LOCUS       NM_001145176            6470 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens shisa family member 7 (SHISA7), mRNA.
ACCESSION   NM_001145176 XM_001131873 XM_001719724 XR_041409 XR_041410
            XR_041411
VERSION     NM_001145176.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6470)
  AUTHORS   Lee,H.E., Park,S.J., Huh,J.W., Imai,H. and Kim,H.S.
  TITLE     Enhancer Function of MicroRNA-3681 Derived from Long Terminal
            Repeats Represses the Activity of Variable Number Tandem Repeats in
            the 3' UTR of SHISA7
  JOURNAL   Mol Cells 43 (7), 607-618 (2020)
   PUBMED   32655015
  REMARK    GeneRIF: Enhancer Function of MicroRNA-3681 Derived from Long
            Terminal Repeats Represses the Activity of Variable Number Tandem
            Repeats in the 3' UTR of SHISA7.
REFERENCE   2  (bases 1 to 6470)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC135592.2.
            
            On Nov 20, 2020 this sequence version replaced NM_001145176.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DY654896.1, DY654596.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376325.10/ ENSP00000365503.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1108              AC135592.2         34408-35515         c
            1109-1263           AC135592.2         32826-32980         c
            1264-1413           AC135592.2         29820-29969         c
            1414-6470           AC135592.2         20955-26011         c
FEATURES             Location/Qualifiers
     source          1..6470
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..6470
                     /gene="SHISA7"
                     /gene_synonym="CKAMP59"
                     /note="shisa family member 7"
                     /db_xref="GeneID:729956"
                     /db_xref="HGNC:HGNC:35409"
                     /db_xref="MIM:617328"
     exon            1..1108
                     /gene="SHISA7"
                     /gene_synonym="CKAMP59"
                     /inference="alignment:Splign:2.1.0"
     CDS             438..2054
                     /gene="SHISA7"
                     /gene_synonym="CKAMP59"
                     /note="protein shisa-7; UPF0626 protein A; shisa homolog
                     7; GABA(A) receptor auxiliary subunit Shisa7; cystine-knot
                     AMPAR modulating protein of 59 kDa"
                     /codon_start=1
                     /product="protein shisa-7 precursor"
                     /protein_id="NP_001138648.1"
                     /db_xref="CCDS:CCDS46193.1"
                     /db_xref="GeneID:729956"
                     /db_xref="HGNC:HGNC:35409"
                     /db_xref="MIM:617328"
                     /translation="MPALLLLVLLASSAGQARARPSNATSAEPAGPLPALLAHLRRLT
                     GALTGGGGAASPGANGTRTGPAGGAGAAARAPPPAELCHGYYDVMGQYDATFNCSTGS
                     YRFCCGTCHYRFCCEHRHMRLAQASCSNYDTPRWATTPPPLAGGAGGAGGAGGGPGPG
                     QAGWLEGGRTGGAGGRGGEGPGGSTAYVVCGVISFALAVGVGAKVAFSKASRAPRAHR
                     DINVPRALVDILRHQAGPGTRPDRARSSSLTPGIGGPDSMPPRTPKNLYNTVKTPNLD
                     WRALPPPSPSLHYSTLSCSRSFHNLSHLPPSYEAAVKSELNRYSSLKRLAEKDLDEAY
                     LKRRPLELPRGTLPLHALRRPGTGGGYRMEAWGGPEELGLAPAPNPRRVMSQEHLLGD
                     GGRSRYEFTLPRARLVSQEHLLLSSPEALRQSREHLLSPPRSPALPPDPTARASLAAS
                     HSNLLLGPGGPPTPLRGLPPPSSLHAHHHHALHGSPQPAWMSDAGGGGGTLARRPPFQ
                     RQGTLEQLQFIPGHHLPQHLRTASKNEVTV"
     exon            1109..1263
                     /gene="SHISA7"
                     /gene_synonym="CKAMP59"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1413
                     /gene="SHISA7"
                     /gene_synonym="CKAMP59"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..6470
                     /gene="SHISA7"
                     /gene_synonym="CKAMP59"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6450..6455
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SHISA7"
                     /gene_synonym="CKAMP59"
                     /note="hexamer: AATAAA"
     polyA_site      6470
                     /gene="SHISA7"
                     /gene_synonym="CKAMP59"
                     /note="major polyA site"
ORIGIN      
        1 gccgcccccg tttcttctcc ttacatcgcg cctcgcctcg ctcctcgtcc taatgtctgc
       61 acacccctct ggtgtctgtc gaccctccca atcgcttctc ccgcattcat ctctcgcctg
      121 atcccggttc tgtccgccca tgctcatttc tctcccccag ccgtgcccgg gcgcgtttcc
      181 attactctcc catcgtcgcc caccgcgcgt ggggcggcca acttgggccc acgcagctca
      241 gctccctccg cccttcctgc ctcctggcgc ctgttgctcc ccacactctg ccgccccccg
      301 cccgccctcc ccagcctctc tgcccaccca tctctacgtt tctcaccctc tgaccgtttc
      361 tctcccgccc agcgctccaa cctctgctct cgttctcccc gcagcctggc ggcccagtgc
      421 gaccccctgc aagccccatg ccggccctcc tgctcctcgt actcctggcc tctagcgccg
      481 gccaggccag ggcgcgcccg tccaacgcca cgagcgccga gcccgcgggc ccgctgcccg
      541 ccctgctggc gcacctgcgg cgcctgaccg gggcgctgac gggcggcggg ggcgcggcga
      601 gcccaggcgc caacggcacc aggaccggcc ccgcgggcgg ggcgggcgcg gcggcccggg
      661 cgccccctcc cgccgagctc tgccacggct actacgatgt catgggccag tacgacgcca
      721 ccttcaactg cagcaccggc tcctaccgct tctgctgtgg cacctgccac taccgcttct
      781 gctgtgagca ccgtcacatg cgcctggcgc aggcctcctg ctccaactac gacacgccgc
      841 gctgggccac cacgccgccg ccgctagctg ggggcgccgg gggcgctggg ggtgcgggcg
      901 gggggccagg gcccggccag gccgggtggt tggaaggggg ccggactggg ggtgccgggg
      961 gccgcggggg cgagggcccc gggggcagca cagcctacgt cgtgtgcggg gtcatcagct
     1021 tcgccctggc cgtgggcgtc ggcgccaaag tggccttcag caaggcgtcc cgtgcgcccc
     1081 gggcgcaccg ggatatcaac gtgcccagag ctctggtgga cattctgaga catcaggcgg
     1141 ggcctgggac ccgcccggac cgggcccgaa gcagctccct gaccccgggg atcggcggtc
     1201 ccgacagcat gccccccagg acgcccaaga acctctacaa caccgtgaag acccccaacc
     1261 tcgactggcg agccttgccg ccgcccagcc cctccttgca ctactccacg ctgtcctgct
     1321 ctcggtcctt ccacaacctc tcgcatctgc ccccgtccta cgaggctgcc gtgaaatccg
     1381 agctgaaccg ctactcttcc ctcaagaggc tggccgagaa ggatctggac gaggcctacc
     1441 tgaagcgccg gcccctggaa ttgccccgcg gcacgctgcc cctgcacgcg ctgcggcggc
     1501 cgggcacggg gggcggctat cgcatggagg cctggggcgg cccagaggag ctgggcctgg
     1561 cgcccgcgcc caacccccgg cgggtcatgt cccaggagca cctgctgggc gatggtggcc
     1621 gttcgcgcta cgagttcacg ctgccgcgcg cgcgcctggt gtcgcaggag cacctgctgc
     1681 tgtcctcgcc cgaggccctg cgccagagtc gcgagcacct gctgtcgccc ccgcgcagcc
     1741 ccgcgctgcc ccccgacccc accgcccggg ccagcctggc cgcctcgcac tccaacctgc
     1801 tgctggggcc cggggggccc ccaacaccgc tgcgcgggct gccgccaccg tccagcctgc
     1861 acgcccacca ccaccacgcc ctgcacggct cgccgcagcc ggcctggatg tccgacgccg
     1921 gcgggggcgg gggcacactg gcccgcaggc cgcccttcca gcgccagggc acgctggagc
     1981 agctgcagtt catcccgggc caccacctgc cccagcacct gcgcacggcc agcaagaacg
     2041 aggtgactgt ctgaggccag ggccgggtct ggggggctgc ggcctcccgg gccccccgtc
     2101 ccagcctgga tcccccgaca caggcgcaca catgccaggg gcctggggcc cagatcggcc
     2161 cttggacagg agtgaaagcc tccttctggg atgtcctggc agacaagatt cctcctccta
     2221 ttacttcact gcttgagcca aggcctcctt cccatgatgt catcccagag gaagaggccg
     2281 gctcatgagg tcatcactag caaaaatgtc tgtgttctgt gatgtcatca cagggacaaa
     2341 gcctcgttcc catgaggtca tcacagagga agaggccggc ccgtgaggtc agcgctggag
     2401 gccatgtcca tgttctatgg tgtcctcaga ggcttccttc ttgtggtata ataacagaga
     2461 cgacgccttg ttccatgaca ttccttcctg tggtgtcact gcagagacaa tctcacctgg
     2521 atgatgtcat ctctaactcc aaggcctctt ttggcatcat cgccatgggg aagatatttt
     2581 ctccctgtgt ctttgcagca gagaagatgc ctctgtccta tgatgtcatc attacagaca
     2641 aagccatctt cctgggacac gtcgcagggg aaaatgcctc accgattgtg tcctcactag
     2701 acataaggtc cccttttcac aacatcatca cagggaccct gcctccttcc tgtgatgcca
     2761 tcaccagaga aggtgccttg ccctatgacg tcatcagagg gaccgtgcct cttcctgtga
     2821 tgtcatcacc agagatgacc acccactctg ggacctctcc aggaggaggt cccttctgtg
     2881 atgtcgccca gatgctatgt gctctgagat ggcacaaaga gatgcctcca ctgctgccac
     2941 catgttgtag aaggcagggc aggcccagag tccaggacca ccccagggaa gatgccagag
     3001 agcagagagg ggccctgtcc tgagatgttg tctgaaggaa gcatcgctgg ggagccgccc
     3061 atgtggaggg cctcctccag agatgatggt ctgtgtaggc tgttggcagt gacaccccta
     3121 cccccaatgc tgtgatggca tcaccagagc ttcctcctca gaggcactgc ccactctgga
     3181 aggccatcgg tattggtggt gtcaccagag ttactgcctt gtcccaccat gacttagctt
     3241 ggttgctccc tccccagact ccagggacat gtccagcagg atctctgcca gaccctctga
     3301 ggggaaatgg ggccttggat cccacatctg tgccatgact cctgggagac aggacctcca
     3361 gatggccttc tgctcccagg aggccactct ggatcaccag gatcctggag ttctggcact
     3421 cataggtgtc ccatagcctg gcctcacttt tctttctgcc atatctagag acaatcacct
     3481 ctgtcaacaa agtcctagcc ttctactggg gggaggtgct tggggtacac ctactcttgc
     3541 cctcactgac actgtcagca tcacacaaca cccgccactc atgatggcac cacacccggg
     3601 gtcaagtgtt acccatgtct gaggatggaa tccttcccca ggattaccta tgacccacaa
     3661 ctatggtatc atcttcttcc aggatttacc atgactaatg gtgtcaccat ctgccaagac
     3721 tccccatagc caatggtgtc accatcctcc atgattcctc acaaccatgg tgtcatcatc
     3781 tttcaggagc caccacagct gacggtgtca tcatctccta gattccacca tgaccagtga
     3841 tgacattacc ttccagaatc cactacacct gacagagaca tcctctactg aaatccacta
     3901 ggactgatga ttccaccatt tcccataatc cctcatgatt ttggtgtcat cacctcccaa
     3961 gacccatgat gcccaatagt gtcatcatca tttgcaggga tgcatggtgt catcatctcc
     4021 agggatccac ttcaaccatg tgccaccacc tcccaggatt tcattcaaac atgtgccact
     4081 acctcccagt atccacttca actatggtgt tatcacctgc caggatccac gagagccaat
     4141 gctgtcacca tccactagga tccaccataa ccctggtgtc atcatctcct gtgatccatg
     4201 aggtccagtg ctgtcaccat ccactaggat ccaccatgac cctggtgtca tcatctcctg
     4261 tgatccatga ggtccagtgc tgtcaccatc cactaggatc caccataacc ctggtgtcat
     4321 catctcccag gatccatgag gtccagtgct gtctgtcacc atccactagt atccaccata
     4381 accctggtgt catcttctcc caggatccat gaggtccagt gctgtcacca tccactagga
     4441 tccgccataa ccctggtgtc atcatccgtg atccatgagg tccagtgctg tcaccatcca
     4501 ctaggatcca ccataaccct ggtgtcatca tctcccagga tccatgaggt ccagtgttgt
     4561 caccatctac taggatccac catgaccctg gtgttatcat ctcccaggat ccatgaggtc
     4621 cagtgttgtc accatctatt aggatccacc atgaccctgg tgttatcatc tcccaggatc
     4681 catgaggtcc agtgctgtca ccacccacta ggatccacca taaccctggt gtcatcccag
     4741 agtccactgc aaccatgtgc catcatcccc caagagccat catcttagga gccaagtacc
     4801 gtgacgggct gtatttcagt tgtcctctgg ggccgcatgg tacttacagt tgttcactta
     4861 aggggaacca gcacaacagg ccatattccc gtttccacta aaaggacagg ggtggggcca
     4921 gctgtccccc tctgaagact tcacccctac tctggccctc cttatgtcac tgcctcactc
     4981 ctgaccgagg atgatgcctg catcaatccc accacagatg tggcctcagc caacctcacc
     5041 ttaccccccg gtgaggcacc caggcccctc ctgacagcag cgctgtccct cacccagcca
     5101 tctgattggt gacagggtca acccagcaac ctctcattat caccagagag gaagcatttc
     5161 aaccctcagg tgacgccact gccccctgcc caatccctgt cacttgggcc cctaccagga
     5221 tcagcactcc actggccccg gccaaattct cctcagagat ccctgacccc cgcgggatag
     5281 gtcaaagctg gtgaccgact ggggccttca gtgctgtctt ctgctggcct catcctgcag
     5341 cagggacact ggagagcaat ggtccctgcc agcacatctg cgggaccagg ggtgctcctt
     5401 cacctccctc cctaacacct taacacccgg ggagcctccg ggggtggcag gaagtcccca
     5461 gcacccaatg cacaatcttc cctcaattct ctttgtacat agccatgttg cgggggcggc
     5521 cattccccca ctcttaaagg gctacacgcc cctcccccag cccctagggc gaggtggggg
     5581 gggcctcttc ttcctcccct gggccgtccc cctccctctt atgtctcccc gcaaacactg
     5641 gcacctcaca ctccttcttg tcaggagctt ggggcagaca actggccctt ggttcccacc
     5701 acactgagga aatgggggtt acccaaatcc acctgggccc tggtgccagt ttttcaaccc
     5761 cacggcttct agctgctctg aggggctcct cccatccctt ccagggcctc cccagccccg
     5821 cactgctcag gccaactgtg acttccccag aaaggagcca gcttgagcac ccaccccctc
     5881 ccagccccct cccctctgct caacacctcc gcggaacact cagctttctc cagctgccgg
     5941 gatttggggg tctgggcctt tcagcttttt tatcccccct ccactagctc tagcccagcc
     6001 tggattccag ggatcccacc cctagccctg tccctattca gttggcacag gctgcctgac
     6061 cctggggcct tgatttgatc tcaaataagc catagaggag agaggtcttg aggggtggga
     6121 gcaggtgtgt actgacaatt cccctccaca tgtcttgagc tgggacctcg tcatctgaga
     6181 cttccccatg ccccaacaaa tgcaaatgca cacaaaccca tgcatacaca agcacacaca
     6241 cacaggcatc tccccgtctg gttgggggag catgggaggg ggcacttcac agggagaaga
     6301 taaatagttc cacacctgaa gaccctccaa cagcttctgc ctccctcctc atcacttcct
     6361 ctctccaccc cctctccaac actggcccct tcccctaatt aattccctgg tgaggacagc
     6421 cagaggagct gcgacttggt attttttgga ataaatagac attttcctga
//
