LOCUS       NM_001042693             924 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens shisa like 2A (SHISAL2A), transcript variant 1, mRNA.
ACCESSION   NM_001042693
VERSION     NM_001042693.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 924)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 924)
  AUTHORS   Pei,J. and Grishin,N.V.
  TITLE     Unexpected diversity in Shisa-like proteins suggests the importance
            of their roles as transmembrane adaptors
  JOURNAL   Cell Signal 24 (3), 758-769 (2012)
   PUBMED   22120523
REFERENCE   3  (bases 1 to 924)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   4  (bases 1 to 924)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL356976.30, AK128236.1, AY358621.1 and BG192125.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001042693.2.
            
            Transcript Variant: This variant (1) encodes the supported protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279847.971.1, AY358621.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000517870.2/ ENSP00000429726.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               AL356976.30        35149-35324
            177-402             AK128236.1         1-226
            403-923             AY358621.1         1-521
            924-924             BG192125.1         420-420
FEATURES             Location/Qualifiers
     source          1..924
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.3"
     gene            1..924
                     /gene="SHISAL2A"
                     /gene_synonym="FAM159A; PRO7171; WWLS2783"
                     /note="shisa like 2A"
                     /db_xref="GeneID:348378"
                     /db_xref="HGNC:HGNC:28757"
                     /db_xref="MIM:620218"
     exon            1..508
                     /gene="SHISAL2A"
                     /gene_synonym="FAM159A; PRO7171; WWLS2783"
                     /inference="alignment:Splign:2.1.0"
     CDS             327..899
                     /gene="SHISAL2A"
                     /gene_synonym="FAM159A; PRO7171; WWLS2783"
                     /note="membrane protein FAM159A; family with sequence
                     similarity 159 member A"
                     /codon_start=1
                     /product="protein shisa-like-2A"
                     /protein_id="NP_001036158.1"
                     /db_xref="CCDS:CCDS41336.1"
                     /db_xref="GeneID:348378"
                     /db_xref="HGNC:HGNC:28757"
                     /db_xref="MIM:620218"
                     /translation="MSGACTSYVSAEQEVVRGFSCPRPGGEAAAVFCCGFRDHKYCCD
                     DPHSFFPYEHSYMWWLSIGALIGLSVAAVVLLAFIVTACVLCYLFISSKPHTKLDLGL
                     SLQTAGPEEVSPDCQGVNTGMAAEVPKVSPLQQSYSCLNPQLESNEGQAVNSKRLLHH
                     CFMATVTTSDIPGSPEEASVPNPDLCGPVP"
     exon            509..648
                     /gene="SHISAL2A"
                     /gene_synonym="FAM159A; PRO7171; WWLS2783"
                     /inference="alignment:Splign:2.1.0"
     exon            649..924
                     /gene="SHISAL2A"
                     /gene_synonym="FAM159A; PRO7171; WWLS2783"
                     /inference="alignment:Splign:2.1.0"
     regulatory      906..911
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SHISAL2A"
                     /gene_synonym="FAM159A; PRO7171; WWLS2783"
                     /note="hexamer: AATAAA"
     polyA_site      924
                     /gene="SHISAL2A"
                     /gene_synonym="FAM159A; PRO7171; WWLS2783"
                     /note="major polyA site"
ORIGIN      
        1 agagccaggc gagcacgcgg ctcccggccc agctccccgc gtccgctccg gctcctgccg
       61 cgttccagca gccgtcactc ccgccgccgg cccccgccgc ccgccccgcc tgcccctacc
      121 cctccgcgcg ggccgggcac ctggccgccg ctcggtcctc ggggccccgc gctgctgtct
      181 ctgtctcggc ttctctcggc ccctgggtct cttcgtctct gccgttctca ggctcagctc
      241 cgtctcgctc ggtccctcgc ttccccgccg ggctctagcc ggccgtctgg tggcccgagg
      301 tggcggcggg ctgggcgcgg ggcgcgatga gcggcgcctg cacgagctac gtgagcgcag
      361 agcaggaggt ggtgcgcggc ttcagctgcc cgcggccggg gggcgaggcg gccgctgtct
      421 tctgctgcgg cttccgcgac cacaagtact gctgcgacga cccgcacagc ttcttcccct
      481 acgagcacag ctacatgtgg tggctcagca ttggcgctct cataggcctg tccgtagcag
      541 cagtggttct tctcgccttc attgttaccg cctgtgtgct ctgctacctg ttcatcagct
      601 ctaagcccca cacaaagttg gacctgggct tgagcttaca gacagcaggc cctgaggagg
      661 tttctcctga ctgccaaggt gtgaacacag gcatggcggc agaagtgcca aaagtgagcc
      721 ctctccagca gagttactcc tgcttgaacc cgcagctgga gagcaatgag gggcaggctg
      781 tgaactccaa acgcctcctc catcattgct tcatggccac agtgaccacc agtgacattc
      841 caggcagccc tgaggaagcc tctgtaccca accctgacct atgtggacca gtcccataaa
      901 cattcaataa atgtctccat acca
//
