LOCUS       NM_001207020            1823 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens shisa family member 8 (SHISA8), transcript variant 3,
            mRNA.
ACCESSION   NM_001207020 XM_496530
VERSION     NM_001207020.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1823)
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium
  TITLE     Biological insights from 108 schizophrenia-associated genetic loci
  JOURNAL   Nature 511 (7510), 421-427 (2014)
   PUBMED   25056061
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            Z99716.4.
            
            On Aug 14, 2020 this sequence version replaced NM_001207020.2.
            
            Transcript Variant: This variant (3) uses an alternate in-frame
            splice junction compared to variant 1. The resulting isoform (3)
            has the same N- and C-termini but is shorter compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA1966682, SAMEA1968540
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000621082.2/ ENSP00000481203.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-937               Z99716.4           57378-58314         c
            938-1071            Z99716.4           54456-54589         c
            1072-1218           Z99716.4           53648-53794         c
            1219-1823           Z99716.4           52783-53387         c
FEATURES             Location/Qualifiers
     source          1..1823
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.2"
     gene            1..1823
                     /gene="SHISA8"
                     /gene_synonym="C22orf17; Orf26"
                     /note="shisa family member 8"
                     /db_xref="GeneID:440829"
                     /db_xref="HGNC:HGNC:18351"
                     /db_xref="MIM:617329"
     exon            1..937
                     /gene="SHISA8"
                     /gene_synonym="C22orf17; Orf26"
                     /inference="alignment:Splign:2.1.0"
     CDS             408..1601
                     /gene="SHISA8"
                     /gene_synonym="C22orf17; Orf26"
                     /note="isoform 3 precursor is encoded by transcript
                     variant 3; putative protein shisa-8; shisa homolog 8;
                     CTA-250D10.17"
                     /codon_start=1
                     /product="protein shisa-8 isoform 3 precursor"
                     /protein_id="NP_001193949.1"
                     /db_xref="CCDS:CCDS74872.1"
                     /db_xref="GeneID:440829"
                     /db_xref="HGNC:HGNC:18351"
                     /db_xref="MIM:617329"
                     /translation="MARAGARGLLGGRRPPGLRLALALRLALLLARPPSGRAGAPEAQ
                     GPAAPGTTAPEGGDRCRGYYDVMGQWDPPFNCSSGAYSFCCGTCGYRFCCHDGPRRLD
                     QSRCSNYDTPAWVQTGRPPARARDTAAPRDPGRERSHTAVYAVCGVAALLVLAGIGAR
                     LGLERAHSPRARRTVTRALTELLKQPGPQEPLPPTLGPPLGGCVQVQMGDGLPRGSPH
                     NSADKKRLNNAPRGSAAPGPPRGPRLQGGGSLTLQPDYAKYATFKAAALKAAEAAPRD
                     FCQRFPALEPSPRQPPARAPRPSPDLPAPLDACPWAPPVYAPPAAPGPYAAWTSSRPA
                     RPAPLSHPTARAFQVPRRPGHAARRQFSVKMPETFNPQLPGLYGSAGRGSRYLRTNSK
                     TEVTV"
     exon            938..1071
                     /gene="SHISA8"
                     /gene_synonym="C22orf17; Orf26"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1218
                     /gene="SHISA8"
                     /gene_synonym="C22orf17; Orf26"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1823
                     /gene="SHISA8"
                     /gene_synonym="C22orf17; Orf26"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1793..1798
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SHISA8"
                     /gene_synonym="C22orf17; Orf26"
                     /note="hexamer: AATAAA"
     polyA_site      1823
                     /gene="SHISA8"
                     /gene_synonym="C22orf17; Orf26"
                     /note="major polyA site"
ORIGIN      
        1 agagcgcggg ctgtactgag agcgcggcgg gaaggtagcg cagtcgggcg gcccgcggcc
       61 ccggcgcggc ctccgctagg gccaagaccc gcacacctgc cgggccgggg agaagccggg
      121 ggccgcgcgc aggcgaggac ccgccgcccg gcccggggaa gatctcagga cgcggaccgg
      181 gcagctcggg tccgaggtga gcccgggcgg aggacgcgcc caccggaggt gcggcctcgg
      241 agctccagac ccagcccact cggggctggg gtccccagag gaggccgacg gccgaggcgg
      301 cgtgcgccgg gagccagcgc gatccctgcg ggagcggagg agccgagccg gagggagccg
      361 cggcgcccgg ccatgcaccg ggcgcagtag cgggaggcgc gggcccgatg gcgcgggccg
      421 gggcgcgggg actgctcggc ggccgccgtc ctcccggcct ccggctcgcg ctcgcgcttc
      481 ggctcgcgtt gctgctggcg cggccgccgt cgggccgcgc gggagccccc gaggcgcagg
      541 gtcccgcggc gcccggcacg acagccccgg aggggggcga ccgctgccgc ggctactacg
      601 acgtgatggg ccagtgggac ccgcccttca actgcagctc cggagcctac agcttctgct
      661 gcggcacgtg cggctaccgc ttctgctgcc acgacgggcc gcggcgcctc gaccagagcc
      721 gctgttccaa ctacgacacg ccggcctggg tccagacagg ccggccgccc gcccgcgccc
      781 gcgacaccgc agcgccccgg gaccccggcc gcgagcgcag ccatacggcc gtctacgctg
      841 tgtgcggcgt cgcagcgctg ctggtgctgg ccggcatcgg ggcgcgcctg ggactggaga
      901 gggcgcacag cccgcgcgcg cggcgcacag tgaccagggc gctgacagag cttctgaagc
      961 agccgggccc ccaggagcca ctgcctccca ccctgggccc acccctgggt ggctgtgtcc
     1021 aggtgcagat gggggacggc ctcccccggg gctcccccca caacagcgca gacaagaagc
     1081 gcctcaacaa cgcgccccgg gggtcggccg ccccggggcc cccgcgcggc ccgcggctgc
     1141 agggcggcgg cagcctgacg ctgcagccag actacgccaa gtacgccacg ttcaaggccg
     1201 ccgcgctcaa ggccgcagag gccgccccgc gggacttctg tcagcgtttc cccgccctcg
     1261 agccgtcccc gcggcaaccc ccggcgcggg ctccgcgacc atccccggac ttgcctgcgc
     1321 cgctggacgc ctgcccctgg gccccgccgg tctacgcgcc ccctgccgcg ccgggcccct
     1381 atgccgcctg gacctccagt cgcccggccc ggcccgcccc gctcagccac ccgacggctc
     1441 gggccttcca ggtaccccgg cgacccgggc acgcggcccg gcgccagttc agtgtgaaga
     1501 tgcctgagac cttcaacccg cagctccccg gcctttacgg cagcgcgggc cgcgggtccc
     1561 ggtacctaag gaccaatagc aagaccgagg tcaccgtgtg aagcggggcc gcggtgccct
     1621 cgaggcatgg gctggggtcc tgtctgcccg tcggagcctc aggccacagg gagaggagcg
     1681 cctgccgtaa ggccagctct tctgtctgcc tcaacggcag tggtgtcttg gagcctgcag
     1741 gccgcgggtt cgtcttgtaa ataagccctt ttatgtggtt cctgcccctg agaataaaga
     1801 agccccagcg tggctgcgag gca
//
