LOCUS       NM_000451               7934 bp    mRNA    linear   PRI 13-OCT-2024
DEFINITION  Homo sapiens SHOX homeobox (SHOX), transcript variant 1, mRNA.
ACCESSION   NM_000451
VERSION     NM_000451.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7934)
  AUTHORS   Hattori,A., Seki,A., Inaba,N., Nakabayashi,K., Takeda,K.,
            Tatsusmi,K., Naiki,Y., Nakamura,A., Ishiwata,K., Matsumoto,K.,
            Nasu,M., Okamura,K., Michigami,T., Katoh-Fukui,Y., Umezawa,A.,
            Ogata,T., Kagami,M. and Fukami,M.
  TITLE     Expression levels and DNA methylation profiles of the growth gene
            SHOX in cartilage tissues and chondrocytes
  JOURNAL   Sci Rep 14 (1), 8069 (2024)
   PUBMED   38580675
  REMARK    GeneRIF: Expression levels and DNA methylation profiles of the
            growth gene SHOX in cartilage tissues and chondrocytes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7934)
  AUTHORS   Srivastava,P., Tyagi,A., Bamba,C., Kumari,A., Kaur,H., Seth,S.,
            Kaur,A., Panigrahi,I., Dayal,D., Pramanik,S. and Mandal,K.
  TITLE     SHOX Variations in Idiopathic Short Stature in North India and a
            Review of Cases from Asian Countries
  JOURNAL   J Clin Res Pediatr Endocrinol 16 (1), 41-49 (2024)
   PUBMED   37750395
  REMARK    GeneRIF: SHOX Variations in Idiopathic Short Stature in North India
            and a Review of Cases from Asian Countries.
            Review article
REFERENCE   3  (bases 1 to 7934)
  AUTHORS   Dantas,N.C.B., Funari,M.F.A., Lerario,A.M., Andrade,N.L.M.,
            Rezende,R.C., Cellin,L.P., Alves,C., Crisostomo,L.G.,
            Arnhold,I.J.P., Mendonca,B., Scalco,R.C. and Jorge,A.A.L.
  TITLE     Identification of a second genetic alteration in patients with SHOX
            deficiency individuals: a potential explanation for phenotype
            variability
  JOURNAL   Eur J Endocrinol 189 (3), 387-395 (2023)
   PUBMED   37695807
  REMARK    GeneRIF: Identification of a second genetic alteration in patients
            with SHOX deficiency individuals: a potential explanation for
            phenotype variability.
REFERENCE   4  (bases 1 to 7934)
  AUTHORS   Vodopiutz,J., Steurer,L.M., Haufler,F., Laccone,F.,
            Garczarczyk-Asim,D., Hilkenmeier,M., Steinbauer,P. and Janecke,A.R.
  TITLE     Leri-Weill Dyschondrosteosis Caused by a Leaky Homozygous SHOX
            Splice-Site Variant
  JOURNAL   Genes (Basel) 14 (4), 877 (2023)
   PUBMED   37107635
  REMARK    GeneRIF: Leri-Weill Dyschondrosteosis Caused by a Leaky Homozygous
            SHOX Splice-Site Variant.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7934)
  AUTHORS   Li,L., Fu,F., Li,R., Jing,X., Yu,Q., Zhou,H., Wang,Y., Yang,X.,
            Pan,M., Han,J., Zhen,L., Li,D. and Liao,C.
  TITLE     Genetic Analysis and Sonography Characteristics in Fetus with SHOX
            Haploinsufficiency
  JOURNAL   Genes (Basel) 14 (1), 140 (2023)
   PUBMED   36672881
  REMARK    GeneRIF: Genetic Analysis and Sonography Characteristics in Fetus
            with SHOX Haploinsufficiency.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7934)
  AUTHORS   Ogata,T., Yoshizawa,A., Muroya,K., Matsuo,N., Fukushima,Y.,
            Rappold,G. and Yokoya,S.
  TITLE     Short stature in a girl with partial monosomy of the
            pseudoautosomal region distal to DXYS15: further evidence for the
            assignment of the critical region for a pseudoautosomal growth
            gene(s)
  JOURNAL   J Med Genet 32 (10), 831-834 (1995)
   PUBMED   8558568
REFERENCE   7  (bases 1 to 7934)
  AUTHORS   Kuznetzova,T., Baranov,A., Ivaschenko,T., Savitsky,G.A.,
            Lanceva,O.E., Wang,M.R., Giollant,M., Malet,P., Kascheeva,T.,
            Vakharlovsky,V. et al.
  TITLE     X;Y translocation in a girl with short stature and some features of
            Turner's syndrome: cytogenetic and molecular studies
  JOURNAL   J Med Genet 31 (8), 649-651 (1994)
   PUBMED   7815426
REFERENCE   8  (bases 1 to 7934)
  AUTHORS   Binder,G. and Rappold,G.A.
  TITLE     SHOX Deficiency Disorders
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301394
REFERENCE   9  (bases 1 to 7934)
  AUTHORS   Ballabio,A., Bardoni,B., Carrozzo,R., Andria,G., Bick,D.,
            Campbell,L., Hamel,B., Ferguson-Smith,M.A., Gimelli,G., Fraccaro,M.
            et al.
  TITLE     Contiguous gene syndromes due to deletions in the distal short arm
            of the human X chromosome
  JOURNAL   Proc Natl Acad Sci U S A 86 (24), 10001-10005 (1989)
   PUBMED   2602357
REFERENCE   10 (bases 1 to 7934)
  AUTHORS   Zuffardi,O., Maraschio,P., Lo Curto,F., Muller,U., Giarola,A. and
            Perotti,L.
  TITLE     The role of Yp in sex determination: new evidence from X/Y
            translocations
  JOURNAL   Am J Med Genet 12 (2), 175-184 (1982)
   PUBMED   6954848
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX004827.19.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 25, 2021 this sequence version replaced NM_000451.3.
            
            Summary: This gene belongs to the paired homeobox family and is
            located in the pseudoautosomal region 1 (PAR1) of X and Y
            chromosomes. Defects in this gene are associated with idiopathic
            growth retardation and in the short stature phenotype of Turner
            syndrome patients. This gene is highly conserved across species
            from mammals to fish to flies. Alternatively spliced transcript
            variants encoding different isoforms have been noted for this gene.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (SHOXa).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.4103426.1,
                                           SRR14038197.1094870.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467142, SAMEA2467143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000686671.1/ ENSP00000508521.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-384               BX004827.19        31275-31658
            385-593             BX004827.19        35102-35310
            594-651             BX004827.19        41305-41362
            652-740             BX004827.19        41483-41571
            741-7934            BX004827.19        44875-52068
FEATURES             Location/Qualifiers
     source          1..7934
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /chromosome="Y"
                     /map="X"
                     /map="Y"
     gene            1..7934
                     /gene="SHOX"
                     /gene_synonym="GCFX; PHOG; SHOX1; SHOXY; SS"
                     /note="SHOX homeobox"
                     /db_xref="GeneID:6473"
                     /db_xref="HGNC:HGNC:10853"
                     /db_xref="MIM:312865"
                     /db_xref="MIM:400020"
     exon            1..384
                     /gene="SHOX"
                     /gene_synonym="GCFX; PHOG; SHOX1; SHOXY; SS"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..986
                     /gene="SHOX"
                     /gene_synonym="GCFX; PHOG; SHOX1; SHOXY; SS"
                     /note="isoform SHOXa is encoded by transcript variant 1;
                     growth control factor, X-linked; short stature homeobox;
                     pseudoautosomal homeobox-containing osteogenic protein"
                     /codon_start=1
                     /product="short stature homeobox protein isoform SHOXa"
                     /protein_id="NP_000442.1"
                     /db_xref="CCDS:CCDS14107.1"
                     /db_xref="GeneID:6473"
                     /db_xref="HGNC:HGNC:10853"
                     /db_xref="MIM:312865"
                     /db_xref="MIM:400020"
                     /translation="MEELTAFVSKSFDQKSKDGNGGGGGGGGKKDSITYREVLESGLA
                     RSRELGTSDSSLQDITEGGGHCPVHLFKDHVDNDKEKLKEFGTARVAEGIYECKEKRE
                     DVKSEDEDGQTKLKQRRSRTNFTLEQLNELERLFDETHYPDAFMREELSQRLGLSEAR
                     VQVWFQNRRAKCRKQENQMHKGVILGTANHLDACRVAPYVNMGALRMPFQQVQAQLQL
                     EGVAHAHPHLHPHLAAHAPYLMFPPPPFGLPIASLAESASAAAVVAAAAKSNSKNSSI
                     ADLRLKARKHAEALGL"
     exon            385..593
                     /gene="SHOX"
                     /gene_synonym="GCFX; PHOG; SHOX1; SHOXY; SS"
                     /inference="alignment:Splign:2.1.0"
     exon            594..651
                     /gene="SHOX"
                     /gene_synonym="GCFX; PHOG; SHOX1; SHOXY; SS"
                     /inference="alignment:Splign:2.1.0"
     exon            652..740
                     /gene="SHOX"
                     /gene_synonym="GCFX; PHOG; SHOX1; SHOXY; SS"
                     /inference="alignment:Splign:2.1.0"
     exon            741..7934
                     /gene="SHOX"
                     /gene_synonym="GCFX; PHOG; SHOX1; SHOXY; SS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7913..7918
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SHOX"
                     /gene_synonym="GCFX; PHOG; SHOX1; SHOXY; SS"
                     /note="hexamer: AATAAA"
     polyA_site      7934
                     /gene="SHOX"
                     /gene_synonym="GCFX; PHOG; SHOX1; SHOXY; SS"
                     /note="major polyA site"
ORIGIN      
        1 gtaaataaca gcgctggtga tccacccgcg cgcacgggcc gtcctctccg cgcggggaga
       61 cgcgcgcatc caccagcccc ggctgctcgc cagccccggc cccagccatg gaagagctca
      121 cggcttttgt atccaagtct tttgaccaga aaagcaagga cggtaacggc ggaggcggag
      181 gcggcggagg taagaaggat tccattacgt accgggaagt tttggagagc ggactggcgc
      241 gctcccggga gctggggacg tcggattcca gcctccagga catcacggag ggcggcggcc
      301 actgcccggt gcatttgttc aaggaccacg tagacaatga caaggagaaa ctgaaagaat
      361 tcggcaccgc gagagtggca gaagggattt atgaatgcaa agagaagcgc gaggacgtga
      421 agtcggagga cgaggacggg cagaccaagc tgaaacagag gcgcagccgc accaacttca
      481 cgctggagca gctgaacgag ctcgagcgac tcttcgacga gacccattac cccgacgcct
      541 tcatgcgcga ggagctcagc cagcgcctgg ggctctccga ggcgcgcgtg caggtttggt
      601 tccagaaccg gagagccaag tgccgcaaac aagagaatca gatgcataaa ggcgtcatct
      661 tgggcacagc caaccaccta gacgcctgcc gagtggcacc ctacgtcaac atgggagcct
      721 tacggatgcc tttccaacag gtccaggctc agctgcagct ggaaggcgtg gcccacgcgc
      781 acccgcacct gcacccgcac ctggcggcgc acgcgcccta cctgatgttc cccccgccgc
      841 ccttcgggct gcccatcgcg tcgctggccg agtccgcctc ggccgccgcc gtggtcgccg
      901 ccgccgccaa aagcaacagc aagaattcca gcatcgccga cctgcggctc aaggcgcgga
      961 agcacgcgga ggccctgggg ctctgacccg ccgcgcagcc ccccgcgcgc ccggactccc
     1021 gggctccgcg caccccgcct gcaccgcgcg tcctgcactc aaccccgcct ggagctcctt
     1081 ccgcggccac cgtgctccgg gcaccccggg agctcctgca agaggcctga ggagggaggc
     1141 tcccgggacc gtccacgcac gacccagcca gaccctcgcg gagatggtgc agaaggcgga
     1201 gcgggtgagc ggccgtgcgt ccagcccggg cctctccaag gctgcccgtg cgtcctggga
     1261 ccctggagaa gggtaaaccc ccgcctggct gcgtcttcct ctgctatacc ctatgcatgc
     1321 ggttaactac acacgtttgg aagatcctta gagtctattg aaactgcaaa gatcccggag
     1381 ctggtctccg atgaaaatgc catttcttcg ttgccaacga ttttctttac taccatgctc
     1441 cttccttcat cccgagaggc tgcggaacgg gtgtggattt gaatgtggac ttcggaatcc
     1501 caggaggcag gggccgggct ctcctccacc gctcccccgg agcctcccag gcagcaataa
     1561 ggaaatagtt ctctggctga ggctgaggac gtgaaccgcg ggctttggaa agggagggga
     1621 gggagacccg aacctcccac gttgggactc ccacgttccg gggacctgaa tgaggaccga
     1681 ctttataact tttccagtgt ttgattccca aattgggtct ggttttgttt tggattggta
     1741 tttttttttt tttttttttt tttttttttt tttgctgtgt tacaggattc agacgcaaaa
     1801 gacttgcata agagacggac gcgtggttgc aaggtgtcat actgatatgc agcattaact
     1861 ttactgacat ggagtgaagt gcaatattat aaatattata gattaaaaaa aaaatagccg
     1921 tgcactcttg accccgtcag cgtccaacgt ggaaaaggcg ttacctcttc tcccagcgct
     1981 ggccgcctgg ccactgaggg ccctttgcaa aaatcacggg tgtagagatg gccctgggcg
     2041 cgctgggagt gtggttgtgt ttctgaaggg gataaaagag ggcacggtgg tgccaagata
     2101 tcagtttggt acctgagctg tttctggttg ggaagcgtaa aagccaggga gagatccaga
     2161 gagttttcaa gtttttgcag atgtaggtgg ttccagcttt tctttctccc ctactccatc
     2221 ttctgcgttc ccccagttct tttatttctt tgttttttat ttttgagaca gagacttgct
     2281 ttgtcgccca ggctggagtg cagtggcgca atgtcagctc actgccacct ccgcctcccg
     2341 ggttcaagcg atgctcctgc ctcagcctcc cgagtagctg ggactacagg cacctgccac
     2401 cacccccggc taattttttg tatttatagt agagacgggg tttcaccgtg ttggccaggc
     2461 tcgtctcgaa ctcctgacct caggtgatct gcccgcctcg gcctcccaac gtgcccccag
     2521 ttttataaac agcagatagc aacttgtcgt cacagctggc atgggctgga cagttgcttg
     2581 aaatgaccta accaaaaaca ttcaagggtt ctgcccccag atttcgggag atccacgttc
     2641 catgttctga ttggttttct gggaacacag caaggggttt ggtgacctcc gagaagatcc
     2701 atctgcatga ttggcattag ttaccacagc ctgcccagag agaaactatc ttctcccaac
     2761 atttactaac atccactggt caactctctt atttccataa cacatttgca tctttctgga
     2821 ttcaagcttg gtggttttct ttcctaactt ctgatttaga tacttctccc tgaggtgggg
     2881 ataaaagaaa aaaaaaaaca acttcttttt ttcttccgca taacactttc tatcttgtca
     2941 ctgagctgaa ctgtagatcc atttggaccc gtctcatttg tatcttctga tattctttat
     3001 acaaaccaaa agtccccttc aacatttttt atgtcaaaat gttacaaccg ctgtaaaatg
     3061 acggagagag agagaaagaa tcccagacat taacggtatt agagagtttg cctcattcat
     3121 ccatttttct taaaagctgg aaattaaaaa aaaaaaagag agagagaggc tttaatagtt
     3181 aagctgaaat ttttatcgaa aagaagaatt gcattttgaa tctttgggaa gtaggttcat
     3241 tcatcagagt atgtaaccct ttggaaaagt ggttggtaag atatgtacag ccctagattt
     3301 ttttttttta accaaaaagg ctgagtaatt ttgaaaaatc gaaacataac agtgtgtcat
     3361 catttcctcc caagaaaaag ctcactccac gtgagtagaa agacatctac ctggtccctg
     3421 tagaatctga acgtttctct ttagagacgg aatttcaatc ttgtccccca ggctggagtg
     3481 cagtggcaca atctcggctc accgcaacct ccgcctcccg ggttcaagcc attctcctgc
     3541 ctcagcctcc cgagtagctg ggattacagg cacctgccac caggcctggg taactttctg
     3601 gtatttttag tagagacagg gtttcagcct cccgagtagc tgggattaca ggcacctgcc
     3661 accaggcctg ggtaactttc tggtattttt agtagagaca gggtttcagc ctcccgagta
     3721 gctgggatta caggcacctg ccaccaggcc tgggtaactt tctggtattt ttagtagaga
     3781 cagggtttca gcctcccgag tagctgggat tacaggcacc tgccaccagg cctgggtaac
     3841 tttctggtat ttttagtaga gacagggttt cggcctcccg agtagctggg attacaggca
     3901 cctgccacca ggcctgggta actttctggt atttttagta gagacagggt ttcggcctcc
     3961 cgagtagctg ggattacagg cacctgccac caggcctggg taactttctg gtatttttag
     4021 tagagacagg gtttcagcct cccgagtagc tgggattaca ggcacctgcc accaggcctg
     4081 ggtaactttc tggtattttt agtagagaca gggtttcggc ctcccgagta gctgggatta
     4141 caggcacctg ccaccaggcc tgggtaactt tctggtattt ttagtacaga cagggtttca
     4201 gcctcccgag tagctgggat tacaggcacc tgccaccagg cctgggtaac tttctggtat
     4261 ttttagtaga gacagggttt cggcctcccg agtagctggg attacaggca cctgccacca
     4321 ggcctgggta actttctggt atttttagta gagacagggt ttcggcctcc cgagtagctg
     4381 ggattacagg cacctgccac caggcctggg taactttctg gtatttttag tagagacagg
     4441 gtttcggcct cctgagtagc tgggattaca ggcacctgcc accaggcctg ggtaactttc
     4501 tggtattttt agtagagaca gggtttcagc ctcccgagta gctgggatta caggcacctg
     4561 ccaccaggcc tgggtaactt tctggtattt ttagtacaga cagggtttcg gcctcctgag
     4621 tagctgggat tacaggcacc tgccaccagg cctgggtaac tttctggtag ttttagtaga
     4681 gacagggttt cagcctcccg agtagctggg attacaggca cctgccacca ggcctgggta
     4741 atttttttgc atttttggta gagacaggtt tttgctgtgt tggcccggct ggtctcaaac
     4801 tcctgacctc aggttgacct gcccgctttg tccctcgcaa agtgctggga ttacaggcgt
     4861 gagccaccgc acctggcctg aatctgaact tttaaaaggg agttactgac tctcaactgt
     4921 gcggggacgg tttcagtttg atttaatatg gaaagagggc caagtgtcat cctcacaaat
     4981 gggtccccga agcagatcaa acgcagagaa ctgtgagggt gggacacgag tgtctgtgga
     5041 cactggctgc ctttggcttt tctcctgcga gagaagttgg gtgactttct gtaggtggat
     5101 gagtgatccc tgaatgagtg tggggtacgt gtatgctagc tgcttctttc tccctgaaac
     5161 tctcggatgg aaggaagtaa gaaattcagc ttgggctgtg accagttctc accaccaacg
     5221 ccctcttctc tctcccttct ccttccttcc ttccttcctt tctttctttt tctttctttc
     5281 tctctttctt tcttttcttt ctttctgttt ctttcctttt tatctttctc tctttttctt
     5341 tctcttttcc ttttttgttt ctttctttct ttttctttct ttctttttct ttcttctttc
     5401 tttcttcgat gaagtctcac tctgtcaccc aggctggagt gcagtggtgc aatcccagct
     5461 cactgcatcc tctacctcct ggcttcaaga aattctcctg cctcagcctc ccaagtagct
     5521 gggatgacag gcacccacca ccattcccgg ataatttttg tattttttag tagagaccgg
     5581 gtttcgccat gttggccagg ctggtcttga actcctgacc tcacatgatc cacccgcctc
     5641 agcctcccag agtgctggga ttacggggtg aggcaccgcg cccggcctcc tctctctttt
     5701 tctgagatgt ttaggaagga ctgggctgat ggggaccctc tgtatgtgat gtgcgtgggt
     5761 ttggtttccc ggaaggccct ccagagacac gtttgcgtga acattcagca tggaaacaac
     5821 atacgtctct ccacaggagg tgagaaattg aatttatggg gtgggtgtac gctggcgatt
     5881 cttggtgctt tttgctcaaa acaaggttct tttgaaagtc acgttcctgc tttccctgtg
     5941 gcttcccggt gagctcgctc gcagagcaag gaataccacc cagagagcaa cgtgggctgt
     6001 gttccgatgt aacgccgttg cagagagagg atttggtgtg tgagatccgt accagctcca
     6061 gcacactgat aggaacacgt tgctggccga actgaacgat gctgggttgg gtcctgattg
     6121 atacgtattt tcttccctcc tctccccaaa acttggccaa atagtccgtg gagggttgtc
     6181 agtcgccgca gttgagcaaa aaacacttct tcctttgagt ggctgttctg gtgaaatctg
     6241 tttctgacat atccactttt ctctctcttt tctctctctc tgactgcgaa gcacccacag
     6301 ggagaaggaa ttggatgtat cggatgttgc tattagattt tctttctccg ttcgagtctc
     6361 tgactggtgc atactttgca aaggtgtgtt cctggcaatt gccaagagtt agaaaaatgc
     6421 accttctctg gtggccgttg gggtgttgtt tcacaggcag tggtgacagg gccccttggc
     6481 tgtggctgtc ttctccagcg ccgtggataa agagatggga cagattctgt gcctctgtac
     6541 gatttagagc gtaactgacc gcgtccaaca cccgtttttc cacttacaaa gctggtggtg
     6601 cgacgggctt ggtgtctccc gtacgggaag gaggcctttg ggccgctcca aagacgccct
     6661 gtcgtaggaa tggcctctcc atcccgccaa agtccagcca ggcccccgaa atggtcccat
     6721 ttccttggaa gcctgagttt ctgttctggt cttgctgctg tccttggcca cgtcagcacg
     6781 tgggagcatc tgtggatacc gcagagtctg gggacagctg ggcgtttaac cgaaatgaag
     6841 ccgagacggg tttcaggttt tggtgccaag ctctggtcag gatgaaaggg aaataccaga
     6901 gtcctctgtc ctcgcctctg ggtttcatgc tgacctttct aacatttgtt ttcccctaag
     6961 aacaagcaga agcctccagc tccctttagc tccacagttt tcccggggac atagcgagga
     7021 tggcacacgg cagccactcc cacgacacac atttcggagg cactttgctg gaagccgctt
     7081 gtctcctcca gctttgggag gtctggggag gagagaggct ttcggtggac acgtttgaca
     7141 ttaaaaaaaa aaaaaaaaaa aaaaaaaaac tggtgcctaa tttattaaag agaattagct
     7201 tagcgagtat atgctgatat tcttcgacac acgtgggtaa gttgatgcca tttataaatg
     7261 ttttattgaa atttgatatt taatgagaag ccggttaagg aatgtagaca atatcccgtt
     7321 tcaaagctat gaaatgtgct atttattgaa aggggatgtg gcttcacgag ttcagcccat
     7381 tgtacgtgca ggtcccgtgg gaaggaggca aaagcccctg cttcttactt tgtgatgtat
     7441 gtgcatttgt tatttatttt tttttccttg gtcggacgtt cataaatatg tactatttta
     7501 attatgtcga gtgtaaattt gacatcgcgt tgcatttatt tttatatttc tgaaaactgt
     7561 tgctttttct ttttccctcc cccattgacg acatagcggc ccccgcgtcc gggttacaaa
     7621 tacatctaca gatattttca gggattgctt cagatgaaaa caaatcacac accgtttccc
     7681 aaaccaacag tcttcacatt tctatccctc tgttattgtc ggcaggcggt gaggggtaga
     7741 aaaaaaacaa acaaacaaac agaaaaaaaa accaaaaaaa accaccctga gtttctctgg
     7801 tgacgccctc attctcctaa cgttcaataa tctcaatgtt gagttgcagc aacagactgt
     7861 atttttgtga cgccccgtag tatgaatgta catcttgtaa aactgagata taaataaact
     7921 tataaatatt tgta
//
