LOCUS       XM_047418602            6137 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens SNF2 histone linker PHD RING helicase
            (SHPRH), transcript variant X10, mRNA.
ACCESSION   XM_047418602
VERSION     XM_047418602.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000006.12) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 4% of CDS bases
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..6137
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
     gene            1..6137
                     /gene="SHPRH"
                     /gene_synonym="bA545I5.2; RAD5"
                     /note="SNF2 histone linker PHD RING helicase; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 12 ESTs, 305 long SRA reads, 2 Proteins, and 96%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 99 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:257218"
                     /db_xref="HGNC:HGNC:19336"
                     /db_xref="MIM:608048"
     CDS             661..5184
                     /gene="SHPRH"
                     /gene_synonym="bA545I5.2; RAD5"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase SHPRH isoform X6"
                     /protein_id="XP_047274558.1"
                     /db_xref="GeneID:257218"
                     /db_xref="HGNC:HGNC:19336"
                     /db_xref="MIM:608048"
                     /translation="MSSRRKRAPPVRVDEEKRQQLHWNMHEDRRNEPIIISDDDEQPC
                     PGSDTSSAHYIILSDSLKEEVAHRDKKRCSKVVSFSKPIEKEETVGIFSPLSVKLNIV
                     ISPYHFDNSWKAFLGELTLQLLPAQSLIENFSERSITLMSSESSNQFLIYVHSKGEDV
                     EKQKKEPMSICDKGILVESSFSGEMLEDLGWLQKKRRIKLYQKPEGNHIIKVGIYLLE
                     AGLAKLDFLSDANSRMKKFNQLMKKVMEKLHNSIIPDVLEEDEDDPESEPEGQDIDEL
                     YHFVKQTHQQETQSIQVDVQHPALIPVLRPYQREAVNWMLQQECFRSSPATESALHFL
                     WREIVTSEGLKLYYNPYTGCIIREYPNSGPQLLGGILADEMGLGKTVEVLALILTHTR
                     QDVKQDALTLPEGKVVNYFIPSHYFGGKLKKTEIQNIEFEPKEKVQCPPTRVMILTAV
                     KEMNGKKGVSILSIYKYVSSIYRYDVQRNRSLLKRMLKCLIFEGLVKQIKGHGFSGTF
                     TLGKNYKEEDICDKTKKQAVGSPRKIQKETRKSGNKDTDSEYLPSDTSDDDDDPYYYY
                     YKSRRNRSKLRKKLVPSTKKGKSQPFINPDSQGHCPATSDSGITDVAMSKSTCISEFN
                     QEHETEDCAESLNHADSDVPPSNTMSPFNTSDYRFECICGELDQIDRKPRVQCLKCHL
                     WQHAKCVNYDEKNLKIKPFYCPHCLVAMEPVSTRATLIISPSSICHQWVDEINRHVRS
                     SSLRVLVYQGVKKDGFLQPHFLAEQDIVIITYDVLRSELNYVDIPHSNSEDGRRLRNQ
                     KRYMAIPSPLVAVEWWRICLDEAQMVECPTVKAAEMAQRLSGINRWCISGTPVQRGLE
                     DLFGLVVFLGIEPYCVKHWWVRLLYRPYCKKNPQHLYSFIAKILWRSAKKDVIDQIQI
                     PPQTEEIHWLHFSPVERHFYHRQHEVCCQDVVVKLRKISDWALKLSSLDRRTVTSILY
                     PLLRLRQACCHPQAVRGEFLPLQKSTMTMEELLTSLQKKCGTECEEAHRQLVCALNGL
                     AGIHIIKGEYALAAELYREVLRSSEEHKGKLKTDSLQRLHATHNLMELLIARHPGIPP
                     TLRDGRLEEEAKQLREHYMSKCNTEVAEAQQALYPVQQTIHELQRKIHSNSPWWLNVI
                     HRAIEFTIDEELVQRVRNEITSNYKQQTGKLSMSEKFRDCRGLQFLLTTQMEELNKCQ
                     KLVREAVKNLEGPPSRNVIESATVCHLRPARLPLNCCVFCKADELFTEYESKLFSNTV
                     KGQTAIFEEMIEDEEGLVDDRAPTTTRGLWAISETERSMKAILSFAKSHRFDVEFVDE
                     GSTSMDLFEAWKKEYKLLHEYWMALRNRVSAVDELAMATERLRVRDPREPKPNPPVLH
                     IIEPHEVEQNRIKLLNDKAVATSQLQKKLGQLLYLTNLEKSQDKTSGGVNPEPCPICA
                     RQLGKQWAVLTCGHCFCNECISIIIEQYSVGSHRSSIKCAICRQTTSHKEISYVFTSE
                     KANQEEDIPVKVK"
     polyA_site      6137
                     /gene="SHPRH"
                     /gene_synonym="bA545I5.2; RAD5"
                     /experiment="COORDINATES: polyA evidence [ECO:0006239]"
ORIGIN      
        1 acgctacagc gcgcgcccgg cagctaggcg ctgtggtttc tgggtctccc gggggacccc
       61 tacacgttcc ggcaaaaagc gctcgtgccc acctcaagcc catgttcggt gggtggcgaa
      121 tgcgtgcccg tgatctgctg ggtctgtaga ggagcgcagg cctggtgcaa acagactcaa
      181 gaggctcgga gaaccagctt gggtaggcgc ttgggtgatg gaaggtcagg ggtcagaggt
      241 cgggagggag ggagggaggt ggtctttggc ctccgggacc agggagggag gacgctggtt
      301 gtcctggagc ccgggaagct caagggctga gagggagccg ctgcgcgagt cttccccacc
      361 tcttcccgat cccggactag cgaacttcgg accaccacgt ccctccgggg ataaagtggg
      421 gtcgtgggaa aggaggctgt gcttctcctc atgcactggg gcctgcggtg tttgtctcga
      481 gcgtccaaca cactaggatc cgggagtccg tcgtcacgct ccttggcctc gcggtcgctt
      541 gtttgctcgg cctgctggga gcgatccggc gctgacagcc ccgctcagac tccgggagcc
      601 gcttgtgggt ctttcggaag ataactgaag ttcacagtta ccagccaaga aaacttgaaa
      661 atgagcagcc gacggaaacg tgctcctcca gtgagggtag atgaggaaaa gaggcagcag
      721 cttcattgga atatgcatga ggacagaagg aatgaaccta tcatcataag tgatgatgac
      781 gagcagccct gcccaggttc agatacctct tctgctcatt atatcattct aagtgatagt
      841 ctaaaggaag aagtggctca cagagataag aagaggtgtt caaaagtggt gagcttctca
      901 aaaccaattg aaaaagaaga gactgttggt attttttccc ctttgtctgt aaagttaaat
      961 attgtgattt ctccctatca ttttgataat tcctggaaag catttctagg agaattaact
     1021 cttcagcttc ttcctgcaca gagtttaatt gaaaattttt ccgaaaggag tattacattg
     1081 atgagttcag agtcaagcaa tcagttcctg atttatgttc attcaaaagg tgaagatgta
     1141 gagaaacaaa aaaaagaacc gatgagtatt tgtgacaagg gtattctggt ggagtcatcc
     1201 ttcagtggtg aaatgttaga agatttgggg tggctacaaa agaagagaag aataaaactc
     1261 tatcagaaac cagaaggaaa tcacattatc aaggttggaa tttatctttt ggaagctggc
     1321 ctagcaaaac tagacttctt gagtgatgca aattcaagaa tgaaaaagtt caatcagctc
     1381 atgaagaaag taatggaaaa gttacacaat tctattattc cagatgtgtt ggaagaggat
     1441 gaagatgatc cggagagtga gccagaggga caagacattg acgagctgta tcactttgtg
     1501 aaacaaacac atcagcaaga aacgcagtcc atccaagtgg atgtccagca tcctgcattg
     1561 atccctgtgt tgagacccta ccaaagagag gctgtcaatt ggatgctaca acaagagtgt
     1621 ttcagaagca gtcctgctac tgaaagtgcc ctgcacttct tatggcgaga gattgttaca
     1681 tctgagggtc tgaaactcta ctataatcca tatacaggct gcatcattcg tgagtaccca
     1741 aattctgggc cgcagttgct tggtggaatt ttagcagatg agatgggtct tggaaagaca
     1801 gtggaggttt tggctctgat tctgacacat actcgacaag atgtcaagca agatgctctc
     1861 actcttcccg agggaaaagt ggtgaattat tttattccgt cacattattt tggaggaaaa
     1921 ctgaaaaaga cagaaatcca gaatatcgaa tttgaaccaa aagaaaaagt tcaatgccct
     1981 cctacacgtg tgatgatact gacagctgtg aaagaaatga atggaaaaaa aggagtgtcc
     2041 atcctttcca tctataagta tgtcagttct atatatagat acgatgttca acggaacagg
     2101 agtcttttga aacggatgct gaaatgttta atttttgaag gtctcgtgaa acagatcaaa
     2161 ggccatggtt tttctgggac ttttacattg ggaaagaatt acaaggaaga ggatatatgt
     2221 gataaaacaa aaaagcaggc agtagggagt ccaaggaaaa ttcagaaaga aactagaaaa
     2281 tcagggaaca aggacacaga ttctgaatac ttgccatcag acacctctga tgatgatgat
     2341 gatccttact attattatta taagtccagg agaaatcgca gtaaattgag gaaaaagctt
     2401 gttccatcca caaaaaaagg aaaaagtcaa ccatttatca atcccgattc acaaggtcac
     2461 tgtccagcta ctagcgactc tggaataact gatgttgcta tgtctaaaag tacatgtatc
     2521 tctgaattca accaagaaca tgaaacagag gactgtgctg aatctctaaa tcatgctgat
     2581 agtgatgtac caccttctaa taccatgagt ccctttaaca cctctgatta ccgctttgag
     2641 tgtatatgtg gtgaacttga tcagatagat cgtaagcctc gtgttcaatg cctgaagtgt
     2701 cacctgtggc aacatgcaaa gtgtgtgaat tatgatgaga aaaatctgaa gatcaagcct
     2761 ttttactgcc cccactgcct tgttgcaatg gaaccagtgt caacaagagc aactctgatc
     2821 atctctccaa gttccatctg tcaccagtgg gtggatgaga tcaacaggca tgtgaggtcg
     2881 tcatctcttc gagtcttggt atatcaagga gtgaagaaag atggcttttt acaacctcat
     2941 tttttggcag aacaggatat agttatcatt acctatgatg tactgcgttc agaattaaat
     3001 tatgtcgata tcccacatag caatagtgag gatgggcgtc gcctacggaa ccagaagcgc
     3061 tatatggcta tcccgagccc cctggtagct gtggagtggt ggaggatctg ccttgatgaa
     3121 gctcagatgg ttgagtgtcc cacagtaaaa gctgcagaaa tggcccagcg tttgagtggg
     3181 attaatcgat ggtgtatcag tggcactcca gtacagagag gattagagga tctttttggg
     3241 ttagtggtct ttcttggtat tgaaccttac tgtgtcaaac actggtgggt tcgacttctc
     3301 tatcggcctt actgcaagaa gaatcctcag catctctaca gctttattgc caagatactg
     3361 tggaggtctg caaagaaaga tgtgattgac caaatccaaa taccaccaca aaccgaagaa
     3421 atacactggc tccacttttc tccagtggaa aggcatttct atcaccgtca gcatgaggtg
     3481 tgctgccagg atgtggtggt aaaactcagg aagatttctg actgggctct gaagctcagc
     3541 agcctagaca gaaggactgt cacctctatc ctgtatccat tgctgaggct cagacaggcc
     3601 tgctgtcacc cacaggctgt tcgtggagag ttcttgccac tccaaaaaag caccatgaca
     3661 atggaagagc tgctgacatc tttgcagaag aaatgtggaa ctgaatgtga agaagcacat
     3721 cgacagctag tttgtgctct caatggctta gcaggcattc atattattaa aggtgagtat
     3781 gccttggcag cagaattgta cagagaagtg ttgcgctcct cggaggaaca caaaggaaaa
     3841 ctcaaaactg attcacttca aagacttcat gctacccata acttgatgga attgttgata
     3901 gccaggcacc cagggatacc acctaccttg cgtgatggcc gacttgagga agaggccaaa
     3961 cagctgcgag agcactacat gagcaagtgt aatacagaag ttgctgaagc ccagcaagct
     4021 ttatatcctg tgcagcagac catccatgag cttcaaagaa agattcattc taattctcct
     4081 tggtggctaa atgtgatcca cagagcaata gaatttacta ttgatgagga gctagttcag
     4141 cgagtgcgaa atgaaataac cagcaactac aagcaacaaa ctggcaagct ttctatgtca
     4201 gagaagttcc gtgattgcag aggtcttcag ttcttactta caacacaaat ggaagagcta
     4261 aataaatgcc agaagctagt aagagaggct gtaaaaaacc tggagggacc tccatctcgt
     4321 aatgttattg agtctgcaac agtctgtcac ctccgaccag ccagacttcc tctcaactgc
     4381 tgtgtctttt gtaaagctga tgaattgttc acagagtatg aatcaaagct attttccaac
     4441 acagtcaaag gccagactgc aatatttgag gagatgatag aagatgaaga aggactggtg
     4501 gatgatcgag cacctaccac cacccggggt ctctgggcaa taagtgagac agagcgatct
     4561 atgaaagcaa tactatcatt tgcaaaatca cataggtttg atgttgaatt tgttgatgaa
     4621 ggaagcactt caatggatct ctttgaagca tggaagaagg aatataagtt gcttcatgaa
     4681 tattggatgg ctctgaggaa tcgtgtgtct gctgttgatg aacttgcaat ggctacagaa
     4741 cgactaagag tgcgtgatcc tagggagcca aagcctaatc cgcctgttct tcatatcatt
     4801 gaaccacatg aggtagaaca aaaccgaata aaactactaa atgataaagc tgttgctaca
     4861 tcacagcttc agaaaaaact tgggcagctt ctttacctaa ctaatttgga gaagtctcaa
     4921 gataaaacat cgggaggtgt taatccagaa ccttgcccaa tctgtgctcg acagctagga
     4981 aaacagtggg cggtactgac ctgtggtcac tgtttctgta atgaatgcat ttctataatt
     5041 attgaacaat acagcgtggg atctcacaga agctccatta agtgtgcaat ctgccgccag
     5101 accacatctc acaaagaaat ctcgtatgtc tttacctcag agaaagcaaa ccaggaggag
     5161 gacatccctg tgaaggtaaa gtaggtcagg aacacataga agcataggta aggcaatata
     5221 atataggaag cagtatctga ttaagaaagc atgaacatca gaacaagctt gacagtgaat
     5281 aggtagacgc cactgttgtc tgtagataca ctgcctgaaa gcctcagctt aaccatgtaa
     5341 tttttaattg taggaggaac acagaacact tattcaaaca tggttagcga tagtcatgta
     5401 cactgtgact aaaatgtaac atcttaaaat tacagtttcc tatcctctat aatatttcta
     5461 tccaccacaa gtagacagag gtctggttac attagagatt tatttaaaga aagagttttc
     5521 ctcattcttt tacacatccc tgaatgtaag gaaaaaagga tgtgtctaac taaacagaag
     5581 gataaaataa attggctaat gaagacagct acaagaaaga gggtaatgtg ctttttaaac
     5641 agcatagatt gatattccag gataaagcca aattttggct ttattttcct aatttttttc
     5701 catgcttcat tcagaatttt aagaaaatta ctataatgtg atatccagac tggatctgta
     5761 attggattta ctgcttttaa ggggtattta ataaaaagcc aagactattt tgctctttct
     5821 tttccttaaa tatgcttttt taatattttt tttctaacca aacttgaaca aaggacacat
     5881 cggtatctaa atttagtagc aaatgtgggc tttaaggaat agagaatgag aattagagaa
     5941 tgatggggtt gactcttaag caagatgaag tattctttat taattccttc tgagtttttg
     6001 atactcctca cttttaagta atgtgttttt taagtagaat cagctacaag ttgaaattca
     6061 ctaccagtag ttaagcagtt attagggtac ccttctccca agaaaactgt agctgcatta
     6121 aagaactttt aattgct
//
