LOCUS       NM_016479               2034 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens shisa family member 5 (SHISA5), transcript variant 1,
            mRNA.
ACCESSION   NM_016479
VERSION     NM_016479.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2034)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2034)
  AUTHORS   Kim,N., Kim,M.J., Sung,P.S., Bae,Y.C., Shin,E.C. and Yoo,J.Y.
  TITLE     Interferon-inducible protein SCOTIN interferes with HCV replication
            through the autolysosomal degradation of NS5A
  JOURNAL   Nat Commun 7, 10631 (2016)
   PUBMED   26868272
  REMARK    GeneRIF: IFN-beta-induced SCOTIN recruits the HCV NS5A protein to
            autophagosomes for degradation, thereby restricting HCV
            replication.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2034)
  AUTHORS   So,H.C., Fong,P.Y., Chen,R.Y., Hui,T.C., Ng,M.Y., Cherny,S.S.,
            Mak,W.W., Cheung,E.F., Chan,R.C., Chen,E.Y., Li,T. and Sham,P.C.
  TITLE     Identification of neuroglycan C and interacting partners as
            potential susceptibility genes for schizophrenia in a Southern
            Chinese population
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 153B (1), 103-113 (2010)
   PUBMED   19367581
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   4  (bases 1 to 2034)
  AUTHORS   Draeby,I., Woods,Y.L., la Cour,J.M., Mollerup,J., Bourdon,J.C. and
            Berchtold,M.W.
  TITLE     The calcium binding protein ALG-2 binds and stabilizes Scotin, a
            p53-inducible gene product localized at the endoplasmic reticulum
            membrane
  JOURNAL   Arch Biochem Biophys 467 (1), 87-94 (2007)
   PUBMED   17889823
  REMARK    GeneRIF: ALG-2 binding to Scotin is strictly calcium dependent,
            indicating a role of this interaction in calcium signaling pathways
REFERENCE   5  (bases 1 to 2034)
  AUTHORS   Ludes-Meyers,J.H., Kil,H., Bednarek,A.K., Drake,J., Bedford,M.T.
            and Aldaz,C.M.
  TITLE     WWOX binds the specific proline-rich ligand PPXY: identification of
            candidate interacting proteins
  JOURNAL   Oncogene 23 (29), 5049-5055 (2004)
   PUBMED   15064722
REFERENCE   6  (bases 1 to 2034)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
REFERENCE   7  (bases 1 to 2034)
  AUTHORS   Bourdon,J.C., Renzing,J., Robertson,P.L., Fernandes,K.N. and
            Lane,D.P.
  TITLE     Scotin, a novel p53-inducible proapoptotic protein located in the
            ER and the nuclear membrane
  JOURNAL   J Cell Biol 158 (2), 235-246 (2002)
   PUBMED   12135983
  REMARK    GeneRIF: Scotin plays a role in p53-dependent apoptosis
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC134772.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 19, 2020 this sequence version replaced NM_016479.5.
            
            Summary: This gene encodes a member of the shisa family. The
            encoded protein is localized to the endoplasmic reticulum, and
            together with p53 induces apoptosis in a caspase-dependent manner.
            Alternative splicing results in multiple transcript variants.
            Related pseudogenes of this gene are found on chromosome X.
            [provided by RefSeq, Apr 2016].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF520698.1, AK075441.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296444.7/ ENSP00000296444.2
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               AC134772.2         117697-117852       c
            157-313             AC134772.2         114815-114971       c
            314-394             AC134772.2         92855-92935         c
            395-510             AC134772.2         83406-83521         c
            511-723             AC134772.2         83039-83251         c
            724-2034            AC134772.2         81554-82864         c
FEATURES             Location/Qualifiers
     source          1..2034
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..2034
                     /gene="SHISA5"
                     /gene_synonym="SCOTIN"
                     /note="shisa family member 5"
                     /db_xref="GeneID:51246"
                     /db_xref="HGNC:HGNC:30376"
                     /db_xref="MIM:607290"
     exon            1..156
                     /gene="SHISA5"
                     /gene_synonym="SCOTIN"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..803
                     /gene="SHISA5"
                     /gene_synonym="SCOTIN"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; putative NF-kappa-B-activating protein 120;
                     shisa homolog 5"
                     /codon_start=1
                     /product="protein shisa-5 isoform a precursor"
                     /protein_id="NP_057563.3"
                     /db_xref="CCDS:CCDS2770.1"
                     /db_xref="GeneID:51246"
                     /db_xref="HGNC:HGNC:30376"
                     /db_xref="MIM:607290"
                     /translation="MTAPVPAPRILLPLLLLLLLTPPPGARGEVCMASRGLSLFPESC
                     PDFCCGTCDDQYCCSDVLKKFVWSEERCAVPEASVPASVEPVEQLGSALRFRPGYNDP
                     MSGFGATLAVGLTIFVLSVVTIIICFTCSCCCLYKTCRRPRPVVTTTTSTTVVHAPYP
                     QPPSVPPSYPGPSYQGYHTMPPQPGMPAAPYPMQYPPPYPAQPMGPPAYHETLAGGAA
                     APYPASQPPYNPAYMDAPKAAL"
     exon            157..313
                     /gene="SHISA5"
                     /gene_synonym="SCOTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            314..394
                     /gene="SHISA5"
                     /gene_synonym="SCOTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            395..510
                     /gene="SHISA5"
                     /gene_synonym="SCOTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            511..723
                     /gene="SHISA5"
                     /gene_synonym="SCOTIN"
                     /inference="alignment:Splign:2.1.0"
     exon            724..2034
                     /gene="SHISA5"
                     /gene_synonym="SCOTIN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2015..2020
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SHISA5"
                     /gene_synonym="SCOTIN"
                     /note="hexamer: AATAAA"
     polyA_site      2034
                     /gene="SHISA5"
                     /gene_synonym="SCOTIN"
                     /note="major polyA site"
ORIGIN      
        1 gggcggccgc gcggatcact gaggctgtgg cggcactgcg cccggcgctc gcgtccgtcc
       61 gcccgtccgc ccgcccagcc atgactgcgc cggtccccgc gccgcggatc ctgttgccgt
      121 tgctgttgct gctgctgcta acgccgcctc cgggtgcacg tggtgaggtg tgtatggctt
      181 cccgtggact cagcctcttc cccgagtcct gtccagattt ctgctgtggt acctgtgatg
      241 accaatactg ctgctctgac gtgctgaaga aatttgtgtg gagcgaggaa aggtgtgctg
      301 tgcctgaggc cagcgtgcct gccagtgtag agccggtgga gcagctgggc tcggcgctga
      361 ggtttcgccc tggctacaac gaccccatgt cagggttcgg agcgaccttg gccgttggcc
      421 tgaccatctt tgtgctgtct gtcgtcacta tcatcatctg cttcacctgc tcctgctgct
      481 gcctttacaa gacgtgccgc cgaccacgtc cggttgtcac caccaccaca tccaccactg
      541 tggtgcatgc cccttatcct cagcctccaa gtgtgccgcc cagctaccct ggaccaagct
      601 accagggcta ccacaccatg ccgcctcagc cagggatgcc agcagcaccc tacccaatgc
      661 agtacccacc accttaccca gcccagccca tgggcccacc ggcctaccac gagaccctgg
      721 ctggaggagc agccgcgccc taccccgcca gccagcctcc ttacaacccg gcctacatgg
      781 atgccccgaa ggcggccctc tgagcattcc ctggcctctc tggctgccac ttggttatgt
      841 tgtgtgtgtg cgtgagtggt gtgcaggcgc ggttccttac gccccatgtg tgctgtgtgt
      901 gtccaggcac ggttccttac gccccatgtg tgctgtgtgt gtcctgcctg tatatgtggc
      961 ttcctctgat gctgacaagg tggggaacaa tccttgccag agtgggctgg gaccagactt
     1021 tgttctcttc ctcacctgaa attatgcttc ctaaaatctc aagccaaact caaagaatgg
     1081 ggtggtgggg ggcaccctgt gaggtggccc ctgagaggtg ggggcctctc cagggcacat
     1141 ctggagttct tctccagctt accctagggt gaccaagtag ggcctgtcac accagggtgg
     1201 cgcagctttc tgtgtgatgc agatgtgtcc tggtttcggc agcgtagcca gctgctgctt
     1261 gaggccatgg ctcgtccccg gagttggggg tacccgttgc agagccaggg acatgatgca
     1321 ggcgaagctt gggatctggc caagttggac tttgatcctt tgggcagatg tcccattgct
     1381 ccctggagcc tgtcatgcct gttggggatc aggcagcctc ctgatgccag aacacctcag
     1441 gcagagccct actcagctgt acctgtctgc ctggactgtc ccctgtcccc gcatctcccc
     1501 tgggaccagc tggagggcca catgcacaca cagcctagct gcccccaggg agctctgctg
     1561 cccttgctgg ccctgccctt cccacaggtg agcagggctc ctgtccacca gcacactcag
     1621 ttctcttccc tgcagtgttt tcattttatt ttagccaaac attttgcctg ttttctgttt
     1681 caaacatgat agttgatatg agactgaaac ccctgggttg tggagggaaa ttggctcaga
     1741 gatggacaac ctggcaactg tgagtccctg cttcccgaca ccagcctcat ggaatatgca
     1801 acaactcctg taccccagtc cacggtgttc tggcagcagg gacacctggg ccaatgggcc
     1861 atctggacca aaggtggggt gtggggccct ggatggcagc tctggcccag acatgaatac
     1921 ctcgtgttcc tcctccctct attactgttt caccagagct gtcttagctc aaatctgttg
     1981 tgtttctgag tctagggtct gtacacttgt ttataataaa tgcaatcgtt tgga
//
