LOCUS       NM_001099294            6853 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens shisa like 1 (SHISAL1), mRNA.
ACCESSION   NM_001099294 XM_376018
VERSION     NM_001099294.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6853)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 6853)
  AUTHORS   Pei,J. and Grishin,N.V.
  TITLE     Unexpected diversity in Shisa-like proteins suggests the importance
            of their roles as transmembrane adaptors
  JOURNAL   Cell Signal 24 (3), 758-769 (2012)
   PUBMED   22120523
REFERENCE   3  (bases 1 to 6853)
  AUTHORS   Hirosawa,M., Nagase,T., Murahashi,Y., Kikuno,R. and Ohara,O.
  TITLE     Identification of novel transcribed sequences on human chromosome
            22 by expressed sequence tag mapping
  JOURNAL   DNA Res 8 (1), 1-9 (2001)
   PUBMED   11258795
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671760.9, AL591914.3, AL022339.1 and AL031595.4.
            
            On Nov 23, 2018 this sequence version replaced NM_001099294.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            CDS exon combination :: SRR3476690.1153780.1, BC104183.1
                                    [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA2155974 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381176.5/ ENSP00000370568.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-201               AL671760.9         225-425
            202-300             AL591914.3         14463-14561         c
            301-514             AL591914.3         10256-10469         c
            515-832             AL022339.1         2672-2989
            833-2473            AL022339.1         38732-40372
            2474-6853           AL031595.4         98360-102739        c
FEATURES             Location/Qualifiers
     source          1..6853
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.31"
     gene            1..6853
                     /gene="SHISAL1"
                     /gene_synonym="KIAA1644"
                     /note="shisa like 1"
                     /db_xref="GeneID:85352"
                     /db_xref="HGNC:HGNC:29335"
                     /db_xref="MIM:620220"
     exon            1..201
                     /gene="SHISAL1"
                     /gene_synonym="KIAA1644"
                     /inference="alignment:Splign:2.1.0"
     exon            202..300
                     /gene="SHISAL1"
                     /gene_synonym="KIAA1644"
                     /inference="alignment:Splign:2.1.0"
     CDS             234..833
                     /gene="SHISAL1"
                     /gene_synonym="KIAA1644"
                     /note="protein shisa-like-1"
                     /codon_start=1
                     /product="protein shisa-like-1 precursor"
                     /protein_id="NP_001092764.1"
                     /db_xref="CCDS:CCDS43025.1"
                     /db_xref="GeneID:85352"
                     /db_xref="HGNC:HGNC:29335"
                     /db_xref="MIM:620220"
                     /translation="MTSCGQQSLNVLAVLFSLLFSAVLSAHFRVCEPYTDHKGRYHFG
                     FHCPRLSDNKTFILCCHHNNTVFKYCCNETEFQAVMQANLTASSEGYMHNNYTALLGV
                     WIYGFFVLMLLVLDLLYYSAMNYDICKVYLARWGIQGRWMKQDPRRWGNPARAPRPGQ
                     RAPQPQPPPGPLPQAPQAVHTLRGDAHSPPLMTFQSSSA"
     exon            301..514
                     /gene="SHISAL1"
                     /gene_synonym="KIAA1644"
                     /inference="alignment:Splign:2.1.0"
     exon            515..832
                     /gene="SHISAL1"
                     /gene_synonym="KIAA1644"
                     /inference="alignment:Splign:2.1.0"
     exon            833..6853
                     /gene="SHISAL1"
                     /gene_synonym="KIAA1644"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6823..6828
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SHISAL1"
                     /gene_synonym="KIAA1644"
                     /note="hexamer: AATAAA"
     polyA_site      6853
                     /gene="SHISAL1"
                     /gene_synonym="KIAA1644"
                     /note="major polyA site"
ORIGIN      
        1 acactgaatt cttgtcagca cacagaggcc agcctgcgct ggaaaacact cttttgccta
       61 tacaaggctc gaccaagttg ctctcctttt attggggttt aaggttggtg gcaaccagga
      121 gccggggaag aggccagcag ctgcagggag accgcagcca gcggaggggg cttctgatcc
      181 ctcagtcaca gggctcggca ggcagctctg gacggatcaa tgcaagccag acgatgacca
      241 gttgtggcca gcagtccttg aacgtgctcg ccgtcctctt ctcattgctg ttttctgcag
      301 tcttgtctgc acatttccgg gtctgtgaac catacacaga ccacaaaggc cgctaccact
      361 ttggcttcca ctgcccccgg ctctcggaca acaagacctt catcctctgt tgtcaccata
      421 acaacacggt cttcaaatac tgctgcaacg agacggagtt ccaggcggtg atgcaggcga
      481 acctcacggc cagctccgag ggttacatgc acaacaatta caccgccttg ttgggagtgt
      541 ggatctatgg atttttcgtg ttgatgctgc tggttctgga ccttttgtat tactcggcaa
      601 tgaactacga catctgcaag gtctacctgg cacggtgggg catccaagga cgatggatga
      661 aacaggaccc ccggcggtgg gggaaccccg ctcgggcccc tcggccgggt cagcgggccc
      721 cacagccgca gcctccccca ggcccgctgc cacaagcccc acaggccgtg cacacattgc
      781 ggggagatgc tcacagccca ccgctgatga ccttccagag ttcgtctgcc tgaaaacgct
      841 tttgctgtgc ctcaggatgg gggagatgag atctgaagca cccggtgcag cctccgagaa
      901 gaacaacttc tacagagatg ccagggacag ccgaggtagc ggcggtggca caggaggaaa
      961 tgctgcctgt gcccaaagcc cccttccgcg gacttctaag attaggagca aactcagggg
     1021 taggggctgg gggtgcaggg gaggggattc tgagccacct gtccgcaagc aatagtccta
     1081 ttttgggctg gtggcttctg agaggtgact cattgtggac tcaggatgac caagacaaag
     1141 caactctggc tgattccagc caggaggatt gaggcctgtg agttatacct gtggttgaaa
     1201 accgaagctt cccttgcccc tgctccctcc agtagtggcc ccttggggct atttgtgtca
     1261 gaatattgaa tgtgcgtgtg tgtgtgcgtg tgtgtgattt ggggtgttct ttttgtttgc
     1321 ttggttggtt ggtttttatt ggggcttccc ccctcaagtt ctctgatggg catgagtcac
     1381 cctccggctg ggggttctca tccgtgtcaa tgtccgagcc gcaagcttat tgctaagcac
     1441 agggtacggc ccctctgtgt ctcggggagc actggggatt tgaaaatgcc agtcagggtt
     1501 gtttcttaca gaattcgttc ctgtaacaat agtaatacta agggctgcat ctcaggctga
     1561 ccacagggca ggtgccaagt taagtgtttt catgcactcc ctctctcacc acctgggagg
     1621 caggtatgat taaccccctg cagaaaaact cacagtgggg aagcggtgcc ggaacccaaa
     1681 gtccaggctc caactccctg gacgtgacat gctcgccagc cggggtacac cctgcacaat
     1741 gctgggagca tctccttgat gcctccacca tcaccgcctg gagcgctgat ccactcagca
     1801 cattctggct aagcatctgc tgtgtgccag gccccgtgct gggcagtgat gggaatgaaa
     1861 gatgagttag atctcatctc tgcccccggg gagcctccca tctggtggga gacacagaca
     1921 cgtggatctt tgctggaaag ggtaacaagg ccatggaaac ccaggcagga gcgttctaga
     1981 aatccatcca ctttcaagta ggacttccat gcccgtaaca tccacccacc gagctaatca
     2041 cccccactcc tgccccgctg ccctgggaca cctatgagat ggcatcacct aaatcatcac
     2101 aaacatctcc aaaggccatg ctgccagtgt agacacactc attccatggg tgttagtgat
     2161 accaaatctc ccccagctct tagctcggga ggccctgctt gatcaatgtg tgtgtcctct
     2221 gacgcagttt cctcatttca tcagacctag tgttctcaca ctgaccaccc atccattcac
     2281 cagacacgac agtgagcaag gcaggtccct gctcactgtg ctagctttct agctggggca
     2341 ggaagacagt gaagaaggaa ggtggcgaag gcagtgagtg ctctgccggg aactcagtgc
     2401 caggaactca gttcgaggga cacgtgagtg agacccttgt ggacctgggg tggtctggga
     2461 aggccgcctt gagcagatga ttgaagccca gatttgaatg acacacagga gccagtaatg
     2521 ggcgttaaag ataggaaaag agcattccag gcagaaggaa cggctagtgc aaagatcctg
     2581 cggcagccac aggcttggtg gtttcaagga agcacaagaa agccaggtgg cacaagaaag
     2641 ccaggtggct ggggacccag agggaaggca gaaggagatg agggtgatag tgcccagctc
     2701 tgggctctgc tgtgagtcaa gctgtgcaaa cacaatgtcc tgcctttgga aaagcagaac
     2761 aaacttgcta gggtataaag catcctccat tctgcctggc tgtccatcct ctcaacagcc
     2821 ccatgaagaa ggggctctcc ccattttatg gacaagaaga cagactcagc tgggtcaagt
     2881 ggcttgccca ggatcacaca ggtcagctgt ggaagaccca ggcccctggc ttcagtcttt
     2941 gggtccagct gtctcctcca ggcagtgctg ccagtgtcca ggcatatggc ttggcaaagt
     3001 gggagaacct ctgcttgggg tctcgattgg agaaaggaat ggcttcctct cccctgatgt
     3061 gagccgtccc agggccatgt tgccgtaagg gggtgcacag cctgtccact agcccagctg
     3121 cggaagccac agctgtgtcc cacgtgcagt gcctcagaag gcagaggaag ccttgaggtg
     3181 ggggcccaag acccagattc tgacatcagc tctgccactg agaacagcgt gacctcaggc
     3241 aaggtctgtt acctcagttt ccccatcggt aagaggaagg agtcagatgg gtatttaagg
     3301 agtttgcaac cctcgtgtcc tgctgtcctg gacaatgctc tgtaggtgct tcctctgcca
     3361 aaaaggaact ggtggccttg cctccctctc ctggacacct ggggtcaaag gtcactgcca
     3421 aatagacagc tagaactggg gttcacctaa gcatcccttg agatgtacaa ccttctagga
     3481 ggacattcct cctgcctgcc cccctccccg caagaggtct tttcaggaat aactgaaaaa
     3541 cccatggggt ttgtggtcct gctgctctgc caagtccctc ttgggcagct gggctgagga
     3601 ctggaacatt ctgtggcaag caggaggcct cagcagagat caccaagacc cagcacacct
     3661 ggtgcagaca gccacggcat cctccttcct gcaggtcacc cccacgagcc acttaacctc
     3721 tcagagcctc tgcttctcac ctgtcaagtg tgtgaggtag ggtaccagtt agtcacggta
     3781 cttgctgtct cacagaggag ccgacaggtg agaacagtgt gcatgtgggt gtgaacactc
     3841 agtgtggaaa gcaggtgtgt gtgtattcaa tcccccaatg gtgtcaaggg ctcctcaaaa
     3901 tgccatgggt ccccaggtca ttgtgataaa cactgtcccc atcctgctgt ggttgtggct
     3961 ggaaggtccc tcaaggagta gactgtccct gagaacaaga tggatgcagg gtagtgacga
     4021 gttcaagcat agctagagtt actgtttttt agcaactcaa cctgattttt taagctgcct
     4081 acttttactt tttactgtga gcttctgtcc atcaccatgt aatttgtaat aataataata
     4141 caaaaagaaa aacgagagag agaagaggac aagatgtcca cagaggaatc tgcattcgag
     4201 gctgtttgca gaactaccgc gtttgtaagg actgtttccc actgggaact gtgtgtaatt
     4261 aatgagcagt tttatgcttt ccctctcgtc tgtgtacggt gtgattgttg tgtgtttcag
     4321 aatctctatt cagaaccaat agctggtaat gcctgctggc tcgctgccct caagttagcc
     4381 tctgaacgtg ccctgcacct agagaagcag ccttctcacc cgcctcacct ggctgctcca
     4441 gcggccaggc cagccacctg accatgacca ttgctgatgt gcaacaggcc ttaattgaaa
     4501 aaacacacaa gtacatacat gcacatgcgc gcacacacac aggtgatttc acaggtagat
     4561 ctggtccctc ttgctgtctc caatgctcta gaaagcagca agtaggcagc tgacagtgtt
     4621 cccagggtga gtggcatctc ccctcatcat cagaaagatt cagtcaaatt ttggcccaga
     4681 gctgaagagg aggacttggg aatgtcaggg aaaacatgac agggctaggg gttaacaggc
     4741 ttctttggcc aggagatggt ttccagttca ccgtcaaccc aaaagctctc ttcaggtcat
     4801 ggcaaacaga ccagggctgt gggtgtggct gtgcttggca ctgactcccc cacaggccgc
     4861 tgtccaggtt ggctcaggat tccagctgcc atccccaggc aggcccctcc gctggctcgg
     4921 ctgctttcac aatcaccatg tctgtctatt agagactgtg ccattcaagg agacggggtc
     4981 cccgggggtg cagacttgta aaatttttta atttttcaac ttggctgaac tggtccccat
     5041 caacaggaaa agccttcgga agtgaattta cagatttctc ccatgtttga aattaacata
     5101 acatgaaccc agaaggcaga gcttgcagtg agctgagatc gcaccagtgc actccagcct
     5161 gggcaacaga gtgagactct gtctaggtag gtaggtaaga aggaaggaag gaagaacaga
     5221 cctggatgga gttattggga acatgtctta tcaatgttga agggccccct atcactgtag
     5281 ggagacatcc acgtgggttg ttttcgtctg ctgtgaaaat ctagggttgg aatcatggaa
     5341 gcaaactgca ggaattctta atcatcctgc tcacgtggtg ggcatcagag ggtgtctgct
     5401 tggcccccac agcactggga cagtcagaga ggccatgagt ggatgacgcc ctgatcactg
     5461 ccctttgcag tccaggaata cctcactggg ctggggccat accctgtgcc ctctggaaga
     5521 caagcctgcg cacttactat gtgccagatg ccatgcacag tgccctagtt ccttgctgta
     5581 gcaccaacac gtcccacgct ggtgcttaaa tgcacgcaaa caactttggt ggttgtggcc
     5641 cgaaaagctc aaatgttaaa gttaagcagt caggcaagct agaagaggtg aggagcctcc
     5701 tagaaaactc attcgatgac acgcgcttcc ctcacctatt cagatacttg ccgagtgcct
     5761 gccacttgcc tggccctgta cccagggccc atctgggagc cattcctgct atagctggga
     5821 ccacttgtga aacggctagt tgtgcctaac agacatgctc agattcacaa aatgaattca
     5881 gaacacttac ctgtcccacc cgtgaaagtg accttggagg tgtcattgcc ccccaccacc
     5941 ccagtttcta gtccaagcca acagctggtg ctagatagat gcttgatgaa tgagcagatt
     6001 tgactgttag ttactctgta cctaaaactc ctatctttac atcaaagccc tgacagattt
     6061 gcccttgaca gactgaaatc cggggctgct gcagggttca cctccaggag gcaccattca
     6121 cgacactgtc ccataaatgg taatgggctc ccagggatac tgtttacata gactgcactg
     6181 agaacggtga cccttaggtt tgtacaatga ggtaccctgt tgaatgaccc taaaccagcc
     6241 tccaaaatgt gcaggatccc acattggtca gcgccaaccc tgagcacagg atctaaaact
     6301 atagatgata tggccaccct ggccacagct ggaaccaagc tggtggccca agagagagcc
     6361 tcttcttgga attgcatgtc agtttctcat acgcagtttc ttcctatttt tcccatttcc
     6421 cgttttaaag ctagtggcat acctcacagt caaataacca agtggtcagt gtctcgacaa
     6481 tgtgcagtaa cgaggtgggg gctgcaaggg tgaggggctc agtcacctta acaaggcagg
     6541 agacctccca caaaaggctg atgtgtcgtc cccagggcca gctggacaag ggcatgcagc
     6601 gcaggggtag ggggatggaa atattttctc tcccgtaaac tctgacttca tgtgagcagg
     6661 catggggtct ccctgagagc tgataaccgg gaaaaccaaa accaataata ttcctaataa
     6721 taatactaga atgtaagaat aatcatgtgt ttttcactga ccgctgttgc tctgcttttg
     6781 tctttatata cagtagtttt tataacaatg tccctaggtt ttaataaagg agtgtcatgt
     6841 caactgttcc cta
//
