LOCUS       NM_003031               2110 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens siah E3 ubiquitin protein ligase 1 (SIAH1), transcript
            variant 1, mRNA.
ACCESSION   NM_003031 NM_001006611
VERSION     NM_003031.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2110)
  AUTHORS   Liu,Z., Hu,Q., Cao,K., Sun,J., Cui,L., Ji,M., Shan,W., Yang,W.,
            Zhang,G., Tian,Z., Shi,H., Zhang,B. and Wang,R.
  TITLE     Deficiency of SIAH1 promotes the formation of filopodia by
            increasing the accumulation of FASN in liver cancer
  JOURNAL   Cell Death Dis 15 (7), 537 (2024)
   PUBMED   39075049
  REMARK    GeneRIF: Deficiency of SIAH1 promotes the formation of filopodia by
            increasing the accumulation of FASN in liver cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2110)
  AUTHORS   Wu,J. and Yan,Y.
  TITLE     SIAH1 Promotes the Pyroptosis of Cardiomyocytes in Diabetic
            Cardiomyopathy via Regulating IkappaB-alpha/NF-kappacapital VE,
            Cyrillic Signaling
  JOURNAL   Crit Rev Eukaryot Gene Expr 34 (5), 45-57 (2024)
   PUBMED   38842203
  REMARK    GeneRIF: SIAH1 Promotes the Pyroptosis of Cardiomyocytes in
            Diabetic Cardiomyopathy via Regulating
            IkappaB-alpha/NF-kappacapital VE, Cyrillic Signaling.
REFERENCE   3  (bases 1 to 2110)
  AUTHORS   Scortegagna,M., Du,Y., Bradley,L.M., Wang,K., Molinolo,A.,
            Ruppin,E., Murad,R. and Ronai,Z.A.
  TITLE     Ubiquitin Ligases Siah1a/2 Control Alveolar Macrophage Functions to
            Limit Carcinogen-Induced Lung Adenocarcinoma
  JOURNAL   Cancer Res 83 (12), 2016-2033 (2023)
   PUBMED   37078793
REFERENCE   4  (bases 1 to 2110)
  AUTHORS   Wang,Y., Wang,K., Fu,J., Zhang,Y., Mao,Y., Wang,X., Wang,X., Yu,R.
            and Zhou,X.
  TITLE     FRK inhibits glioblastoma progression via phosphorylating YAP and
            inducing its ubiquitylation and degradation by Siah1
  JOURNAL   Neuro Oncol 24 (12), 2107-2120 (2022)
   PUBMED   35723276
  REMARK    GeneRIF: FRK inhibits glioblastoma progression via phosphorylating
            YAP and inducing its ubiquitylation and degradation by Siah1.
REFERENCE   5  (bases 1 to 2110)
  AUTHORS   Liu,Y., Li,Q., Geng,L., Zhou,X., Zhou,X., Dong,Y. and Zhang,Y.
  TITLE     Siah1 promotes the proliferation of NSCLC cells through
            ubiquitinating and stabilizing Notch1
  JOURNAL   Exp Cell Res 419 (1), 113305 (2022)
   PUBMED   35961388
  REMARK    GeneRIF: Siah1 promotes the proliferation of NSCLC cells through
            ubiquitinating and stabilizing Notch1.
REFERENCE   6  (bases 1 to 2110)
  AUTHORS   Block,K.L., Vornlocher,H.P. and Hershey,J.W.
  TITLE     Characterization of cDNAs encoding the p44 and p35 subunits of
            human translation initiation factor eIF3
  JOURNAL   J Biol Chem 273 (48), 31901-31908 (1998)
   PUBMED   9822659
REFERENCE   7  (bases 1 to 2110)
  AUTHORS   Matsuzawa,S., Takayama,S., Froesch,B.A., Zapata,J.M. and Reed,J.C.
  TITLE     p53-inducible human homologue of Drosophila seven in absentia
            (Siah) inhibits cell growth: suppression by BAG-1
  JOURNAL   EMBO J 17 (10), 2736-2747 (1998)
   PUBMED   9582267
REFERENCE   8  (bases 1 to 2110)
  AUTHORS   Hu,G., Chung,Y.L., Glover,T., Valentine,V., Look,A.T. and
            Fearon,E.R.
  TITLE     Characterization of human homologs of the Drosophila seven in
            absentia (sina) gene
  JOURNAL   Genomics 46 (1), 103-111 (1997)
   PUBMED   9403064
REFERENCE   9  (bases 1 to 2110)
  AUTHORS   Hu,G., Zhang,S., Vidal,M., Baer,J.L., Xu,T. and Fearon,E.R.
  TITLE     Mammalian homologs of seven in absentia regulate DCC via the
            ubiquitin-proteasome pathway
  JOURNAL   Genes Dev 11 (20), 2701-2714 (1997)
   PUBMED   9334332
REFERENCE   10 (bases 1 to 2110)
  AUTHORS   Nemani,M., Linares-Cruz,G., Bruzzoni-Giovanelli,H., Roperch,J.P.,
            Tuynder,M., Bougueleret,L., Cherif,D., Medhioub,M., Pasturaud,P.,
            Alvaro,V., der Sarkissan,H., Cazes,L., Le Paslier,D., Le Gall,I.,
            Israeli,D., Dausset,J., Sigaux,F., Chumakov,I., Oren,M., Calvo,F.,
            Amson,R.B., Cohen,D. and Telerman,A.
  TITLE     Activation of the human homologue of the Drosophila sina gene in
            apoptosis and tumor suppression
  JOURNAL   Proc Natl Acad Sci U S A 93 (17), 9039-9042 (1996)
   PUBMED   8799150
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC023818.5, BC035562.1 and
            BC018193.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_003031.3.
            
            Summary: This gene encodes a protein that is a member of the seven
            in absentia homolog (SIAH) family. The protein is an E3 ligase and
            is involved in ubiquitination and proteasome-mediated degradation
            of specific proteins. The activity of this ubiquitin ligase has
            been implicated in the development of certain forms of Parkinson's
            disease, the regulation of the cellular response to hypoxia and
            induction of apoptosis. Alternative splicing results in several
            additional transcript variants, some encoding different isoforms
            and others that have not been fully characterized. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the smaller isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1101421.1,
                                           SRR3476690.27408.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394725.3/ ENSP00000378214.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                AC023818.5         44138-44232
            96-1587             BC035562.1         1-1492
            1588-2098           BC018193.1         1481-1991
            2099-2110           AC023818.5         69009-69020
FEATURES             Location/Qualifiers
     source          1..2110
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q12.1"
     gene            1..2110
                     /gene="SIAH1"
                     /gene_synonym="BURHAS; SIAH1A"
                     /note="siah E3 ubiquitin protein ligase 1"
                     /db_xref="GeneID:6477"
                     /db_xref="HGNC:HGNC:10857"
                     /db_xref="MIM:602212"
     exon            1..210
                     /gene="SIAH1"
                     /gene_synonym="BURHAS; SIAH1A"
                     /inference="alignment:Splign:2.1.0"
     exon            211..2110
                     /gene="SIAH1"
                     /gene_synonym="BURHAS; SIAH1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..1061
                     /gene="SIAH1"
                     /gene_synonym="BURHAS; SIAH1A"
                     /EC_number="2.3.2.27"
                     /note="isoform a is encoded by transcript variant 1;
                     RING-type E3 ubiquitin transferase SIAH1; E3
                     ubiquitin-protein ligase SIAH1; seven in absentia homolog
                     1; siah-1a"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase SIAH1 isoform a"
                     /protein_id="NP_003022.3"
                     /db_xref="CCDS:CCDS10735.1"
                     /db_xref="GeneID:6477"
                     /db_xref="HGNC:HGNC:10857"
                     /db_xref="MIM:602212"
                     /translation="MSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVC
                     FDYVLPPILQCQSGHLVCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYAS
                     SGCEITLPHTEKADHEELCEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQG
                     EDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQA
                     ENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGIN
                     VTISMC"
     regulatory      2081..2086
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SIAH1"
                     /gene_synonym="BURHAS; SIAH1A"
                     /note="hexamer: ATTAAA"
     polyA_site      2110
                     /gene="SIAH1"
                     /gene_synonym="BURHAS; SIAH1A"
                     /note="major polyA site"
ORIGIN      
        1 gaggacgcgc gaaacggcgg cggcggcggc ggccaggggg gagccggggc ggccgttgcg
       61 gggcgcgctc tcgagaggcg gcggcggccc agggtgtccc gtcggtctcg gcgccgggaa
      121 gaggcggtgg cgctgcccgc ggtggcgggg gttggcgacg gagcgcgttg gtgccaggac
      181 cggggtccga ggcgcgctct ccgcccacag aaatgagccg tcagactgct acagcattac
      241 ctaccggtac ctcgaagtgt ccaccatccc agagggtgcc tgccctgact ggcacaactg
      301 catccaacaa tgacttggcg agtctttttg agtgtccagt ctgctttgac tatgtgttac
      361 cgcccattct tcaatgtcag agtggccatc ttgtttgtag caactgtcgc ccaaagctca
      421 catgttgtcc aacttgccgg ggccctttgg gatccattcg caacttggct atggagaaag
      481 tggctaattc agtacttttc ccctgtaaat atgcgtcttc tggatgtgaa ataactctgc
      541 cacacacaga aaaagcagac catgaagagc tctgtgagtt taggccttat tcctgtccgt
      601 gccctggtgc ttcctgtaaa tggcaaggct ctctggatgc tgtaatgccc catctgatgc
      661 atcagcataa gtccattaca accctacagg gagaggatat agtttttctt gctacagaca
      721 ttaatcttcc tggtgctgtt gactgggtga tgatgcagtc ctgttttggc tttcacttca
      781 tgttagtctt agagaaacag gaaaaatacg atggtcacca gcagttcttc gcaatcgtac
      841 agctgatagg aacacgcaag caagctgaaa attttgctta ccgacttgag ctaaatggtc
      901 ataggcgacg attgacttgg gaagcgactc ctcgatctat tcatgaagga attgcaacag
      961 ccattatgaa tagcgactgt ctagtctttg acaccagcat tgcacagctt tttgcagaaa
     1021 atggcaattt aggcatcaat gtaactattt ccatgtgttg aaatggcaat caaacatttt
     1081 ctggccagtg tttaaaactt cagtttcaca gaaaataagg cacccatctg tctgccaacc
     1141 taaaactctt tcggtaggtg gaagctagac acatgaaggt aaataaaaag aaaggctgtt
     1201 aaatacagga aacagttgca tgtagtaaca ctaatatatt taaaaataag tcaacagtaa
     1261 accactgaaa aaatatatgt atatacaccc aagatgggca tcttttgtat taagaaagga
     1321 agcattgtaa aataattctg agttttgtgt ttgttgtaga ttgattgtat tgttgaaaaa
     1381 gtttgttttt gcgtgggagt gtgtgcctgc gtgggtgtgt gcgtgtttgg gtttttttcc
     1441 tttaactgac aagccatctt gagtggtcat gggccactgc ttttcccttt gtgagtcaat
     1501 acatagtgct gctgtgtgct ttttttgtgt gtatttgcta atttttatta attttagttt
     1561 ttcattaaat aaatttgact tttctgtaat tcaggttttt cctttttttg taccatttta
     1621 aagttagtat cttttgatat gcatatttgt ttatggtaaa aaatttataa cgtgttcaat
     1681 attttctttt cccccattaa tcagttcatt agaaatattt taaaatcagc tattttgtga
     1741 agccatgagt tccagaaagt aaaggtgaca tcggaaaaat aatcaaaagc tatttaaagc
     1801 atctataagg tgctctcttt ctgtcttcta cagatgagtc acacctttga gcttaatctt
     1861 tgaaaggtta gagaataaat tgatttttat aaatactgca aatcaggctt ttgtttcctt
     1921 tttcagatat cttggacaaa tcacatattt taaaatttgt tcttgtattt attggttttg
     1981 cagaagaagg catcgtcatg cacagtattt gtaattaaaa gcaaatcatt tgtttaaaaa
     2041 ggcagtttgc aaaaaatgtt tttggtcttt tataattctc attaaaagaa tatctggcaa
     2101 attaaaaaaa
//
