LOCUS       NM_001649               7474 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens shroom family member 2 (SHROOM2), transcript variant
            1, mRNA.
ACCESSION   NM_001649
VERSION     NM_001649.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7474)
  AUTHORS   Yuan,J., Chen,L., Xiao,J., Qi,X.K., Zhang,J., Li,X., Wang,Z.,
            Lian,Y.F., Xiang,T., Zhang,Y., Chen,M.Y., Bei,J.X., Zeng,Y.X. and
            Feng,L.
  TITLE     SHROOM2 inhibits tumor metastasis through RhoA-ROCK
            pathway-dependent and -independent mechanisms in nasopharyngeal
            carcinoma
  JOURNAL   Cell Death Dis 10 (2), 58 (2019)
   PUBMED   30683844
  REMARK    GeneRIF: SHROOM2 is downregulated in nasopharyngeal carcinoma and
            is implicated in the suppression of cancer cell invasion and
            metastasis by preventing EMT, which is largely independent of
            Rho-ROCK signaling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7474)
  AUTHORS   Fabian-Jessing,B.K., Vestergaard,E.M., Plomp,A.S., Bergen,A.A.,
            Dreschler,W.A., Duno,M., Winiarska,B.S., Neumann,L., Gaihede,M.,
            Vorum,H. and Petersen,M.B.
  TITLE     Ocular albinism with infertility and late-onset sensorineural
            hearing loss
  JOURNAL   Am J Med Genet A 176 (7), 1587-1593 (2018)
   PUBMED   30160833
  REMARK    GeneRIF: SHROOM2 deletion is associated with Ocular albinism with
            infertility and late-onset sensorineural hearing loss.
REFERENCE   3  (bases 1 to 7474)
  AUTHORS   Chen,Z., Kuang,L., Finnell,R.H. and Wang,H.
  TITLE     Genetic and functional analysis of SHROOM1-4 in a Chinese neural
            tube defect cohort
  JOURNAL   Hum Genet 137 (3), 195-202 (2018)
   PUBMED   29423651
  REMARK    GeneRIF: These findings provide genetic and molecular insights into
            the effects of rare damaging variants in SHROOM2, indicating that
            such variants of SHROOM2 might contribute to the risk of human
            Neural tube defects
REFERENCE   4  (bases 1 to 7474)
  AUTHORS   Eeles,R.A., Olama,A.A., Benlloch,S., Saunders,E.J.,
            Leongamornlert,D.A., Tymrakiewicz,M., Ghoussaini,M., Luccarini,C.,
            Dennis,J., Jugurnauth-Little,S., Dadaev,T., Neal,D.E., Hamdy,F.C.,
            Donovan,J.L., Muir,K., Giles,G.G., Severi,G., Wiklund,F.,
            Gronberg,H., Haiman,C.A., Schumacher,F., Henderson,B.E., Le
            Marchand,L., Lindstrom,S., Kraft,P., Hunter,D.J., Gapstur,S.,
            Chanock,S.J., Berndt,S.I., Albanes,D., Andriole,G., Schleutker,J.,
            Weischer,M., Canzian,F., Riboli,E., Key,T.J., Travis,R.C.,
            Campa,D., Ingles,S.A., John,E.M., Hayes,R.B., Pharoah,P.D.,
            Pashayan,N., Khaw,K.T., Stanford,J.L., Ostrander,E.A.,
            Signorello,L.B., Thibodeau,S.N., Schaid,D., Maier,C., Vogel,W.,
            Kibel,A.S., Cybulski,C., Lubinski,J., Cannon-Albright,L.,
            Brenner,H., Park,J.Y., Kaneva,R., Batra,J., Spurdle,A.B.,
            Clements,J.A., Teixeira,M.R., Dicks,E., Lee,A., Dunning,A.M.,
            Baynes,C., Conroy,D., Maranian,M.J., Ahmed,S., Govindasami,K.,
            Guy,M., Wilkinson,R.A., Sawyer,E.J., Morgan,A., Dearnaley,D.P.,
            Horwich,A., Huddart,R.A., Khoo,V.S., Parker,C.C., Van As,N.J.,
            Woodhouse,C.J., Thompson,A., Dudderidge,T., Ogden,C., Cooper,C.S.,
            Lophatananon,A., Cox,A., Southey,M.C., Hopper,J.L., English,D.R.,
            Aly,M., Adolfsson,J., Xu,J., Zheng,S.L., Yeager,M., Kaaks,R.,
            Diver,W.R., Gaudet,M.M., Stern,M.C., Corral,R., Joshi,A.D.,
            Shahabi,A., Wahlfors,T., Tammela,T.L., Auvinen,A., Virtamo,J.,
            Klarskov,P., Nordestgaard,B.G., Roder,M.A., Nielsen,S.F.,
            Bojesen,S.E., Siddiq,A., Fitzgerald,L.M., Kolb,S., Kwon,E.M.,
            Karyadi,D.M., Blot,W.J., Zheng,W., Cai,Q., McDonnell,S.K.,
            Rinckleb,A.E., Drake,B., Colditz,G., Wokolorczyk,D.,
            Stephenson,R.A., Teerlink,C., Muller,H., Rothenbacher,D.,
            Sellers,T.A., Lin,H.Y., Slavov,C., Mitev,V., Lose,F.,
            Srinivasan,S., Maia,S., Paulo,P., Lange,E., Cooney,K.A.,
            Antoniou,A.C., Vincent,D., Bacot,F., Tessier,D.C., Kote-Jarai,Z.
            and Easton,D.F.
  CONSRTM   COGS-Cancer Research UK GWAS-ELLIPSE (part of GAME-ON) Initiative;
            Australian Prostate Cancer Bioresource; UK Genetic Prostate Cancer
            Study Collaborators/British Association of Urological Surgeons'
            Section of Oncology; UK ProtecT (Prostate testing for cancer and
            Treatment) Study Collaborators; PRACTICAL (Prostate Cancer
            Association Group to Investigate Cancer-Associated Alterations in
            the Genome) Consortium
  TITLE     Identification of 23 new prostate cancer susceptibility loci using
            the iCOGS custom genotyping array
  JOURNAL   Nat Genet 45 (4), 385-391 (2013)
   PUBMED   23535732
REFERENCE   5  (bases 1 to 7474)
  AUTHORS   Dunlop,M.G., Dobbins,S.E., Farrington,S.M., Jones,A.M., Palles,C.,
            Whiffin,N., Tenesa,A., Spain,S., Broderick,P., Ooi,L.Y.,
            Domingo,E., Smillie,C., Henrion,M., Frampton,M., Martin,L.,
            Grimes,G., Gorman,M., Semple,C., Ma,Y.P., Barclay,E.,
            Prendergast,J., Cazier,J.B., Olver,B., Penegar,S., Lubbe,S.,
            Chander,I., Carvajal-Carmona,L.G., Ballereau,S., Lloyd,A.,
            Vijayakrishnan,J., Zgaga,L., Rudan,I., Theodoratou,E., Starr,J.M.,
            Deary,I., Kirac,I., Kovacevic,D., Aaltonen,L.A.,
            Renkonen-Sinisalo,L., Mecklin,J.P., Matsuda,K., Nakamura,Y.,
            Okada,Y., Gallinger,S., Duggan,D.J., Conti,D., Newcomb,P.,
            Hopper,J., Jenkins,M.A., Schumacher,F., Casey,G., Easton,D.,
            Shah,M., Pharoah,P., Lindblom,A., Liu,T., Smith,C.G., West,H.,
            Cheadle,J.P., Midgley,R., Kerr,D.J., Campbell,H., Tomlinson,I.P.
            and Houlston,R.S.
  CONSRTM   Colorectal Tumour Gene Identification (CORGI) Consortium; Swedish
            Low-Risk Colorectal Cancer Study Group; COIN Collaborative Group
  TITLE     Common variation near CDKN1A, POLD3 and SHROOM2 influences
            colorectal cancer risk
  JOURNAL   Nat Genet 44 (7), 770-776 (2012)
   PUBMED   22634755
  REMARK    GeneRIF: We identified three new CRC risk loci at 6p21 (rs1321311,
            near CDKN1A; P = 1.14 x 10(-10)), 11q13.4 (rs3824999, intronic to
            POLD3; P = 3.65 x 10(-10)) and Xp22.2 (rs5934683, near SHROOM2; P =
            7.30 x 10(-10)).
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7474)
  AUTHORS   Dietz,M.L., Bernaciak,T.M., Vendetti,F., Kielec,J.M. and
            Hildebrand,J.D.
  TITLE     Differential actin-dependent localization modulates the
            evolutionarily conserved activity of Shroom family proteins
  JOURNAL   J Biol Chem 281 (29), 20542-20554 (2006)
   PUBMED   16684770
REFERENCE   7  (bases 1 to 7474)
  AUTHORS   Hagens,O., Ballabio,A., Kalscheuer,V., Kraehenbuhl,J.P.,
            Schiaffino,M.V., Smith,P., Staub,O., Hildebrand,J. and
            Wallingford,J.B.
  TITLE     A new standard nomenclature for proteins related to Apx and Shroom
  JOURNAL   BMC Cell Biol 7, 18 (2006)
   PUBMED   16615870
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 7474)
  AUTHORS   Ross,M.T., Grafham,D.V., Coffey,A.J., Scherer,S., McLay,K.,
            Muzny,D., Platzer,M., Howell,G.R., Burrows,C., Bird,C.P.,
            Frankish,A., Lovell,F.L., Howe,K.L., Ashurst,J.L., Fulton,R.S.,
            Sudbrak,R., Wen,G., Jones,M.C., Hurles,M.E., Andrews,T.D.,
            Scott,C.E., Searle,S., Ramser,J., Whittaker,A., Deadman,R.,
            Carter,N.P., Hunt,S.E., Chen,R., Cree,A., Gunaratne,P., Havlak,P.,
            Hodgson,A., Metzker,M.L., Richards,S., Scott,G., Steffen,D.,
            Sodergren,E., Wheeler,D.A., Worley,K.C., Ainscough,R.,
            Ambrose,K.D., Ansari-Lari,M.A., Aradhya,S., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Ballabio,A., Banerjee,R., Barker,G.E.,
            Barlow,K.F., Barrett,I.P., Bates,K.N., Beare,D.M., Beasley,H.,
            Beasley,O., Beck,A., Bethel,G., Blechschmidt,K., Brady,N.,
            Bray-Allen,S., Bridgeman,A.M., Brown,A.J., Brown,M.J., Bonnin,D.,
            Bruford,E.A., Buhay,C., Burch,P., Burford,D., Burgess,J.,
            Burrill,W., Burton,J., Bye,J.M., Carder,C., Carrel,L., Chako,J.,
            Chapman,J.C., Chavez,D., Chen,E., Chen,G., Chen,Y., Chen,Z.,
            Chinault,C., Ciccodicola,A., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S., Clerc-Blankenburg,K., Clifford,K., Cobley,V., Cole,C.G.,
            Conquer,J.S., Corby,N., Connor,R.E., David,R., Davies,J., Davis,C.,
            Davis,J., Delgado,O., Deshazo,D., Dhami,P., Ding,Y., Dinh,H.,
            Dodsworth,S., Draper,H., Dugan-Rocha,S., Dunham,A., Dunn,M.,
            Durbin,K.J., Dutta,I., Eades,T., Ellwood,M., Emery-Cohen,A.,
            Errington,H., Evans,K.L., Faulkner,L., Francis,F., Frankland,J.,
            Fraser,A.E., Galgoczy,P., Gilbert,J., Gill,R., Glockner,G.,
            Gregory,S.G., Gribble,S., Griffiths,C., Grocock,R., Gu,Y.,
            Gwilliam,R., Hamilton,C., Hart,E.A., Hawes,A., Heath,P.D.,
            Heitmann,K., Hennig,S., Hernandez,J., Hinzmann,B., Ho,S., Hoffs,M.,
            Howden,P.J., Huckle,E.J., Hume,J., Hunt,P.J., Hunt,A.R.,
            Isherwood,J., Jacob,L., Johnson,D., Jones,S., de Jong,P.J.,
            Joseph,S.S., Keenan,S., Kelly,S., Kershaw,J.K., Khan,Z.,
            Kioschis,P., Klages,S., Knights,A.J., Kosiura,A., Kovar-Smith,C.,
            Laird,G.K., Langford,C., Lawlor,S., Leversha,M., Lewis,L., Liu,W.,
            Lloyd,C., Lloyd,D.M., Loulseged,H., Loveland,J.E., Lovell,J.D.,
            Lozado,R., Lu,J., Lyne,R., Ma,J., Maheshwari,M., Matthews,L.H.,
            McDowall,J., McLaren,S., McMurray,A., Meidl,P., Meitinger,T.,
            Milne,S., Miner,G., Mistry,S.L., Morgan,M., Morris,S., Muller,I.,
            Mullikin,J.C., Nguyen,N., Nordsiek,G., Nyakatura,G., O'Dell,C.N.,
            Okwuonu,G., Palmer,S., Pandian,R., Parker,D., Parrish,J.,
            Pasternak,S., Patel,D., Pearce,A.V., Pearson,D.M., Pelan,S.E.,
            Perez,L., Porter,K.M., Ramsey,Y., Reichwald,K., Rhodes,S.,
            Ridler,K.A., Schlessinger,D., Schueler,M.G., Sehra,H.K.,
            Shaw-Smith,C., Shen,H., Sheridan,E.M., Shownkeen,R., Skuce,C.D.,
            Smith,M.L., Sotheran,E.C., Steingruber,H.E., Steward,C.A.,
            Storey,R., Swann,R.M., Swarbreck,D., Tabor,P.E., Taudien,S.,
            Taylor,T., Teague,B., Thomas,K., Thorpe,A., Timms,K., Tracey,A.,
            Trevanion,S., Tromans,A.C., d'Urso,M., Verduzco,D., Villasana,D.,
            Waldron,L., Wall,M., Wang,Q., Warren,J., Warry,G.L., Wei,X.,
            West,A., Whitehead,S.L., Whiteley,M.N., Wilkinson,J.E.,
            Willey,D.L., Williams,G., Williams,L., Williamson,A.,
            Williamson,H., Wilming,L., Woodmansey,R.L., Wray,P.W., Yen,J.,
            Zhang,J., Zhou,J., Zoghbi,H., Zorilla,S., Buck,D., Reinhardt,R.,
            Poustka,A., Rosenthal,A., Lehrach,H., Meindl,A., Minx,P.J.,
            Hillier,L.W., Willard,H.F., Wilson,R.K., Waterston,R.H., Rice,C.M.,
            Vaudin,M., Coulson,A., Nelson,D.L., Weinstock,G., Sulston,J.E.,
            Durbin,R., Hubbard,T., Gibbs,R.A., Beck,S., Rogers,J. and
            Bentley,D.R.
  TITLE     The DNA sequence of the human X chromosome
  JOURNAL   Nature 434 (7031), 325-337 (2005)
   PUBMED   15772651
REFERENCE   9  (bases 1 to 7474)
  AUTHORS   Jin,J., Smith,F.D., Stark,C., Wells,C.D., Fawcett,J.P.,
            Kulkarni,S., Metalnikov,P., O'Donnell,P., Taylor,P., Taylor,L.,
            Zougman,A., Woodgett,J.R., Langeberg,L.K., Scott,J.D. and Pawson,T.
  TITLE     Proteomic, functional, and domain-based analysis of in vivo 14-3-3
            binding proteins involved in cytoskeletal regulation and cellular
            organization
  JOURNAL   Curr Biol 14 (16), 1436-1450 (2004)
   PUBMED   15324660
REFERENCE   10 (bases 1 to 7474)
  AUTHORS   Schiaffino,M.V., Bassi,M.T., Rugarli,E.I., Renieri,A., Galli,L. and
            Ballabio,A.
  TITLE     Cloning of a human homologue of the Xenopus laevis APX gene from
            the ocular albinism type 1 critical region
  JOURNAL   Hum Mol Genet 4 (3), 373-382 (1995)
   PUBMED   7795590
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC090481.9, X83543.1,
            BC140866.1 and BM678914.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001649.3.
            
            Summary: This gene represents the human homolog of Xenopus laevis
            apical protein (APX) gene, which is implicated in
            amiloride-sensitive sodium channel activity. It is expressed in
            endothelial cells and facilitates the formation of a contractile
            network within endothelial cells. Depletion of this gene results in
            an increase in endothelial sprouting, migration, and angiogenesis.
            This gene is highly expressed in the retina, and is a strong
            candidate for ocular albinism type 1 syndrome. Alternatively
            spliced transcript variants have been found for this gene.
            [provided by RefSeq, Mar 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X83543.1, BC140866.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380913.8/ ENSP00000370299.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AC090481.9         32295-32321
            28-515              X83543.1           1-488
            516-6815            BC140866.1         450-6749
            6816-7472           X83543.1           6789-7445
            7473-7474           BM678914.1         17-18               c
FEATURES             Location/Qualifiers
     source          1..7474
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp22.2"
     gene            1..7474
                     /gene="SHROOM2"
                     /gene_synonym="APXL; HSAPXL"
                     /note="shroom family member 2"
                     /db_xref="GeneID:357"
                     /db_xref="HGNC:HGNC:630"
                     /db_xref="MIM:300103"
     exon            1..282
                     /gene="SHROOM2"
                     /gene_synonym="APXL; HSAPXL"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..4968
                     /gene="SHROOM2"
                     /gene_synonym="APXL; HSAPXL"
                     /note="isoform 1 is encoded by transcript variant 1; APX
                     homolog of Xenopus; apical-like protein"
                     /codon_start=1
                     /product="protein Shroom2 isoform 1"
                     /protein_id="NP_001640.1"
                     /db_xref="CCDS:CCDS14135.1"
                     /db_xref="GeneID:357"
                     /db_xref="HGNC:HGNC:630"
                     /db_xref="MIM:300103"
                     /translation="MEGAEPRARPERLAEAETRAADGGRLVEVQLSGGAPWGFTLKGG
                     REHGEPLVITKIEEGSKAAAVDKLLAGDEIVGINDIGLSGFRQEAICLVKGSHKTLKL
                     VVKRRSELGWRPHSWHATKFSDSHPELAASPFTSTSGCPSWSGRHHASSSSHDLSSSW
                     EQTNLQRTLDHFSSLGSVDSLDHPSSRLSVAKSNSSIDHLGSHSKRDSAYGSFSTSSS
                     TPDHTLSKADTSSAENILYTVGLWEAPRQGGRQAQAAGDPQGSEEKLSCFPPRVPGDS
                     GKGPRPEYNAEPKLAAPGRSNFGPVWYVPDKKKAPSSPPPPPPPLRSDSFAATKSHEK
                     AQGPVFSEAAAAQHFTALAQAQPRGDRRPELTDRPWRSAHPGSLGKGSGGPGCPQEAH
                     ADGSWPPSKDGASSRLQASLSSSDVRFPQSPHSGRHPPLYSDHSPLCADSLGQEPGAA
                     SFQNDSPPQVRGLSSCDQKLGSGWQGPRPCVQGDLQAAQLWAGCWPSDTALGALESLP
                     PPTVGQSPRHHLPQPEGPPDARETGRCYPLDKGAEGCSAGAQEPPRASRAEKASQRLA
                     ASITWADGESSRICPQETPLLHSLTQEGKRRPESSPEDSATRPPPFDAHVGKPTRRSD
                     RFATTLRNEIQMHRAKLQKSRSTVALTAAGEAEDGTGRWRAGLGGGTQEGPLAGTYKD
                     HLKEAQARVLRATSFKRRDLDPNPGDLYPESLEHRMGDPDTVPHFWEAGLAQPPSSTS
                     GGPHPPRIGGRRRFTAEQKLKSYSEPEKMNEVGLTRGYSPHQHPRTSEDTVGTFADRW
                     KFFEETSKPVPQRPAQKQALHGIPRDKPERPRTAGRTCEGTEPWSRTTSLGDSLNAHS
                     AAEKAGTSDLPRRLGTFAEYQASWKEQRKPLEARSSGRCHSADDILDVSLDPQERPQH
                     VHGRSRSSPSTDHYKQEASVELRRQAGDPGEPREELPSAVRAEEGQSTPRQADAQCRE
                     GSPGSQQHPPSQKAPNPPTFSELSHCRGAPELPREGRGRAGTLPRDYRYSEESTPADL
                     GPRAQSPGSPLHARGQDSWPVSSALLSKRPAPQRPPPPKREPRRYRATDGAPADAPVG
                     VLGRPFPTPSPASLDVYVARLSLSHSPSVFSSAQPQDTPKATVCERGSQHVSGDASRP
                     LPEALLPPKQQHLRLQTATMETSRSPSPQFAPQKLTDKPPLLIQDEDSTRIERVMDNN
                     TTVKMVPIKIVHSESQPEKESRQSLACPAEPPALPHGLEKDQIKTLSTSEQFYSRFCL
                     YTRQGAEPEAPHRAQPAEPQPLGTQVPPEKDRCTSPPGLSYMKAKEKTVEDLKSEELA
                     REIVGKDKSLADILDPSVKIKTTMDLMEGIFPKDEHLLEEAQQRRKLLPKIPSPRSTE
                     ERKEEPSVPAAVSLATNSTYYSTSAPKAELLIKMKDLQEQQEHEEDSGSDLDHDLSVK
                     KQELIESISRKLQVLREARESLLEDVQANTVLGAEVEAIVKGVCKPSEFDKFRMFIGD
                     LDKVVNLLLSLSGRLARVENALNNLDDGASPGDRQSLLEKQRVLIQQHEDAKELKENL
                     DRRERIVFDILANYLSEESLADYEHFVKMKSALIIEQRELEDKIHLGEEQLKCLLDSL
                     QPERGK"
     exon            283..434
                     /gene="SHROOM2"
                     /gene_synonym="APXL; HSAPXL"
                     /inference="alignment:Splign:2.1.0"
     exon            435..566
                     /gene="SHROOM2"
                     /gene_synonym="APXL; HSAPXL"
                     /inference="alignment:Splign:2.1.0"
     exon            567..2907
                     /gene="SHROOM2"
                     /gene_synonym="APXL; HSAPXL"
                     /inference="alignment:Splign:2.1.0"
     exon            2908..3008
                     /gene="SHROOM2"
                     /gene_synonym="APXL; HSAPXL"
                     /inference="alignment:Splign:2.1.0"
     exon            3009..3704
                     /gene="SHROOM2"
                     /gene_synonym="APXL; HSAPXL"
                     /inference="alignment:Splign:2.1.0"
     exon            3705..4256
                     /gene="SHROOM2"
                     /gene_synonym="APXL; HSAPXL"
                     /inference="alignment:Splign:2.1.0"
     exon            4257..4428
                     /gene="SHROOM2"
                     /gene_synonym="APXL; HSAPXL"
                     /inference="alignment:Splign:2.1.0"
     exon            4429..4701
                     /gene="SHROOM2"
                     /gene_synonym="APXL; HSAPXL"
                     /inference="alignment:Splign:2.1.0"
     exon            4702..7474
                     /gene="SHROOM2"
                     /gene_synonym="APXL; HSAPXL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6369..6374
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SHROOM2"
                     /gene_synonym="APXL; HSAPXL"
                     /note="hexamer: ATTAAA"
     polyA_site      6390
                     /gene="SHROOM2"
                     /gene_synonym="APXL; HSAPXL"
     regulatory      7450..7455
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SHROOM2"
                     /gene_synonym="APXL; HSAPXL"
                     /note="hexamer: AATAAA"
     polyA_site      7474
                     /gene="SHROOM2"
                     /gene_synonym="APXL; HSAPXL"
                     /note="major polyA site"
ORIGIN      
        1 actttctttc caagttacgg cgcaagttct gcggcgctcg gagcctccct tgcgatccca
       61 cggccgggac tgcccggagt gcatgggcgc gggccaggga cgctgagcgg tcgcgccatg
      121 gagggcgccg agccccgcgc gcggcccgag cgcctggccg aggccgagac gcgggcggcg
      181 gacggcgggc gcctggtgga ggtgcagctg agcggcggcg ccccgtgggg cttcaccctg
      241 aagggcggcc gcgagcacgg cgagccgctg gtcatcacca agattgaaga gggcagtaaa
      301 gccgcggcgg tcgacaagtt actggctgga gatgagatcg tcggcatcaa tgacattggt
      361 ctctcagggt ttagacagga agcgatttgc ctggtgaagg ggtcccataa gaccctgaag
      421 ctggtcgtca aaaggaggag cgagctgggc tggaggcctc actcctggca tgccaccaag
      481 ttctctgaca gccaccccga gctagcggcc tccccattca cctccaccag cggctgtcct
      541 tcctggtccg gccgacacca cgcgagttct tcctcccacg acctgtccag ttcctgggag
      601 cagacgaacc tacagcgcac cttagatcac ttcagctcct tggggagcgt tgacagcctg
      661 gaccacccct ccagtcgcct ctcggtggcc aagtccaaca gcagcatcga ccacctgggc
      721 agccacagca agcgcgactc ggcctacggc tccttctcca ccagctctag cactcctgac
      781 cacaccttgt ccaaagccga cacgtcctcc gcagagaaca tcctctacac tgtgggcctc
      841 tgggaggctc ccaggcaggg tggccggcag gcccaggccg caggcgaccc tcagggctcg
      901 gaggagaagc tcagttgttt cccgcccagg gtccccggtg acagcggcaa aggccccagg
      961 ccagagtaca atgccgagcc caagctggct gcccctggga ggtccaattt tgggccagtc
     1021 tggtatgttc ccgataagaa gaaagcacca tcatccccac ctcctccccc tccccctctc
     1081 cgcagtgaca gctttgctgc caccaagagc cacgagaagg cccagggccc tgtgttctca
     1141 gaggcggctg cggcacagca ctttacggcc ctggcccagg ctcagcctcg tggtgaccgg
     1201 agaccagagc tcaccgatcg gccttggagg tcagcacacc cggggagcct cgggaaggga
     1261 tcgggaggcc cgggctgccc acaggaggcc cacgcagacg gcagctggcc gccctccaag
     1321 gatggagctt ccagtaggct gcaggcctct ctgtccagct cagatgtgcg cttccctcag
     1381 tctcctcata gcggccgaca ccctccccta tacagcgacc acagccccct ctgtgctgac
     1441 agccttgggc aggagccagg ggctgccagc ttccagaacg acagccctcc tcaggtgagg
     1501 gggctcagca gctgtgacca gaagctgggg agcggctggc agggtccccg gccctgtgtg
     1561 cagggagacc tgcaagcagc acagctctgg gcgggatgct ggccttctga cacagccctt
     1621 ggagccctcg agagtcttcc cccacccacg gtgggccaga gcccacgcca tcacctacct
     1681 cagcctgagg gtcctccgga tgcccgcgag acaggacggt gttacccgct ggacaaaggg
     1741 gccgagggct gctccgcggg agcccaggag cctcccaggg ccagccgtgc agaaaaagcc
     1801 agccagaggc tggcagccag catcacgtgg gcagatgggg agagcagcag gatctgcccg
     1861 caggagacgc ccctgttgca ctccctgacc caggagggga agcgccggcc tgagagcagt
     1921 ccagaggaca gcgccaccag accgccaccg ttcgacgccc acgtgggcaa gcccacccga
     1981 agaagcgacc gctttgccac caccctgcgg aatgagatcc agatgcatag agccaagctg
     2041 cagaagagcc ggagcacagt ggctctgact gcagcagggg aggcggagga tggcaccggc
     2101 cgctggaggg ccgggttggg aggtggcacc caggaaggac ccctcgctgg cacctataaa
     2161 gaccacctga aagaggccca agcccgggtc ctgagggcca cgtccttcaa gcgccgcgac
     2221 ttggacccca acccaggaga cctatacccg gagtcactgg aacaccggat gggggatcca
     2281 gacactgtcc cccacttctg ggaggcaggc ctggcccagc caccctcatc tacaagtggc
     2341 gggccccacc cgccccgcat cggaggccgg agacggttca cagctgagca gaaattgaag
     2401 tcctactcgg aacctgagaa gatgaacgag gtgggcctca cgaggggcta cagtcctcac
     2461 cagcacccca ggacatctga ggatactgtg ggcacgtttg ctgacaggtg gaagtttttt
     2521 gaggaaacga gcaaacctgt tccccagagg cctgcccaga agcaagctct tcacggaatc
     2581 ccgagagaca agccagagag gccgcggaca gcgggccgca catgtgaggg cacggagccc
     2641 tggtcgcgca ccacctccct tggggacagc ctcaacgctc acagcgcagc ggagaaggca
     2701 gggacttcag acctgccgcg gaggctcggc acctttgcag agtatcaggc ctcttggaag
     2761 gaacagagga aacctctgga ggccaggagc tctgggcgct gccactcagc ggatgacatc
     2821 ctggatgtga gcctggaccc acaggagagg ccgcagcacg ttcatgggag gtcccggtct
     2881 tcaccgtcca cagaccacta caagcaggaa gcttctgtcg aactgcgaag gcaggcaggg
     2941 gaccccggcg agcccagaga agagcttccc tccgcagtcc gggccgagga gggacagtcc
     3001 acgccgagac aagcagatgc ccagtgtcgg gaaggcagcc caggatcaca gcagcaccca
     3061 ccgagtcaga aggcaccgaa cccacccaca ttctctgaac tatctcactg ccggggagcc
     3121 ccagagctgc cccgggaggg ccggggccga gcgggaaccc tacctcgaga ttatagatac
     3181 tcggaggaga gcaccccagc agacttggga ccccgagccc agagccctgg ctcacccctg
     3241 catgctcgag gacaagactc gtggccagtg agctcagccc tgctctccaa gaggccagcc
     3301 ccacagaggc caccgccacc caagcgcgag cccaggagat acagggccac agacggcgca
     3361 cctgctgacg cccccgtggg cgtcctcggc aggcccttcc caacgccatc ccctgcgtcc
     3421 ctggatgtgt atgtggcccg cctgtccctc tcccacagcc cctctgtgtt cagcagtgcc
     3481 cagccccagg acaccccgaa ggccactgtc tgtgagcgtg gaagccagca tgtgagcggg
     3541 gacgcatcac gtcctctgcc agaagcactg ctccctccca agcagcagca cctgcgcctg
     3601 cagacggcca ccatggagac ctcgcgctcc ccctcgcccc agttcgcccc ccagaaactg
     3661 acggacaaac ctcccctgct catccaggat gaggattcaa ccagaattga gcgggtgatg
     3721 gacaacaaca ccacggtgaa gatggtgccc atcaagatcg tgcactcgga gagccagcca
     3781 gagaaggaga gccgccagag cctggcatgc cccgccgagc cacctgccct gccccacggg
     3841 ctggagaaag accagatcaa gacgctgagc acatctgagc agttctactc gcgcttctgt
     3901 ctgtacacgc ggcagggtgc tgagcccgag gccccacata gggcccagcc ggctgagccc
     3961 cagcccctgg gcacccaggt gccccccgag aaagaccgct gcacctcccc tccagggctc
     4021 agctacatga aggccaaaga gaagactgtg gaagacctga agtcggagga gctggccagg
     4081 gagatcgtgg ggaaggataa gtccctggcc gacatcctgg atcccagtgt gaagatcaaa
     4141 accactatgg acttgatgga aggcatcttc cccaaagacg agcacctcct ggaagaagcc
     4201 cagcaacgga ggaagctgct ccccaaaatc ccctctccta gaagcacaga ggagaggaaa
     4261 gaggagccca gcgtgcctgc ggccgtgtcc ctggccacca attctaccta ctacagcacg
     4321 tcggccccca aggcggagct gctgatcaag atgaaggacc tgcaggagca gcaggagcac
     4381 gaagaggatt cgggaagcga cttggaccac gacctgtcgg tgaagaagca ggagctcatc
     4441 gagagcatca gccgcaagct gcaggtgctc cgggaggccc gcgagagcct gctggaggac
     4501 gtgcaggcca acaccgtgct gggggccgag gtggaggcca tcgtgaaagg cgtctgcaag
     4561 cccagcgagt ttgacaagtt ccggatgttc attggagacc tggacaaagt ggtgaacctc
     4621 ctgctgtcgc tgtcaggccg cctggcccgg gtggagaatg ccctcaataa tttggacgac
     4681 ggcgcttctc ccggtgatcg gcaatcactg cttgagaagc agagagtcct gatccagcag
     4741 cacgaggacg ccaaggagct caaggagaac ctggaccgcc gcgagcgcat cgtctttgac
     4801 attttggcca actatctgag cgaggagagc ctcgcggact atgagcactt cgtgaagatg
     4861 aagtcggccc tcatcatcga gcagcgggag ctggaagata aaatccacct tggtgaagag
     4921 cagctgaagt gcttattgga cagccttcag cccgaaaggg gcaaataaga gaccagtccc
     4981 cggtggagga ggggcacggg gcctccgagc tccagctccg ttcccaagga tactcgtgaa
     5041 gaccccatct gtgttcatgg cctggaaaga gacttctccc atagcaaaga ggctgttata
     5101 aaagcaataa cttttgtgtt tgtgtgggat gatttattta attttttagt ttcccctttg
     5161 attgctgaga gccattttcc tttacacata actacacctg acaccaggct ctgctggatg
     5221 tgagtttcca ctgcatgggc tgtgggctgg gcctgtggtg cctgccgagt ggtcactgtc
     5281 agtgggaaac ccgttgttcc tcccgtcttc agatgctgag ccaactgctt ggacagcagc
     5341 cagcgcgtca tgacgtgcat gagaggggga ccctggtgct catcttctct tgtcattcat
     5401 ccaggcatgg gctgccaggt tttgtccctg ctcgttcaac agtgtgagca tttgtctctg
     5461 ttatctaatg atgttctctg acccagcaga aatcatcatc atgatgatga taatttatta
     5521 actttttgga agggtgaata gtttcctaat ggttaaaaac caactgtgaa aggaaccacc
     5581 tgtgtggttg ggttcactca ttctcagatt aaattgccac ttaaagaaat aacgtgcatg
     5641 ctttaaaaaa cacagtcacg caccaagcag gcaaatagct ttagtccttc tcacctcaca
     5701 tcacagttgt tctgcaaagt aaaatttttt ggttaagagc gtgtccagta gtaatgtgct
     5761 tgttagctgt ttctcaagac caacagaaga ttttttcagt tactttcccc ccatgtattt
     5821 tgtatgcata tgattgtccg tgataattgg ctacttttcc attgtttcct ccttaaatcg
     5881 tttagcatgg catgagggcc acattccatg gacgggaaga ccccttcctc ttcagaggtc
     5941 ccgtggacta cacagctcct gagcttgatc tttttctgcc atgaagttta aagattctat
     6001 gcccatttcc ttgattgaaa tggcaggatt ctaaagagag cctggtttgt taaaagaaaa
     6061 cactgtcatg ctgtcagttc ccaattgaca agtcacagac tgggagaaaa tatttgcaaa
     6121 tcgtgtatct gacaaaaggt ttgtgtccag gatgtacaaa gaactctcaa accggatagt
     6181 aagaaaacaa acagcccaag tgaaaagcag gcaaaagact tgaatagaca cttcaccaaa
     6241 gagcatacac gcgtggcaaa caagcacacg aaaagacgtt cagccgccga tggcttggtt
     6301 ataatttata acttacttat ttttatctaa taattgtaga ttcagtgtat ttcttcaaaa
     6361 aatgtttaat taaatgcatg ttaatggtga gtgaatccct tgggtgactt cgtgtttagg
     6421 tcgtattagg gcatttgttg gatcaacgga tcattttaac cctgacttcc ccttattccc
     6481 ataaaagaag ttttccagtg gaatggagat ttcattttgt cagcagcagt gaccacagcc
     6541 ttaccaaagc agacgcgtgc gcgtgcacag atgcacacac acagatgtct taaaagacta
     6601 gaatccacac ttcctgagcc agaggggccg tgttgacggt aatgcattct ctatagagcc
     6661 aagtccaaac tggcaagctc aatgatgcag gcaataaacc gcctttttgg cagcctacca
     6721 atgccaaaag gataaatgtc tttccaaaag tgtgtattcc tgttaaatta agctcttgct
     6781 aacttgaaaa atccctgttc tgccagcgaa gcttcctcct cctctccagc tggtagtcac
     6841 ttgcgtgaat gctggtcagt ctgaaaaggt gaagctggct gtgcacttac ccccatcttt
     6901 ctccctcggg gagacgaccc aaggaatttc agagtatttt gtttggcaga gcttttacct
     6961 gttattcttt gccctcaaat acagtattgt ggtcattttg atgatatgtg tgtaaaatgt
     7021 gaataatcca attggtgtct gtactcagcc ttttgatgtc tttttaggac tttctcttct
     7081 acacagcaat acgtcgtgct cgagtatcct tgtagcaaag cacatagagc cagctgtcct
     7141 gtcagttccc ctgtttgcct ctgaaacgtc tggttagtgg ggacccaaag attctagtga
     7201 gtcaacatcc ataactctgt atctagttgt attattcata gaaaatcaat ctggtgctaa
     7261 tggttggccc tggtgttgtt gggtggcagc tgctccttcg ccctcttgta gtgtggctgt
     7321 ggagggctct gcctatgggg ggtggcctgt ggcttgtatc cttcagtcca ccacagcaaa
     7381 tgtgtgtaga tttcatgctc gacacttacc actcacctat caacagatca tcctgcttga
     7441 ctgtaacaaa ataaatagtg tctcttcaag tgaa
//
