LOCUS       NM_007373               3884 bp    mRNA    linear   PRI 10-DEC-2024
DEFINITION  Homo sapiens SHOC2 leucine rich repeat scaffold protein (SHOC2),
            transcript variant 1, mRNA.
ACCESSION   NM_007373 XM_005270186
VERSION     NM_007373.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3884)
  AUTHORS   Xu,W., Zhong,Z., Gu,L., Xiao,Y., Chen,B. and Hu,W.
  TITLE     circCPA4 induces malignant behaviors of prostate cancer via
            miR-491-5p/SHOC2 feedback loop
  JOURNAL   Clinics (Sao Paulo) 79, 100314 (2024)
   PUBMED   38219533
  REMARK    GeneRIF: circCPA4 induces malignant behaviors of prostate cancer
            via miR-491-5p/SHOC2 feedback loop.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3884)
  AUTHORS   Geng,W., Cao,M., Dong,K., An,J. and Gao,H.
  TITLE     SHOC2 mediates the drug-resistance of triple-negative breast cancer
            cells to everolimus
  JOURNAL   Cancer Biol Ther 24 (1), 2206362 (2023)
   PUBMED   37170083
  REMARK    GeneRIF: SHOC2 mediates the drug-resistance of triple-negative
            breast cancer cells to everolimus.
REFERENCE   3  (bases 1 to 3884)
  AUTHORS   Rigante,D., Leoni,C., Onesimo,R., Giorgio,V., Trevisan,V. and
            Zampino,G.
  TITLE     Aberrant N-myristoylation as a prelude to autoimmune manifestations
            in patients with SHOC2 mutations
  JOURNAL   Autoimmun Rev 22 (11), 103462 (2023)
   PUBMED   37793491
  REMARK    GeneRIF: Aberrant N-myristoylation as a prelude to autoimmune
            manifestations in patients with SHOC2 mutations.
REFERENCE   4  (bases 1 to 3884)
  AUTHORS   Du,H., Hou,S., Zhang,L., Liu,C., Yu,T. and Zhang,W.
  TITLE     LncRNA FALEC increases the proliferation, migration and drug
            resistance of cholangiocarcinoma through competitive regulation of
            miR-20a-5p/SHOC2 axis
  JOURNAL   Aging (Albany NY) 15 (9), 3759-3770 (2023)
   PUBMED   37166421
  REMARK    GeneRIF: LncRNA FALEC increases the proliferation, migration and
            drug resistance of cholangiocarcinoma through competitive
            regulation of miR-20a-5p/SHOC2 axis.
REFERENCE   5  (bases 1 to 3884)
  AUTHORS   Cordeddu,V., Di Schiavi,E., Pennacchio,L.A., Ma'ayan,A.,
            Sarkozy,A., Fodale,V., Cecchetti,S., Cardinale,A., Martin,J.,
            Schackwitz,W., Lipzen,A., Zampino,G., Mazzanti,L., Digilio,M.C.,
            Martinelli,S., Flex,E., Lepri,F., Bartholdi,D., Kutsche,K.,
            Ferrero,G.B., Anichini,C., Selicorni,A., Rossi,C., Tenconi,R.,
            Zenker,M., Merlo,D., Dallapiccola,B., Iyengar,R., Bazzicalupo,P.,
            Gelb,B.D. and Tartaglia,M.
  TITLE     Mutation of SHOC2 promotes aberrant protein N-myristoylation and
            causes Noonan-like syndrome with loose anagen hair
  JOURNAL   Nat Genet 41 (9), 1022-1026 (2009)
   PUBMED   19684605
  REMARK    GeneRIF: Mutation of SHOC2 promotes aberrant protein
            N-myristoylation and causes Noonan-like syndrome with loose anagen
            hair.
REFERENCE   6  (bases 1 to 3884)
  AUTHORS   Rodriguez-Viciana,P., Oses-Prieto,J., Burlingame,A., Fried,M. and
            McCormick,F.
  TITLE     A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic
            subunit of PP1 functions as an M-Ras effector to modulate Raf
            activity
  JOURNAL   Mol Cell 22 (2), 217-230 (2006)
   PUBMED   16630891
REFERENCE   7  (bases 1 to 3884)
  AUTHORS   Dai,P., Xiong,W.C. and Mei,L.
  TITLE     Erbin inhibits RAF activation by disrupting the sur-8-Ras-Raf
            complex
  JOURNAL   J Biol Chem 281 (2), 927-933 (2006)
   PUBMED   16301319
  REMARK    GeneRIF: Erbin has a regulatory role in the Ras-Raf-MEK pathway and
            may inhibit ERK activation by disrupting the Sur-8-Ras/Raf
            interaction
REFERENCE   8  (bases 1 to 3884)
  AUTHORS   Li,W., Han,M. and Guan,K.L.
  TITLE     The leucine-rich repeat protein SUR-8 enhances MAP kinase
            activation and forms a complex with Ras and Raf
  JOURNAL   Genes Dev 14 (8), 895-900 (2000)
   PUBMED   10783161
REFERENCE   9  (bases 1 to 3884)
  AUTHORS   Sieburth,D.S., Sun,Q. and Han,M.
  TITLE     SUR-8, a conserved Ras-binding protein with leucine-rich repeats,
            positively regulates Ras-mediated signaling in C. elegans
  JOURNAL   Cell 94 (1), 119-130 (1998)
   PUBMED   9674433
REFERENCE   10 (bases 1 to 3884)
  AUTHORS   Selfors,L.M., Schutzman,J.L., Borland,C.Z. and Stern,M.J.
  TITLE     soc-2 encodes a leucine-rich repeat protein implicated in
            fibroblast growth factor receptor signaling
  JOURNAL   Proc Natl Acad Sci U S A 95 (12), 6903-6908 (1998)
   PUBMED   9618511
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB451165.1, BC050445.1 and
            BC044752.1.
            
            On Dec 4, 2019 this sequence version replaced NM_007373.3.
            
            Summary: This gene encodes a protein that consists almost entirely
            of leucine-rich repeats, a domain implicated in protein-protein
            interactions. The protein may function as a scaffold linking RAS to
            downstream signal transducers in the RAS/ERK MAP kinase signaling
            cascade. Mutations in this gene have been associated with
            Noonan-like syndrome with loose anagen hair. [provided by RefSeq,
            May 2010].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Variants 1, 3, and 4 all encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853567.4393.1,
                                           SRR11853558.3368.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369452.9/ ENSP00000358464.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               DB451165.1         266-470
            206-3537            BC050445.1         122-3453
            3538-3884           BC044752.1         3535-3881
FEATURES             Location/Qualifiers
     source          1..3884
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q25.2"
     gene            1..3884
                     /gene="SHOC2"
                     /gene_synonym="NSLH1; SIAA0862; SOC2; SUR8"
                     /note="SHOC2 leucine rich repeat scaffold protein"
                     /db_xref="GeneID:8036"
                     /db_xref="HGNC:HGNC:15454"
                     /db_xref="MIM:602775"
     exon            1..54
                     /gene="SHOC2"
                     /gene_synonym="NSLH1; SIAA0862; SOC2; SUR8"
                     /inference="alignment:Splign:2.1.0"
     exon            55..991
                     /gene="SHOC2"
                     /gene_synonym="NSLH1; SIAA0862; SOC2; SUR8"
                     /inference="alignment:Splign:2.1.0"
     CDS             289..2037
                     /gene="SHOC2"
                     /gene_synonym="NSLH1; SIAA0862; SOC2; SUR8"
                     /note="isoform 1 is encoded by transcript variant 1; soc-2
                     suppressor of clear homolog"
                     /codon_start=1
                     /product="leucine-rich repeat protein SHOC-2 isoform 1"
                     /protein_id="NP_031399.2"
                     /db_xref="CCDS:CCDS7568.1"
                     /db_xref="GeneID:8036"
                     /db_xref="HGNC:HGNC:15454"
                     /db_xref="MIM:602775"
                     /translation="MSSSLGKEKDSKEKDPKVPSAKEREKEAKASGGFGKESKEKEPK
                     TKGKDAKDGKKDSSAAQPGVAFSVDNTIKRPNPAPGTRKKSSNAEVIKELNKCREENS
                     MRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTS
                     LPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLS
                     MLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDL
                     PDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLN
                     SLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLT
                     SLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKL
                     RELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTH
                     LPEEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLPPQIVAGGPS
                     FIIQFLKMQGPYRAMV"
     exon            992..1129
                     /gene="SHOC2"
                     /gene_synonym="NSLH1; SIAA0862; SOC2; SUR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1260
                     /gene="SHOC2"
                     /gene_synonym="NSLH1; SIAA0862; SOC2; SUR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1449
                     /gene="SHOC2"
                     /gene_synonym="NSLH1; SIAA0862; SOC2; SUR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1450..1572
                     /gene="SHOC2"
                     /gene_synonym="NSLH1; SIAA0862; SOC2; SUR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1710
                     /gene="SHOC2"
                     /gene_synonym="NSLH1; SIAA0862; SOC2; SUR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1828
                     /gene="SHOC2"
                     /gene_synonym="NSLH1; SIAA0862; SOC2; SUR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..3884
                     /gene="SHOC2"
                     /gene_synonym="NSLH1; SIAA0862; SOC2; SUR8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3851..3856
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SHOC2"
                     /gene_synonym="NSLH1; SIAA0862; SOC2; SUR8"
                     /note="hexamer: TATAAA"
     polyA_site      3884
                     /gene="SHOC2"
                     /gene_synonym="NSLH1; SIAA0862; SOC2; SUR8"
                     /note="major polyA site"
ORIGIN      
        1 gaagaggagg aaggagggcg agcgaggagg atggcggagt cggggctcct gacggaactc
       61 taatgaatca ttgattgacc agcactattt taccagttgg aatgaatgat cagaaatggg
      121 catagtgctt ttagatccaa catgtaacag atggatgtta ctccatgctg attacttctt
      181 caagccagta cttttttgat tgtgtaggat ctttgtctct tcatctttga attcaattac
      241 tggaaaataa aaggagttca tgtagttttt gtccaggctt gagtcaccat gagtagtagt
      301 ttaggaaaag aaaaagactc taaagaaaaa gatcccaaag taccatcagc caaggaaaga
      361 gaaaaggagg caaaagcctc tggaggtttt gggaaagaga gcaaagaaaa agaacctaag
      421 accaaaggga aagatgccaa agatggaaag aaggactcca gtgctgccca accaggggtg
      481 gcattttcag ttgacaatac gatcaaacgg ccaaacccag cacctgggac tagaaaaaaa
      541 tccagcaatg cagaggtgat taaagagctc aacaaatgcc gggaagagaa ttcaatgcgt
      601 ttggacttat ccaagagatc tatacacata ttgccatcat caatcaaaga gttgactcaa
      661 ttaacagaac tttatttata cagtaacaaa ttgcagtccc tcccagcaga ggtgggatgt
      721 ttagtaaatc tcatgacact ggctctaagt gaaaattcac ttaccagttt gcctgactct
      781 cttgataact tgaagaagct gcggatgctt gatttacggc ataataaact gagagaaatt
      841 ccttcagtgg tgtataggct ggattctctc accactcttt accttcgctt taatcgtata
      901 actactgtgg aaaaggacat caaaaacttg tcaaaactca gcatgcttag cattcgagag
      961 aacaaaatta aacaactacc tgctgaaatt ggtgaattat gtaacctcat tacgctggat
     1021 gtagctcaca atcaacttga acaccttcca aaggagattg gaaactgtac acagataacc
     1081 aaccttgact tgcagcacaa tgaactgcta gacctcccag atactatagg aaacctgtcc
     1141 agtttaagtc gtcttggtct gagatataac agactgtcag caatacccag atcattagca
     1201 aaatgcagtg cacttgaaga attaaattta gagaacaata acatttctac tttaccagag
     1261 agtcttttat caagtcttgt gaaactgaat agtttgacct tagctagaaa ttgcttccag
     1321 ttgtatccag tgggtggtcc atctcagttt tctaccatct attccctcaa catggaacac
     1381 aatcgaatca acaaaattcc atttggaatt ttctccagag caaaagtatt aagtaagctg
     1441 aatatgaagg acaatcagtt aacatcactt cccttggatt ttggaacttg gaccagtatg
     1501 gtagaattga atttagccac taatcagctc acaaagatcc ctgaggatgt gtctggtctc
     1561 gtttctcttg aggttcttat cttatcaaac aatcttctaa agaagcttcc ccatggtctt
     1621 ggaaacctta ggaagttaag agagttggat ctagaagaga acaaattgga atccttgcca
     1681 aatgaaattg catatcttaa ggatttacag aaattagtct tgacaaacaa ccagttgacc
     1741 actcttccca gaggcattgg tcaccttact aatctcacac atctgggcct tggagagaac
     1801 ctacttactc accttcctga agaaattggt acactggaga acctagaaga actgtatttg
     1861 aatgacaacc ccaacctgca tagccttccc tttgagctgg cactctgcag caagctttca
     1921 atcatgagta ttgagaactg tccactcagt caccttccac ctcagattgt tgctgggggg
     1981 ccttctttca tcattcagtt cttaaagatg cagggtccat atcgtgccat ggtctgatat
     2041 aaatctgctg gtcccacaca ctgttcaaaa atagactgcc attaatgttt cttatctata
     2101 tctgtatcta tttatgtaga tattggtata tggcagattt ataaaaattg cattatgtgt
     2161 ttctgctaat agaggaatca tagccattta gaattttttt taaattctgt acaaaaggct
     2221 tatataagtt ttctttgctg aatttgatgg atgtttttct gttgtgtaat ctgatatgcc
     2281 agtttgctta aaacatttgc caacacatta tgaagttatt aaatttaagg gacagaggta
     2341 gtatagttag atatactttc tcttaggaaa aataatgggc aaaaattttt gttgcaactt
     2401 ttcatatata ttttcccctt accaattgtt ttatccttat agtattgtag gccctgaaag
     2461 tagaattttt ctttaactta ttttgagatt tgagatttaa attttatgta ttgtttacag
     2521 tcagagtaaa tcactggatt tcttttgttt gttttgattt gctctgtttt attcagtcaa
     2581 atctagagtt tgaatcctct gctaaagaat ttgcatccac tggtgtaaac agtgaaaggt
     2641 atttgcttgt tgaaaaaaaa aactggcaaa gtgaaaagat acagtcaaaa atctagaatt
     2701 tctttaattt tgcttctctg acgagttgtg aagcaaaata cctgaagtga gtctttgggt
     2761 aggggaaggg tattgagacc ttttctagta tgaatatttt ttaagtttgg gggaagagaa
     2821 acttgcagtg aaaaggagtt ttttcattcc tgaaagttgc agatccacaa aactaacagg
     2881 ataattgggc aaataaatta catataaaca cacacaatct atatatgtat atacaatgct
     2941 atatagatat gtatttatta tatcataaac tacagtaggt aactttaagg atttcttcct
     3001 atccttgtac aatgacatga atgtctttct ttgaaaactg caatgtatgt atgtttcaag
     3061 gttatttaac agtgtactat ggttttatat cttgacttgc cttgtacatc tttcaattct
     3121 ggaatatctg tgtctaagca caatatcttc acactgtgct gtattgctgc tgaactaaat
     3181 gcacttttcc ccacatatgg ggcactggct tcaaacaatt cagttcagta tcattacttt
     3241 taatctcatc tttcctttct tggtagttgt taatacagtt atggaaaaga ggcacattgc
     3301 atagaagcca ttggggagtt cagtggaagt tctgtaagat gtgcatgtac tatttgatgc
     3361 gttttctttg cttcactgct tttaatactt agcagtattg ttggtctaag tcaatttgat
     3421 tattgaggag tctcagagca aggtgcgttc tagatgtcat cctaaaaaac acttcatata
     3481 taattaatca ctattttgta taattacata ttgctgcttg tgtgtttttt tttttttcca
     3541 tttagttggg cgttgtgttt tacacaaaac catttttgaa ttaaggctat gatattaaga
     3601 tagaaatttg gactgttgtt ctgcttttcc tggcactcaa attcatgact agttttgagg
     3661 tcaaacctat gttcgtaatg agagatttta taaggatcaa ctaagaaatg gaaggcaggt
     3721 gaagatataa aaccctagaa tgcttaaatg tgctgtaaaa ctattgtaga tgtcactgga
     3781 ttttaccaag taatatcctt tctttttttt ttccccccat ctgctgtggc ttttcagtta
     3841 aaattttgtt tataaaagga atttgtttat tacagctcta ccta
//
