LOCUS       NM_001135054            1743 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens single Ig and TIR domain containing (SIGIRR),
            transcript variant 1, mRNA.
ACCESSION   NM_001135054
VERSION     NM_001135054.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1743)
  AUTHORS   Mariotti,F.R., Supino,D., Landolina,N., Garlanda,C., Mantovani,A.,
            Moretta,L. and Maggi,E.
  TITLE     IL-1R8: A molecular brake of anti-tumor and anti-viral activity of
            NK cells and ILC
  JOURNAL   Semin Immunol 66, 101712 (2023)
   PUBMED   36753974
  REMARK    GeneRIF: IL-1R8: A molecular brake of anti-tumor and anti-viral
            activity of NK cells and ILC.
            Review article
REFERENCE   2  (bases 1 to 1743)
  AUTHORS   Yu,W., Haque,I., Venkatraman,A., Menden,H.L., Mabry,S.M., Roy,B.C.,
            Xia,S., Prokop,J.W., Umar,S., Geurts,A.M. and Sampath,V.
  TITLE     SIGIRR Mutation in Human Necrotizing Enterocolitis (NEC) Disrupts
            STAT3-Dependent microRNA Expression in Neonatal Gut
  JOURNAL   Cell Mol Gastroenterol Hepatol 13 (2), 425-440 (2022)
   PUBMED   34563711
  REMARK    GeneRIF: SIGIRR Mutation in Human Necrotizing Enterocolitis (NEC)
            Disrupts STAT3-Dependent microRNA Expression in Neonatal Gut.
REFERENCE   3  (bases 1 to 1743)
  AUTHORS   Jia,C., Zhuge,Y., Zhang,S., Ni,C., Wang,L., Wu,R., Niu,C., Wen,Z.,
            Rong,X., Qiu,H. and Chu,M.
  TITLE     IL-37b alleviates endothelial cell apoptosis and inflammation in
            Kawasaki disease through IL-1R8 pathway
  JOURNAL   Cell Death Dis 12 (6), 575 (2021)
   PUBMED   34083516
  REMARK    GeneRIF: IL-37b alleviates endothelial cell apoptosis and
            inflammation in Kawasaki disease through IL-1R8 pathway.
            Erratum:[Cell Death Dis. 2021 Aug 2;12(8):759. doi:
            10.1038/s41419-021-04044-5.. PMID: 34341339]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1743)
  AUTHORS   Yang,X., Zhang,M., Xu,S., Pan,H., Leng,R. and Shuai,Z.
  TITLE     Single Immunoglobulin IL-1-Related Receptor (SIGIRR) Gene rs7396562
            Polymorphism and Expression Level in Rheumatoid Arthritis
  JOURNAL   Biomed Res Int 2021, 6683148 (2021)
   PUBMED   34036103
  REMARK    GeneRIF: Single Immunoglobulin IL-1-Related Receptor (SIGIRR) Gene
            rs7396562 Polymorphism and Expression Level in Rheumatoid
            Arthritis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1743)
  AUTHORS   Sanchez-Fernandez,A., Zandee,S., Amo-Aparicio,J., Charabati,M.,
            Prat,A., Garlanda,C., Eisenmesser,E.Z., Dinarello,C.A. and
            Lopez-Vales,R.
  TITLE     IL-37 exerts therapeutic effects in experimental autoimmune
            encephalomyelitis through the receptor complex IL-1R5/IL-1R8
  JOURNAL   Theranostics 11 (1), 1-13 (2021)
   PUBMED   33391457
  REMARK    GeneRIF: IL-37 exerts therapeutic effects in experimental
            autoimmune encephalomyelitis through the receptor complex
            IL-1R5/IL-1R8.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1743)
  AUTHORS   Polentarutti,N., Rol,G.P., Muzio,M., Bosisio,D., Camnasio,M.,
            Riva,F., Zoja,C., Benigni,A., Tomasoni,S., Vecchi,A., Garlanda,C.
            and Mantovani,A.
  TITLE     Unique pattern of expression and inhibition of IL-1 signaling by
            the IL-1 receptor family member TIR8/SIGIRR
  JOURNAL   Eur Cytokine Netw 14 (4), 211-218 (2003)
   PUBMED   14715412
REFERENCE   7  (bases 1 to 1743)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   8  (bases 1 to 1743)
  AUTHORS   Wald,D., Qin,J., Zhao,Z., Qian,Y., Naramura,M., Tian,L., Towne,J.,
            Sims,J.E., Stark,G.R. and Li,X.
  TITLE     SIGIRR, a negative regulator of Toll-like receptor-interleukin 1
            receptor signaling
  JOURNAL   Nat Immunol 4 (9), 920-927 (2003)
   PUBMED   12925853
REFERENCE   9  (bases 1 to 1743)
  AUTHORS   Du,X., Poltorak,A., Wei,Y. and Beutler,B.
  TITLE     Three novel mammalian toll-like receptors: gene structure,
            expression, and evolution
  JOURNAL   Eur Cytokine Netw 11 (3), 362-371 (2000)
   PUBMED   11022119
REFERENCE   10 (bases 1 to 1743)
  AUTHORS   Thomassen,E., Renshaw,B.R. and Sims,J.E.
  TITLE     Identification and characterization of SIGIRR, a molecule
            representing a novel subtype of the IL-1R superfamily
  JOURNAL   Cytokine 11 (6), 389-399 (1999)
   PUBMED   10346978
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB112269.1, AK172830.1, BX369506.2 and AK025099.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001135054.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. All three variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC106007.1, SRR14038196.2424677.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000431843.7/ ENSP00000403104.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-579               DB112269.1         1-579
            580-1264            AK172830.1         476-1160
            1265-1462           BX369506.2         360-557
            1463-1743           AK025099.1         1359-1639
FEATURES             Location/Qualifiers
     source          1..1743
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.5"
     gene            1..1743
                     /gene="SIGIRR"
                     /gene_synonym="IL-1R8; TIR8"
                     /note="single Ig and TIR domain containing"
                     /db_xref="GeneID:59307"
                     /db_xref="HGNC:HGNC:30575"
                     /db_xref="MIM:605478"
     exon            1..177
                     /gene="SIGIRR"
                     /gene_synonym="IL-1R8; TIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            178..337
                     /gene="SIGIRR"
                     /gene_synonym="IL-1R8; TIR8"
                     /inference="alignment:Splign:2.1.0"
     CDS             331..1563
                     /gene="SIGIRR"
                     /gene_synonym="IL-1R8; TIR8"
                     /note="single Ig IL-1R-related molecule; single
                     immunoglobulin domain IL1R1 related; toll/interleukin-1
                     receptor 8; single immunoglobulin domain-containing
                     IL1R-related protein; single immunoglobulin and
                     toll-interleukin 1 receptor (TIR) domain"
                     /codon_start=1
                     /product="single Ig IL-1-related receptor"
                     /protein_id="NP_001128526.1"
                     /db_xref="CCDS:CCDS31325.1"
                     /db_xref="GeneID:59307"
                     /db_xref="HGNC:HGNC:30575"
                     /db_xref="MIM:605478"
                     /translation="MPGVCDRAPDFLSPSEDQVLRPALGSSVALNCTAWVVSGPHCSL
                     PSVQWLKDGLPLGIGGHYSLHEYSWVKANLSEVLVSSVLGVNVTSTEVYGAFTCSIQN
                     ISFSSFTLQRAGPTSHVAAVLASLLVLLALLLAALLYVKCRLNVLLWYQDAYGEVEIN
                     DGKLYDAYVSYSDCPEDRKFVNFILKPQLERRRGYKLFLDDRDLLPRAEPSADLLVNL
                     SRCRRLIVVLSDAFLSRAWCSHSFREGLCRLLELTRRPIFITFEGQRRDPAHPALRLL
                     RQHRHLVTLLLWRPGSVTPSSDFWKEVQLALPRKVQYRPVEGDPQTQLQDDKDPMLIL
                     RGRVPEGRALDSEVDPDPEGDLGVRGPVFGEPSAPPHTSGVSLGESRSSEVDVSDLGS
                     RNYSARTDFYCLVSKDDM"
     exon            338..536
                     /gene="SIGIRR"
                     /gene_synonym="IL-1R8; TIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            537..670
                     /gene="SIGIRR"
                     /gene_synonym="IL-1R8; TIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            671..811
                     /gene="SIGIRR"
                     /gene_synonym="IL-1R8; TIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            812..955
                     /gene="SIGIRR"
                     /gene_synonym="IL-1R8; TIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1058
                     /gene="SIGIRR"
                     /gene_synonym="IL-1R8; TIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1209
                     /gene="SIGIRR"
                     /gene_synonym="IL-1R8; TIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1399
                     /gene="SIGIRR"
                     /gene_synonym="IL-1R8; TIR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1743
                     /gene="SIGIRR"
                     /gene_synonym="IL-1R8; TIR8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1722..1727
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIGIRR"
                     /gene_synonym="IL-1R8; TIR8"
                     /note="hexamer: AATAAA"
     polyA_site      1743
                     /gene="SIGIRR"
                     /gene_synonym="IL-1R8; TIR8"
                     /note="major polyA site"
ORIGIN      
        1 gaaagttctg atcaaaatac acaaagacac aagccaggtc cccaccgcgc ttggcgatgc
       61 atccatagca gccttggtgc tgtggacact ccctggggcc cagcgaaggg gagagtttgc
      121 tcccaaaggc gcaccaatga ccaacatttg ccccccggag gaaagaactg gaaccagcct
      181 ctgacctgtc caggtgccct gtccagctga ctgcaaggac agagaggagt cctgcccagc
      241 tcttggatca gtctgctggc cgaggagccc ggtggagcca ggggtgaccc tggagcccag
      301 cctgccccga ggaggccccg gctcagagcc atgccaggtg tctgtgatag ggcccctgac
      361 ttcctctccc cgtctgaaga ccaggtgctg aggcctgcct tgggcagctc agtggctctg
      421 aactgcacgg cttgggtagt ctctgggccc cactgctccc tgccttcagt ccagtggctg
      481 aaagacgggc ttccattggg aattgggggc cactacagcc tccacgagta ctcctgggtc
      541 aaggccaacc tgtcagaggt gcttgtgtcc agtgtcctgg gggtcaacgt gaccagcact
      601 gaagtctatg gggccttcac ctgctccatc cagaacatca gcttctcctc cttcactctt
      661 cagagagctg gccctacaag ccacgtggct gcggtgctgg cctccctcct ggtcctgctg
      721 gccctgctgc tggccgccct gctctatgtc aagtgccgtc tcaacgtgct gctctggtac
      781 caggacgcgt atggggaggt ggagataaac gacgggaagc tctacgacgc ctacgtctcc
      841 tacagcgact gccccgagga ccgcaagttc gtgaacttca tcctaaagcc gcagctggag
      901 cggcgtcggg gctacaagct cttcctggac gaccgcgacc tcctgccgcg cgctgagccc
      961 tccgccgacc tcttggtgaa cctgagccgc tgccgacgcc tcatcgtggt gctttcggac
     1021 gccttcctga gccgggcctg gtgcagccac agcttccggg agggcctgtg ccggctgctg
     1081 gagctcaccc gcagacccat cttcatcacc ttcgagggcc agaggcgcga ccccgcgcac
     1141 ccggcgctcc gcctgctgcg ccagcaccgc cacctggtga ccttgctgct ctggaggccc
     1201 ggctccgtga ctccttcctc cgatttttgg aaagaagtgc agctggcgct gccgcggaag
     1261 gtgcagtaca ggcctgtgga aggagacccc cagacgcagc tgcaggacga caaggacccc
     1321 atgctgattc ttcgaggccg agtccctgag ggccgggccc tggactcaga ggtggacccg
     1381 gaccctgagg gcgacctggg tgtccggggg cctgtctttg gagagccatc agctccaccg
     1441 cacaccagtg gggtctcgct gggagagagc cggagcagcg aagtggacgt ctcggatctc
     1501 ggctcgcgaa actacagtgc ccgcacagac ttctactgcc tggtgtccaa ggatgatatg
     1561 tagctcccac cccagagtgc aggatcatag ggacagcggg ggccagggca gcggcgtcgc
     1621 tcctctgctc aacaggacca caacccctgc cagcagccct gggaccctgc cagcagccct
     1681 gggaaaaggc tgtggcctca gggcgcctcc cagtgccaga aaataaagtc cttttggatt
     1741 ctg
//
