LOCUS       NM_001135163            2895 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens sialic acid binding Ig like lectin 11 (SIGLEC11),
            transcript variant 2, mRNA.
ACCESSION   NM_001135163
VERSION     NM_001135163.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2895)
  AUTHORS   Hane,M., Chen,D.Y. and Varki,A.
  TITLE     Human-specific microglial Siglec-11 transcript variant has the
            potential to affect polysialic acid-mediated brain functions at a
            distance
  JOURNAL   Glycobiology 31 (3), 231-242 (2021)
   PUBMED   32845322
  REMARK    GeneRIF: Human-specific microglial Siglec-11 transcript variant has
            the potential to affect polysialic acid-mediated brain functions at
            a distance.
REFERENCE   2  (bases 1 to 2895)
  AUTHORS   Schwarz,F., Landig,C.S., Siddiqui,S., Secundino,I., Olson,J.,
            Varki,N., Nizet,V. and Varki,A.
  TITLE     Paired Siglec receptors generate opposite inflammatory responses to
            a human-specific pathogen
  JOURNAL   EMBO J 36 (6), 751-760 (2017)
   PUBMED   28100677
  REMARK    GeneRIF: The authors demonstrated that the human-specific pathogen
            Escherichia coli K1 uses its polysialic acid capsule as a molecular
            mimic to engage Siglec-11 and escape killing. In contrast,
            engagement of the activating counterpart Siglec-16 increases
            elimination of bacteria.
REFERENCE   3  (bases 1 to 2895)
  AUTHORS   Wang,X., Chow,R., Deng,L., Anderson,D., Weidner,N., Godwin,A.K.,
            Bewtra,C., Zlotnik,A., Bui,J., Varki,A. and Varki,N.
  TITLE     Expression of Siglec-11 by human and chimpanzee ovarian stromal
            cells, with uniquely human ligands: implications for human ovarian
            physiology and pathology
  JOURNAL   Glycobiology 21 (8), 1038-1048 (2011)
   PUBMED   21467073
  REMARK    GeneRIF: The results indicate potential roles for Siglec-11 in
            ovarian physiology and human evolution.
REFERENCE   4  (bases 1 to 2895)
  AUTHORS   Wang,Y. and Neumann,H.
  TITLE     Alleviation of neurotoxicity by microglial human Siglec-11
  JOURNAL   J Neurosci 30 (9), 3482-3488 (2010)
   PUBMED   20203208
  REMARK    GeneRIF: Siglec-11 ectopically expressed on murine microglia
            interacts with PSA on neurons, reduces LPS-induced gene
            transcription of proinflammatory mediators, impairs phagocytosis
            and alleviates microglial neurotoxicity.
REFERENCE   5  (bases 1 to 2895)
  AUTHORS   Cao,H., Lakner,U., de Bono,B., Traherne,J.A., Trowsdale,J. and
            Barrow,A.D.
  TITLE     SIGLEC16 encodes a DAP12-associated receptor expressed in
            macrophages that evolved from its inhibitory counterpart SIGLEC11
            and has functional and non-functional alleles in humans
  JOURNAL   Eur J Immunol 38 (8), 2303-2315 (2008)
   PUBMED   18629938
  REMARK    GeneRIF: SIGLEC16 encodes a DAP12-associated receptor expressed in
            macrophages that evolved from its inhibitory counterpart SIGLEC11
            and has functional and non-functional alleles in humans.
REFERENCE   6  (bases 1 to 2895)
  AUTHORS   Hayakawa,T., Angata,T., Lewis,A.L., Mikkelsen,T.S., Varki,N.M. and
            Varki,A.
  TITLE     A human-specific gene in microglia
  JOURNAL   Science 309 (5741), 1693 (2005)
   PUBMED   16151003
  REMARK    GeneRIF: expressed in human but not in chimpanzee brain microglia;
            findings indicate that human SIGLEC11 emerged through
            human-specific gene conversion by an adjacent pseudogene
REFERENCE   7  (bases 1 to 2895)
  AUTHORS   Angata,T., Kerr,S.C., Greaves,D.R., Varki,N.M., Crocker,P.R. and
            Varki,A.
  TITLE     Cloning and characterization of human Siglec-11. A recently evolved
            signaling molecule that can interact with SHP-1 and SHP-2 and is
            expressed by tissue macrophages, including brain microglia
  JOURNAL   J Biol Chem 277 (27), 24466-24474 (2002)
   PUBMED   11986327
  REMARK    GeneRIF: cloning and characterization; a recently evolved signaling
            that can interact with SHP-1 and SHP-2 and is expressed by tissue
            macrophages including brain microglia
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF337818.1, AY358135.1 and
            AC011452.6.
            
            Summary: This gene encodes a member of the sialic acid-binding
            immunoglobulin-like lectin family. These cell surface lectins are
            characterized by structural motifs in the immunoglobulin (Ig)-like
            domains and sialic acid recognition sites in the first Ig V set
            domain. This family member mediates anti-inflammatory and
            immunosuppressive signaling. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Oct 2011].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the mid coding region, compared to variant 1, resulting in
            an isoform (2) that is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358135.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153031 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1185              AF337818.1         1-1185
            1186-1809           AY358135.1         1064-1687
            1810-2874           AC011452.6         55500-56564         c
            2875-2895           AF337818.1         3163-3183
FEATURES             Location/Qualifiers
     source          1..2895
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.33"
     gene            1..2895
                     /gene="SIGLEC11"
                     /note="sialic acid binding Ig like lectin 11"
                     /db_xref="GeneID:114132"
                     /db_xref="HGNC:HGNC:15622"
                     /db_xref="MIM:607157"
     exon            1..167
                     /gene="SIGLEC11"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..1900
                     /gene="SIGLEC11"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; siglec-11"
                     /codon_start=1
                     /product="sialic acid-binding Ig-like lectin 11 isoform 2
                     precursor"
                     /protein_id="NP_001128635.1"
                     /db_xref="CCDS:CCDS46150.1"
                     /db_xref="GeneID:114132"
                     /db_xref="HGNC:HGNC:15622"
                     /db_xref="MIM:607157"
                     /translation="MVPGQAQPQSPEMLLLPLLLPVLGAGSLNKDPSYSLQVQRQVPV
                     PEGLCVIVSCNLSYPRDGWDESTAAYGYWFKGRTSPKTGAPVATNNQSREVEMSTRDR
                     FQLTGDPGKGSCSLVIRDAQREDEAWYFFRVERGSRVRHSFLSNAFFLKVTALTKKPD
                     VYIPETLEPGQPVTVICVFNWAFKKCPAPSFSWTGAALSPRRTRPSTSHFSVLSFTPS
                     PQDHDTDLTCHVDFSRKGVSAQRTVRLRVAYAPKDLIISISHDNTSALELQGNVIYLE
                     VQKGQFLRLLCAADSQPPATLSWVLQDRVLSSSHPWGPRTLGLELRGVRAGDSGRYTC
                     RAENRLGSQQQALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLRLVCV
                     THSSPPARLSWTRWGQTVGPSQPSDPGVLELPPIQMEHEGEFTCHAQHPLGSQHVSLS
                     LSVHWKLEHGGGLGLGAALGAGVAALLAFCSCLVVFRVKICRKEARKRAAAEQDVPST
                     LGPISQGHQHECSAGSSQDHPPPGAATYTPGKGEEQELHYASLSFQGLRLWEPADQEA
                     PSTTEYSEIKIHTGQPLRGPGFGLQLEREMSGMVPK"
     exon            168..551
                     /gene="SIGLEC11"
                     /inference="alignment:Splign:2.1.0"
     exon            552..836
                     /gene="SIGLEC11"
                     /inference="alignment:Splign:2.1.0"
     exon            837..884
                     /gene="SIGLEC11"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1148
                     /gene="SIGLEC11"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1196
                     /gene="SIGLEC11"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1454
                     /gene="SIGLEC11"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1551
                     /gene="SIGLEC11"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1633
                     /gene="SIGLEC11"
                     /inference="alignment:Splign:2.1.0"
     exon            1634..2877
                     /gene="SIGLEC11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2868..2873
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIGLEC11"
     polyA_site      2877
                     /gene="SIGLEC11"
ORIGIN      
        1 cgaggctcct cctctgtgga tggtcactgc ccctccacca ggcttcctgc tggaggagtt
       61 tccttcccag ccaggccggc ccagaagcca gatggtcccg ggacaggccc agccccagag
      121 cccagagatg ctgctgctgc ccctgctgct gcccgtgctg ggggcggggt ccctgaacaa
      181 ggatcccagt tacagtcttc aagtgcagag gcaggtgccg gtgccggagg gcctgtgtgt
      241 catcgtgtct tgcaacctct cctacccccg ggatggctgg gacgagtcta ctgctgctta
      301 tggctactgg ttcaaaggac ggaccagccc aaagacgggt gctcctgtgg ccactaacaa
      361 ccagagtcga gaggtggaaa tgagcacccg ggaccgattc cagctcactg gggatcccgg
      421 caaagggagc tgctccttgg tgatcagaga cgcgcagagg gaggatgagg catggtactt
      481 ctttcgggtg gagagaggaa gccgtgtgag acatagtttc ctgagcaatg cgttctttct
      541 aaaagtaaca gccctgacta agaagcctga tgtctacatc cccgagaccc tggagcccgg
      601 gcagccggtg acggtcatct gtgtgtttaa ctgggctttc aagaaatgtc cagccccttc
      661 tttctcctgg acgggggctg ccctctcccc tagaagaacc agaccaagca cctcccactt
      721 ctcagtgctc agcttcacgc ccagccccca ggaccacgac accgacctca cctgccatgt
      781 ggacttctcc agaaagggtg tgagcgcaca gaggaccgtc cgactccgtg tggcctatgc
      841 ccccaaagac cttattatca gcatttcaca tgacaacacg tcagccctgg aactccaggg
      901 aaacgtcata tatctggaag ttcagaaagg ccagttcctg cggctcctct gtgctgctga
      961 cagccagccc cctgccacgc tgagctgggt cctgcaggac agagtcctct cctcgtccca
     1021 cccctggggc cccagaaccc tggggctgga gctgcgtggg gtaagggccg gggattcagg
     1081 gcgctacacc tgccgagcgg agaacaggct tggctcccag cagcaagccc tggacctctc
     1141 tgtgcagtat cctccagaga acctgagagt gatggtttcc caagcaaaca ggacagtcct
     1201 ggaaaacctc gggaacggca catccctccc ggtcctggag ggccaaagcc tgcgcctggt
     1261 ctgtgtcacc cacagcagcc ccccagccag gctgagctgg acccggtggg gacagaccgt
     1321 gggcccctcc cagccctcag accccggggt cctggagctg ccacccattc aaatggagca
     1381 cgaaggagag ttcacctgcc acgctcagca ccctctgggc tcccagcacg tctctctcag
     1441 cctctccgtg cactggaagc tggagcatgg gggaggactt ggcctggggg ctgccctggg
     1501 agctggcgtc gctgccctgc tcgctttctg ttcctgcctt gtcgtcttca gggtgaagat
     1561 ctgcaggaag gaagctcgca agagggcagc agctgagcag gacgtgccct ccaccctggg
     1621 acccatctcc cagggtcacc agcatgaatg ctcggcaggc agctcccaag accacccgcc
     1681 cccaggtgca gccacctaca ccccggggaa gggggaagag caggagctcc actatgcctc
     1741 cctcagcttc cagggcctga ggctctggga gcctgcggac caggaggccc ccagcaccac
     1801 cgagtactcg gagatcaaga tccacacagg acagcccctg aggggcccag gctttgggct
     1861 tcaattggag agggagatgt cagggatggt tccaaagtga agaggtctcc atggcaacag
     1921 gacaccagca agtgtgtggg agtcgcactg gtgtgacggc cagaactgga ctcagatttc
     1981 agccccatcc ccaatgaaga gcttgagttt gaagattata ctttttttga gacagggtct
     2041 gactctgtcc tccaggccag agtccagtgg tgcaatctca gctcactgta gcctcaacct
     2101 gccaggttga agtgagcctc ccatttcagc ctcccaagta gctgggacta caattgtgag
     2161 ccaccatgcc aggctcattg ttatattttt agtagagaca gggttttgcc atgtttccct
     2221 ggctggtctc agactcctgg gctcaagcaa tctgcccgcc tctgcctccc aaagtgctgg
     2281 gattacagac gtgagccacc acagctggct gaagattata ctttcaattc agagcgagtt
     2341 tgaagatgac actttgaggc atcgtgtcta tggttcatta ctacagaagc ttctctggat
     2401 gtgtaaagca caggaaacca ggcagaggag gcacagggtg ctctccagaa cgagaagcca
     2461 gctcctggag ttgtttgctg caactgccat tccccgttga tgaccatgct cttccttcag
     2521 aagagggaga gtgagaggac caagtccaag tggttcccat ttgaacattt aaaaaaaaaa
     2581 aaaaggctgg gcatggtggc tcacgcctgt aatctcaaca ctttgggagg ctgaagtggg
     2641 tggatcacaa gtcaggagtt caagaccagc ctgggcaaga tggtgaaacc ccatctctac
     2701 taaaaataca aaaattagcc gggcatggtg gcgggcgcct aaaatcccag ctactcggga
     2761 gactaggcag agaattggtt gaacccggga ggtggaggtt gcagtgagcc gagatcgtcc
     2821 cactgcactc cagcctgggc aacagagtga gactctgttt ctaaataaat aaatgaaaaa
     2881 aaaaaaaaaa aaaaa
//
