGV
                     RLHVTAAPRIVNISVLPSPAHAFRALCTAEGEPPPALAWSGPALGNSLAAVRSPREGH
                     GHLVTAELPALTHDGRYTCTAANSLGRSEASVYLFRFHGASGASTVALLLGALGFKAL
                     LLLGVLAARAARRRPEHLDTPDTPPRSQAQESNYENLSQMNPRSPPATMCSP"
     exon            107..166
                     /gene="SIGLEC15"
                     /gene_synonym="CD33L3; HsT1361; SIGLEC-15"
                     /inference="alignment:Splign:2.1.0"
     exon            167..550
                     /gene="SIGLEC15"
                     /gene_synonym="CD33L3; HsT1361; SIGLEC-15"
                     /inference="alignment:Splign:2.1.0"
     exon            551..928
                     /gene="SIGLEC15"
                     /gene_synonym="CD33L3; HsT1361; SIGLEC-15"
                     /inference="alignment:Splign:2.1.0"
     exon            929..959
                     /gene="SIGLEC15"
                     /gene_synonym="CD33L3; HsT1361; SIGLEC-15"
                     /inference="alignment:Splign:2.1.0"
     exon            960..2948
                     /gene="SIGLEC15"
                     /gene_synonym="CD33L3; HsT1361; SIGLEC-15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1388..1393
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIGLEC15"
                     /gene_synonym="CD33L3; HsT1361; SIGLEC-15"
                     /note="hexamer: AGTAAA"
     polyA_site      1410
                     /gene="SIGLEC15"
                     /gene_synonym="CD33L3; HsT1361; SIGLEC-15"
                     /note="major polyA site"
     polyA_site      1437
                     /gene="SIGLEC15"
                     /gene_synonym="CD33L3; HsT1361; SIGLEC-15"
ORIGIN      
        1 actggggagg tggccgagag cgggtctggc ctggggtgtt cagatgctca cagcatggaa
       61 aagtccatct ggctgctggc ctgcttggcg tgggttctcc cgacaggctc atttgtgaga
      121 actaaaatag atactacgga gaacttgctc aacacagagg tgcacagctc gccagcgcag
      181 cgctggtcca tgcaggtgcc acccgaggtg agcgcggagg caggcgacgc ggcagtgctg
      241 ccctgcacct tcacgcaccc gcaccgccac tacgacgggc cgctgacggc catctggcgc
      301 gcgggcgagc cctatgcggg cccgcaggtg ttccgctgcg ctgcggcgcg gggcagcgag
      361 ctctgccaga cggcgctgag cctgcacggc cgcttccggc tgctgggcaa cccgcgccgc
      421 aacgacctct cgctgcgcgt cgagcgcctc gccctggctg acgaccgccg ctacttctgc
      481 cgcgtcgagt tcgccggcga cgtccatgac cgctacgaga gccgccacgg cgtccggctg
      541 cacgtgacag ccgcgccgcg gatcgtcaac atctcggtgc tgcccagtcc ggctcacgcc
      601 ttccgcgcgc tctgcactgc cgaaggggag ccgccgcccg ccctcgcctg gtccggcccg
      661 gccctgggca acagcttggc agccgtgcgg agcccgcgtg agggtcacgg ccacctagtg
      721 accgccgaac tgcccgcact gacccatgac ggccgctaca cgtgtacggc cgccaacagc
      781 ctgggccgct ccgaggccag cgtctacctg ttccgcttcc atggcgccag cggggcctcg
      841 acggtcgccc tcctgctcgg cgctctcggc ttcaaggcgc tgctgctgct cggggtcctg
      901 gccgcccgcg ctgcccgccg ccgcccagag catctggaca ccccggacac cccaccacgg
      961 tcccaggccc aggagtccaa ttatgaaaat ttgagccaga tgaacccccg gagcccacca
     1021 gccaccatgt gctcaccgtg aggagtccct cagccaccaa catccatttc agcactgtaa
     1081 agaacaaagg ccagtgcgag gcttggctgg cacagccagt cctggttctc gggcaccttg
     1141 gcagccccca gctgggtggc tcctcccctg ctcaaggtca agaccctgct caaggaggct
     1201 catctggcct cctatgtgga caaccatttc ggagctccct gatatttttg ccagcatttc
     1261 gtaaatgtgc atacgtctgt gtgtgtgtgt gtgtgtgaga gagagagaga gagagtacac
     1321 gcattagctt gagcgtgaaa cttccagaaa tgttcccttg ccctttctta cctagaacac
     1381 ctgctatagt aaagcagaca ggaaactgtt tacagggcct ggaggcccag tcttgtcctc
     1441 ctctgtcacc gacttgctgt gtggacctgg gacactctct tcacttctct gggtctcaat
     1501 tcatttactg ttgaacacgg acaatcatat tcttccctcc tggctgggag gactacaaag
     1561 atctgaggaa ataatggata tgaaggggct ttggaaagta caaagccatc ttctcatgag
     1621 gggcatgaca gaaccctctt tgcagagtga cctttggacg tgcagtcagt tcttggagaa
     1681 gtgtggcccc tgcagcagtg tcacggagaa cacagagttc cagagagcaa gcctggggca
     1741 ggggctgtgc aaacgtgtgg tcagaggaac atcaaatcct ggaaacttgg tggcagggag
     1801 aggcctgggg cctttacccc atgccccctg ggatctccac tgtgactgtc ccacaccctc
     1861 tgcccaactc ttgccccatc agctgccctg cattgccttg agctgggacc cctaggaaat
     1921 ggaaaccagg ctcccctctc tcaaggtatc tgggaaccac tgtctcagga gctgaagccg
     1981 ggagacctga ggggaggtct ggccggagag tccgtgcgta aagcagctac agctctgacc
     2041 tctctgacct gcagcctctc agggcgtgcg aagtccaaac gcactggcaa cttcaccccc
     2101 tttgccctaa cgcgggcagg ctgacttgga ggggtgcttc cctatttaca cctcagggtg
     2161 aatttgttga tcaccttagc tcctgtggtc cttggggctt agggagagga gggaggcatg
     2221 cctgggtccc aggtaagctg gcaagaggaa agggccacag gctaggggaa taacgaggcc
     2281 atgaacaaga catctcaccc cagttacaat ggcttttatc caaaagacag gcaatgacaa
     2341 atgctgatga gaaagtggag aaagaggaat ccccatatac tattggtggg aatgtaaatt
     2401 agtatagcca ctatggagaa cagtacagtt tcctcaaaaa actaaaaata ggctgggcgt
     2461 ggtggctcat gcctgtaatc ccagcaccct gggaggccga ggcaggtgga tcacttgagg
     2521 tcaggagttc gagaccagcc tagctaacat ggtaaaactc tgtctctact aaaaatacaa
     2581 aaattagctg ggcgtgctgg cacgtgccta tagtcccagc aacttgggag gctgaggcag
     2641 aagtattgct tgaacccagg aggcagaggt tgcagtgagc tgagatcacc ccactgtcct
     2701 ccagcctggg caacagagag actgtctcca aagaaaaaaa aagaaataga actaccatat
     2761 gatccagtaa tcccactgct gggtatctgt cagcaaggaa atcagtatat tgaaaagata
     2821 ccagtactcc catgtttact gcagcactat ttgcaatagc caagatatgg aatcagccta
     2881 agtgtccatc cacgaatgaa tgaagaaaat gaacacacaa tgaaatattc agccataaaa
     2941 aaaaaaaa
//
