LOCUS       NM_001041               6012 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens sucrase-isomaltase (SI), mRNA.
ACCESSION   NM_001041
VERSION     NM_001041.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6012)
  AUTHORS   Iryanci,F.I., Guven,B. and Cakir,M.
  TITLE     Congenital Sucrase-Isomaltase Deficiency: Same Mutation with
            Different Clinical Presentations
  JOURNAL   Turk J Gastroenterol 35 (4), 343-349 (2024)
   PUBMED   39128102
  REMARK    GeneRIF: Congenital Sucrase-Isomaltase Deficiency: Same Mutation
            with Different Clinical Presentations.
REFERENCE   2  (bases 1 to 6012)
  AUTHORS   Zamfir-Taranu,A., Loscher,B.S., Husein,D.M., Hoter,A.,
            Garcia-Etxebarria,K., Etxeberria,U., Gayoso,L., Mayr,G.,
            Nilholm,C., Gustafsson,R.J., Ozaydin,O., Zheng,T.,
            Esteban-Blanco,C., Bozzarelli,I., Bonfiglio,F., Rizk,S., Franke,A.,
            Bujanda,L., Naim,H.Y., Ohlsson,B. and D'Amato,M.
  TITLE     Sucrase-isomaltase genotype and response to a starch-reduced and
            sucrose-reduced diet in IBS-D patients
  JOURNAL   Gut 73 (4), 706-708 (2024)
   PUBMED   36878682
  REMARK    GeneRIF: Sucrase-isomaltase genotype and response to a
            starch-reduced and sucrose-reduced diet in IBS-D patients.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6012)
  AUTHORS   Tannous,S., Stellbrinck,T., Hoter,A. and Naim,H.Y.
  TITLE     Interaction between the alpha-glucosidases, sucrase-isomaltase and
            maltase-glucoamylase, in human intestinal brush border membranes
            and its potential impact on disaccharide digestion
  JOURNAL   Front Mol Biosci 10, 1160860 (2023)
   PUBMED   36968271
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6012)
  AUTHORS   Taskin,D.G., Civan,H.A., Sari,E.E., Altuntas,C., Ersoy,M.,
            Tuncel,T., Onay,H. and Selimoglu,A.
  TITLE     Prevalence of congenital sucrase-isomaltase deficiency in Turkey
            may be much higher than the estimates
  JOURNAL   J Genet 102 (2023)
   PUBMED   37349966
  REMARK    GeneRIF: Prevalence of congenital sucrase-isomaltase deficiency in
            Turkey may be much higher than the estimates.
REFERENCE   5  (bases 1 to 6012)
  AUTHORS   Hoter,A. and Naim,H.Y.
  TITLE     The glucose-regulated protein GRP94 interacts avidly in the
            endoplasmic reticulum with sucrase-isomaltase isoforms that are
            associated with congenital sucrase-isomaltase deficiency
  JOURNAL   Int J Biol Macromol 186, 237-243 (2021)
   PUBMED   34242650
  REMARK    GeneRIF: The glucose-regulated protein GRP94 interacts avidly in
            the endoplasmic reticulum with sucrase-isomaltase isoforms that are
            associated with congenital sucrase-isomaltase deficiency.
REFERENCE   6  (bases 1 to 6012)
  AUTHORS   Chantret,I., Lacasa,M., Chevalier,G., Ruf,J., Islam,I., Mantei,N.,
            Edwards,Y., Swallow,D. and Rousset,M.
  TITLE     Sequence of the complete cDNA and the 5' structure of the human
            sucrase-isomaltase gene. Possible homology with a yeast
            glucoamylase
  JOURNAL   Biochem J 285 (Pt 3) (Pt 3), 915-923 (1992)
   PUBMED   1353958
REFERENCE   7  (bases 1 to 6012)
  AUTHORS   Wu,G.D., Wang,W. and Traber,P.G.
  TITLE     Isolation and characterization of the human sucrase-isomaltase gene
            and demonstration of intestine-specific transcriptional elements
  JOURNAL   J Biol Chem 267 (11), 7863-7870 (1992)
   PUBMED   1560017
REFERENCE   8  (bases 1 to 6012)
  AUTHORS   Fransen,J.A., Hauri,H.P., Ginsel,L.A. and Naim,H.Y.
  TITLE     Naturally occurring mutations in intestinal sucrase-isomaltase
            provide evidence for the existence of an intracellular sorting
            signal in the isomaltase subunit
  JOURNAL   J Cell Biol 115 (1), 45-57 (1991)
   PUBMED   1717481
  REMARK    Erratum:[J Cell Biol 1991 Dec;115(5):following 1473]
REFERENCE   9  (bases 1 to 6012)
  AUTHORS   Gorvel,J.P., Ferrero,A., Chambraud,L., Rigal,A., Bonicel,J. and
            Maroux,S.
  TITLE     Expression of sucrase-isomaltase and dipeptidylpeptidase IV in
            human small intestine and colon
  JOURNAL   Gastroenterology 101 (3), 618-625 (1991)
   PUBMED   1677636
REFERENCE   10 (bases 1 to 6012)
  AUTHORS   Green,F., Edwards,Y., Hauri,H.P., Povey,S., Ho,M.W., Pinto,M. and
            Swallow,D.
  TITLE     Isolation of a cDNA probe for a human jejunal brush-border
            hydrolase, sucrase-isomaltase, and assignment of the gene locus to
            chromosome 3
  JOURNAL   Gene 57 (1), 101-110 (1987)
   PUBMED   2962903
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC140119.3, DA919374.1,
            BC132860.1, AC092695.8 and BG187733.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001041.3.
            
            Summary: This gene encodes a sucrase-isomaltase enzyme that is
            expressed in the intestinal brush border. The encoded protein is
            synthesized as a precursor protein that is cleaved by pancreatic
            proteases into two enzymatic subunits sucrase and isomaltase. These
            two subunits heterodimerize to form the sucrose-isomaltase complex.
            This complex is essential for the digestion of dietary
            carbohydrates including starch, sucrose and isomaltose. Mutations
            in this gene are the cause of congenital sucrase-isomaltase
            deficiency.[provided by RefSeq, Apr 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X63597.1, BC132834.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264382.8/ ENSP00000264382.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC140119.3         72146-72146
            2-8                 DA919374.1         3-9
            9-106               BC132860.1         1-98
            107-107             AC140119.3         74672-74672
            108-4632            BC132860.1         100-4624
            4633-4633           AC092695.8         39841-39841
            4634-5638           BC132860.1         4626-5630
            5639-6012           BG187733.1         164-537
FEATURES             Location/Qualifiers
     source          1..6012
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q26.1"
     gene            1..6012
                     /gene="SI"
                     /note="sucrase-isomaltase"
                     /db_xref="GeneID:6476"
                     /db_xref="HGNC:HGNC:10856"
                     /db_xref="MIM:609845"
     exon            1..64
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..5548
                     /gene="SI"
                     /EC_number="3.2.1.10"
                     /EC_number="3.2.1.48"
                     /note="oligosaccharide alpha-1,6-glucosidase;
                     alpha-glucosidase; Oligo-1,6-glucosidase;
                     Alpha-methylglucosidase"
                     /codon_start=1
                     /product="sucrase-isomaltase, intestinal"
                     /protein_id="NP_001032.2"
                     /db_xref="CCDS:CCDS3196.1"
                     /db_xref="GeneID:6476"
                     /db_xref="HGNC:HGNC:10856"
                     /db_xref="MIM:609845"
                     /translation="MARKKFSGLEISLIVLFVIVTIIAIALIVVLATKTPAVDEISDS
                     TSTPATTRVTTNPSDSGKCPNVLNDPVNVRINCIPEQFPTEGICAQRGCCWRPWNDSL
                     IPWCFFVDNHGYNVQDMTTTSIGVEAKLNRIPSPTLFGNDINSVLFTTQNQTPNRFRF
                     KITDPNNRRYEVPHQYVKEFTGPTVSDTLYDVKVAQNPFSIQVIRKSNGKTLFDTSIG
                     PLVYSDQYLQISTRLPSDYIYGIGEQVHKRFRHDLSWKTWPIFTRDQLPGDNNNNLYG
                     HQTFFMCIEDTSGKSFGVFLMNSNAMEIFIQPTPIVTYRVTGGILDFYILLGDTPEQV
                     VQQYQQLVGLPAMPAYWNLGFQLSRWNYKSLDVVKEVVRRNREAGIPFDTQVTDIDYM
                     EDKKDFTYDQVAFNGLPQFVQDLHDHGQKYVIILDPAISIGRRANGTTYATYERGNTQ
                     HVWINESDGSTPIIGEVWPGLTVYPDFTNPNCIDWWANECSIFHQEVQYDGLWIDMNE
                     VSSFIQGSTKGCNVNKLNYPPFTPDILDKLMYSKTICMDAVQNWGKQYDVHSLYGYSM
                     AIATEQAVQKVFPNKRSFILTRSTFAGSGRHAAHWLGDNTASWEQMEWSITGMLEFSL
                     FGIPLVGADICGFVAETTEELCRRWMQLGAFYPFSRNHNSDGYEHQDPAFFGQNSLLV
                     KSSRQYLTIRYTLLPFLYTLFYKAHVFGETVARPVLHEFYEDTNSWIEDTEFLWGPAL
                     LITPVLKQGADTVSAYIPDAIWYDYESGAKRPWRKQRVDMYLPADKIGLHLRGGYIIP
                     IQEPDVTTTASRKNPLGLIVALGENNTAKGDFFWDDGETKDTIQNGNYILYTFSVSNN
                     TLDIVCTHSSYQEGTTLAFQTVKILGLTDSVTEVRVAENNQPMNAHSNFTYDASNQVL
                     LIADLKLNLGRNFSVQWNQIFSENERFNCYPDADLATEQKCTQRGCVWRTGSSLSKAP
                     ECYFPRQDNSYSVNSARYSSMGITADLQLNTANARIKLPSDPISTLRVEVKYHKNDML
                     QFKIYDPQKKRYEVPVPLNIPTTPISTYEDRLYDVEIKENPFGIQIRRRSSGRVIWDS
                     WLPGFAFNDQFIQISTRLPSEYIYGFGEVEHTAFKRDLNWNTWGMFTRDQPPGYKLNS
                     YGFHPYYMALEEEGNAHGVFLLNSNAMDVTFQPTPALTYRTVGGILDFYMFLGPTPEV
                     ATKQYHEVIGHPVMPAYWALGFQLCRYGYANTSEVRELYDAMVAANIPYDVQYTDIDY
                     MERQLDFTIGEAFQDLPQFVDKIRGEGMRYIIILDPAISGNETKTYPAFERGQQNDVF
                     VKWPNTNDICWAKVWPDLPNITIDKTLTEDEAVNASRAHVAFPDFFRTSTAEWWAREI
                     VDFYNEKMKFDGLWIDMNEPSSFVNGTTTNQCRNDELNYPPYFPELTKRTDGLHFRTI
                     CMEAEQILSDGTSVLHYDVHNLYGWSQMKPTHDALQKTTGKRGIVISRSTYPTSGRWG
                     GHWLGDNYARWDNMDKSIIGMMEFSLFGMSYTGADICGFFNNSEYHLCTRWMQLGAFY
                     PYSRNHNIANTRRQDPASWNETFAEMSRNILNIRYTLLPYFYTQMHEIHANGGTVIRP
                     LLHEFFDEKPTWDIFKQFLWGPAFMVTPVLEPYVQTVNAYVPNARWFDYHTGKDIGVR
                     GQFQTFNASYDTINLHVRGGHILPCQEPAQNTFYSRQKHMKLIVAADDNQMAQGSLFW
                     DDGESIDTYERDLYLSVQFNLNQTTLTSTILKRGYINKSETRLGSLHVWGKGTTPVNA
                     VTLTYNGNKNSLPFNEDTTNMILRIDLTTHNVTLEEPIEINWS"
     exon            65..182
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     exon            183..319
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     exon            320..437
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     exon            438..547
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     exon            548..699
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     exon            700..871
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     exon            872..971
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1084
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1210
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1342
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1462
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1576
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1661
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1779
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..1951
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2068
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     exon            2069..2223
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     exon            2224..2308
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     exon            2309..2365
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     exon            2366..2490
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     exon            2491..2579
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     exon            2580..2629
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     exon            2630..2800
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     exon            2801..2956
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     exon            2957..3163
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     exon            3164..3318
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     exon            3319..3487
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     exon            3488..3584
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     exon            3585..3697
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     exon            3698..3823
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     exon            3824..3952
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     exon            3953..4063
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     exon            4064..4126
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     exon            4127..4243
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     exon            4244..4331
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     exon            4332..4470
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     exon            4471..4604
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     exon            4605..4639
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     exon            4640..4756
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     exon            4757..4905
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     exon            4906..4990
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     exon            4991..5047
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     exon            5048..5172
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     exon            5173..5261
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     exon            5262..5311
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     exon            5312..5479
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     exon            5480..6012
                     /gene="SI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5994..5999
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SI"
                     /note="hexamer: AATAAA"
     polyA_site      6012
                     /gene="SI"
                     /note="major polyA site"
ORIGIN      
        1 attattttgg cagccttatc caagtctggt acaacatagc aaagagaaca ggctatgaaa
       61 taagatggca agaaagaaat ttagtggatt ggaaatctct ctgattgtcc tttttgtcat
      121 agttactata atagctattg ccttaattgt tgttttagca actaagacac ctgctgttga
      181 tgaaattagt gattctactt caactccagc tactactcgt gtgactacaa atccttctga
      241 ttcaggaaaa tgtccaaatg tgttaaatga tcctgtcaat gtgagaataa actgcattcc
      301 agaacaattc ccaacagagg gaatttgtgc acagagaggc tgctgctgga ggccgtggaa
      361 tgactctctt attccttggt gcttcttcgt tgataatcat ggttataacg ttcaagacat
      421 gacaacaaca agtattggag ttgaagccaa attaaacagg ataccttcac ctacactatt
      481 tggaaatgac atcaacagtg ttctcttcac aactcaaaat cagacaccca atcgtttccg
      541 gttcaagatt actgatccaa ataatagaag atatgaagtt cctcatcagt atgtaaaaga
      601 gtttactgga cccacagttt ctgatacgtt gtatgatgtg aaggttgccc aaaacccatt
      661 tagcatccaa gttattagga aaagcaacgg taaaactttg tttgacacca gcattggtcc
      721 cttagtgtac tctgaccagt acttacagat ctcaacccgt cttccaagtg attatattta
      781 tggtattgga gaacaagttc ataagagatt tcgtcatgat ttatcctgga aaacatggcc
      841 aatttttact cgagaccaac ttcctggtga taataataat aatttatacg gccatcaaac
      901 attctttatg tgtattgaag atacatctgg aaagtcattc ggtgtttttt taatgaatag
      961 caatgcaatg gagattttta tccagcctac tccaatagta acatatagag ttaccggtgg
     1021 cattctggat ttttacatcc ttctaggaga tacaccagaa caagtagttc aacagtatca
     1081 acagcttgtt ggactaccag caatgccagc atattggaat cttggattcc aactaagtcg
     1141 ctggaattat aagtcactag atgtagtgaa agaagtggta aggagaaacc gggaagctgg
     1201 cataccattt gatacacagg tcactgatat tgactacatg gaagacaaga aagactttac
     1261 ttatgatcaa gttgcgttta acggactccc tcaatttgtg caagatttgc atgaccatgg
     1321 acagaaatat gtcatcatct tggaccctgc aatttccata ggtcgacgtg ccaatggaac
     1381 aacatatgca acctatgaga ggggaaacac acaacatgtg tggataaatg agtcagatgg
     1441 aagtacacca attattggag aggtatggcc aggattaaca gtataccctg atttcactaa
     1501 cccaaactgc attgattggt gggcaaatga atgcagtatt ttccatcaag aagtgcaata
     1561 tgatggactt tggattgaca tgaatgaagt ttccagcttt attcaaggtt caacaaaagg
     1621 atgtaatgta aacaaattga attatccacc gtttactcct gatattcttg acaaactcat
     1681 gtattccaaa acaatttgca tggatgctgt gcagaactgg ggtaaacagt atgatgttca
     1741 tagcctctat ggatacagca tggctatagc cacagagcaa gctgtacaaa aagtttttcc
     1801 taataagaga agcttcattc ttacccgctc aacatttgct ggatctggaa gacatgctgc
     1861 gcattggtta ggagacaata ctgcttcatg ggaacaaatg gaatggtcta taactggaat
     1921 gctggagttc agtttgtttg gaataccttt ggttggagca gacatctgtg gatttgtggc
     1981 tgaaaccaca gaagaacttt gcagaagatg gatgcaactt ggggcatttt atccattttc
     2041 cagaaaccat aattctgacg gatatgaaca tcaggatcct gcattttttg ggcagaattc
     2101 acttttggtt aaatcatcaa ggcagtattt aactattcgc tacaccttat tacccttcct
     2161 ctacactctg ttttataaag cccatgtgtt tggagaaaca gtagcaagac cagttcttca
     2221 tgagttttat gaggatacga acagctggat tgaggacact gagtttttgt ggggccctgc
     2281 attacttatt actcctgttc taaaacaggg agcagatact gtgagtgcct acatccctga
     2341 tgctatttgg tatgattatg aatctggtgc aaaaaggcca tggaggaaac aacgggttga
     2401 tatgtatctt ccagcagaca aaataggatt acatcttaga ggaggttata tcatccccat
     2461 tcaagaacca gatgtaacaa caacagcaag ccgtaagaat cctctaggac ttatagtcgc
     2521 attaggtgaa aacaacacag ccaaaggaga ctttttctgg gatgatggag aaactaaaga
     2581 tacaatacaa aatggcaact acatattata tacattttca gtttctaata acacattaga
     2641 tattgtgtgc acacattcat catatcagga aggaactacc ttagcatttc agactgtaaa
     2701 aatccttggg ttgacagaca gtgttacaga agttagagtg gcggaaaata atcaaccaat
     2761 gaacgctcat tccaatttca cttatgatgc ttctaaccag gttctcctaa ttgcagatct
     2821 caaacttaat cttggaagaa actttagtgt tcaatggaat caaattttct cagaaaatga
     2881 aagatttaat tgttatccag atgcagattt ggcaactgaa caaaagtgca cacaacgtgg
     2941 ctgtgtatgg agaacgggtt cttctctatc caaagcacct gagtgttact ttcccagaca
     3001 agataactct tattcagtca actcagctcg ctattcatcc atgggtataa cagctgacct
     3061 ccaactaaat actgcaaatg ccagaataaa gttaccttct gaccccatct caactcttcg
     3121 tgtggaggtg aaatatcaca aaaatgatat gttgcagttt aagatttatg atccccaaaa
     3181 gaagagatat gaagtaccag taccgttaaa cattccaacc accccaataa gtacttatga
     3241 agacagactt tatgatgtgg aaatcaagga aaatcctttt ggcatccaga ttcgacggag
     3301 aagcagtgga agagtcattt gggattcttg gctgcctgga tttgctttta atgaccagtt
     3361 cattcaaata tcgactcgcc tgccatcaga atatatatat ggttttgggg aagtggaaca
     3421 tacagcattt aagcgagatc tgaactggaa tacttgggga atgttcacaa gagaccaacc
     3481 ccctggttac aaacttaatt cctatggatt tcatccctat tacatggctc tggaagagga
     3541 gggcaatgct catggtgttt tcttactcaa cagcaatgca atggatgtta cattccagcc
     3601 aactcctgct ctaacttacc gtacagttgg agggatcttg gatttttata tgtttttggg
     3661 cccaactcca gaagttgcaa caaagcaata ccatgaagta attggccatc cagtcatgcc
     3721 agcttattgg gctttgggat tccaattatg tcgttatgga tatgcaaata cttcagaggt
     3781 tcgggaatta tatgacgcta tggtggctgc taacatcccc tatgatgttc agtacacaga
     3841 cattgactac atggaaaggc agctagactt tacaattggt gaagcattcc aggaccttcc
     3901 tcagtttgtt gacaaaataa gaggagaagg aatgagatac attattatcc tggatccagc
     3961 aatttcagga aatgaaacaa agacttaccc tgcatttgaa agaggacagc agaatgatgt
     4021 ctttgtcaaa tggccaaaca ccaatgacat ttgttgggca aaggtttggc cagatttgcc
     4081 caacataaca atagataaaa ctctaacgga agatgaagct gttaatgctt ccagagctca
     4141 tgtagctttc ccagatttct tcaggacttc cacagcagag tggtgggcca gagaaattgt
     4201 ggacttttac aatgaaaaga tgaagtttga tggtttgtgg attgatatga atgagccatc
     4261 aagttttgta aatggaacaa ctactaatca atgcagaaat gacgaactaa attatccacc
     4321 ttatttccca gaactcacaa aaagaactga tggattacat ttcagaacaa tttgcatgga
     4381 agctgagcag attcttagtg atggaacatc agttttgcat tacgatgttc acaatctcta
     4441 tggatggtca cagatgaaac ctactcatga tgcattgcag aagacaactg gaaaaagagg
     4501 gattgtaatt tctcgttcca cgtatcctac tagtggacga tggggaggac actggcttgg
     4561 agacaactat gcacgatggg acaacatgga caaatcaatc attggtatga tggaatttag
     4621 tctgtttgga atgtcatata ctggagcaga catctgtggt tttttcaaca actcagaata
     4681 tcatctctgt acccgctgga tgcaacttgg agcattttat ccatactcaa ggaatcacaa
     4741 cattgcaaat actagaagac aagatcccgc ttcctggaat gaaacttttg ctgaaatgtc
     4801 aaggaatatt ctaaatatta gatacacctt attgccctat ttttacacac aaatgcatga
     4861 aattcatgct aatggtggca ctgttatccg accccttttg catgagttct ttgatgaaaa
     4921 accaacctgg gatatattca agcagttctt atggggtcca gcatttatgg ttaccccagt
     4981 actggaacct tatgttcaaa ctgtaaatgc ctacgtcccc aatgctcggt ggtttgacta
     5041 ccatacaggc aaagatattg gcgtcagagg acaatttcaa acatttaatg cttcttatga
     5101 cacaataaac ctacatgtcc gtggtggtca catcctacca tgtcaagagc cagctcaaaa
     5161 cacattttac agtcgacaaa aacacatgaa gctcattgtt gctgcagatg ataatcagat
     5221 ggcacagggt tctctgtttt gggatgatgg agagagtata gacacctatg aaagagacct
     5281 atatttatct gtacaattta atttaaacca gaccacctta acaagcacta tattgaagag
     5341 aggttacata aataaaagtg aaacgaggct tggatccctt catgtatggg ggaaaggaac
     5401 tactcctgtc aatgcagtta ctctaacgta taacggaaat aaaaattcgc ttccttttaa
     5461 tgaagacact accaacatga tattacgtat tgatctgacc acacacaatg ttactctaga
     5521 agaaccaata gaaatcaact ggtcatgaag atcaccatca attttagttg tcaatgggaa
     5581 aaaacaccag gatttaagtt tcacagcact tacaattttc cctcttcact tggttcttgt
     5641 actctacaaa atatagcttt cataacatcg aaaagttatt ttgtagcgta catcaatgat
     5701 aatgctaatt ttattatagt aatgtgactt ggattcaatt ttaaggcata tttaacaaaa
     5761 tttgaatagc cctatttatc cttgttaagt atcagctaca attgtaaact agttactaaa
     5821 catgtatgta aatagctaag atataattta aacgtgattt ttaaattaaa taaaattttt
     5881 atgtaattat atatactata tttttctcaa tgtttagcag atttaagata tgtaacaaca
     5941 attatttgaa gatttaatta cttcttagta tgtgcattta attagaaaaa gagaataaaa
     6001 aatgtaagtg ta
//
