LOCUS       NM_005067               2311 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens siah E3 ubiquitin protein ligase 2 (SIAH2), mRNA.
ACCESSION   NM_005067
VERSION     NM_005067.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2311)
  AUTHORS   Hu,Q., Liu,Z., Liu,Y., Qiu,J., Zhang,X., Sun,J., Zhang,B. and
            Shi,H.
  TITLE     SIAH2 suppresses c-JUN pathway by promoting the polyubiquitination
            and degradation of HBx in hepatocellular carcinoma
  JOURNAL   J Cell Mol Med 28 (11), e18484 (2024)
   PUBMED   38842124
  REMARK    GeneRIF: SIAH2 suppresses c-JUN pathway by promoting the
            polyubiquitination and degradation of HBx in hepatocellular
            carcinoma.
REFERENCE   2  (bases 1 to 2311)
  AUTHORS   Shu,F., Shi,Y., Shan,X., Zha,W., Fan,R. and Xue,W.
  TITLE     SIAH2-Mediated Degradation of ACSL4 Inhibits the Anti-Tumor
            Activity of CD8+ T Cells in Hepatocellular Carcinoma
  JOURNAL   Crit Rev Eukaryot Gene Expr 34 (5), 1-13 (2024)
   PUBMED   38842200
  REMARK    GeneRIF: SIAH2-Mediated Degradation of ACSL4 Inhibits the
            Anti-Tumor Activity of CD8+ T Cells in Hepatocellular Carcinoma.
REFERENCE   3  (bases 1 to 2311)
  AUTHORS   Scortegagna,M., Du,Y., Bradley,L.M., Wang,K., Molinolo,A.,
            Ruppin,E., Murad,R. and Ronai,Z.A.
  TITLE     Ubiquitin Ligases Siah1a/2 Control Alveolar Macrophage Functions to
            Limit Carcinogen-Induced Lung Adenocarcinoma
  JOURNAL   Cancer Res 83 (12), 2016-2033 (2023)
   PUBMED   37078793
REFERENCE   4  (bases 1 to 2311)
  AUTHORS   Jeong,S.Y., Hariharasudhan,G., Kim,M.J., Lim,J.Y., Jung,S.M.,
            Choi,E.J., Chang,I.Y., Kee,Y., You,H.J. and Lee,J.H.
  TITLE     SIAH2 regulates DNA end resection and replication fork recovery by
            promoting CtIP ubiquitination
  JOURNAL   Nucleic Acids Res 50 (18), 10469-10486 (2022)
   PUBMED   36155803
  REMARK    GeneRIF: SIAH2 regulates DNA end resection and replication fork
            recovery by promoting CtIP ubiquitination.
REFERENCE   5  (bases 1 to 2311)
  AUTHORS   Zheng,H., Zheng,W.J., Wang,Z.G., Tao,Y.P., Huang,Z.P., Yang,L.,
            Ouyang,L., Duan,Z.Q., Zhang,Y.N., Chen,B.N., Xiang,D.M., Jin,G.,
            Fang,L., Zhou,F. and Liang,B.
  TITLE     Decreased Expression of Programmed Death Ligand-L1 by Seven in
            Absentia Homolog 2 in Cholangiocarcinoma Enhances T-Cell-Mediated
            Antitumor Activity
  JOURNAL   Front Immunol 13, 845193 (2022)
   PUBMED   35154166
  REMARK    GeneRIF: Decreased Expression of Programmed Death Ligand-L1 by
            Seven in Absentia Homolog 2 in Cholangiocarcinoma Enhances
            T-Cell-Mediated Antitumor Activity.
            Erratum:[Front Immunol. 2022 Dec 08;13:1093403. doi:
            10.3389/fimmu.2022.1093403.. PMID: 36591292]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2311)
  AUTHORS   Relaix,F., Wei,Xj., Li,W., Pan,J., Lin,Y., Bowtell,D.D.,
            Sassoon,D.A. and Wu,X.
  TITLE     Pw1/Peg3 is a potential cell death mediator and cooperates with
            Siah1a in p53-mediated apoptosis
  JOURNAL   Proc Natl Acad Sci U S A 97 (5), 2105-2110 (2000)
   PUBMED   10681424
REFERENCE   7  (bases 1 to 2311)
  AUTHORS   Germani,A., Romero,F., Houlard,M., Camonis,J., Gisselbrecht,S.,
            Fischer,S. and Varin-Blank,N.
  TITLE     hSiah2 is a new Vav binding protein which inhibits Vav-mediated
            signaling pathways
  JOURNAL   Mol Cell Biol 19 (5), 3798-3807 (1999)
   PUBMED   10207103
REFERENCE   8  (bases 1 to 2311)
  AUTHORS   Hu,G. and Fearon,E.R.
  TITLE     Siah-1 N-terminal RING domain is required for proteolysis function,
            and C-terminal sequences regulate oligomerization and binding to
            target proteins
  JOURNAL   Mol Cell Biol 19 (1), 724-732 (1999)
   PUBMED   9858595
REFERENCE   9  (bases 1 to 2311)
  AUTHORS   Hu,G., Chung,Y.L., Glover,T., Valentine,V., Look,A.T. and
            Fearon,E.R.
  TITLE     Characterization of human homologs of the Drosophila seven in
            absentia (sina) gene
  JOURNAL   Genomics 46 (1), 103-111 (1997)
   PUBMED   9403064
REFERENCE   10 (bases 1 to 2311)
  AUTHORS   Hu,G., Zhang,S., Vidal,M., Baer,J.L., Xu,T. and Fearon,E.R.
  TITLE     Mammalian homologs of seven in absentia regulate DCC via the
            ubiquitin-proteasome pathway
  JOURNAL   Genes Dev 11 (20), 2701-2714 (1997)
   PUBMED   9334332
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011317.23, BC013082.3, AK223565.1, BX110898.1 and CK823254.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005067.6.
            
            Summary: This gene encodes a protein that is a member of the seven
            in absentia homolog (SIAH) family. The protein is an E3 ligase and
            is involved in ubiquitination and proteasome-mediated degradation
            of specific proteins. The activity of this ubiquitin ligase has
            been implicated in regulating cellular response to hypoxia.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.421326.1,
                                           SRR1163657.375482.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2146411, SAMEA2149398
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000312960.4/ ENSP00000322457.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                AC011317.23        105408-105428       c
            22-1588             BC013082.3         7-1573
            1589-1691           AK223565.1         1545-1647
            1692-2076           BX110898.1         429-813
            2077-2311           CK823254.1         24-258              c
FEATURES             Location/Qualifiers
     source          1..2311
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q25.1"
     gene            1..2311
                     /gene="SIAH2"
                     /gene_synonym="hSiah2"
                     /note="siah E3 ubiquitin protein ligase 2"
                     /db_xref="GeneID:6478"
                     /db_xref="HGNC:HGNC:10858"
                     /db_xref="MIM:602213"
     exon            1..737
                     /gene="SIAH2"
                     /gene_synonym="hSiah2"
                     /inference="alignment:Splign:2.1.0"
     CDS             321..1295
                     /gene="SIAH2"
                     /gene_synonym="hSiah2"
                     /EC_number="2.3.2.27"
                     /note="siah-2; seven in absentia homolog 2; RING-type E3
                     ubiquitin transferase SIAH2"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase SIAH2"
                     /protein_id="NP_005058.3"
                     /db_xref="CCDS:CCDS3152.1"
                     /db_xref="GeneID:6478"
                     /db_xref="HGNC:HGNC:10858"
                     /db_xref="MIM:602213"
                     /translation="MSRPSSTGPSANKPCSKQPPPQPQHTPSPAAPPAAATISAAGPG
                     SSAVPAAAAVISGPGGGGGAGPVSPQHHELTSLFECPVCFDYVLPPILQCQAGHLVCN
                     QCRQKLSCCPTCRGALTPSIRNLAMEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDI
                     CEYRPYSCPCPGASCKWQGSLEAVMSHLMHAHKSITTLQGEDIVFLATDINLPGAVDW
                     VMMQSCFGHHFMLVLEKQEKYEGHQQFFAIVLLIGTRKQAENFAYRLELNGNRRRLTW
                     EATPRSIHDGVAAAIMNSDCLVFDTAIAHLFADNGNLGINVTISTCCP"
     exon            738..2311
                     /gene="SIAH2"
                     /gene_synonym="hSiah2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2289..2294
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIAH2"
                     /gene_synonym="hSiah2"
                     /note="hexamer: AATAAA"
     polyA_site      2311
                     /gene="SIAH2"
                     /gene_synonym="hSiah2"
                     /note="major polyA site"
ORIGIN      
        1 gcttgcgtca gcggctgttc cagaagcggg tgggccaggg ctctgcgcac cgctggggtt
       61 cggggcccgg gacgccgccg ggaggagggc accgcgcggg gtccgacgcg gaggcgtgct
      121 cggaacgccg ggggctgcgg agtgcatcag cgcggtccag ccctccgcct gccgggcgcc
      181 gagcgtctcc gccgcccgga cctgggctgg gcgccgtggc gttgcctcgg agctcgctgc
      241 ccgcggggcg cgcaccgcct tgacccgggc ggccccgcgg caggcaggcg cccgcagttc
      301 catggttggt tcggagcgcg atgagccgcc cgtcctccac cggccccagc gctaataaac
      361 cctgcagcaa gcagccgccg ccgcagcccc agcacactcc gtccccggct gcgcccccgg
      421 ccgccgccac catctcggct gcgggccccg gctcgtccgc ggtgcccgcc gcggcggcgg
      481 tgatctcggg ccccggcggc ggcggcgggg ccggcccggt gtccccgcag caccacgagc
      541 tgacctcgct cttcgagtgt ccggtctgct ttgactatgt cctgcctcct attctgcagt
      601 gccaggccgg gcacctggtg tgtaaccaat gccgccagaa gttgagctgc tgcccgacgt
      661 gcaggggcgc cctgacgccc agcatcagga acctggctat ggagaaggtg gcctcggcag
      721 tcctgtttcc ctgtaagtat gccaccacgg gctgttccct gaccctgcac catacggaga
      781 aaccagaaca tgaagacata tgtgaatacc gtccctactc ctgcccatgt cctggtgctt
      841 cctgcaagtg gcaggggtcc ctggaagctg tgatgtccca tctcatgcac gcccacaaga
      901 gcattaccac ccttcaggga gaagacatcg tctttctagc tacagacatt aacttgccag
      961 gggctgtcga ctgggtgatg atgcagtcat gttttggcca tcacttcatg ctggtgctgg
     1021 agaaacaaga gaagtacgaa ggccaccagc agttttttgc catcgtcctg ctcattggca
     1081 cccgcaagca agccgagaac tttgcctaca gactggagtt gaatgggaac cggcggagat
     1141 tgacctggga ggccacgccc cgttcgattc atgacggtgt ggctgcggcc atcatgaaca
     1201 gcgactgcct tgttttcgac acagccatag cacatctttt tgcagataat gggaaccttg
     1261 gaatcaatgt tactatttct acatgttgtc catgatgtga ctttcgtaaa ccttcaaaat
     1321 tatttgggca tagtgctcta tgtttaataa aggtttttat agatgtttta ttccatatgt
     1381 cttcacaagt caggacccac aattacccgt gttttgtttg aacagcagtg tcccatctgg
     1441 cttcgaccca acaaagttca ttaacctggg atgaatgggg ttggcctgtt ggtgatttgg
     1501 atgctgttct gtgatctaaa acaactctta ttgaattgta tttactccct aaacaacact
     1561 tgacaggctg ttgcacaggg cttctataga tcagtgtgtt aggaatggga ggccccttcc
     1621 tgcctgcctt cccatattgg tcccttgaca ttgacaaaag cacagtgact gtcagcagat
     1681 tcctttactt ttgtttgtgg gaggtaggaa ttgttttaat gcattttaaa cagtgtttct
     1741 gaaattggat ggctggctaa tagacactga atcacccgga gtgcttatct taaaattgca
     1801 gatttaggga gcctgccaat ttaacagtct catcaggtga ttcttttcaa cagtaatgtt
     1861 tgagaattac tgggttaaat tgtgggaaag ggtccagatt ttaaaggtgc tttaaggttg
     1921 ccctctgccg atactgtttg tctttctact gtttcatccc ctaacttccc ccaaccctca
     1981 aattaaaact agaactatag atccacatga acgcacgcct gagatttggc cactcaccta
     2041 tgttttgggt ggattgccta ggaaagcaag tcatatggcc attgatagtt ctcatgtaat
     2101 tagttttgct caccactagt acagatgacc cgtttacacg tggcttccct cggaagccct
     2161 cctcaacagt agctggtgtg aaagactaaa tcagtagagt tggaaaagct ttataaccgg
     2221 tgtgtcatat gcttgctatt taaagctgtg tgttggtttt gtttttctgc cacattcact
     2281 agttttttaa taaatatttt ccaaaaatgg a
//
