LOCUS       NM_052884               3173 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens sialic acid binding Ig like lectin 11 (SIGLEC11),
            transcript variant 1, mRNA.
ACCESSION   NM_052884
VERSION     NM_052884.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3173)
  AUTHORS   Hane,M., Chen,D.Y. and Varki,A.
  TITLE     Human-specific microglial Siglec-11 transcript variant has the
            potential to affect polysialic acid-mediated brain functions at a
            distance
  JOURNAL   Glycobiology 31 (3), 231-242 (2021)
   PUBMED   32845322
  REMARK    GeneRIF: Human-specific microglial Siglec-11 transcript variant has
            the potential to affect polysialic acid-mediated brain functions at
            a distance.
REFERENCE   2  (bases 1 to 3173)
  AUTHORS   Schwarz,F., Landig,C.S., Siddiqui,S., Secundino,I., Olson,J.,
            Varki,N., Nizet,V. and Varki,A.
  TITLE     Paired Siglec receptors generate opposite inflammatory responses to
            a human-specific pathogen
  JOURNAL   EMBO J 36 (6), 751-760 (2017)
   PUBMED   28100677
  REMARK    GeneRIF: The authors demonstrated that the human-specific pathogen
            Escherichia coli K1 uses its polysialic acid capsule as a molecular
            mimic to engage Siglec-11 and escape killing. In contrast,
            engagement of the activating counterpart Siglec-16 increases
            elimination of bacteria.
REFERENCE   3  (bases 1 to 3173)
  AUTHORS   Wang,X., Chow,R., Deng,L., Anderson,D., Weidner,N., Godwin,A.K.,
            Bewtra,C., Zlotnik,A., Bui,J., Varki,A. and Varki,N.
  TITLE     Expression of Siglec-11 by human and chimpanzee ovarian stromal
            cells, with uniquely human ligands: implications for human ovarian
            physiology and pathology
  JOURNAL   Glycobiology 21 (8), 1038-1048 (2011)
   PUBMED   21467073
  REMARK    GeneRIF: The results indicate potential roles for Siglec-11 in
            ovarian physiology and human evolution.
REFERENCE   4  (bases 1 to 3173)
  AUTHORS   Wang,Y. and Neumann,H.
  TITLE     Alleviation of neurotoxicity by microglial human Siglec-11
  JOURNAL   J Neurosci 30 (9), 3482-3488 (2010)
   PUBMED   20203208
  REMARK    GeneRIF: Siglec-11 ectopically expressed on murine microglia
            interacts with PSA on neurons, reduces LPS-induced gene
            transcription of proinflammatory mediators, impairs phagocytosis
            and alleviates microglial neurotoxicity.
REFERENCE   5  (bases 1 to 3173)
  AUTHORS   Cao,H., Lakner,U., de Bono,B., Traherne,J.A., Trowsdale,J. and
            Barrow,A.D.
  TITLE     SIGLEC16 encodes a DAP12-associated receptor expressed in
            macrophages that evolved from its inhibitory counterpart SIGLEC11
            and has functional and non-functional alleles in humans
  JOURNAL   Eur J Immunol 38 (8), 2303-2315 (2008)
   PUBMED   18629938
  REMARK    GeneRIF: SIGLEC16 encodes a DAP12-associated receptor expressed in
            macrophages that evolved from its inhibitory counterpart SIGLEC11
            and has functional and non-functional alleles in humans.
REFERENCE   6  (bases 1 to 3173)
  AUTHORS   Hayakawa,T., Angata,T., Lewis,A.L., Mikkelsen,T.S., Varki,N.M. and
            Varki,A.
  TITLE     A human-specific gene in microglia
  JOURNAL   Science 309 (5741), 1693 (2005)
   PUBMED   16151003
  REMARK    GeneRIF: expressed in human but not in chimpanzee brain microglia;
            findings indicate that human SIGLEC11 emerged through
            human-specific gene conversion by an adjacent pseudogene
REFERENCE   7  (bases 1 to 3173)
  AUTHORS   Angata,T., Kerr,S.C., Greaves,D.R., Varki,N.M., Crocker,P.R. and
            Varki,A.
  TITLE     Cloning and characterization of human Siglec-11. A recently evolved
            signaling molecule that can interact with SHP-1 and SHP-2 and is
            expressed by tissue macrophages, including brain microglia
  JOURNAL   J Biol Chem 277 (27), 24466-24474 (2002)
   PUBMED   11986327
  REMARK    GeneRIF: cloning and characterization; a recently evolved signaling
            that can interact with SHP-1 and SHP-2 and is expressed by tissue
            macrophages including brain microglia
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF337818.1 and AC011452.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_052884.2.
            
            Summary: This gene encodes a member of the sialic acid-binding
            immunoglobulin-like lectin family. These cell surface lectins are
            characterized by structural motifs in the immunoglobulin (Ig)-like
            domains and sialic acid recognition sites in the first Ig V set
            domain. This family member mediates anti-inflammatory and
            immunosuppressive signaling. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Oct 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF337818.1, AB072038.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153031 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            MANE Ensembl match               :: ENST00000447370.6/
                                                ENSP00000412361.2
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2346              AF337818.1         1-2346
            2347-3162           AC011452.6         55500-56315         c
            3163-3165           AF337818.1         3163-3165
            3166-3173           AC011452.6         55489-55496         c
FEATURES             Location/Qualifiers
     source          1..3173
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..3173
                     /gene="SIGLEC11"
                     /note="sialic acid binding Ig like lectin 11"
                     /db_xref="GeneID:114132"
                     /db_xref="HGNC:HGNC:15622"
                     /db_xref="MIM:607157"
     exon            1..167
                     /gene="SIGLEC11"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..2188
                     /gene="SIGLEC11"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; siglec-11"
                     /codon_start=1
                     /product="sialic acid-binding Ig-like lectin 11 isoform 1
                     precursor"
                     /protein_id="NP_443116.2"
                     /db_xref="CCDS:CCDS12790.2"
                     /db_xref="GeneID:114132"
                     /db_xref="HGNC:HGNC:15622"
                     /db_xref="MIM:607157"
                     /translation="MVPGQAQPQSPEMLLLPLLLPVLGAGSLNKDPSYSLQVQRQVPV
                     PEGLCVIVSCNLSYPRDGWDESTAAYGYWFKGRTSPKTGAPVATNNQSREVEMSTRDR
                     FQLTGDPGKGSCSLVIRDAQREDEAWYFFRVERGSRVRHSFLSNAFFLKVTALTKKPD
                     VYIPETLEPGQPVTVICVFNWAFKKCPAPSFSWTGAALSPRRTRPSTSHFSVLSFTPS
                     PQDHDTDLTCHVDFSRKGVSAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLE
                     VQKGQFLRLLCAADSQPPATLSWVLQDRVLSSSHPWGPRTLGLELRGVRAGDSGRYTC
                     RAENRLGSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCV
                     THSSPPARLSWTRWGQTVGPSQPSDPGVLELPPIQMEHEGEFTCHAQHPLGSQHVSLS
                     LSVHYPPQLLGPSCSWEAEGLHCSCSSQASPAPSLRWWLGEELLEGNSSQGSFEVTPS
                     SAGPWANSSLSLHGGLSSGLRLRCKAWNVHGAQSGSVFQLLPGKLEHGGGLGLGAALG
                     AGVAALLAFCSCLVVFRVKICRKEARKRAAAEQDVPSTLGPISQGHQHECSAGSSQDH
                     PPPGAATYTPGKGEEQELHYASLSFQGLRLWEPADQEAPSTTEYSEIKIHTGQPLRGP
                     GFGLQLEREMSGMVPK"
     exon            168..551
                     /gene="SIGLEC11"
                     /inference="alignment:Splign:2.1.0"
     exon            552..836
                     /gene="SIGLEC11"
                     /inference="alignment:Splign:2.1.0"
     exon            837..884
                     /gene="SIGLEC11"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1148
                     /gene="SIGLEC11"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1196
                     /gene="SIGLEC11"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1454
                     /gene="SIGLEC11"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1742
                     /gene="SIGLEC11"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1839
                     /gene="SIGLEC11"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..1921
                     /gene="SIGLEC11"
                     /inference="alignment:Splign:2.1.0"
     exon            1922..3173
                     /gene="SIGLEC11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3156..3161
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIGLEC11"
                     /note="hexamer: AATAAA"
     polyA_site      3173
                     /gene="SIGLEC11"
                     /note="major polyA site"
ORIGIN      
        1 cgaggctcct cctctgtgga tggtcactgc ccctccacca ggcttcctgc tggaggagtt
       61 tccttcccag ccaggccggc ccagaagcca gatggtcccg ggacaggccc agccccagag
      121 cccagagatg ctgctgctgc ccctgctgct gcccgtgctg ggggcggggt ccctgaacaa
      181 ggatcccagt tacagtcttc aagtgcagag gcaggtgccg gtgccggagg gcctgtgtgt
      241 catcgtgtct tgcaacctct cctacccccg ggatggctgg gacgagtcta ctgctgctta
      301 tggctactgg ttcaaaggac ggaccagccc aaagacgggt gctcctgtgg ccactaacaa
      361 ccagagtcga gaggtggaaa tgagcacccg ggaccgattc cagctcactg gggatcccgg
      421 caaagggagc tgctccttgg tgatcagaga cgcgcagagg gaggatgagg catggtactt
      481 ctttcgggtg gagagaggaa gccgtgtgag acatagtttc ctgagcaatg cgttctttct
      541 aaaagtaaca gccctgacta agaagcctga tgtctacatc cccgagaccc tggagcccgg
      601 gcagccggtg acggtcatct gtgtgtttaa ctgggctttc aagaaatgtc cagccccttc
      661 tttctcctgg acgggggctg ccctctcccc tagaagaacc agaccaagca cctcccactt
      721 ctcagtgctc agcttcacgc ccagccccca ggaccacgac accgacctca cctgccatgt
      781 ggacttctcc agaaagggtg tgagcgcaca gaggaccgtc cgactccgtg tggcctatgc
      841 ccccaaagac cttattatca gcatttcaca tgacaacacg tcagccctgg aactccaggg
      901 aaacgtcata tatctggaag ttcagaaagg ccagttcctg cggctcctct gtgctgctga
      961 cagccagccc cctgccacgc tgagctgggt cctgcaggac agagtcctct cctcgtccca
     1021 cccctggggc cccagaaccc tggggctgga gctgcgtggg gtaagggccg gggattcagg
     1081 gcgctacacc tgccgagcgg agaacaggct tggctcccag cagcaagccc tggacctctc
     1141 tgtgcagtat cctccagaga acctgagagt gatggtttcc caagcaaaca ggacagtcct
     1201 ggaaaacctc gggaacggca catccctccc ggtcctggag ggccaaagcc tgcgcctggt
     1261 ctgtgtcacc cacagcagcc ccccagccag gctgagctgg acccggtggg gacagaccgt
     1321 gggcccctcc cagccctcag accccggggt cctggagctg ccacccattc aaatggagca
     1381 cgaaggagag ttcacctgcc acgctcagca ccctctgggc tcccagcacg tctctctcag
     1441 cctctccgtg cactaccctc cacagctgct gggcccctcc tgctcctggg aggctgaggg
     1501 tctgcactgc agctgctcct cccaggccag cccggccccc tctctgcgct ggtggcttgg
     1561 ggaggagctg ctggagggga acagcagtca gggctccttc gaggtcaccc ccagctcagc
     1621 cgggccctgg gccaacagct ccctgagcct ccatggaggg ctcagctccg gcctcaggct
     1681 ccgctgtaag gcctggaacg tccacggggc ccagagtggc tctgtcttcc agctgctacc
     1741 agggaagctg gagcatgggg gaggacttgg cctgggggct gccctgggag ctggcgtcgc
     1801 tgccctgctc gctttctgtt cctgccttgt cgtcttcagg gtgaagatct gcaggaagga
     1861 agctcgcaag agggcagcag ctgagcagga cgtgccctcc accctgggac ccatctccca
     1921 gggtcaccag catgaatgct cggcaggcag ctcccaagac cacccgcccc caggtgcagc
     1981 cacctacacc ccggggaagg gggaagagca ggagctccac tatgcctccc tcagcttcca
     2041 gggcctgagg ctctgggagc ctgcggacca ggaggccccc agcaccaccg agtactcgga
     2101 gatcaagatc cacacaggac agcccctgag gggcccaggc tttgggcttc aattggagag
     2161 ggagatgtca gggatggttc caaagtgaag aggtctccat ggcaacagga caccagcaag
     2221 tgtgtgggag tcgcactggt gtgacggcca gaactggact cagatttcag ccccatcccc
     2281 aatgaagagc ttgagtttga agattatact ttttttgaga cagggtctga ctctgtcctc
     2341 caggccagag tccagtggtg caatctcagc tcactgtagc ctcaacctgc caggttgaag
     2401 tgagcctccc atttcagcct cccaagtagc tgggactaca attgtgagcc accatgccag
     2461 gctcattgtt atatttttag tagagacagg gttttgccat gtttccctgg ctggtctcag
     2521 actcctgggc tcaagcaatc tgcccgcctc tgcctcccaa agtgctggga ttacagacgt
     2581 gagccaccac agctggctga agattatact ttcaattcag agcgagtttg aagatgacac
     2641 tttgaggcat cgtgtctatg gttcattact acagaagctt ctctggatgt gtaaagcaca
     2701 ggaaaccagg cagaggaggc acagggtgct ctccagaacg agaagccagc tcctggagtt
     2761 gtttgctgca actgccattc cccgttgatg accatgctct tccttcagaa gagggagagt
     2821 gagaggacca agtccaagtg gttcccattt gaacatttaa aaaaaaaaaa aaggctgggc
     2881 atggtggctc acgcctgtaa tctcaacact ttgggaggct gaagtgggtg gatcacaagt
     2941 caggagttca agaccagcct gggcaagatg gtgaaacccc atctctacta aaaatacaaa
     3001 aattagccgg gcatggtggc gggcgcctaa aatcccagct actcgggaga ctaggcagag
     3061 aattggttga acccgggagg tggaggttgc agtgagccga gatcgtccca ctgcactcca
     3121 gcctgggcaa cagagtgaga ctctgtttct aaataaataa atgaataaat aaa
//
