LOCUS       NM_001040455            4396 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens SID1 transmembrane family member 2 (SIDT2), mRNA.
ACCESSION   NM_001040455
VERSION     NM_001040455.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4396)
  AUTHORS   Sampieri,A., Asanov,A., Mendez-Acevedo,K.M. and Vaca,L.
  TITLE     SIDT2 Associates with Apolipoprotein A1 (ApoA1) and Facilitates
            ApoA1 Secretion in Hepatocytes
  JOURNAL   Cells 12 (19), 2353 (2023)
   PUBMED   37830567
  REMARK    GeneRIF: SIDT2 Associates with Apolipoprotein A1 (ApoA1) and
            Facilitates ApoA1 Secretion in Hepatocytes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4396)
  AUTHORS   Qian,D., Cong,Y., Wang,R., Chen,Q., Yan,C. and Gong,D.
  TITLE     Structural insight into the human SID1 transmembrane family member
            2 reveals its lipid hydrolytic activity
  JOURNAL   Nat Commun 14 (1), 3568 (2023)
   PUBMED   37322007
  REMARK    GeneRIF: Structural insight into the human SID1 transmembrane
            family member 2 reveals its lipid hydrolytic activity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4396)
  AUTHORS   Xu,J., Geng,M., Liu,H., Pei,W., Gu,J., Qi,M., Zhang,Y., Lu,K.,
            Song,Y., Liu,M., Hu,X., Yu,C., He,C., Wang,L. and Gao,J.
  TITLE     [Lysosomal membrane protein Sidt2 knockout induces apoptosis of
            human hepatocytes in vitro independent of the autophagy-lysosomal
            pathway]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 43 (4), 637-643 (2023)
   PUBMED   37202201
  REMARK    GeneRIF: [Lysosomal membrane protein Sidt2 knockout induces
            apoptosis of human hepatocytes in vitro independent of the
            autophagy-lysosomal pathway].
REFERENCE   4  (bases 1 to 4396)
  AUTHORS   Leon-Reyes,G., Argoty-Pantoja,A.D., Rivera-Paredez,B.,
            Hidalgo-Bravo,A., Flores,Y.N., Salmeron,J. and Velazquez-Cruz,R.
  TITLE     Interaction between SIDT2 and ABCA1 Variants with Nutrients on
            HDL-c Levels in Mexican Adults
  JOURNAL   Nutrients 15 (2), 370 (2023)
   PUBMED   36678241
  REMARK    GeneRIF: Interaction between SIDT2 and ABCA1 Variants with
            Nutrients on HDL-c Levels in Mexican Adults.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4396)
  AUTHORS   Fujiwara,Y., Kabuta,C., Sano,T., Murayama,S., Saito,Y. and
            Kabuta,T.
  TITLE     Pathology-associated change in levels and localization of SIDT2 in
            postmortem brains of Parkinson's disease and dementia with Lewy
            bodies patients
  JOURNAL   Neurochem Int 152, 105243 (2022)
   PUBMED   34800582
  REMARK    GeneRIF: Pathology-associated change in levels and localization of
            SIDT2 in postmortem brains of Parkinson's disease and dementia with
            Lewy bodies patients.
REFERENCE   6  (bases 1 to 4396)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   7  (bases 1 to 4396)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 4396)
  AUTHORS   Schroder,B., Wrocklage,C., Pan,C., Jager,R., Kosters,B.,
            Schafer,H., Elsasser,H.P., Mann,M. and Hasilik,A.
  TITLE     Integral and associated lysosomal membrane proteins
  JOURNAL   Traffic 8 (12), 1676-1686 (2007)
   PUBMED   17897319
REFERENCE   9  (bases 1 to 4396)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   10 (bases 1 to 4396)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP005018.1 and AY358442.1.
            
            On May 17, 2019 this sequence version replaced NM_001040455.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358442.1, AK292501.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000324225.9/ ENSP00000314023.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-480               AP005018.1         42004-42483
            481-4396            AY358442.1         10-3925
FEATURES             Location/Qualifiers
     source          1..4396
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.3"
     gene            1..4396
                     /gene="SIDT2"
                     /gene_synonym="CGI-40"
                     /note="SID1 transmembrane family member 2"
                     /db_xref="GeneID:51092"
                     /db_xref="HGNC:HGNC:24272"
                     /db_xref="MIM:617551"
     exon            1..704
                     /gene="SIDT2"
                     /gene_synonym="CGI-40"
                     /inference="alignment:Splign:2.1.0"
     CDS             522..3020
                     /gene="SIDT2"
                     /gene_synonym="CGI-40"
                     /codon_start=1
                     /product="SID1 transmembrane family member 2 precursor"
                     /protein_id="NP_001035545.1"
                     /db_xref="CCDS:CCDS31682.1"
                     /db_xref="GeneID:51092"
                     /db_xref="HGNC:HGNC:24272"
                     /db_xref="MIM:617551"
                     /translation="MFALGLPFLVLLVASVESHLGVLGPKNVSQKDAEFERTYVDEVN
                     SELVNIYTFNHTVTRNRTEGVRVSVNVLNKQKGAPLLFVVRQKEAVVSFQVPLILRGM
                     FQRKYLYQKVERTLCQPPTKNESEIQFFYVDVSTLSPVNTTYQLRVSRMDDFVLRTGE
                     QFSFNTTAAQPQYFKYEFPEGVDSVIVKVTSNKAFPCSVISIQDVLCPVYDLDNNVAF
                     IGMYQTMTKKAAITVQRKDFPSNSFYVVVVVKTEDQACGGSLPFYPFAEDEPVDQGHR
                     QKTLSVLVSQAVTSEAYVSGMLFCLGIFLSFYLLTVLLACWENWRQKKKTLLVAIDRA
                     CPESGHPRVLADSFPGSSPYEGYNYGSFENVSGSTDGLVDSAGTGDLSYGYQGRSFEP
                     VGTRPRVDSMSSVEEDDYDTLTDIDSDKNVIRTKQYLYVADLARKDKRVLRKKYQIYF
                     WNIATIAVFYALPVVQLVITYQTVVNVTGNQDICYYNFLCAHPLGNLSAFNNILSNLG
                     YILLGLLFLLIILQREINHNRALLRNDLCALECGIPKHFGLFYAMGTALMMEGLLSAC
                     YHVCPNYTNFQFDTSFMYMIAGLCMLKLYQKRHPDINASAYSAYACLAIVIFFSVLGV
                     VFGKGNTAFWIVFSIIHIIATLLLSTQLYYMGRWKLDSGIFRRILHVLYTDCIRQCSG
                     PLYVDRMVLLVMGNVINWSLAAYGLIMRPNDFASYLLAIGICNLLLYFAFYIIMKLRS
                     GERIKLIPLLCIVCTSVVWGFALFFFFQGLSTWQKTPAESREHNRDCILLDFFDDHDI
                     WHFLSSIAMFGSFLVLLTLDDDLDTVQRDKIYVF"
     exon            705..826
                     /gene="SIDT2"
                     /gene_synonym="CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            827..991
                     /gene="SIDT2"
                     /gene_synonym="CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1037
                     /gene="SIDT2"
                     /gene_synonym="CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1139
                     /gene="SIDT2"
                     /gene_synonym="CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1223
                     /gene="SIDT2"
                     /gene_synonym="CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1323
                     /gene="SIDT2"
                     /gene_synonym="CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1389
                     /gene="SIDT2"
                     /gene_synonym="CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1483
                     /gene="SIDT2"
                     /gene_synonym="CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1536
                     /gene="SIDT2"
                     /gene_synonym="CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1608
                     /gene="SIDT2"
                     /gene_synonym="CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1680
                     /gene="SIDT2"
                     /gene_synonym="CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1799
                     /gene="SIDT2"
                     /gene_synonym="CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1873
                     /gene="SIDT2"
                     /gene_synonym="CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..1940
                     /gene="SIDT2"
                     /gene_synonym="CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2014
                     /gene="SIDT2"
                     /gene_synonym="CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            2015..2138
                     /gene="SIDT2"
                     /gene_synonym="CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            2139..2256
                     /gene="SIDT2"
                     /gene_synonym="CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            2257..2393
                     /gene="SIDT2"
                     /gene_synonym="CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            2394..2502
                     /gene="SIDT2"
                     /gene_synonym="CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            2503..2579
                     /gene="SIDT2"
                     /gene_synonym="CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            2580..2626
                     /gene="SIDT2"
                     /gene_synonym="CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            2627..2732
                     /gene="SIDT2"
                     /gene_synonym="CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            2733..2843
                     /gene="SIDT2"
                     /gene_synonym="CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            2844..2957
                     /gene="SIDT2"
                     /gene_synonym="CGI-40"
                     /inference="alignment:Splign:2.1.0"
     exon            2958..4396
                     /gene="SIDT2"
                     /gene_synonym="CGI-40"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4379..4384
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIDT2"
                     /gene_synonym="CGI-40"
                     /note="hexamer: AATAAA"
     polyA_site      4396
                     /gene="SIDT2"
                     /gene_synonym="CGI-40"
                     /note="major polyA site"
ORIGIN      
        1 agtgttcgtg cgtcgggacg gcgcgtccgc ccgcccttaa agggcccgca cctcggaaaa
       61 ctcgcagccc agcacggcgt cgggtagcta ccacctatca cgcccctcac tctgcgactc
      121 gccttcctcc gcggccagcc cccgccgccg gctcttcctc cctccccttt cccggcgtct
      181 ccaggctccc ggcaaccagc cgccctcctt ctcacggccc tggcccgggg ctccagggtc
      241 tcaggtcgta ctcagcccct cgcgagctgg gaccccttcc cgtagccagc atcccctccc
      301 tccccgcccc ctcccggccg ccccctcccc tgcggggacc ctgggagcct cttcggggct
      361 cttgggaggg gacatttcct aatctcaggc cggggttaaa gttctggtcc tggtgagatg
      421 ctggaagctg cggccgcagc cgcaacccgt cccggaggtg tcctgtctcc tgtcgccgcc
      481 gccgccgcca ccaccgctgc cactgccgcc ctgccggggc catgttcgct ctgggcttgc
      541 ccttcttggt gctcttggtg gcctcggtcg agagccatct gggggttctg gggcccaaga
      601 acgtctcgca gaaagacgcc gagtttgagc gcacctacgt ggacgaggtc aacagcgagc
      661 tggtcaacat ctacaccttc aaccatactg tgacccgcaa caggacagag ggcgtgcgtg
      721 tgtctgtgaa cgtcctgaac aagcagaagg gggcgccgtt gctgtttgtg gtccgccaga
      781 aggaggctgt ggtgtccttc caggtgcccc taatcctgcg agggatgttt cagcgcaagt
      841 acctctacca aaaagtggaa cgaaccctgt gtcagccccc caccaagaat gagtcggaga
      901 ttcagttctt ctacgtggat gtgtccaccc tgtcaccagt caacaccaca taccagctcc
      961 gggtcagccg catggacgat tttgtgctca ggactgggga gcagttcagc ttcaatacca
     1021 cagcagcaca gccccagtac ttcaagtatg agttccctga aggcgtggac tcggtaattg
     1081 tcaaggtgac ctccaacaag gccttcccct gctcagtcat ctccattcag gatgtgctgt
     1141 gtcctgtcta tgacctggac aacaacgtag ccttcatcgg catgtaccag acgatgacca
     1201 agaaggcggc catcaccgta cagcgcaaag acttccccag caacagcttt tatgtggtgg
     1261 tggtggtgaa gaccgaagac caagcctgcg ggggctccct gcctttctac cccttcgcag
     1321 aagatgaacc ggtcgatcaa gggcaccgcc agaaaaccct gtcagtgctg gtgtctcaag
     1381 cagtcacgtc tgaggcatac gtcagtggga tgctcttttg cctgggtata tttctctcct
     1441 tttacctgct gaccgtcctc ctggcctgct gggagaactg gaggcagaag aagaagaccc
     1501 tgctggtggc cattgaccga gcctgcccag aaagcggtca ccctcgagtc ctggctgatt
     1561 cttttcctgg cagttcccct tatgagggtt acaactatgg ctcctttgag aatgtttctg
     1621 gatctaccga tggtctggtt gacagcgctg gcactgggga cctctcttac ggttaccagg
     1681 gccgctcctt tgaacctgta ggtactcggc cccgagtgga ctccatgagc tctgtggagg
     1741 aggatgacta cgacacattg accgacatcg attccgacaa gaatgtcatt cgcaccaagc
     1801 aatacctcta tgtggctgac ctggcacgga aggacaagcg tgttctgcgg aaaaagtacc
     1861 agatctactt ctggaacatt gccaccattg ctgtcttcta tgcccttcct gtggtgcagc
     1921 tggtgatcac ctaccagacg gtggtgaatg tcacagggaa tcaggacatc tgctactaca
     1981 acttcctctg cgcccaccca ctgggcaatc tcagcgcctt caacaacatc ctcagcaacc
     2041 tggggtacat cctgctgggg ctgcttttcc tgctcatcat cctgcaacgg gagatcaacc
     2101 acaaccgggc cctgctgcgc aatgacctct gtgccctgga atgtgggatc cccaaacact
     2161 ttgggctttt ctacgccatg ggcacagccc tgatgatgga ggggctgctc agtgcttgct
     2221 atcatgtgtg ccccaactat accaatttcc agtttgacac atcgttcatg tacatgatcg
     2281 ccggactctg catgctgaag ctctaccaga agcggcaccc ggacatcaac gccagcgcct
     2341 acagtgccta cgcctgcctg gccattgtca tcttcttctc tgtgctgggc gtggtctttg
     2401 gcaaagggaa cacggcgttc tggatcgtct tctccatcat tcacatcatc gccaccctgc
     2461 tcctcagcac gcagctctat tacatgggcc ggtggaaact ggactcgggg atcttccgcc
     2521 gcatcctcca cgtgctctac acagactgca tccggcagtg cagcgggccg ctctacgtgg
     2581 accgcatggt gctgctggtc atgggcaacg tcatcaactg gtcgctggct gcctatgggc
     2641 ttatcatgcg ccccaatgat ttcgcttcct acttgttggc cattggcatc tgcaacctgc
     2701 tcctttactt cgccttctac atcatcatga agctccggag tggggagagg atcaagctca
     2761 tccccctgct ctgcatcgtt tgcacctccg tggtctgggg cttcgcgctc ttcttcttct
     2821 tccagggact cagcacctgg cagaaaaccc ctgcagagtc gagggagcac aaccgggact
     2881 gcatcctcct cgacttcttt gacgaccacg acatctggca cttcctctcc tccatcgcca
     2941 tgttcgggtc cttcctggtg ttgctgacac tggatgacga cctggatact gtgcagcggg
     3001 acaagatcta tgtcttctag caggagctgg gcccttcgct tcacctcaag gggccctgag
     3061 ctcctttgtg tcatagaccg gtcactctgt cgtgctgtgg ggatgagtcc cagcaccgct
     3121 gcccagcact ggatggcagc aggacagcca ggtctagctt aggcttggcc tgggacagcc
     3181 atggggtggc atggaacctt gcagctgccc tctgccgagg agcaggcctg ctcccctgga
     3241 acccccagat gttggccaaa ttgctgcttt cttctcagtg ttggggcctt ccatgggccc
     3301 ctgtcctttg gctctccatt tgtccctttg caagaggaag gatggaaggg acaccctccc
     3361 catttcatgc cttgcatttt gcccgtcctc ctccccacaa tgccccagcc tgggacctaa
     3421 ggcctctttt tcctcccata ctcccactcc agggcctagt ctggggcctg aatctctgtc
     3481 ctgtatcagg gccccagttc tctttgggct gtccctggct gccatcactg cccattccag
     3541 tcagccagga tggatggggg tatgagattt tgggggttgg ccagctggtg ccagactttt
     3601 ggtgctaagg cctgcaaggg gcctggggca gtgcgtattc tcttccctct gacctgtgct
     3661 cagggctggc tctttagcaa tgcgctcagc ccaatttgag aaccgccttc tgattcaaga
     3721 ggctgaattc agaggtcacc tcttcatccc atcagctccc agactgatgc cagcaccagg
     3781 actggaggga gaagcgcctc accccttccc ttccttcttt ccaggccctt agtcttgcca
     3841 aaccccagct ggtggccttt cagtgccatt gacactgccc aagaatgtcc aggggcaaag
     3901 gagggatgat acagagttca gcccgttctg cctccacagc tgtgggcacc ccagtgccta
     3961 ccttagaaag gggcttcagg aagggatgtg ctgtttccct ctacgtgccc agtcctagcc
     4021 tcgctctagg acccagggct ggcttctaag tttccgtcca gtcttcaggc aagttctgtg
     4081 ttagtcatgc acacacatac ctatgaaacc ttggagttta caaagaattg ccccagctct
     4141 gggcaccctg gccaccctgg tccttggatc cccttcgtcc cacctggtcc accccagatg
     4201 ctgaggatgg gggagctcag gcggggcctc tgctttgggg atgggaatgt gtttttctcc
     4261 caaacttgtt tttatagctc tgcttgaagg gctgggagat gaggtgggtc tggatctttt
     4321 ctcagagcgt ctccatgcta tggttgcatt tccgttttct atgaatgaat ttgcattcaa
     4381 taaacaacca gactca
//
