LOCUS       NM_033130               3234 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens sialic acid binding Ig like lectin 10 (SIGLEC10),
            transcript variant 1, mRNA.
ACCESSION   NM_033130
VERSION     NM_033130.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3234)
  AUTHORS   Wang,C., He,L., Peng,J., Lu,C., Zhang,M., Qi,X., Zhang,M. and
            Wang,Y.
  TITLE     Identification of Siglec-10 as a new dendritic cell checkpoint for
            cervical cancer immunotherapy
  JOURNAL   J Immunother Cancer 12 (8), e009404 (2024)
   PUBMED   39209455
  REMARK    GeneRIF: Identification of Siglec-10 as a new dendritic cell
            checkpoint for cervical cancer immunotherapy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3234)
  AUTHORS   Yoshida,C., Kadota,K., Ibuki,E., Ishikawa,R., Haba,R. and Yajima,T.
  TITLE     Siglec10 Expression on Tumor-associated Macrophages Is an
            Independent Prognostic Factor in Stage I Lung Adenocarcinoma
  JOURNAL   Anticancer Res 44 (3), 1289-1297 (2024)
   PUBMED   38423652
  REMARK    GeneRIF: Siglec10 Expression on Tumor-associated Macrophages Is an
            Independent Prognostic Factor in Stage I Lung Adenocarcinoma.
REFERENCE   3  (bases 1 to 3234)
  AUTHORS   Sakkaki,E., Jafari,B., Gharesouran,J. and Rezazadeh,M.
  TITLE     Gene expression patterns of CRYM and SIGLEC10 in Alzheimer's
            disease: potential early diagnostic indicators
  JOURNAL   Mol Biol Rep 51 (1), 349 (2024)
   PUBMED   38401023
  REMARK    GeneRIF: Gene expression patterns of CRYM and SIGLEC10 in
            Alzheimer's disease: potential early diagnostic indicators.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3234)
  AUTHORS   Lin,H., Gao,L. and Huang,Y.
  TITLE     High Expression and Significance of Siglec10/CD24 in Unexplained
            Missed Abortion
  JOURNAL   Immunol Invest 52 (8), 997-1007 (2023)
   PUBMED   37933581
  REMARK    GeneRIF: High Expression and Significance of Siglec10/CD24 in
            Unexplained Missed Abortion.
REFERENCE   5  (bases 1 to 3234)
  AUTHORS   Gao,S., Liu,X.Z., Wu,L.Y., Peng,Z., Chen,X.X., Wang,H., Lu,Y.,
            Zhuang,Z., Tan,Q., Hang,C.H. and Li,W.
  TITLE     Long-Term Elevated Siglec-10 in Cerebral Spinal Fluid Heralds
            Better Prognosis for Patients with Aneurysmal Subarachnoid
            Hemorrhage
  JOURNAL   Dis Markers 2022, 5382100 (2022)
   PUBMED   36188429
  REMARK    GeneRIF: Long-Term Elevated Siglec-10 in Cerebral Spinal Fluid
            Heralds Better Prognosis for Patients with Aneurysmal Subarachnoid
            Hemorrhage.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3234)
  AUTHORS   Szafranski,K., Schindler,S., Taudien,S., Hiller,M., Huse,K.,
            Jahn,N., Schreiber,S., Backofen,R. and Platzer,M.
  TITLE     Violating the splicing rules: TG dinucleotides function as
            alternative 3' splice sites in U2-dependent introns
  JOURNAL   Genome Biol 8 (8), R154 (2007)
   PUBMED   17672918
  REMARK    GeneRIF: the apparent occurrence of an unusual TG 3' splice site in
            intron 11 is discussed
REFERENCE   7  (bases 1 to 3234)
  AUTHORS   Kitzig,F., Martinez-Barriocanal,A., Lopez-Botet,M. and Sayos,J.
  TITLE     Cloning of two new splice variants of Siglec-10 and mapping of the
            interaction between Siglec-10 and SHP-1
  JOURNAL   Biochem Biophys Res Commun 296 (2), 355-362 (2002)
   PUBMED   12163025
REFERENCE   8  (bases 1 to 3234)
  AUTHORS   Li,N., Zhang,W., Wan,T., Zhang,J., Chen,T., Yu,Y., Wang,J. and
            Cao,X.
  TITLE     Cloning and characterization of Siglec-10, a novel sialic acid
            binding member of the Ig superfamily, from human dendritic cells
  JOURNAL   J Biol Chem 276 (30), 28106-28112 (2001)
   PUBMED   11358961
REFERENCE   9  (bases 1 to 3234)
  AUTHORS   Yousef,G.M., Ordon,M.H., Foussias,G. and Diamandis,E.P.
  TITLE     Molecular characterization, tissue expression, and mapping of a
            novel Siglec-like gene (SLG2) with three splice variants
  JOURNAL   Biochem Biophys Res Commun 284 (4), 900-910 (2001)
   PUBMED   11409878
REFERENCE   10 (bases 1 to 3234)
  AUTHORS   Munday,J., Kerr,S., Ni,J., Cornish,A.L., Zhang,J.Q., Nicoll,G.,
            Floyd,H., Mattei,M.G., Moore,P., Liu,D. and Crocker,P.R.
  TITLE     Identification, characterization and leucocyte expression of
            Siglec-10, a novel human sialic acid-binding receptor
  JOURNAL   Biochem J 355 (Pt 2), 489-497 (2001)
   PUBMED   11284738
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008750.9.
            
            On Nov 23, 2018 this sequence version replaced NM_033130.4.
            
            Summary: SIGLECs are members of the immunoglobulin superfamily that
            are expressed on the cell surface. Most SIGLECs have 1 or more
            cytoplasmic immune receptor tyrosine-based inhibitory motifs, or
            ITIMs. SIGLECs are typically expressed on cells of the innate
            immune system, with the exception of the B-cell expressed SIGLEC6
            (MIM 604405).[supplied by OMIM, Jul 2002].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.208081.1,
                                           SRR1803612.247369.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339313.10/ ENSP00000345243.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                AC008750.9         90495-90592         c
            99-482              AC008750.9         90032-90415         c
            483-767             AC008750.9         89616-89900         c
            768-815             AC008750.9         89260-89307         c
            816-1085            AC008750.9         88848-89117         c
            1086-1133           AC008750.9         88518-88565         c
            1134-1391           AC008750.9         88131-88388         c
            1392-1676           AC008750.9         87774-88058         c
            1677-1770           AC008750.9         87372-87465         c
            1771-1882           AC008750.9         86662-86773         c
            1883-3234           AC008750.9         82970-84321         c
FEATURES             Location/Qualifiers
     source          1..3234
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..3234
                     /gene="SIGLEC10"
                     /gene_synonym="PRO940; SIGLEC-10; SLG2"
                     /note="sialic acid binding Ig like lectin 10"
                     /db_xref="GeneID:89790"
                     /db_xref="HGNC:HGNC:15620"
                     /db_xref="MIM:606091"
     exon            1..98
                     /gene="SIGLEC10"
                     /gene_synonym="PRO940; SIGLEC-10; SLG2"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..2155
                     /gene="SIGLEC10"
                     /gene_synonym="PRO940; SIGLEC-10; SLG2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; siglec-like gene 2; sialic acid binding Ig-like
                     lectin 10 Ig-like lectin 7; siglec-like protein 2"
                     /codon_start=1
                     /product="sialic acid-binding Ig-like lectin 10 isoform 1
                     precursor"
                     /protein_id="NP_149121.2"
                     /db_xref="CCDS:CCDS12832.1"
                     /db_xref="GeneID:89790"
                     /db_xref="HGNC:HGNC:15620"
                     /db_xref="MIM:606091"
                     /translation="MLLPLLLSSLLGGSQAMDGRFWIRVQESVMVPEGLCISVPCSFS
                     YPRQDWTGSTPAYGYWFKAVTETTKGAPVATNHQSREVEMSTRGRFQLTGDPAKGNCS
                     LVIRDAQMQDESQYFFRVERGSYVRYNFMNDGFFLKVTALTQKPDVYIPETLEPGQPV
                     TVICVFNWAFEECPPPSFSWTGAALSSQGTKPTTSHFSVLSFTPRPQDHNTDLTCHVD
                     FSRKGVSAQRTVRLRVAYAPRDLVISISRDNTPALEPQPQGNVPYLEAQKGQFLRLLC
                     AADSQPPATLSWVLQNRVLSSSHPWGPRPLGLELPGVKAGDSGRYTCRAENRLGSQQR
                     ALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLCLVCVTHSSPPARLSW
                     TQRGQVLSPSQPSDPGVLELPRVQVEHEGEFTCHARHPLGSQHVSLSLSVHYSPKLLG
                     PSCSWEAEGLHCSCSSQASPAPSLRWWLGEELLEGNSSQDSFEVTPSSAGPWANSSLS
                     LHGGLSSGLRLRCEAWNVHGAQSGSILQLPDKKGLISTAFSNGAFLGIGITALLFLCL
                     ALIIMKILPKRRTQTETPRPRFSRHSTILDYINVVPTAGPLAQKRNQKATPNSPRTPL
                     PPGAPSPESKKNQKKQYQLPSFPEPKSSTQAPESQESQEELHYATLNFPGVRPRPEAR
                     MPKGTQADYAEVKFQ"
     exon            99..482
                     /gene="SIGLEC10"
                     /gene_synonym="PRO940; SIGLEC-10; SLG2"
                     /inference="alignment:Splign:2.1.0"
     exon            483..767
                     /gene="SIGLEC10"
                     /gene_synonym="PRO940; SIGLEC-10; SLG2"
                     /inference="alignment:Splign:2.1.0"
     exon            768..815
                     /gene="SIGLEC10"
                     /gene_synonym="PRO940; SIGLEC-10; SLG2"
                     /inference="alignment:Splign:2.1.0"
     exon            816..1085
                     /gene="SIGLEC10"
                     /gene_synonym="PRO940; SIGLEC-10; SLG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1133
                     /gene="SIGLEC10"
                     /gene_synonym="PRO940; SIGLEC-10; SLG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1391
                     /gene="SIGLEC10"
                     /gene_synonym="PRO940; SIGLEC-10; SLG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1676
                     /gene="SIGLEC10"
                     /gene_synonym="PRO940; SIGLEC-10; SLG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1770
                     /gene="SIGLEC10"
                     /gene_synonym="PRO940; SIGLEC-10; SLG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1771..1882
                     /gene="SIGLEC10"
                     /gene_synonym="PRO940; SIGLEC-10; SLG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..3234
                     /gene="SIGLEC10"
                     /gene_synonym="PRO940; SIGLEC-10; SLG2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3213..3218
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIGLEC10"
                     /gene_synonym="PRO940; SIGLEC-10; SLG2"
                     /note="hexamer: AATAAA"
     polyA_site      3234
                     /gene="SIGLEC10"
                     /gene_synonym="PRO940; SIGLEC-10; SLG2"
                     /note="major polyA site"
ORIGIN      
        1 actcacagca cgaccagaga acaggcctgt ctcaggcagg ccctgcgcct cctatgcgga
       61 gatgctactg ccactgctgc tgtcctcgct gctgggcggg tcccaggcta tggatgggag
      121 attctggata cgagtgcagg agtcagtgat ggtgccggag ggcctgtgca tctctgtgcc
      181 ctgctctttc tcctaccccc gacaggactg gacagggtct accccagctt atggctactg
      241 gttcaaagca gtgactgaga caaccaaggg tgctcctgtg gccacaaacc accagagtcg
      301 agaggtggaa atgagcaccc ggggccgatt ccagctcact ggggatcccg ccaaggggaa
      361 ctgctccttg gtgatcagag acgcgcagat gcaggatgag tcacagtact tctttcgggt
      421 ggagagagga agctatgtga gatataattt catgaacgat gggttctttc taaaagtaac
      481 agccctgact cagaagcctg atgtctacat ccccgagacc ctggagcccg ggcagccggt
      541 gacggtcatc tgtgtgttta actgggcctt tgaggaatgt ccaccccctt ctttctcctg
      601 gacgggggct gccctctcct cccaaggaac caaaccaacg acctcccact tctcagtgct
      661 cagcttcacg cccagacccc aggaccacaa caccgacctc acctgccatg tggacttctc
      721 cagaaagggt gtgagcgcac agaggaccgt ccgactccgt gtggcctatg cccccagaga
      781 ccttgttatc agcatttcac gtgacaacac gccagccctg gagccccagc cccagggaaa
      841 tgtcccatac ctggaagccc aaaaaggcca gttcctgcgg ctcctctgtg ctgctgacag
      901 ccagccccct gccacactga gctgggtcct gcagaacaga gtcctctcct cgtcccatcc
      961 ctggggccct agacccctgg ggctggagct gcccggggtg aaggctgggg attcagggcg
     1021 ctacacctgc cgagcggaga acaggcttgg ctcccagcag cgagccctgg acctctctgt
     1081 gcagtatcct ccagagaacc tgagagtgat ggtttcccaa gcaaacagga cagtcctgga
     1141 aaaccttggg aacggcacgt ctctcccagt actggagggc caaagcctgt gcctggtctg
     1201 tgtcacacac agcagccccc cagccaggct gagctggacc cagaggggac aggttctgag
     1261 cccctcccag ccctcagacc ccggggtcct ggagctgcct cgggttcaag tggagcacga
     1321 aggagagttc acctgccacg ctcggcaccc actgggctcc cagcacgtct ctctcagcct
     1381 ctccgtgcac tactccccga agctgctggg cccctcctgc tcctgggagg ctgagggtct
     1441 gcactgcagc tgctcctccc aggccagccc ggccccctct ctgcgctggt ggcttgggga
     1501 ggagctgctg gaggggaaca gcagccagga ctccttcgag gtcaccccca gctcagccgg
     1561 gccctgggcc aacagctccc tgagcctcca tggagggctc agctccggcc tcaggctccg
     1621 ctgtgaggcc tggaacgtcc atggggccca gagtggatcc atcctgcagc tgccagataa
     1681 gaagggactc atctcaacgg cattctccaa cggagcgttt ctgggaatcg gcatcacggc
     1741 tcttcttttc ctctgcctgg ccctgatcat catgaagatt ctaccgaaga gacggactca
     1801 gacagaaacc ccgaggccca ggttctcccg gcacagcacg atcctggatt acatcaatgt
     1861 ggtcccgacg gctggccccc tggctcagaa gcggaatcag aaagccacac caaacagtcc
     1921 tcggacccct cttccaccag gtgctccctc cccagaatca aagaagaacc agaaaaagca
     1981 gtatcagttg cccagtttcc cagaacccaa atcatccact caagccccag aatcccagga
     2041 gagccaagag gagctccatt atgccacgct caacttccca ggcgtcagac ccaggcctga
     2101 ggcccggatg cccaagggca cccaggcgga ttatgcagaa gtcaagttcc aatgagggtc
     2161 tcttaggctt taggactggg acttcggcta gggaggaagg tagagtaaga ggttgaagat
     2221 aacagagtgc aaagtttcct tctctccctc tctctctctc tttctctctc tctctctctt
     2281 tctctctctt ttaaaaaaac atctggccag ggcacagtgg ctcacgcctg taatcccagc
     2341 actttgggag gttgaggtgg gcagatcgcc tgaggtcggg agttcgagac cagcctggcc
     2401 aacttggtga aaccccgtct ctactaaaaa tacaaaaatt agctgggcat ggtggcaggc
     2461 gcctgtaatc ctacctactt gggaagctga ggcaggagaa tcacttgaac ctgggagacg
     2521 gaggttgcag tgagccaaga tcacaccatt gcacgccagc ctgggcaaca aagcgagact
     2581 ccatctcaaa aaaaaaatcc tccaaatggg ttgggtgtct gtaatcccag cactttggga
     2641 ggctaaggtg ggtggattgc ttgagcccag gagttcgaga ccagcctggg caacatggtg
     2701 aaaccccatc tctacaaaaa atacaaaaca tagctgggct tggtggtgtg tgcctgtagt
     2761 cccagctgtc agacatttaa accagagcaa ctccatctgg aataggagct gaataaaatg
     2821 aggctgagac ctactgggct gcattctcag acagtggagg cattctaagt cacaggatga
     2881 gacaggaggt ccgtacaaga tacaggtcat aaagactttg ctgataaaac agattgcagt
     2941 aaagaagcca accaaatccc accaaaacca agttggccac gagagtgacc tctggtcgtc
     3001 ctcactgcta cactcctgac agcaccatga cagtttacaa atgccatggc aacatcagga
     3061 agttacccga tatgtcccaa aagggggagg aatgaataat ccaccccttg tttagcaaat
     3121 aagcaagaaa taaccataaa agtgggcaac cagcagctct aggcgctgct cttgtctatg
     3181 gagtagccat tcttttgttc ctttactttc ttaataaact tgctttcacc ttac
//
