LOCUS       NM_198849               7075 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens siah E3 ubiquitin protein ligase family member 3
            (SIAH3), mRNA.
ACCESSION   NM_198849 XM_210264
VERSION     NM_198849.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7075)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 7075)
  AUTHORS   Li,X., Chu,S.G., Shen,X.N., Hou,X.H., Xu,W., Ou,Y.N., Dong,Q.,
            Tan,L. and Yu,J.T.
  TITLE     Genome-wide association study identifies SIAH3 locus influencing
            the rate of ventricular enlargement in non-demented elders
  JOURNAL   Aging (Albany NY) 11 (21), 9862-9874 (2019)
   PUBMED   31711042
  REMARK    GeneRIF: Genome-wide association study identifies SIAH3 locus
            influencing the rate of ventricular enlargement in non-demented
            elders.
REFERENCE   3  (bases 1 to 7075)
  AUTHORS   Pepper,I.J., Van Sciver,R.E. and Tang,A.H.
  TITLE     Phylogenetic analysis of the SINA/SIAH ubiquitin E3 ligase family
            in Metazoa
  JOURNAL   BMC Evol Biol 17 (1), 182 (2017)
   PUBMED   28784114
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7075)
  AUTHORS   Wang,Y. and Tatakis,D.N.
  TITLE     Human gingiva transcriptome during wound healing
  JOURNAL   J Clin Periodontol 44 (4), 394-402 (2017)
   PUBMED   28005267
  REMARK    GeneRIF: SIAH3 expression is significantly downregulated in human
            masticatory mucosa during wound healing
REFERENCE   5  (bases 1 to 7075)
  AUTHORS   Hasson,S.A., Kane,L.A., Yamano,K., Huang,C.H., Sliter,D.A.,
            Buehler,E., Wang,C., Heman-Ackah,S.M., Hessa,T., Guha,R.,
            Martin,S.E. and Youle,R.J.
  TITLE     High-content genome-wide RNAi screens identify regulators of parkin
            upstream of mitophagy
  JOURNAL   Nature 504 (7479), 291-295 (2013)
   PUBMED   24270810
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL157819.15, BC041372.2 and DA804734.1.
            
            On Nov 22, 2018 this sequence version replaced NM_198849.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC041372.2, DR000833.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000400405.4/ ENSP00000383256.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                AL157819.15        96974-97015         c
            43-44               BC041372.2         1-2
            45-575              DA804734.1         28-558
            576-1046            BC041372.2         534-1004
            1047-1223           BC041372.2         1006-1182
            1224-4047           BC041372.2         1184-4007
            4048-7075           AL157819.15        22504-25531         c
FEATURES             Location/Qualifiers
     source          1..7075
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.13"
     gene            1..7075
                     /gene="SIAH3"
                     /note="siah E3 ubiquitin protein ligase family member 3"
                     /db_xref="GeneID:283514"
                     /db_xref="HGNC:HGNC:30553"
                     /db_xref="MIM:615609"
     exon            1..259
                     /gene="SIAH3"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..934
                     /gene="SIAH3"
                     /note="siah-3"
                     /codon_start=1
                     /product="seven in absentia homolog 3"
                     /protein_id="NP_942146.2"
                     /db_xref="CCDS:CCDS41883.1"
                     /db_xref="GeneID:283514"
                     /db_xref="HGNC:HGNC:30553"
                     /db_xref="MIM:615609"
                     /translation="MLFFTQCFGAVLDLIHLRFQHYKAKRVFSAAGQLVCVVNPTHNL
                     KYVSSRRAVTQSAPEQGSFHPHHLSHHHCHHRHHHHLRHHAHPHHLHHQEAGLHANPV
                     TPCLCMCPLFSCQWEGRLEVVVPHLRQIHRVDILQGAEIVFLATDMHLPAPADWIIMH
                     SCLGHHFLLVLRKQERHEGHPQFFATMMLIGTPTQADCFTYRLELNRNHRRLKWEATP
                     RSVLECVDSVITDGDCLVLNTSLAQLFSDNGSLAIGIAITATEVLPSEAEM"
     exon            260..7075
                     /gene="SIAH3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7045..7050
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIAH3"
                     /note="hexamer: ATTAAA"
     polyA_site      7075
                     /gene="SIAH3"
                     /note="major polyA site"
ORIGIN      
        1 gaatatgaag gcgcgctaag ccgggctgga gcggagtgtc tcagaggctg cgctccttcc
       61 agggcccaag gactcacagc ttcctccgct gccttcccgg accaacaacc ccccaaaagt
      121 tgtgatgctt ttctttaccc agtgctttgg ggctgtatta gatctcattc atctccggtt
      181 tcagcactac aaggctaaac gggttttctc cgctgccggg caacttgtct gtgtcgtcaa
      241 ccccacacac aacctaaagt atgtgtccag tcggcgcgcc gtcactcaga gcgctccaga
      301 gcaaggcagc ttccaccctc accatctctc ccaccaccac tgccaccacc gccaccacca
      361 ccacctccgc caccacgccc acccccacca ccttcaccac caggaggcgg ggctgcacgc
      421 caacccggtg acgccctgcc tgtgcatgtg tcccttgttc tcctgccagt gggaaggccg
      481 cctggaggtg gtggtgcccc acctgcggca gatccatagg gttgacatcc tccagggagc
      541 cgagatcgtc ttcctggcca cggacatgca cctccccgcg ccggctgatt ggatcatcat
      601 gcactcctgc cttggccacc actttctgtt ggtgctgagg aaacaggaga ggcatgaagg
      661 gcacccccag ttctttgcca ccatgatgct gattgggacc cccacccagg ccgactgctt
      721 cacctatcgc ctggagctca acagaaacca tcggcgcctc aagtgggagg ccacgccccg
      781 gtctgttctt gagtgcgtgg actcggtgat tacggacggg gactgcctcg tcctcaacac
      841 ctcgctggca cagctcttct ctgacaacgg cagccttgcc attgggattg ccatcaccgc
      901 gacagaggtc ctcccctcag aagctgaaat gtgaggccag gagccacgga tgctccccac
      961 acagcctccc taggaaacgc ctgggacctc ccaataccag gactccagac tcctttttat
     1021 tcttctcctt tctttttttt ttttttaatt tttaattatt attatttttt tgtctcaggt
     1081 actttgtgag atttagtttt tgtctgccat gggcattata ttatgtaaac atcctgtaat
     1141 ttaagatctt ggtgtgatgt ttgtcctgcc ttgttggtgt tgttttatag aatgtttgta
     1201 agatttattc agaatagttt tttcctgtca cctccaagtc ctttctccgc tagttttgaa
     1261 aggatcaaaa caccatcaag cagactgttg gggttgaaag gaggcttcgt gtgagaatca
     1321 tttcttgttt ctcttttcag tctatttcag agcaagctaa atctgaacgt gtgcagtcgg
     1381 caggttgggg aaggggccca gctcagagat ggatcacatt tcagaccatc cagacatgac
     1441 tctgacagct tcccaggaac ctcaaggtca aagctgagct agccgggcat gaggagatcg
     1501 tgtctccacc gcagggctgg ggactgggct agaggtgtca ttgtgtgctg agtgctcagg
     1561 ttgatgctgg ggctcaggag agtagtcaga ggcccacctt cctgtgacgg gctcttgtca
     1621 ccttgttccc aggctgtgcc gtcttctcct gctctggaat caaagtcctc agatttttga
     1681 tgctttctta aaaacccctt tgccttctgt tgagcaagta gtagaaaaga ataggcaaga
     1741 tggggggtgg ggatgaaaag caacaggaaa aagagaacat aaaattaatc tcccatctct
     1801 gagagggcac tccctcctca gagagtttta ttatcaagtt ataaaatcca tcagttcctc
     1861 cctagggtgc agttctttca tatcatgcaa aaagcagaac caggactcat catcaaatgc
     1921 aaagaactca gagggtggca cccaggatct ctgacctggc gggctggtca tcacttacaa
     1981 acctgggagg ctctcttccc tttcctcact ttctaaaatg ctcctaccgt cccattcagc
     2041 acgcagacgt gaccacggct caagtatgta ttcagcacct gttgcagtat gaatgacaca
     2101 gtgacggaaa tccatatttc ctctgcgcag gctgctttct cttatttggt tgtcagaaca
     2161 attcatcaac atcttcttgt agaagtctct cgtgtatttg aagaaagtca gcatgtttag
     2221 tcaactttgt cttttctgtt ctaagttgga cacctataag ccttcccagt aggacctctt
     2281 ctagctcctt tttatcgcat ttgtcccccc cctctggctg ctctccagac actgcagaag
     2341 tcaggcaccc catccccagc acattcccat gacagccaaa tgggcctttg gccaaccaga
     2401 cattactctc cgtgccctgt tcctgcacct caccccctcg gcttggtcct ggcaggcatc
     2461 caagtgacta cttagtctca ggcaggttgc cctggctggc catctgcaat tttttctcca
     2521 ccaaaaataa ctgatcctga aacacaacac ccttccccca acaactgggt taattctcca
     2581 gccacttttg gtgccaactt acacccccac gcaccagaag ggaggtgcca gtcgatacaa
     2641 gatttaataa cagaggctgc tctggtcaca cagtaatcgc tgggcccctg gggctgagac
     2701 tgcattccgt cagagccctg agaggggcaa aaaacattgc cacagatgga ggcacatgtc
     2761 agatgctgca gtcgcaaaaa aggattgggg cctgcgcatt ctttgagctc tcagatgccc
     2821 tgccagggca ccagccaccc tcctccaatc acacagatgc ccaagaacac ctgaggctgg
     2881 tccgtctgtg cgtggaaaga ctggctgtct tcctcctcac tgcatcccca atccccttcc
     2941 cagaacctaa gacccccttg gctgtaagtc ttatgccttt agaagccaca ggtcctctcc
     3001 tggtttttga gactcaacca ctttgaaagc atttgtgtag catcacaggt gctccagatc
     3061 aacaaacaaa aacctcacta agaatataac taacattcac agggccttag ggctcctgca
     3121 gacatcacct ttgccttctg gttgtgccaa gttacctgag ccacactggg aatgacttca
     3181 ggttattttc actgcacaca agactgtatt atgaataagt gatcccagat gggagcttat
     3241 atttttgttc ctagaaagct ttaggacaaa gcatgggaaa tgtattatta tcttccatct
     3301 atggtgctcc ccaaaaggcc tctccatatc catatgtgaa gaactggaga agaaggagca
     3361 aactaacaac caagaattgg gaataggaaa tggtaccagc agtttgtatt tgagcttcac
     3421 agttcctgaa gggctctttg atttgagtct caggttaatc ctcattagta tcctcaatat
     3481 actaacagaa tagaggttct aagacatgaa gtgatctttt caaggtcaca catcaggtgg
     3541 ttagaccaca accaaaaccc agatcaactg actgcaaact tggtgttctt gaagtaagac
     3601 tgatccgaaa tattcagcag tcttgccagc ttaccagtgg actgaggacc tgagaatcaa
     3661 ctgagtcttt gtcctgggat agttgaggga gcagggagag aaagactgga gtagatttgc
     3721 ttttagaagc atctctgctt taagaactag gccagggatg gtggctcacg tccataatcc
     3781 caggactttg ggaggccaag gaaggaggat tgcttgagct caggagtttg agaccagcct
     3841 gggcaatata gcgagacttc atttctacaa aaaaaaaaat cagctgggca tggtgacaca
     3901 agcctatagt cttaactact cggaggccaa gacaggggga tggcttgagc ccaggaggtt
     3961 gaggtcacag tgagctgtga ttgcaccact tgtaactcca gcctgggcaa cagagtgaga
     4021 ccctatctct ttagaaaaaa aaaaaaagca ctagtccacc tggaagcagg gggcccagga
     4081 agtgggtggg ctgcagatgg aggcttcagt gcgccaggcc ctttctgaat ccctttgccc
     4141 acacccaggt ttctcacctt agagtcccag gagtccctgc acagaacgct gggatctggt
     4201 tgcctcattc acaccaaggt gcaagagtta atgactcact ctctaaggag taattgcctt
     4261 ttaaaagaag gcctagagag acagcgcact taacagtgaa aaatgagtta ccagtatctg
     4321 aacttcaggc atctgccaga ggtttttttc aggaggtgtg gagagaggag cattcctccc
     4381 cttgaggctg agcctacata catggttgac gccgaaatgg aggtcaggcc acacgaagat
     4441 tgtctttaac aattggtatc tgcatgaatc tgtacctggt aaaccccatc actagctgtg
     4501 gctactctgg acattttagg aatagatcag catagtaacc ataatagtac tcatggctac
     4561 cacttattga ggcttttcta tatgatccag taggctgcgt actttgaata tagtagatca
     4621 tgtaatcccc ataacaacct tagcaagcag gtgctcttta ttgtattcat gttacgggtg
     4681 ggaaacgtaa gctaagagaa tttagccaac ttgcttaaga tcacccagct agcaaatggc
     4741 agagctgggc ctgggaccgg gtacgtatgg cttctgacca acagcaacca tgtcatttct
     4801 atgaacatat ggacccaagg ctcagaagga ccgagtcata aagtgtgaat ggcatagagg
     4861 ccttttagtg ctttcatact caatatggcc ttttagctcc cctttttctc cctctttttt
     4921 caacccaaga cctagtggag tactagagct gcttgtattc tggttgttaa tctttcagga
     4981 attttgcaag ctgattgtta attaagtaca gtcagtatta aaaatgatat acatttacaa
     5041 ttaaataaat tatatttaaa gcaaaggtca aaagtactta aaactcatca cttcctaatt
     5101 atttcactac tctttttatt ctctatgctc ctggggttat ttacatctat cacatctgta
     5161 tgatgaacat actatataat aatgtgctgc accgcatctt ccagctccac atttagtgac
     5221 gtcatggtga ttgcttgaaa ttagccatgg tggaagtatt cataccatgg aaattagcaa
     5281 atgctactag acagggattt ttctccctag aaagccagtt gttaagcact taacagtata
     5341 atcatccctc agtatccttg ggggattggt tccaggaatc tcgtggacac taaaatctga
     5401 agatgctcaa gtcccttata taaaacggca tagtatttgt atataaccta cgcaatcctc
     5461 ccatatactt taaataatct ctagagtact tataatacct aatacaatgt aaatgctatg
     5521 tcaatagttt ttatactgca ttatttctta ttgttgtatt atttcttttt tttttcctga
     5581 atattcttga ttcacagttg gtggaatcca caggtgtgga acatgtggat acagagggtt
     5641 gacttaatac cactgcctag acattgctga tgagcacagc agggtgggag aggggacttt
     5701 ggaaggagaa gcaaggccct ggaaggccgt actgacaagg gcataaatga cagccaagcc
     5761 agcggaacag caaattgttg gggaaacacg aactcttctg gagaagagac tctgaggctt
     5821 aagcagcttc aagagcattt tctgccacag agcaccctct gctttctccc cggacacttc
     5881 cctattgctg ttagtgtgga aagttctatt tggtggcttt catggaaaaa ttgggctccg
     5941 caaactcagc ctattggcta tcccaatcca aaaagcaaaa ccagctctat aaagctcaaa
     6001 tttcctgtta cttgttctta caggtcaccc tccctacctc tttcttacat gctggccaaa
     6061 acctaaagaa atgttttact ttgaaattag aaattggaaa tatctaccat tcaagagaca
     6121 cagcaagcag tggtgtcaaa caccacataa gatgcattat cacaaaagtg ggacccccgt
     6181 aaagcatgaa gctgagggac agaaaacata atgagccaag gaatgtcaca tgaagaacag
     6241 ggccccgggc cttactttcc tacttggcta cctcactttt ttgcaaccca gtaaggaccc
     6301 tgttcacaat ccatagccta cccagaccaa tactctttct aaatctgggg cacagtttcc
     6361 actaggacaa gagtcactgg aaacttccag ctaagtccat tgaagcaggc agaatcttca
     6421 aggtcaatag tgcatcagtt actctgatcc cagtggtttc agtggaaggg atggaagaag
     6481 tgagggttgc tgaagtttct acttggatgc atttctaagg gaaaggggaa gggatcatgg
     6541 gtgggacccc aaagagttag gctttgattg aggttcagct gcaaatagca tcatgagtgg
     6601 cgtctcctag tcagattgtt aaatttcaga tttttttgtt cataagattt tcttcaggaa
     6661 ttggtgagtt ccccattgtg ttcacctgga aaatagccag ctgaagaaaa acttcactga
     6721 aaagaaatct gagagatcta gtgtagataa acattaattt ccccccaaat caggtcatca
     6781 catgaactac ctgggttaga atttgtcttt tccaatattt tctgaaagta tttcaccttg
     6841 gctactatac tataaatact cctcaacctt tttcagtctt ttttttaggg tattgagata
     6901 agaaagagaa aggaaattga gaagcatttt acttgccctg aattaatgta tatataattt
     6961 tctatgcttt cttataatgt taaagacaat aacttggaca aactcaaact gctacttcat
     7021 ctctgccctc tcatagaaaa tgtcattaaa ttgcatttga tattgtttcc ttcga
//
