LOCUS       NM_001378211            5200 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens shortage in chiasmata 1 (SHOC1), transcript variant 4,
            mRNA.
ACCESSION   NM_001378211 XM_006716974
VERSION     NM_001378211.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5200)
  AUTHORS   Wang,W., Meng,L., He,J., Su,L., Li,Y., Tan,C., Xu,X., Nie,H.,
            Zhang,H., Du,J., Lu,G., Luo,M., Lin,G., Tu,C. and Tan,Y.Q.
  TITLE     Bi-allelic variants in SHOC1 cause non-obstructive azoospermia with
            meiosis arrest in humans and mice
  JOURNAL   Mol Hum Reprod 28 (6) (2022)
   PUBMED   35485979
  REMARK    GeneRIF: Bi-allelic variants in SHOC1 cause non-obstructive
            azoospermia with meiosis arrest in humans and mice.
REFERENCE   2  (bases 1 to 5200)
  AUTHORS   Yao,C., Yang,C., Zhao,L., Li,P., Tian,R., Chen,H., Guo,Y.,
            Huang,Y., Zhi,E., Zhai,J., Sun,H., Zhang,J., Hong,Y., Zhang,L.,
            Ji,Z., Zhang,F., Zhou,Z. and Li,Z.
  TITLE     Bi-allelic SHOC1 loss-of-function mutations cause meiotic arrest
            and non-obstructive azoospermia
  JOURNAL   J Med Genet 58 (10), 679-686 (2021)
   PUBMED   32900840
  REMARK    GeneRIF: Bi-allelic SHOC1 loss-of-function mutations cause meiotic
            arrest and non-obstructive azoospermia.
REFERENCE   3  (bases 1 to 5200)
  AUTHORS   Guiraldelli,M.F., Felberg,A., Almeida,L.P., Parikh,A., de
            Castro,R.O. and Pezza,R.J.
  TITLE     SHOC1 is a ERCC4-(HhH)2-like protein, integral to the formation of
            crossover recombination intermediates during mammalian meiosis
  JOURNAL   PLoS Genet 14 (5), e1007381 (2018)
   PUBMED   29742103
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5200)
  AUTHORS   Macaisne,N., Vignard,J. and Mercier,R.
  TITLE     SHOC1 and PTD form an XPF-ERCC1-like complex that is required for
            formation of class I crossovers
  JOURNAL   J Cell Sci 124 (Pt 16), 2687-2691 (2011)
   PUBMED   21771883
REFERENCE   5  (bases 1 to 5200)
  AUTHORS   Macaisne,N., Novatchkova,M., Peirera,L., Vezon,D., Jolivet,S.,
            Froger,N., Chelysheva,L., Grelon,M. and Mercier,R.
  TITLE     SHOC1, an XPF endonuclease-related protein, is essential for the
            formation of class I meiotic crossovers
  JOURNAL   Curr Biol 18 (18), 1432-1437 (2008)
   PUBMED   18812090
REFERENCE   6  (bases 1 to 5200)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL354877.25, AL356491.12 and AL135787.13.
            
            On Jan 31, 2020 this sequence version replaced XM_006716974.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2161674
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000682961.1/ ENSP00000508388.1
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                AL354877.25        19966-20003         c
            39-119              AL354877.25        16440-16520         c
            120-243             AL354877.25        10978-11101         c
            244-331             AL354877.25        5996-6083           c
            332-516             AL356491.12        59207-59391         c
            517-670             AL356491.12        42111-42264         c
            671-782             AL356491.12        41500-41611         c
            783-936             AL356491.12        39741-39894         c
            937-1044            AL356491.12        31508-31615         c
            1045-1153           AL356491.12        29650-29758         c
            1154-1248           AL356491.12        24892-24986         c
            1249-1491           AL356491.12        21696-21938         c
            1492-1908           AL356491.12        11049-11465         c
            1909-2028           AL356491.12        7208-7327           c
            2029-2205           AL356491.12        5825-6001           c
            2206-2310           AL135787.13        161048-161152       c
            2311-2489           AL135787.13        157309-157487       c
            2490-2562           AL135787.13        155964-156036       c
            2563-2632           AL135787.13        150719-150788       c
            2633-2811           AL135787.13        149432-149610       c
            2812-2929           AL135787.13        148111-148228       c
            2930-3041           AL135787.13        146745-146856       c
            3042-3163           AL135787.13        144969-145090       c
            3164-3257           AL135787.13        142818-142911       c
            3258-3389           AL135787.13        137095-137226       c
            3390-3539           AL135787.13        136663-136812       c
            3540-4500           AL135787.13        134415-135375       c
            4501-5200           AL135787.13        129035-129734       c
FEATURES             Location/Qualifiers
     source          1..5200
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q31.3"
     gene            1..5200
                     /gene="SHOC1"
                     /gene_synonym="C9orf84; MZIP2; SPGF75; ZIP2; ZIP2H"
                     /note="shortage in chiasmata 1"
                     /db_xref="GeneID:158401"
                     /db_xref="HGNC:HGNC:26535"
                     /db_xref="MIM:618038"
     exon            1..38
                     /gene="SHOC1"
                     /gene_synonym="C9orf84; MZIP2; SPGF75; ZIP2; ZIP2H"
                     /inference="alignment:Splign:2.1.0"
     exon            39..119
                     /gene="SHOC1"
                     /gene_synonym="C9orf84; MZIP2; SPGF75; ZIP2; ZIP2H"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..4601
                     /gene="SHOC1"
                     /gene_synonym="C9orf84; MZIP2; SPGF75; ZIP2; ZIP2H"
                     /note="isoform 4 is encoded by transcript variant 4;
                     uncharacterized protein C9orf84; protein shortage in
                     chiasmata 1 ortholog; protein ZIP2 homolog; Zip2 homolog"
                     /codon_start=1
                     /product="protein shortage in chiasmata 1 ortholog isoform
                     4"
                     /protein_id="NP_001365140.1"
                     /db_xref="CCDS:CCDS94461.1"
                     /db_xref="GeneID:158401"
                     /db_xref="HGNC:HGNC:26535"
                     /db_xref="MIM:618038"
                     /translation="MFSALKYHAIDYLYENVVRKKFYRDALLLRIPSCLYQDESYHVA
                     VTDNKFRRPWTRVSAVSVPGMTDTSVLDQWKASFFVEDFLEKKTITRMVTQINCEFEE
                     VVPSSNPDSQIEVEEVSLYTHMDYNEVFTPVSCLEKCSALQNQNQDLFIDDKGILFVS
                     SRKHLPTLPTLLSRLKLFLVKDPLLDFKGQIFTEANFSRECFSLQETLEAFVKEDFCM
                     DKVNFCQEKLEDTICLNEPSSFLIEYEFLIPPSLKPEIDIPSLSELKELLNPVPEIIN
                     YVDEKEKLFERDLTNKHGIEDIGDIKFSSTEILTIQSQSEPEECSKPGELEMPLTPLF
                     LTCQHSSVNSLRTELQTFPLSPVCKINLLTAEESANEYYMMWQLERCRSPLNPFLLTV
                     PRIQEPHSQYSVTDLKKIFSVKEESLVINLEKAEWWKQAGLNLKMMETLEHLNTYLCH
                     DNLSSNDTKIEIFLPTKVLQLESCLEHKSHSSPIALIDEKSTNAHLSLPQKSPSLAKE
                     VPDLCFSDDYFSDKGAAKEEKPKNDQEPVNRIIQKKENNDHFELDCTGPSIKSPSSSI
                     IKKASFEHGKKQENDLDLLSDFIMLRNKYKTCTSKTEVTNSDEKHDKEACSLTLQEES
                     PIVHINKTLEEINQERGTDSVIEIQASDSQCQAFCLLEAAASPILKNLVSLCTLPTAN
                     WKFATVIFDQTRFLLKEQEKVVSDAVRQGTIDEREMTFKHAALLHLLVTIRDVLLTCS
                     LDTALGYLSKAKDIYNSILGPYLGDIWRQLEIVQFIRGKKPETNYKIQELQCQILSWM
                     QSQQQIKVLIIIRMDSDGEKHFLIKILNKIEGLTLTVLHSNERKDFLESEGVLRGTSS
                     CVVVHNQYIGADFPWSNFSFVVEYNYVEDSCWTKHCKELNIPYMAFKVILPDTVLERS
                     TLLDRFGGFLLEIQIPYVFFASEGLLNTPDILQLLESNYNISLVERGCSESLKLFGSS
                     ECYVVVTIDEHTAIILQDLEELNYEKASDNIIMRLMALSLQYRYCWIILYTKETLNSE
                     YLLTEKTLHHLALIYAALVSFGLNSEELDVKLIIAPGVEATALIIRQIADHSLMTSKR
                     DPHEWLDKSWLKVSPSEEEMYLLDFPCINPLVAQLMLNKGPSLHWILLATLCQLQELL
                     PEVPEKVLKHFCSITSLFKIGSSSITKSPQISSPQENRNQISTLSSQSSASDLDSVIQ
                     EHNEYYQYLGLGETVQEDKTTILNDNSSIMELKEISSFLPPVTSYNQTSYWKDSSCKS
                     NIGQNTPFLINIESRRPAYNSFLNHSDSESDVFSLGLTQMNCETIKSPTDTQKRVSVV
                     PRFINSQKRRTHEAKGFINKDVSDPIFSLEGTQSPLHWNFKKNIWEQENHPFNLQYGA
                     QQTACNKLYSQKGNLFTDQQKCLSDESEGLTCESSKDETFWRELPSVPSLDLFRASDS
                     NANQKEFNSLYFYQRAGKSLGQKRHHESSFNSGDKESLTGFMCSQLPQFKKRRLAYEK
                     VPGRVDGQTRLRFF"
     exon            120..243
                     /gene="SHOC1"
                     /gene_synonym="C9orf84; MZIP2; SPGF75; ZIP2; ZIP2H"
                     /inference="alignment:Splign:2.1.0"
     exon            244..331
                     /gene="SHOC1"
                     /gene_synonym="C9orf84; MZIP2; SPGF75; ZIP2; ZIP2H"
                     /inference="alignment:Splign:2.1.0"
     exon            332..516
                     /gene="SHOC1"
                     /gene_synonym="C9orf84; MZIP2; SPGF75; ZIP2; ZIP2H"
                     /inference="alignment:Splign:2.1.0"
     exon            517..670
                     /gene="SHOC1"
                     /gene_synonym="C9orf84; MZIP2; SPGF75; ZIP2; ZIP2H"
                     /inference="alignment:Splign:2.1.0"
     exon            671..782
                     /gene="SHOC1"
                     /gene_synonym="C9orf84; MZIP2; SPGF75; ZIP2; ZIP2H"
                     /inference="alignment:Splign:2.1.0"
     exon            783..936
                     /gene="SHOC1"
                     /gene_synonym="C9orf84; MZIP2; SPGF75; ZIP2; ZIP2H"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1044
                     /gene="SHOC1"
                     /gene_synonym="C9orf84; MZIP2; SPGF75; ZIP2; ZIP2H"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1153
                     /gene="SHOC1"
                     /gene_synonym="C9orf84; MZIP2; SPGF75; ZIP2; ZIP2H"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1248
                     /gene="SHOC1"
                     /gene_synonym="C9orf84; MZIP2; SPGF75; ZIP2; ZIP2H"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1491
                     /gene="SHOC1"
                     /gene_synonym="C9orf84; MZIP2; SPGF75; ZIP2; ZIP2H"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1908
                     /gene="SHOC1"
                     /gene_synonym="C9orf84; MZIP2; SPGF75; ZIP2; ZIP2H"
                     /inference="alignment:Splign:2.1.0"
     exon            1909..2028
                     /gene="SHOC1"
                     /gene_synonym="C9orf84; MZIP2; SPGF75; ZIP2; ZIP2H"
                     /inference="alignment:Splign:2.1.0"
     exon            2029..2205
                     /gene="SHOC1"
                     /gene_synonym="C9orf84; MZIP2; SPGF75; ZIP2; ZIP2H"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..2310
                     /gene="SHOC1"
                     /gene_synonym="C9orf84; MZIP2; SPGF75; ZIP2; ZIP2H"
                     /inference="alignment:Splign:2.1.0"
     exon            2311..2489
                     /gene="SHOC1"
                     /gene_synonym="C9orf84; MZIP2; SPGF75; ZIP2; ZIP2H"
                     /inference="alignment:Splign:2.1.0"
     exon            2490..2562
                     /gene="SHOC1"
                     /gene_synonym="C9orf84; MZIP2; SPGF75; ZIP2; ZIP2H"
                     /inference="alignment:Splign:2.1.0"
     exon            2563..2632
                     /gene="SHOC1"
                     /gene_synonym="C9orf84; MZIP2; SPGF75; ZIP2; ZIP2H"
                     /inference="alignment:Splign:2.1.0"
     exon            2633..2811
                     /gene="SHOC1"
                     /gene_synonym="C9orf84; MZIP2; SPGF75; ZIP2; ZIP2H"
                     /inference="alignment:Splign:2.1.0"
     exon            2812..2929
                     /gene="SHOC1"
                     /gene_synonym="C9orf84; MZIP2; SPGF75; ZIP2; ZIP2H"
                     /inference="alignment:Splign:2.1.0"
     exon            2930..3041
                     /gene="SHOC1"
                     /gene_synonym="C9orf84; MZIP2; SPGF75; ZIP2; ZIP2H"
                     /inference="alignment:Splign:2.1.0"
     exon            3042..3163
                     /gene="SHOC1"
                     /gene_synonym="C9orf84; MZIP2; SPGF75; ZIP2; ZIP2H"
                     /inference="alignment:Splign:2.1.0"
     exon            3164..3257
                     /gene="SHOC1"
                     /gene_synonym="C9orf84; MZIP2; SPGF75; ZIP2; ZIP2H"
                     /inference="alignment:Splign:2.1.0"
     exon            3258..3389
                     /gene="SHOC1"
                     /gene_synonym="C9orf84; MZIP2; SPGF75; ZIP2; ZIP2H"
                     /inference="alignment:Splign:2.1.0"
     exon            3390..3539
                     /gene="SHOC1"
                     /gene_synonym="C9orf84; MZIP2; SPGF75; ZIP2; ZIP2H"
                     /inference="alignment:Splign:2.1.0"
     exon            3540..4500
                     /gene="SHOC1"
                     /gene_synonym="C9orf84; MZIP2; SPGF75; ZIP2; ZIP2H"
                     /inference="alignment:Splign:2.1.0"
     exon            4501..5200
                     /gene="SHOC1"
                     /gene_synonym="C9orf84; MZIP2; SPGF75; ZIP2; ZIP2H"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4730..4735
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SHOC1"
                     /gene_synonym="C9orf84; MZIP2; SPGF75; ZIP2; ZIP2H"
                     /note="hexamer: ATTAAA"
     polyA_site      4750
                     /gene="SHOC1"
                     /gene_synonym="C9orf84; MZIP2; SPGF75; ZIP2; ZIP2H"
                     /note="major polyA site"
     regulatory      5181..5186
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SHOC1"
                     /gene_synonym="C9orf84; MZIP2; SPGF75; ZIP2; ZIP2H"
                     /note="hexamer: AATAAA"
     polyA_site      5200
                     /gene="SHOC1"
                     /gene_synonym="C9orf84; MZIP2; SPGF75; ZIP2; ZIP2H"
ORIGIN      
        1 accccaggaa gagatgcagg aggcgatttt tacctcagat gttgaaattt acactgcttt
       61 gaaagaaaga agatatgttt tcagcattga aatatcatgc aatagactat ttatatgaga
      121 atgtggttag aaagaagttt tacagagatg ctttattgct tcgaatccct tcatgtttat
      181 atcaagatga aagttaccat gtagcagtta ctgataataa atttaggagg ccatggacga
      241 gagtctcagc tgtttcagtt ccgggaatga cagatacctc agtcttggac caatggaaag
      301 caagtttctt tgtggaggat ttccttgaga aaaaaacaat tacaagaatg gtgacccaga
      361 ttaattgtga atttgaggaa gttgttccaa gttcaaatcc agactcccaa attgaagtag
      421 aggaggtcag tttatacacc cacatggact acaatgaagt ctttacccct gtcagttgtt
      481 tagaaaaatg ttcagcactt caaaaccaga accaagattt atttattgat gataaaggaa
      541 tactttttgt aagtagtaga aaacacctac caactttgcc tactctcttg agtagactaa
      601 aactgttttt ggtaaaggat cctcttttag atttcaaagg acagatcttc acagaagcta
      661 atttttccag ggaatgtttc tctcttcaag aaactttgga agcttttgtg aaagaagatt
      721 tttgtatgga taaagtgaac ttttgtcaag agaaactaga agatacaata tgtttaaatg
      781 agccgtcaag ttttcttatt gagtatgaat tcttaatacc tccaagcctc aaaccagaaa
      841 ttgatattcc atcactctca gaactgaagg agttattaaa cccagtgcca gaaataataa
      901 actatgtaga tgaaaaggaa aagctttttg aaagagatct tactaacaag catggaattg
      961 aggatatcgg ggatataaaa ttcagctcca cagagatttt gaccattcaa agccagagtg
     1021 aaccagaaga gtgcagtaaa ccaggagagt tagaaatgcc actaactcct ctattcctaa
     1081 catgccaaca ttcttcagtg aattcattac gtacagaact tcagacattt ccattatctc
     1141 cggtttgtaa aattaatttg cttactgctg aagaatcagc taatgaatac tacatgatgt
     1201 ggcaattaga aagatgtaga agccctttga acccattttt gcttacagtg ccaagaattc
     1261 aagagcccca cagccaatat tcagttacag atttgaaaaa gatattttct gttaaagaag
     1321 aaagccttgt gattaatctg gaaaaggcag agtggtggaa acaagcagga ctaaatctga
     1381 aaatgatgga aacattggaa catctgaata catatttatg tcatgataat ttgtcttcta
     1441 atgacactaa aattgagata tttttgccta cgaaagtgct tcaattagaa tcatgtctag
     1501 aacataaaag tcattcttca cctattgcac ttattgatga aaaatctaca aatgctcatt
     1561 tatcacttcc acaaaagagt ccatctctgg caaaagaagt accagatcta tgtttttctg
     1621 atgactattt ctctgataaa ggagcagcaa aagaagaaaa accaaagaat gaccaagaac
     1681 cagtaaacag aataatccaa aagaaagaaa ataacgatca ctttgaactt gactgcacag
     1741 gaccatctat taaatcacct tcctcttcaa taattaaaaa agcatctttt gaacatggca
     1801 aaaaacaaga gaatgatttg gaccttttga gcgactttat tatgctgcga aataaatata
     1861 agacttgcac ctcaaagact gaagtcacaa acagtgatga aaaacatgat aaagaagcat
     1921 gttctttgac acttcaagaa gaaagtccta ttgttcatat taataaaacc ctggaggaaa
     1981 taaatcagga aaggggaaca gatagtgtca ttgaaattca agcgtcagat agccagtgcc
     2041 aagcattttg cctcctcgaa gcagcagctt ctcctatctt aaaaaacctt gtatccttgt
     2101 gtaccctccc tactgctaat tggaaatttg ccactgttat ttttgaccaa acaaggtttc
     2161 tcttaaagga acaagaaaaa gtagtaagtg atgctgttcg ccaaggtaca attgatgaaa
     2221 gagaaatgac tttcaagcat gccgctctct tacatcttct ggtaacaatt agagatgtcc
     2281 ttttaacatg cagcttggac acagcattgg gatatttgtc gaaggcaaaa gatatctaca
     2341 acagcatttt aggcccctat ttgggtgaca tttggagaca gctggagatt gtacagttta
     2401 ttagggggaa aaagcctgaa accaactaca agatacaaga attgcaatgt cagatactaa
     2461 gttggatgca aagtcaacag caaattaagg tactgattat aataagaatg gactcagacg
     2521 gtgaaaaaca ttttctcatt aaaattctta acaaaataga aggtttaaca ctgactgtcc
     2581 ttcattcaaa tgaaagaaaa gattttctgg aatctgaagg tgttttaagg ggtacaagtt
     2641 cctgtgtagt tgtacataat caatatattg gagcagattt cccctggagt aatttctcat
     2701 ttgtggtgga atacaattat gtggaagact cttgttggac taaacactgc aaagagttga
     2761 atattcctta catggccttt aaagtgattc ttccagacac agttttagaa agaagcacct
     2821 tgctggatag atttggaggt tttcttttgg aaattcagat tccatatgtg ttttttgcat
     2881 ctgaaggact tcttaatact ccagacatac ttcagctgct agaatccaac tataacatct
     2941 cactagtaga gagaggctgc agtgagtcat tgaaactctt tggaagttca gagtgttatg
     3001 tagtggtgac aattgatgaa cacactgcca taattttgca ggatctagaa gaattgaatt
     3061 atgagaaggc atcagacaat atcattatga ggctgatggc attatcatta cagtacagat
     3121 attgttggat aattttatat accaaagaaa cattaaattc agagtatctg cttacagaaa
     3181 agacacttca tcacctagca ctgatttatg cagctttggt ttcatttggg ctaaactctg
     3241 aagaactgga tgtaaagctt ataattgccc caggagtaga agcaactgcc ttgataattc
     3301 gacaaattgc tgaccacagt ttaatgacct caaagagaga tcctcatgaa tggttggata
     3361 aatcctggct taaagtttca ccatctgagg aagaaatgta cttacttgat tttccatgta
     3421 ttaacccatt ggtggctcag ctcatgctaa ataaaggacc ttcactgcat tggatattat
     3481 tagcaactct gtgtcaactt caggaactcc tacctgaagt cccagaaaaa gtgttaaagc
     3541 atttttgtag catcacttcc ctattcaaga ttggttcttc ttccataaca aaatcaccgc
     3601 aaatttcgtc acctcaggaa aataggaatc agattagtac cttgtcttct caaagttcag
     3661 cttctgattt agactctgtc attcaagaac ataatgaata ttatcagtat ttaggattag
     3721 gagagacagt gcaggaagac aaaaccacca ttttgaatga caactcttcc attatggaac
     3781 taaaagaaat ctcaagtttt ttaccacctg tgacttcata caatcagacc agctactgga
     3841 aagactccag ctgtaaatct aatatagggc agaatactcc ttttctaatt aatatagaat
     3901 caaggagacc ggcttataac tcctttctaa accacagtga ttcagagtca gatgtctttt
     3961 ctttgggtct aacacaaatg aactgtgaaa ctataaaatc accaactgac actcagaaga
     4021 gagtgtcagt tgtcccccgt tttataaatt ctcagaaaag gagaacacat gaagcaaaag
     4081 gtttcataaa taaagatgta tcggacccta tcttttcact agagggcact caatctcctc
     4141 ttcattggaa ctttaagaaa aatatatggg aacaagagaa tcacccgttc aacttacaat
     4201 atggtgcaca gcagactgca tgtaacaaat tgtactctca gaaaggtaat ttattcactg
     4261 atcagcaaaa atgtctatca gatgagtctg aaggcctcac atgtgaaagt tcaaaagatg
     4321 agactttctg gagagaatta ccatctgtcc ccagtttgga tttatttcgt gcttctgatt
     4381 ctaatgcaaa tcaaaaagaa ttcaacagcc tttatttcta ccaaagagct ggaaaaagtt
     4441 taggacagaa aaggcaccat gaatcttcat ttaactcagg agacaaggaa tcattaacag
     4501 gttttatgtg ctcacaacta ccacaattca aaaaacgacg tctagcatat gaaaaagtcc
     4561 ctggtagagt tgatgggcag actcggctga ggtttttttg aaggaggaga agagcaatgt
     4621 tacatgccat attccactgt ttttgatgct aatccactag cgcaattatt tagatttgct
     4681 catacactaa agaaaacaca attgttcata tatgtctcag tatttctgta ttaaatattc
     4741 ataatatgta ttctgcccta tggtttgcat ctttgtaagt taaatattct aatttatcaa
     4801 ttagcagaat aattatcata agatccaaaa tgtcttccag acacccctgc acacaggcca
     4861 tttaaatgag tctccatcac agtctgaccc tttgagtcag gaagtgaaga tcatcacagt
     4921 taaccctccc acatcaagaa agttaaaacc taggacaaaa ttgaagttag aaaacttcca
     4981 acttaaagta tcattttctg taaacacaat ttaagaacaa attactaaga ggaaatattt
     5041 gcaacccaga taataggaaa aaaagtttac atttctcata tataaagaat tcctacaaat
     5101 tgatagaaag aagacaacct gatagaagaa cgggcaaaat atatgaacag atatttcctc
     5161 agaaaaaaac aaaaattgtc aataaacatt tgaaacacaa
//
