LOCUS       NM_001098612            5134 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens sialic acid binding Ig like lectin 14 (SIGLEC14),
            mRNA.
ACCESSION   NM_001098612
VERSION     NM_001098612.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5134)
  AUTHORS   Yu,Y., Zhang,Z., Dong,X., Yang,R., Duan,Z., Xiang,Z., Li,J., Li,G.,
            Yan,F., Xue,H., Jiao,D., Lu,J., Lu,H., Zhang,W., Wei,Y., Fan,S.,
            Li,J., Jia,J., Zhang,J., Ji,J., Liu,P., Lu,H., Zhao,H., Chen,S.,
            Wei,C., Chen,H. and Zhu,Z.
  TITLE     Pangenomic analysis of Chinese gastric cancer
  JOURNAL   Nat Commun 13 (1), 5412 (2022)
   PUBMED   36109518
  REMARK    GeneRIF: Genes ACOT1, GSTM1, SIGLEC14 and UGT2B17 are identified as
            highly absent genes in gastric cancer population.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5134)
  AUTHORS   Shaw,B.C., Katsumata,Y., Simpson,J.F., Fardo,D.W. and Estus,S.
  TITLE     Analysis of Genetic Variants Associated with Levels of Immune
            Modulating Proteins for Impact on Alzheimer's Disease Risk Reveal a
            Potential Role for SIGLEC14
  JOURNAL   Genes (Basel) 12 (7), 1008 (2021)
   PUBMED   34208838
  REMARK    GeneRIF: Analysis of Genetic Variants Associated with Levels of
            Immune Modulating Proteins for Impact on Alzheimer's Disease Risk
            Reveal a Potential Role for SIGLEC14.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5134)
  AUTHORS   Tsai,C.M., Riestra,A.M., Ali,S.R., Fong,J.J., Liu,J.Z., Hughes,G.,
            Varki,A. and Nizet,V.
  TITLE     Siglec-14 Enhances NLRP3-Inflammasome Activation in Macrophages
  JOURNAL   J Innate Immun 12 (4), 333-343 (2020)
   PUBMED   31805552
  REMARK    GeneRIF: Siglec-14 Enhances NLRP3-Inflammasome Activation in
            Macrophages.
REFERENCE   4  (bases 1 to 5134)
  AUTHORS   Huang,P.J., Low,P.Y., Wang,I., Hsu,S.D. and Angata,T.
  TITLE     Soluble Siglec-14 glycan-recognition protein is generated by
            alternative splicing and suppresses myeloid inflammatory responses
  JOURNAL   J Biol Chem 293 (51), 19645-19658 (2018)
   PUBMED   30377253
  REMARK    GeneRIF: soluble Siglec-14 suppresses pro-inflammatory responses
            triggered by membrane-bound Siglec-14
REFERENCE   5  (bases 1 to 5134)
  AUTHORS   Graustein,A.D., Horne,D.J., Fong,J.J., Schwarz,F., Mefford,H.C.,
            Peterson,G.J., Wells,R.D., Musvosvi,M., Shey,M., Hanekom,W.A.,
            Hatherill,M., Scriba,T.J., Thuong,N.T.T., Mai,N.T.H., Caws,M.,
            Bang,N.D., Dunstan,S.J., Thwaites,G.E., Varki,A., Angata,T. and
            Hawn,T.R.
  TITLE     The SIGLEC14 null allele is associated with Mycobacterium
            tuberculosis- and BCG-induced clinical and immunologic outcomes
  JOURNAL   Tuberculosis (Edinb) 104, 38-45 (2017)
   PUBMED   28454648
  REMARK    GeneRIF: Demonstrate an association between SIGLEC14 expression and
            clinical tuberculosis, mycobacterium tuberculosis replication, and
            BCG-specific T-cell cytokine production.
REFERENCE   6  (bases 1 to 5134)
  AUTHORS   Ali,S.R., Fong,J.J., Carlin,A.F., Busch,T.D., Linden,R., Angata,T.,
            Areschoug,T., Parast,M., Varki,N., Murray,J., Nizet,V. and Varki,A.
  TITLE     Siglec-5 and Siglec-14 are polymorphic paired receptors that
            modulate neutrophil and amnion signaling responses to group B
            Streptococcus
  JOURNAL   J Exp Med 211 (6), 1231-1242 (2014)
   PUBMED   24799499
  REMARK    GeneRIF: Data indicate that the Siglec-5/14 genotype influences
            neutrophil responses to group B Streptococcus.
REFERENCE   7  (bases 1 to 5134)
  AUTHORS   Angata,T., Ishii,T., Motegi,T., Oka,R., Taylor,R.E., Soto,P.C.,
            Chang,Y.C., Secundino,I., Gao,C.X., Ohtsubo,K., Kitazume,S.,
            Nizet,V., Varki,A., Gemma,A., Kida,K. and Taniguchi,N.
  TITLE     Loss of Siglec-14 reduces the risk of chronic obstructive pulmonary
            disease exacerbation
  JOURNAL   Cell Mol Life Sci 70 (17), 3199-3210 (2013)
   PUBMED   23519826
  REMARK    GeneRIF: Siglec-14 and its downstream signaling pathway facilitate
            the 'infection-inflammation-exacerbation' axis of COPD disease
            progression
REFERENCE   8  (bases 1 to 5134)
  AUTHORS   Yamanaka,M., Kato,Y., Angata,T. and Narimatsu,H.
  TITLE     Deletion polymorphism of SIGLEC14 and its functional implications
  JOURNAL   Glycobiology 19 (8), 841-846 (2009)
   PUBMED   19369701
  REMARK    GeneRIF: The presence of the 'SIGLEC14 null' allele in all human
            populations we tested implies an ancient origin, while its allelic
            frequency is higher in Asians compared with Africans and Europeans.
            Siglec-14 may play some role in bacterial infection.
REFERENCE   9  (bases 1 to 5134)
  AUTHORS   Angata,T., Hayakawa,T., Yamanaka,M., Varki,A. and Nakamura,M.
  TITLE     Discovery of Siglec-14, a novel sialic acid receptor undergoing
            concerted evolution with Siglec-5 in primates
  JOURNAL   FASEB J 20 (12), 1964-1973 (2006)
   PUBMED   17012248
  REMARK    GeneRIF: Siglec-14 and Siglec-5 appear to be the first glycan
            binding paired receptors. Near-complete sequence identity of the
            amino-terminal part of human Siglec-14 and Siglec-5 indicates
            partial gene conversion between SIGLEC14 and SIGLEC5.
REFERENCE   10 (bases 1 to 5134)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC018755.3.
            
            On Apr 13, 2021 this sequence version replaced NM_001098612.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY854038.1, AK298284.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000360844.7/ ENSP00000354090.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               AC018755.3         73872-73974         c
            104-487             AC018755.3         73406-73789         c
            488-766             AC018755.3         72931-73209         c
            767-820             AC018755.3         72626-72679         c
            821-1078            AC018755.3         70928-71185         c
            1079-1214           AC018755.3         70686-70821         c
            1215-5134           AC018755.3         66627-70546         c
FEATURES             Location/Qualifiers
     source          1..5134
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..5134
                     /gene="SIGLEC14"
                     /note="sialic acid binding Ig like lectin 14"
                     /db_xref="GeneID:100049587"
                     /db_xref="HGNC:HGNC:32926"
                     /db_xref="MIM:618132"
     exon            1..103
                     /gene="SIGLEC14"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1257
                     /gene="SIGLEC14"
                     /note="siglec-14"
                     /codon_start=1
                     /product="sialic acid-binding Ig-like lectin 14 precursor"
                     /protein_id="NP_001092082.1"
                     /db_xref="CCDS:CCDS42604.1"
                     /db_xref="GeneID:100049587"
                     /db_xref="HGNC:HGNC:32926"
                     /db_xref="MIM:618132"
                     /translation="MLPLLLLPLLWGGSLQEKPVYELQVQKSVTVQEGLCVLVPCSFS
                     YPWRSWYSSPPLYVYWFRDGEIPYYAEVVATNNPDRRVKPETQGRFRLLGDVQKKNCS
                     LSIGDARMEDTGSYFFRVERGRDVKYSYQQNKLNLEVTALIEKPDIHFLEPLESGRPT
                     RLSCSLPGSCEAGPPLTFSWTGNALSPLDPETTRSSELTLTPRPEDHGTNLTCQVKRQ
                     GAQVTTERTVQLNVSYAPQNLAISIFFRNGTGTALRILSNGMSVPIQEGQSLFLACTV
                     DSNPPASLSWFREGKALNPSQTSMSGTLELPNIGAREGGEFTCRVQHPLGSQHLSFIL
                     SVQRSSSSCICVTEKQQGSWPLVLTLIRGALMGAGFLLTYGLTWIYYTRCGGPQQSRA
                     ERPG"
     exon            104..487
                     /gene="SIGLEC14"
                     /inference="alignment:Splign:2.1.0"
     exon            488..766
                     /gene="SIGLEC14"
                     /inference="alignment:Splign:2.1.0"
     exon            767..820
                     /gene="SIGLEC14"
                     /inference="alignment:Splign:2.1.0"
     exon            821..1078
                     /gene="SIGLEC14"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1214
                     /gene="SIGLEC14"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..5134
                     /gene="SIGLEC14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2031..2036
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIGLEC14"
                     /note="hexamer: AATACA"
     polyA_site      2051
                     /gene="SIGLEC14"
                     /note="major polyA site"
     regulatory      2637..2642
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIGLEC14"
                     /note="hexamer: AATAAA"
     polyA_site      2655
                     /gene="SIGLEC14"
     regulatory      5109..5114
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIGLEC14"
                     /note="hexamer: AATAAA"
     polyA_site      5134
                     /gene="SIGLEC14"
                     /note="major polyA site"
ORIGIN      
        1 atttggagca tttccttccc tgacagccgg acctgggact gggctggggc cctggcggat
       61 ggagacatgc tgcccctgct gctgctgccc ctgctgtggg gggggtccct gcaggagaag
      121 ccagtgtacg agctgcaagt gcagaagtcg gtgacggtgc aggagggcct gtgcgtcctt
      181 gtgccctgct ccttctctta cccctggaga tcctggtatt cctctccccc actctacgtc
      241 tactggttcc gggacgggga gatcccatac tacgctgagg ttgtggccac aaacaaccca
      301 gacagaagag tgaagccaga gacccagggc cgattccgcc tccttgggga tgtccagaag
      361 aagaactgct ccctgagcat cggagatgcc agaatggagg acacgggaag ctatttcttc
      421 cgcgtggaga gaggaaggga tgtaaaatat agctaccaac agaataagct gaacttggag
      481 gtgacagccc tgatagagaa acccgacatc cactttctgg agcctctgga gtccggccgc
      541 cccacaaggc tgagctgcag ccttccagga tcctgtgaag cgggaccacc tctcacattc
      601 tcctggacgg ggaatgccct cagccccctg gaccccgaga ccacccgctc ctcggagctc
      661 accctcaccc ccaggcccga ggaccatggc accaacctca cctgtcaggt gaaacgccaa
      721 ggagctcagg tgaccacgga gagaactgtc cagctcaatg tctcctatgc tccacagaac
      781 ctcgccatca gcatcttctt cagaaatggc acaggcacag ccctgcggat cctgagcaat
      841 ggcatgtcgg tgcccatcca ggagggccag tccctgttcc tcgcctgcac agttgacagc
      901 aacccccctg cctcactgag ctggttccgg gagggaaaag ccctcaatcc ttcccagacc
      961 tcaatgtctg ggaccctgga gctgcctaac ataggagcta gagagggagg ggaattcacc
     1021 tgccgggttc agcatccgct gggctcccag cacctgtcct tcatcctttc tgtgcagaga
     1081 agctcctctt cctgcatatg tgtaactgag aaacagcagg gctcctggcc cctcgtcctc
     1141 accctgatca ggggggctct catgggggct ggcttcctcc tcacctatgg cctcacctgg
     1201 atctactata ccaggtgtgg aggcccccag cagagcaggg ctgagaggcc tggctgagcc
     1261 cctcccgctc aagacagaac tgaggtgtgg acacttagcc ctgtgggaca catgcaggac
     1321 atcactgtca gcttctttct ggaagctcac atcccactga ctacccctct tttccttcct
     1381 gccccatacc ccttctactt attcccctct gcttgtgagt cttgccccac cacacctgca
     1441 tccccatctg caccccatcc cctctccacc tgcccttctc ttccctctcc atccaccatc
     1501 tccagccctg tgaagggaat gtactttcgg tcttataccc ccattaccca ttacccaaaa
     1561 gttacctttt tttttttttt ttttttttga gacagagtct cactctgttg cacaggctgg
     1621 agttcagtgg cacaatctcc gttcactgca acctccacct ctggggttca agcaattctc
     1681 ctgcctcagc ctccctagta gctgggatta caggtgcctg ccaccacatc cagttaattt
     1741 tttttttttg tatgttagta gagatggggt tttaccatgt tggccaggtc tcgaactcct
     1801 gacctcaagc aatccactgc attggcctcc caaagtgctg gcattacagg tatgagccac
     1861 cgtgcctggc tgccaaaagt taccttctta acacttgaat ttctggtctc ctcagcttcc
     1921 ctatccatat aggcacagag aggcagcatt tgttttccag ttaaaactct acctcattgt
     1981 gattattatc caatacaatt gttacaaaat aagtaaaact tttatgaaac aatacaacat
     2041 aactgatttt actctttaat gcctctgtga gagtttgtag acaaaaatta tgtctttttt
     2101 ttttttcttt gagacagagt ttctatcttg ttgcccaggc tggagtgcaa tggcaaaatc
     2161 tcagctcact gcaacttctg cctcccaggt tcaagtgatt ctccttctgt ccatatacaa
     2221 gaaggcaata cctgtattgt caggttctgt gcatcgtata actggaacca aacatatttg
     2281 ctttagggtc tgctttcatt tcttcagtgt ggttttccca gtttatccac gttgttacac
     2341 gtatcaatag ctcattctca gttttggtgg ggtttttttt gcttttaata tcgtacagtc
     2401 agccttctgt atccactggt tctgcatttt ccctttaatc acttttgctg caccacaaaa
     2461 gttttgttat gttgtatttt tatattagtt caaaatattt ccttctttcc cctgagattt
     2521 cctttgaatt cacggattgc ttagaagtgt gttgtttaat ttctaagtga ttgcagattt
     2581 tactggtttt ttatttttaa acaaattgtt actactttct ttttaagttc cattttaata
     2641 aatacacatg cttgatatga ttttttttaa cttttaagtt cagggggcac aagtgcaggt
     2701 ttgttacata ggtaaagtgt catgggagtt tgttgtacag attattgcat cacccagata
     2761 ttaagcctag tacccattag ttattttcct catcctctcc ctcctcccac cttccaccct
     2821 ttgaaaggcc ccagtgtgtg ttgctcacct ctatgtatcc atgtgttctc atcatttagc
     2881 tcccacttac aagtgagaac atgtggtatt tggttttctc ttcttgtgat agtttgctga
     2941 ggataatggt ctccagctcc actcatgtcc ctgcaaagga cataatctca ttctttttta
     3001 tggctgctta gtattccatg gtgtatatgt accacatttt ctctatccag tctaccactg
     3061 ataggcagtt aggttgattc catgtcattg ctattgtgaa tagtgctgca gtgaatgtat
     3121 gcatgcatgt gtctttgtaa tagaatgatt tatattcctt tgggtatatg cctaggaatg
     3181 ggattgctga gtcgaatggt atttctatgt ttaggtcttt gaggaatcgc cacactgtct
     3241 tccacaatgg ctgaactaac tttcactttc accaaccgtg agagtctttt atattggtta
     3301 agtttgcttg atgacactgg tctatcttgg tgaatgctcc atgtgtgctt agaaagaatg
     3361 tgtattgccc tgttatggga cgaatattaa atggcaatta gacatagttg tccaatggtg
     3421 ttcagtttta tagctggtaa cttttttgtc taccagctca gtctattact gagagaggaa
     3481 tgttgaagtc tctgatccta atgttggatt tgtcagtttc tcctctcagt ttcatcagtt
     3541 tttgctgcat gtatttttaa actctgtcgt taggtgcata catattaaga attctcatgt
     3601 cttcttaaag aatcaactta aaaaaaattt ttttttgaga cagagtttcg ctctttttgc
     3661 ccaggctgga gtgcaatggc gcgatcttgg ctcactgcaa cctccgcctc ccaggtacaa
     3721 gtgattctcc tgcctcagcc tcccaaatag cttggattac aggcacgcac catcacgcct
     3781 ggctagtttt ttttgtattt agtagagaca aggtttcacc atgtaagtca ggctggtcct
     3841 gaactcctga cttcaggtga tccacccgcc tcagcctcca aagtgctggg attataggcg
     3901 tgagccaccg cagttggctg aatcaactgt tttacattat gtaacatcac tttttgttcc
     3961 tgtgattttc tttgctctta agtgtacttt gtctgctatt aacatagcca ttccagtttt
     4021 cttttgacta gtatttgcat agtatgcatt ttcacatcct ttaagtccta gcctcacctc
     4081 attatatttg aaatggaaag catttatact cagaagctgg agttcctttt ccctagctct
     4141 tccctttcca gaattgttac ctgttgtttc agtgttccta gttgccctgg gcttcatccc
     4201 ttgtttctca gtccagaaag atggaaggag ttgtattaga attttagcag ccactttctg
     4261 cactgtagct ctgacctacc attggaataa agctatttat tccttgttgg tgcctttccc
     4321 caaatattga ctcccgttcc agaatctatt ttcttttatc ccatttccca agtagttttt
     4381 tttccccatt caaagcttat aacttgtaag gattttttgt ttgtttgttt tgttgtgttg
     4441 tggtgagttc actctgctag gagcttactc cttcataata aaagcacgac tccttctctt
     4501 tcgttttgaa ggataatttt ccaaaatgta gaattctagc tttgcatttt tcttttaacc
     4561 ttttggagat gtcattccac tttggagggc gggtgagttt ctcatgacaa ttcagtcatc
     4621 attttcttat tgtggttcca tttaaggcaa tatctgttta tgtcttgctg cttttataat
     4681 ttcttcattc tttttcatga atttaacttt tataaacttc aggtgttttt cttttaattt
     4741 ccctaagtgc atgtagcaaa gagagtgcaa tatttgcttt ttttctatat gctttaactc
     4801 ttgatatact ttatttatgc tataatagaa atgtgtgtct tcccaaaatt tatatgttga
     4861 aatcttaaac ctcaaggtga tggtattaaa aggttggggc tttttggaaa gtgattaacc
     4921 cataatggtg ccatccttca tgaatgggat tagtgttctc ataaaagaaa cagaaggaag
     4981 tgtgttttcc tcttctgcca tgtgaggata ccacgaaaag atactatctg ggaagcaaat
     5041 aattctctcc agacactgaa tccgctggca ccttgatctt ggacttcccg acctccagaa
     5101 ttatgagaaa taaatttctg ttgtttataa atca
//
