LOCUS       NM_017699               4818 bp    mRNA    linear   PRI 12-FEB-2025
DEFINITION  Homo sapiens SID1 transmembrane family member 1 (SIDT1), transcript
            variant 2, mRNA.
ACCESSION   NM_017699
VERSION     NM_017699.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4818)
  AUTHORS   Navratna,V., Kumar,A., Rana,J.K. and Mosalaganti,S.
  TITLE     Structure of the human systemic RNAi defective transmembrane
            protein 1 (hSIDT1) reveals the conformational flexibility of its
            lipid binding domain
  JOURNAL   Life Sci Alliance 7 (9), e202402624 (2024)
   PUBMED   38925866
  REMARK    GeneRIF: Structure of the human systemic RNAi defective
            transmembrane protein 1 (hSIDT1) reveals the conformational
            flexibility of its lipid binding domain.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4818)
  AUTHORS   Hirano,Y., Ohto,U., Ichi,I., Sato,R., Miyake,K. and Shimizu,T.
  TITLE     Cryo-EM analysis reveals human SID-1 transmembrane family member 1
            dynamics underlying lipid hydrolytic activity
  JOURNAL   Commun Biol 7 (1), 664 (2024)
   PUBMED   38811802
  REMARK    GeneRIF: Cryo-EM analysis reveals human SID-1 transmembrane family
            member 1 dynamics underlying lipid hydrolytic activity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4818)
  AUTHORS   Yang,T., Xiao,H., Chen,X., Zheng,L., Guo,H., Wang,J., Jiang,X.,
            Zhang,C.Y., Yang,F. and Ji,X.
  TITLE     Characterization of N-glycosylation and its functional role in
            SIDT1-Mediated RNA uptake
  JOURNAL   J Biol Chem 300 (2), 105654 (2024)
   PUBMED   38237680
  REMARK    GeneRIF: Characterization of N-glycosylation and its functional
            role in SIDT1-Mediated RNA uptake.
REFERENCE   4  (bases 1 to 4818)
  AUTHORS   Sun,C.R., Xu,D., Yang,F., Hou,Z., Luo,Y., Zhang,C.Y., Shan,G.,
            Huang,G., Yao,X., Chen,Y., Li,Q. and Zhou,C.Z.
  TITLE     Human SIDT1 mediates dsRNA uptake via its phospholipase activity
  JOURNAL   Cell Res 34 (1), 84-87 (2024)
   PUBMED   37932444
  REMARK    GeneRIF: Human SIDT1 mediates dsRNA uptake via its phospholipase
            activity.
REFERENCE   5  (bases 1 to 4818)
  AUTHORS   Mendez-Acevedo,K.M., Valdes,V.J., Asanov,A. and Vaca,L.
  TITLE     A novel family of mammalian transmembrane proteins involved in
            cholesterol transport
  JOURNAL   Sci Rep 7 (1), 7450 (2017)
   PUBMED   28785058
  REMARK    GeneRIF: In silico analysis identified SIDT1 and SIDT2 sharing
            identity and conserved cholesterol binding (CRAC) domains with C.
            elegans ChUP-1. Further evidence indicate that SIDT1 and SIDT2 not
            only do not transport RNA, but they are involved in cholesterol
            transport. Single point mutations in the CRAC domains of both
            proteins prevent FRET between SIDT1, SIDT2 and dehydroergosterol
            and alter cholesterol transport.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4818)
  AUTHORS   Eeles,R.A., Olama,A.A., Benlloch,S., Saunders,E.J.,
            Leongamornlert,D.A., Tymrakiewicz,M., Ghoussaini,M., Luccarini,C.,
            Dennis,J., Jugurnauth-Little,S., Dadaev,T., Neal,D.E., Hamdy,F.C.,
            Donovan,J.L., Muir,K., Giles,G.G., Severi,G., Wiklund,F.,
            Gronberg,H., Haiman,C.A., Schumacher,F., Henderson,B.E., Le
            Marchand,L., Lindstrom,S., Kraft,P., Hunter,D.J., Gapstur,S.,
            Chanock,S.J., Berndt,S.I., Albanes,D., Andriole,G., Schleutker,J.,
            Weischer,M., Canzian,F., Riboli,E., Key,T.J., Travis,R.C.,
            Campa,D., Ingles,S.A., John,E.M., Hayes,R.B., Pharoah,P.D.,
            Pashayan,N., Khaw,K.T., Stanford,J.L., Ostrander,E.A.,
            Signorello,L.B., Thibodeau,S.N., Schaid,D., Maier,C., Vogel,W.,
            Kibel,A.S., Cybulski,C., Lubinski,J., Cannon-Albright,L.,
            Brenner,H., Park,J.Y., Kaneva,R., Batra,J., Spurdle,A.B.,
            Clements,J.A., Teixeira,M.R., Dicks,E., Lee,A., Dunning,A.M.,
            Baynes,C., Conroy,D., Maranian,M.J., Ahmed,S., Govindasami,K.,
            Guy,M., Wilkinson,R.A., Sawyer,E.J., Morgan,A., Dearnaley,D.P.,
            Horwich,A., Huddart,R.A., Khoo,V.S., Parker,C.C., Van As,N.J.,
            Woodhouse,C.J., Thompson,A., Dudderidge,T., Ogden,C., Cooper,C.S.,
            Lophatananon,A., Cox,A., Southey,M.C., Hopper,J.L., English,D.R.,
            Aly,M., Adolfsson,J., Xu,J., Zheng,S.L., Yeager,M., Kaaks,R.,
            Diver,W.R., Gaudet,M.M., Stern,M.C., Corral,R., Joshi,A.D.,
            Shahabi,A., Wahlfors,T., Tammela,T.L., Auvinen,A., Virtamo,J.,
            Klarskov,P., Nordestgaard,B.G., Roder,M.A., Nielsen,S.F.,
            Bojesen,S.E., Siddiq,A., Fitzgerald,L.M., Kolb,S., Kwon,E.M.,
            Karyadi,D.M., Blot,W.J., Zheng,W., Cai,Q., McDonnell,S.K.,
            Rinckleb,A.E., Drake,B., Colditz,G., Wokolorczyk,D.,
            Stephenson,R.A., Teerlink,C., Muller,H., Rothenbacher,D.,
            Sellers,T.A., Lin,H.Y., Slavov,C., Mitev,V., Lose,F.,
            Srinivasan,S., Maia,S., Paulo,P., Lange,E., Cooney,K.A.,
            Antoniou,A.C., Vincent,D., Bacot,F., Tessier,D.C., Kote-Jarai,Z.
            and Easton,D.F.
  CONSRTM   COGS-Cancer Research UK GWAS-ELLIPSE (part of GAME-ON) Initiative;
            Australian Prostate Cancer Bioresource; UK Genetic Prostate Cancer
            Study Collaborators/British Association of Urological Surgeons'
            Section of Oncology; UK ProtecT (Prostate testing for cancer and
            Treatment) Study Collaborators; PRACTICAL (Prostate Cancer
            Association Group to Investigate Cancer-Associated Alterations in
            the Genome) Consortium
  TITLE     Identification of 23 new prostate cancer susceptibility loci using
            the iCOGS custom genotyping array
  JOURNAL   Nat Genet 45 (4), 385-391 (2013)
   PUBMED   23535732
REFERENCE   7  (bases 1 to 4818)
  AUTHORS   Wang,X., Shaffer,J.R., Zeng,Z., Begum,F., Vieira,A.R., Noel,J.,
            Anjomshoaa,I., Cuenco,K.T., Lee,M.K., Beck,J., Boerwinkle,E.,
            Cornelis,M.C., Hu,F.B., Crosslin,D.R., Laurie,C.C., Nelson,S.C.,
            Doheny,K.F., Pugh,E.W., Polk,D.E., Weyant,R.J., Crout,R.,
            McNeil,D.W., Weeks,D.E., Feingold,E. and Marazita,M.L.
  TITLE     Genome-wide association scan of dental caries in the permanent
            dentition
  JOURNAL   BMC Oral Health 12, 57 (2012)
   PUBMED   23259602
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4818)
  AUTHORS   Elhassan,M.O., Christie,J. and Duxbury,M.S.
  TITLE     Homo sapiens systemic RNA interference-defective-1 transmembrane
            family member 1 (SIDT1) protein mediates contact-dependent small
            RNA transfer and microRNA-21-driven chemoresistance
  JOURNAL   J Biol Chem 287 (8), 5267-5277 (2012)
   PUBMED   22174421
  REMARK    GeneRIF: SIDT1, facilitates rapid, contact-dependent, bidirectional
            small RNA transfer between human cells, resulting in
            target-specific non-cell-autonomous RNAi
REFERENCE   9  (bases 1 to 4818)
  AUTHORS   Pratt,A.J., Rambo,R.P., Lau,P.W. and MacRae,I.J.
  TITLE     Preparation and characterization of the extracellular domain of
            human Sid-1
  JOURNAL   PLoS One 7 (4), e33607 (2012)
   PUBMED   22509261
  REMARK    GeneRIF: characterization of Sid-1 extracellular domain
REFERENCE   10 (bases 1 to 4818)
  AUTHORS   Duxbury,M.S., Ashley,S.W. and Whang,E.E.
  TITLE     RNA interference: a mammalian SID-1 homologue enhances siRNA uptake
            and gene silencing efficacy in human cells
  JOURNAL   Biochem Biophys Res Commun 331 (2), 459-463 (2005)
   PUBMED   15850781
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB217586.1, DA337075.1,
            AK000181.1, DA217300.1, BG484269.1, BE839090.1 and AI004220.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_017699.2.
            
            Summary: The protein encoded by this gene belongs to SID1 family of
            transmembrane dsRNA-gated channels. Family members transport dsRNA
            into cells and are required for systemic RNA interference.
            [provided by RefSeq, May 2017].
            
            Transcript Variant: This variant (2) encodes isoform 2.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1965299,
                              SAMEA1968540 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264852.9/ ENSP00000264852.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-363               DB217586.1         185-547
            364-517             DA337075.1         422-575
            518-826             AK000181.1         427-735
            827-832             DA217300.1         355-360
            833-2179            AK000181.1         742-2088
            2180-2185           BG484269.1         492-497
            2186-3523           AK000181.1         2095-3432
            3524-3531           BE839090.1         147-154
            3532-4666           AK000181.1         3441-4575
            4667-4818           AI004220.1         20-171              c
FEATURES             Location/Qualifiers
     source          1..4818
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.2"
     gene            1..4818
                     /gene="SIDT1"
                     /gene_synonym="SID-1; SID1"
                     /note="SID1 transmembrane family member 1"
                     /db_xref="GeneID:54847"
                     /db_xref="HGNC:HGNC:25967"
                     /db_xref="MIM:606816"
     exon            1..689
                     /gene="SIDT1"
                     /gene_synonym="SID-1; SID1"
                     /inference="alignment:Splign:2.1.0"
     CDS             468..2951
                     /gene="SIDT1"
                     /gene_synonym="SID-1; SID1"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2"
                     /codon_start=1
                     /product="SID1 transmembrane family member 1 isoform 2
                     precursor"
                     /protein_id="NP_060169.2"
                     /db_xref="CCDS:CCDS2974.1"
                     /db_xref="GeneID:54847"
                     /db_xref="HGNC:HGNC:25967"
                     /db_xref="MIM:606816"
                     /translation="MRGCLRLALLCALPWLLLAASPGHPAKSPRQPPAPRRDPFDAAR
                     GADFDHVYSGVVNLSTENIYSFNYTSQPDQVTAVRVYVNSSSENLNYPVLVVVRQQKE
                     VLSWQVPLLFQGLYQRSYNYQEVSRTLCPSEATNETGPLQQLIFVDVASMAPLGAQYK
                     LLVTKLKHFQLRTNVAFHFTASPSQPQYFLYKFPKDVDSVIIKVVSEMAYPCSVVSVQ
                     NIMCPVYDLDHNVEFNGVYQSMTKKAAITLQKKDFPGEQFFVVFVIKPEDYACGGSFF
                     IQEKENQTWNLQRKKNLEVTIVPSIKESVYVKSSLFSVFIFLSFYLGCLLVGFVHYLR
                     FQRKSIDGSFGSNDGSGNMVASHPIAASTPEGSNYGTIDESSSSPGRQMSSSDGGPPG
                     QSDTDSSVEESDFDTMPDIESDKNIIRTKMFLYLSDLSRKDRRIVSKKYKIYFWNIIT
                     IAVFYALPVIQLVITYQTVVNVTGNQDICYYNFLCAHPLGVLSAFNNILSNLGHVLLG
                     FLFLLIVLRRDILHRRALEAKDIFAVEYGIPKHFGLFYAMGIALMMEGVLSACYHVCP
                     NYSNFQFDTSFMYMIAGLCMLKLYQTRHPDINASAYSAYASFAVVIMVTVLGVVFGKN
                     DVWFWVIFSAIHVLASLALSTQIYYMGRFKIDLGIFRRAAMVFYTDCIQQCSRPLYMD
                     RMVLLVVGNLVNWSFALFGLIYRPRDFASYMLGIFICNLLLYLAFYIIMKLRSSEKVL
                     PVPLFCIVATAVMWAAALYFFFQNLSSWEGTPAESREKNRECILLDFFDDHDIWHFLS
                     ATALFFSFLVLLTLDDDLDVVRRDQIPVF"
     exon            690..811
                     /gene="SIDT1"
                     /gene_synonym="SID-1; SID1"
                     /inference="alignment:Splign:2.1.0"
     exon            812..982
                     /gene="SIDT1"
                     /gene_synonym="SID-1; SID1"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1028
                     /gene="SIDT1"
                     /gene_synonym="SID-1; SID1"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1130
                     /gene="SIDT1"
                     /gene_synonym="SID-1; SID1"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1214
                     /gene="SIDT1"
                     /gene_synonym="SID-1; SID1"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1302
                     /gene="SIDT1"
                     /gene_synonym="SID-1; SID1"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1374
                     /gene="SIDT1"
                     /gene_synonym="SID-1; SID1"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1468
                     /gene="SIDT1"
                     /gene_synonym="SID-1; SID1"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1512
                     /gene="SIDT1"
                     /gene_synonym="SID-1; SID1"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1584
                     /gene="SIDT1"
                     /gene_synonym="SID-1; SID1"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1730
                     /gene="SIDT1"
                     /gene_synonym="SID-1; SID1"
                     /inference="alignment:Splign:2.1.0"
     exon            1731..1804
                     /gene="SIDT1"
                     /gene_synonym="SID-1; SID1"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..1871
                     /gene="SIDT1"
                     /gene_synonym="SID-1; SID1"
                     /inference="alignment:Splign:2.1.0"
     exon            1872..1945
                     /gene="SIDT1"
                     /gene_synonym="SID-1; SID1"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2069
                     /gene="SIDT1"
                     /gene_synonym="SID-1; SID1"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2187
                     /gene="SIDT1"
                     /gene_synonym="SID-1; SID1"
                     /inference="alignment:Splign:2.1.0"
     exon            2188..2324
                     /gene="SIDT1"
                     /gene_synonym="SID-1; SID1"
                     /inference="alignment:Splign:2.1.0"
     exon            2325..2433
                     /gene="SIDT1"
                     /gene_synonym="SID-1; SID1"
                     /inference="alignment:Splign:2.1.0"
     exon            2434..2510
                     /gene="SIDT1"
                     /gene_synonym="SID-1; SID1"
                     /inference="alignment:Splign:2.1.0"
     exon            2511..2557
                     /gene="SIDT1"
                     /gene_synonym="SID-1; SID1"
                     /inference="alignment:Splign:2.1.0"
     exon            2558..2663
                     /gene="SIDT1"
                     /gene_synonym="SID-1; SID1"
                     /inference="alignment:Splign:2.1.0"
     exon            2664..2774
                     /gene="SIDT1"
                     /gene_synonym="SID-1; SID1"
                     /inference="alignment:Splign:2.1.0"
     exon            2775..2888
                     /gene="SIDT1"
                     /gene_synonym="SID-1; SID1"
                     /inference="alignment:Splign:2.1.0"
     exon            2889..4818
                     /gene="SIDT1"
                     /gene_synonym="SID-1; SID1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4796..4801
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIDT1"
                     /gene_synonym="SID-1; SID1"
                     /note="hexamer: AATAAA"
     polyA_site      4818
                     /gene="SIDT1"
                     /gene_synonym="SID-1; SID1"
                     /note="major polyA site"
ORIGIN      
        1 gtatttgaaa cagaccgaat ttcctcctcg atgtggcgtc aggttgactt ttcgagacta
       61 gcgggtattt ctttttaatg actccaatgc ctttttatta ttgctgttat tgaggttgag
      121 ggagaagaga tcggtctaaa ttctggctgg gtaagtgggg ggattctcgg cgatgagaaa
      181 cgggggactt agaagccgga ggaaaatcag cagccccaca tctccacttc tccagtccgc
      241 cctactctcc acccgtgacc tccagtggag accccaggcg gcagcatcag tatttgatcg
      301 gcccttcgtc agcacgctgc cagccctggc cggctgggtt cgccaggcat cacccgctcg
      361 gctctgaagc ggacgcctgg ccctgcaccg ggctttggaa ggaccctctc tgcgctcgcc
      421 ccctccccag ggtggctccg ctttcgagcc cgggcgcggt gcccaccatg cgcggctgcc
      481 tgcggctcgc gctgctctgc gcgctgccct ggctcctgct ggcggcgtcg cccgggcacc
      541 cggcgaaatc ccccaggcag cccccggcac cgcgccgcga ccccttcgac gctgccaggg
      601 gcgccgattt cgatcatgtc tacagcgggg tggtgaacct cagcaccgag aacatctact
      661 ctttcaacta caccagccag cccgaccagg tgacagccgt gagggtgtat gtgaacagtt
      721 cctctgagaa tctcaactac ccggtccttg ttgtggttcg ccagcagaaa gaggtgctgt
      781 cctggcaggt tcctctgctc ttccaaggac tataccagag gagctacaac tatcaagaag
      841 tgagccgcac cttatgtccc tcagaagcaa ccaatgagac gggacccttg cagcaactga
      901 tatttgtaga tgtcgcatcc atggcacccc tgggtgctca gtacaaactg ctagttacca
      961 agctgaagca cttccagctc cggacaaatg ttgcctttca ctttactgcc agcccctctc
     1021 aacctcagta ttttctatac aagtttccca aagacgtgga ctcagttatc attaaagtgg
     1081 tgtctgaaat ggcttatcca tgttctgttg tctcagtcca gaatatcatg tgcccggtgt
     1141 atgatctcga ccacaatgtg gaatttaatg gtgtctatca gtccatgacc aagaaagctg
     1201 ccatcacgct acagaagaag gattttccag gcgagcagtt cttcgtggta tttgtgataa
     1261 agcctgaaga ttatgcctgt ggaggatctt tcttcatcca ggaaaaggaa aaccagacct
     1321 ggaatctaca gcgaaaaaag aaccttgaag tgaccattgt cccttccatt aaagaatctg
     1381 tttatgtgaa atccagtctt ttcagtgtct tcatcttcct gtccttctac ttgggatgcc
     1441 ttcttgttgg gtttgttcat tatctgaggt ttcagagaaa atccattgat ggaagctttg
     1501 ggtccaatga tggctctgga aatatggtgg catctcatcc cattgctgcc agcacacccg
     1561 aagggagcaa ttatgggaca atagatgagt caagctccag tcctggaagg cagatgtcct
     1621 cctccgatgg tgggccaccg ggccagtcag acacagacag ctccgtggag gagagcgact
     1681 tcgacaccat gccagacatt gagagtgata aaaacatcat ccggaccaag atgttccttt
     1741 acctgtcaga tttgtccagg aaggaccgga gaattgtcag caaaaaatat aaaatttatt
     1801 tttggaacat catcaccatt gctgtgtttt acgcgctgcc cgtgatccag ctggtcatta
     1861 cctatcagac agtggtaaat gtcactggca accaggacat ctgttactac aacttcctct
     1921 gtgctcaccc cttgggcgtc ctgagtgcct tcaacaacat tctcagcaat ctgggccacg
     1981 tgcttctggg cttcctcttc ctgctgatag tcttgcgccg cgacatcctc catcggagag
     2041 ccctggaagc caaggacatc tttgctgtgg agtacgggat tcccaaacac tttggtctct
     2101 tctacgctat gggcattgca ttgatgatgg aaggggtgct cagtgcttgc taccatgtct
     2161 gccctaatta ttccaacttc caattcgaca cctccttcat gtacatgatc gctggcctgt
     2221 gcatgctgaa gctctatcag acccgccacc cagacatcaa tgccagcgcc tactctgcct
     2281 atgcctcctt tgctgtggtc atcatggtca ccgtccttgg agtggtgttt ggaaaaaatg
     2341 acgtatggtt ctgggtcatc ttctctgcaa tccacgttct ggcctcgcta gccctcagca
     2401 cccagatata ttatatgggt cgtttcaaga tagatttggg aattttccgg cgggctgcca
     2461 tggtgttcta cacagactgt atccagcagt gtagccgacc tctatatatg gatagaatgg
     2521 tgttgctggt tgtggggaat ctggttaact ggtccttcgc cctctttgga ttgatatacc
     2581 gccccaggga ctttgcttcc tacatgctgg gcatcttcat ctgtaacctt ttgctgtacc
     2641 tggcctttta catcatcatg aagctccgca gctctgaaaa ggtcctccca gtcccgctct
     2701 tctgcatcgt ggccaccgct gtgatgtggg ctgccgccct atattttttc ttccagaatc
     2761 tcagcagctg ggagggaact ccggccgaat cccgggagaa gaaccgcgag tgcattctgc
     2821 tggatttctt cgatgaccat gacatctggc acttcctctc tgctactgct ctgtttttct
     2881 cattcttggt tttgttaact ttggatgatg accttgatgt ggttcggaga gaccagatcc
     2941 ctgtcttctg aacctccaac attaagagag gggagggagc gatcaatctt ggtgctgttt
     3001 cacaaaaatt acagtgacca cagcaaagta accactgcca gatgctccac tcaccctctg
     3061 tagagccaac tctgcattca cacaggaagg agaggggctg cgggagattt aaacctgcaa
     3121 gaaaggaggc agaaggggag ccatgttttg aggacagacg caaacctgag gagctgagaa
     3181 acacttgctc cttccatctg cagctttggg agtgcaacag ggataggcac tgcatccaag
     3241 tcaactcacc atcttggggt ccctcccacc ctcacggaga cttgccagca atggcagaat
     3301 gctgctgcac acttccctcc agttgtcacc ctgcccagaa aggccagcag cttggacttc
     3361 ctgcccagaa actgtgttgg cccccttcac acctctgcaa cacctgctgc tccagcaaga
     3421 ggatgtgatt ctttagaata tggcggggag gtgaccccag gccctgccct actgggatag
     3481 atgttttaat ggcaccagct agtcacctcc cagaagaaac tctgtatatt tcccccaggt
     3541 ttctgatgcc atcagaaggg ctcaggagtg gggtttgtca cacattcctc ttaacaagta
     3601 actgtcactg ggaccgagtc ctgggtgctt acatattcct tcgtgtcttc atctcactga
     3661 cctgtgtgga cctcatcact ctgactctgc cttcttggaa aggccctgtc actccacaga
     3721 tgtctggcca gcttcaaggc agaaggaaaa acaggaaaag ctcttttaac agcagcagga
     3781 acaagagaaa tgactaacca tactaaaaga ctggtaacag cagcagcagc cagacaggcc
     3841 tcaccttaag gacttgggct gccagagcaa attcagcaga gcttatttgg cctcccattc
     3901 acacagctca gttctgtgcc cacatcacct ttggggaaga aatcagcatt ctaatcaggg
     3961 acactacttc aggagtcctc cacagcgagt ccgtcatctg tcactttatg tagatcaggg
     4021 ttctagactt cttccctgag gttctcagaa gcagctctca ggatgaacgt attgtcctct
     4081 tcccctcttc ttgcaaagtg cacagctaat ctaatgttgt ctctcggttg cacctgacat
     4141 tctctcccca gtaaggtgtt ggcaagctca gcatctgggt tccactctca cactgtctgg
     4201 cagctctgtg tctgagaagt tctacattga ccaggccccc ttgttgcctg gagtatgacg
     4261 taatcagaaa atagacgtat aaatgtgcac atgcgtatgt atttgcttgt gaaattaaag
     4321 tcacctcttg cctctgcttt cctgatcatt cgttagagaa atggatcagg cattttttta
     4381 aattattatt ctttctctaa actatttgca ttgtgttcaa aaacccattt tagaagtttg
     4441 aacagcaagc ttttcctgat tttaaaaaca caaagttgct ttcaatgaaa tattttgtga
     4501 tttttttaaa gtccccaaat gtgtacttag ccttctgtta ttccttattc tttaagcagt
     4561 gttggcttcc attgaccata tgaaggccac caattaaatg gttgtgttaa tccaacatgt
     4621 aaaaaacttt ttggcagggc acagtggctc acgcctgtaa tcccaacact ttgggaggct
     4681 gaggcaggag gatcacttga gcccaggaga ttgacgccgc agtgaactat gattgtgccc
     4741 ctgcactcca gcctggatga cagagtgaga ccccatctct taaaaaataa aaaaaaataa
     4801 aaatttgaac ctgtttca
//
