LOCUS       NM_138392               2341 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens SH3KBP1 binding protein 1 (SHKBP1), mRNA.
ACCESSION   NM_138392
VERSION     NM_138392.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2341)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   2  (bases 1 to 2341)
  AUTHORS   Swaney,D.L., Ramms,D.J., Wang,Z., Park,J., Goto,Y., Soucheray,M.,
            Bhola,N., Kim,K., Zheng,F., Zeng,Y., McGregor,M., Herrington,K.A.,
            O'Keefe,R., Jin,N., VanLandingham,N.K., Foussard,H., Von Dollen,J.,
            Bouhaddou,M., Jimenez-Morales,D., Obernier,K., Kreisberg,J.F.,
            Kim,M., Johnson,D.E., Jura,N., Grandis,J.R., Gutkind,J.S.,
            Ideker,T. and Krogan,N.J.
  TITLE     A protein network map of head and neck cancer reveals PIK3CA mutant
            drug sensitivity
  JOURNAL   Science 374 (6563), eabf2911 (2021)
   PUBMED   34591642
REFERENCE   3  (bases 1 to 2341)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2341)
  AUTHORS   Wang,T., Wang,D., Zhang,L., Yang,P., Wang,J., Liu,Q., Yan,F. and
            Lin,F.
  TITLE     The TGFbeta-miR-499a-SHKBP1 pathway induces resistance to EGFR
            inhibitors in osteosarcoma cancer stem cell-like cells
  JOURNAL   J Exp Clin Cancer Res 38 (1), 226 (2019)
   PUBMED   31138318
  REMARK    GeneRIF: Study suggests that an elevated SHKBP1/miR-499a ratio is a
            molecular signature that characterizes the erlotinib-resistant
            overall survival of osteosarcoma cells, which may have clinical
            value as a predictive biomarker.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2341)
  AUTHORS   Bhanushali,A.A., Patra,P.K., Nair,D., Verma,H. and Das,B.R.
  TITLE     Genetic variant in the BCL11A (rs1427407), but not HBS1-MYB
            (rs6934903) loci associate with fetal hemoglobin levels in Indian
            sickle cell disease patients
  JOURNAL   Blood Cells Mol Dis 54 (1), 4-8 (2015)
   PUBMED   25457385
  REMARK    GeneRIF: Genetic variant in the BCL11A (rs1427407), but not
            HBS1-MYB (rs6934903) loci associate with fetal hemoglobin levels in
            Indian sickle cell disease patients.
REFERENCE   6  (bases 1 to 2341)
  AUTHORS   Feng,L., Wang,J.T., Jin,H., Qian,K. and Geng,J.G.
  TITLE     SH3KBP1-binding protein 1 prevents epidermal growth factor receptor
            degradation by the interruption of c-Cbl-CIN85 complex
  JOURNAL   Cell Biochem Funct 29 (7), 589-596 (2011)
   PUBMED   21830225
  REMARK    GeneRIF: SHKBP1 disturbed the translocation of CIN85 to
            EGFR-containing vesicles.
REFERENCE   7  (bases 1 to 2341)
  AUTHORS   Bennett,E.J., Rush,J., Gygi,S.P. and Harper,J.W.
  TITLE     Dynamics of cullin-RING ubiquitin ligase network revealed by
            systematic quantitative proteomics
  JOURNAL   Cell 143 (6), 951-965 (2010)
   PUBMED   21145461
REFERENCE   8  (bases 1 to 2341)
  AUTHORS   Liu,J.P., Liu,N.S., Yuan,H.Y., Guo,Q., Lu,H. and Li,Y.Y.
  TITLE     Human homologue of SETA binding protein 1 interacts with cathepsin
            B and participates in TNF-Induced apoptosis in ovarian cancer cells
  JOURNAL   Mol Cell Biochem 292 (1-2), 189-195 (2006)
   PUBMED   16733801
  REMARK    GeneRIF: hSB1 may function as a regulator of cathepsin B-mediated
            apoptosis.
REFERENCE   9  (bases 1 to 2341)
  AUTHORS   Jin,J., Smith,F.D., Stark,C., Wells,C.D., Fawcett,J.P.,
            Kulkarni,S., Metalnikov,P., O'Donnell,P., Taylor,P., Taylor,L.,
            Zougman,A., Woodgett,J.R., Langeberg,L.K., Scott,J.D. and Pawson,T.
  TITLE     Proteomic, functional, and domain-based analysis of in vivo 14-3-3
            binding proteins involved in cytoskeletal regulation and cellular
            organization
  JOURNAL   Curr Biol 14 (16), 1436-1450 (2004)
   PUBMED   15324660
REFERENCE   10 (bases 1 to 2341)
  AUTHORS   Borinstein,S.C., Hyatt,M.A., Sykes,V.W., Straub,R.E., Lipkowitz,S.,
            Boulter,J. and Bogler,O.
  TITLE     SETA is a multifunctional adapter protein with three SH3 domains
            that binds Grb2, Cbl, and the novel SB1 proteins
  JOURNAL   Cell Signal 12 (11-12), 769-779 (2000)
   PUBMED   11152963
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB038927.1, AF258553.1 and BC007653.1.
            
            On Nov 23, 2018 this sequence version replaced NM_138392.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF258553.1, SRR1803611.185584.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000291842.10/ ENSP00000291842.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                DB038927.1         23-112
            91-1655             AF258553.1         112-1676
            1656-2341           BC007653.1         964-1649
FEATURES             Location/Qualifiers
     source          1..2341
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..2341
                     /gene="SHKBP1"
                     /gene_synonym="PP203; Sb1"
                     /note="SH3KBP1 binding protein 1"
                     /db_xref="GeneID:92799"
                     /db_xref="HGNC:HGNC:19214"
                     /db_xref="MIM:617322"
     exon            1..113
                     /gene="SHKBP1"
                     /gene_synonym="PP203; Sb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..2151
                     /gene="SHKBP1"
                     /gene_synonym="PP203; Sb1"
                     /note="SETA-binding protein 1"
                     /codon_start=1
                     /product="SH3KBP1-binding protein 1"
                     /protein_id="NP_612401.2"
                     /db_xref="CCDS:CCDS12560.1"
                     /db_xref="GeneID:92799"
                     /db_xref="HGNC:HGNC:19214"
                     /db_xref="MIM:617322"
                     /translation="MAAAATAAEGVPSRGPPGEVIHLNVGGKRFSTSRQTLTWIPDSF
                     FSSLLSGRISTLKDETGAIFIDRDPTVFAPILNFLRTKELDPRGVHGSSLLHEAQFYG
                     LTPLVRRLQLREELDRSSCGNVLFNGYLPPPVFPVKRRNRHSLVGPQQLGGRPAPVRR
                     SNTMPPNLGNAGLLGRMLDEKTPPSPSGQPEEPGMVRLVCGHHNWIAVAYTQFLVCYR
                     LKEASGWQLVFSSPRLDWPIERLALTARVHGGALGEHDKMVAAATGSEILLWALQAEG
                     GGSEIGVFHLGVPVEALFFVGNQLIATSHTGRIGVWNAVTKHWQVQEVQPITSYDAAG
                     SFLLLGCNNGSIYYVDVQKFPLRMKDNDLLVSELYRDPAEDGVTALSVYLTPKTSDSG
                     NWIEIAYGTSSGGVRVIVQHPETVGSGPQLFQTFTVHRSPVTKIMLSEKHLISVCADN
                     NHVRTWSVTRFRGMISTQPGSTPLASFKILALESADGHGGCSAGNDIGPYGERDDQQV
                     FIQKVVPSASQLFVRLSSTGQRVCSVRSVDGSPTTAFTVLECEGSRRLGSRPRRYLLT
                     GQANGSLAMWDLTTAMDGLGQAPAGGLTEQELMEQLEHCELAPPAPSAPSWGCLPSPS
                     PRISLTSLHSASSNTSLSGHRGSPSPPQAEARRRGGGSFVERCQELVRSGPDLRRPPT
                     PAPWPSSGLGTPLTPPKMKLNETSF"
     exon            114..167
                     /gene="SHKBP1"
                     /gene_synonym="PP203; Sb1"
                     /inference="alignment:Splign:2.1.0"
     exon            168..213
                     /gene="SHKBP1"
                     /gene_synonym="PP203; Sb1"
                     /inference="alignment:Splign:2.1.0"
     exon            214..287
                     /gene="SHKBP1"
                     /gene_synonym="PP203; Sb1"
                     /inference="alignment:Splign:2.1.0"
     exon            288..346
                     /gene="SHKBP1"
                     /gene_synonym="PP203; Sb1"
                     /inference="alignment:Splign:2.1.0"
     exon            347..427
                     /gene="SHKBP1"
                     /gene_synonym="PP203; Sb1"
                     /inference="alignment:Splign:2.1.0"
     exon            428..589
                     /gene="SHKBP1"
                     /gene_synonym="PP203; Sb1"
                     /inference="alignment:Splign:2.1.0"
     exon            590..680
                     /gene="SHKBP1"
                     /gene_synonym="PP203; Sb1"
                     /inference="alignment:Splign:2.1.0"
     exon            681..871
                     /gene="SHKBP1"
                     /gene_synonym="PP203; Sb1"
                     /inference="alignment:Splign:2.1.0"
     exon            872..987
                     /gene="SHKBP1"
                     /gene_synonym="PP203; Sb1"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1075
                     /gene="SHKBP1"
                     /gene_synonym="PP203; Sb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1192
                     /gene="SHKBP1"
                     /gene_synonym="PP203; Sb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1363
                     /gene="SHKBP1"
                     /gene_synonym="PP203; Sb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1364..1519
                     /gene="SHKBP1"
                     /gene_synonym="PP203; Sb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1616
                     /gene="SHKBP1"
                     /gene_synonym="PP203; Sb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1795
                     /gene="SHKBP1"
                     /gene_synonym="PP203; Sb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1919
                     /gene="SHKBP1"
                     /gene_synonym="PP203; Sb1"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..2341
                     /gene="SHKBP1"
                     /gene_synonym="PP203; Sb1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2322..2327
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SHKBP1"
                     /gene_synonym="PP203; Sb1"
                     /note="hexamer: AATAAA"
     polyA_site      2341
                     /gene="SHKBP1"
                     /gene_synonym="PP203; Sb1"
                     /note="major polyA site"
ORIGIN      
        1 gcgggccagc cggctcgccc gggggccatg gcagcagcgg ctactgcagc cgagggggtc
       61 cccagtcggg ggcctcccgg ggaagtcatt catctgaatg tgggaggcaa gagattcagt
      121 acctctcgcc agactctcac ctggatccca gactccttct tctccagtct tctgagcgga
      181 cgcatctcga cgctgaaaga tgagaccgga gcaatcttca tcgacaggga ccctacagtc
      241 ttcgccccca tcctcaactt cctgcgcacc aaagagttgg atcccagggg tgtccacggt
      301 tccagcctcc tccatgaagc ccagttctat gggctcactc ctctggttcg tcgcctgcag
      361 cttcgagagg agttggatcg atcttcttgt ggaaacgtcc tcttcaatgg ttacctgccg
      421 ccaccagtgt tcccagtgaa gcggcggaac cggcacagcc tagtggggcc tcagcagcta
      481 ggaggacggc cagcccctgt ccgacggagc aacacgatgc cccccaacct tggcaatgca
      541 gggctgctgg gccgaatgct ggatgagaaa acccctccct caccctcagg acaacctgag
      601 gagccgggga tggtgcgcct ggtgtgtgga caccataatt ggatcgctgt ggcctatacc
      661 cagtttctag tctgctacag gttgaaggaa gcctctggct ggcagctggt gttttccagc
      721 ccccgcctgg actggcccat cgaacgactg gcgctcacag cccgggtgca tggtggggct
      781 ttgggtgaac atgacaagat ggtggcagca gccaccggca gcgagatcct gctatgggct
      841 ctgcaggcgg aaggcggtgg ctccgagata ggggtctttc atctgggggt gcctgtggag
      901 gccttgttct tcgtcgggaa ccagctcatt gctacaagcc acacagggcg catcggggtg
      961 tggaatgccg tcaccaagca ctggcaggtc caggaggtgc agcccatcac cagttatgac
     1021 gcggcaggct ccttcctcct cctgggctgc aacaacggct ccatttacta cgtggatgtg
     1081 cagaagttcc ccttgcgcat gaaagacaac gacctccttg tcagcgagct ctatcgggac
     1141 ccagcggagg atggggtcac cgccctcagt gtctacctca cccccaagac cagtgacagt
     1201 gggaactgga tcgagatcgc ctatggcacc agctcagggg gcgtgcgggt catcgtgcag
     1261 cacccggaga ctgtgggctc ggggcctcag ctcttccaga ccttcactgt gcaccgcagc
     1321 cctgtcacca agatcatgct gtcggagaag cacctcatct cagtctgtgc cgacaacaac
     1381 cacgtgcgga catggtctgt gactcgcttc cgcggcatga tttccaccca gcccggctcc
     1441 accccactcg cttcctttaa gatcctggct ctggagtcgg cagatgggca tggcggctgc
     1501 agtgctggca atgacattgg cccctacggt gagcgggacg accagcaagt gttcatccag
     1561 aaggtggtgc ccagtgccag ccagctcttc gtgcgtctct catctactgg gcagcgggtg
     1621 tgctccgtgc gctccgtgga cggctcaccc acgacagcct tcacagtgct ggagtgcgag
     1681 ggctcccggc ggctcggctc tcggccccgg cgctacctgc tcactggcca ggccaacggc
     1741 agcttggcca tgtgggacct aaccaccgcc atggacggcc tcggccaggc ccctgcaggt
     1801 ggcctgacgg agcaagagct gatggaacag ctggaacact gtgagctggc cccgccggct
     1861 ccttcagctc cctcatgggg ctgtctcccc agcccctcac cccgcatctc cctcaccagc
     1921 ctccactcag cctccagcaa cacctccttg tctggccacc gtgggagccc aagccccccg
     1981 caggctgagg cccggcgccg tggtgggggc agctttgtgg aacgctgcca ggaactggtg
     2041 cggagtgggc cagacctccg acggccaccc acaccagccc cgtggccctc cagcggtctc
     2101 ggcactcccc tcacacctcc caagatgaag ctcaatgaaa cttccttttg aacaacgcag
     2161 ctgccatgat gccttgggat gccctggtcc tgggggactc aggtgcctcc ctgattcctg
     2221 tgggaacccc gggttcaggg ccagggcctc cttggaataa atggttattg ttactaggtc
     2281 cccaccttcc ctcttttctg gaagccaaag tcaccctccc caataaagtc ctcactgcca
     2341 a
//
