LOCUS       NM_198149               1432 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens shisa family member 4 (SHISA4), transcript variant 1,
            mRNA.
ACCESSION   NM_198149 XM_086502
VERSION     NM_198149.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1432)
  AUTHORS   Fekete,J.T. and Gyorffy,B.
  TITLE     New Transcriptomic Biomarkers of 5-Fluorouracil Resistance
  JOURNAL   Int J Mol Sci 24 (2), 1508 (2023)
   PUBMED   36675023
  REMARK    GeneRIF: New Transcriptomic Biomarkers of 5-Fluorouracil
            Resistance.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1432)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1432)
  AUTHORS   Furushima,K., Yamamoto,A., Nagano,T., Shibata,M., Miyachi,H.,
            Abe,T., Ohshima,N., Kiyonari,H. and Aizawa,S.
  TITLE     Mouse homologues of Shisa antagonistic to Wnt and Fgf signalings
  JOURNAL   Dev Biol 306 (2), 480-492 (2007)
   PUBMED   17481602
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC111855.1 and AK294106.1.
            
            On Nov 30, 2019 this sequence version replaced NM_198149.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the functional protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK294106.1, CN310958.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000362011.7/ ENSP00000355064.7
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1147              BC111855.1         210-1356
            1148-1432           AK294106.1         1125-1409
FEATURES             Location/Qualifiers
     source          1..1432
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..1432
                     /gene="SHISA4"
                     /gene_synonym="C1orf40; TMEM58"
                     /note="shisa family member 4"
                     /db_xref="GeneID:149345"
                     /db_xref="HGNC:HGNC:27139"
                     /db_xref="MIM:617326"
     exon            1..170
                     /gene="SHISA4"
                     /gene_synonym="C1orf40; TMEM58"
                     /inference="alignment:Splign:2.1.0"
     CDS             98..691
                     /gene="SHISA4"
                     /gene_synonym="C1orf40; TMEM58"
                     /note="transmembrane protein 58; protein shisa-4; shisa
                     homolog 4"
                     /codon_start=1
                     /product="protein shisa-4 precursor"
                     /protein_id="NP_937792.2"
                     /db_xref="CCDS:CCDS1416.1"
                     /db_xref="GeneID:149345"
                     /db_xref="HGNC:HGNC:27139"
                     /db_xref="MIM:617326"
                     /translation="MPPAGLRRAAPLTAIALLVLGAPLVLAGEDCLWYLDRNGSWHPG
                     FNCEFFTFCCGTCYHRYCCRDLTLLITERQQKHCLAFSPKTIAGIASAVILFVAVVAT
                     TICCFLCSCCYLYRRRQQLQSPFEGQEIPMTGIPVQPVYPYPQDPKAGPAPPQPGFIY
                     PPSGPAPQYPLYPAGPPVYNPAAPPPYMPPQPSYPGA"
     exon            171..342
                     /gene="SHISA4"
                     /gene_synonym="C1orf40; TMEM58"
                     /inference="alignment:Splign:2.1.0"
     exon            343..476
                     /gene="SHISA4"
                     /gene_synonym="C1orf40; TMEM58"
                     /inference="alignment:Splign:2.1.0"
     exon            477..644
                     /gene="SHISA4"
                     /gene_synonym="C1orf40; TMEM58"
                     /inference="alignment:Splign:2.1.0"
     exon            645..1432
                     /gene="SHISA4"
                     /gene_synonym="C1orf40; TMEM58"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1127..1132
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SHISA4"
                     /gene_synonym="C1orf40; TMEM58"
                     /note="hexamer: ATTAAA"
     polyA_site      1151
                     /gene="SHISA4"
                     /gene_synonym="C1orf40; TMEM58"
                     /note="major polyA site"
ORIGIN      
        1 ggccgcgggc tgggccccgc cgcagctcca gctggccggc ttggtcctgc ggtcccttct
       61 ctgggaggcc cgaccccggc cgcgcccagc ccccaccatg ccacccgcgg ggctccgccg
      121 ggccgcgccg ctcaccgcaa tcgctctgtt ggtgctgggg gctcccctgg tgctggccgg
      181 cgaggactgc ctgtggtacc tggaccggaa tggctcctgg catccggggt ttaactgcga
      241 gttcttcacc ttctgctgcg ggacctgcta ccatcggtac tgctgcaggg acctgacctt
      301 gcttatcacc gagaggcagc agaagcactg cctggccttc agccccaaga ccatagcagg
      361 catcgcctca gctgtgatcc tctttgttgc tgtggttgcc accaccatct gctgcttcct
      421 ctgttcctgt tgctacctgt accgccggcg ccagcagctc cagagcccat ttgaaggcca
      481 ggagattcca atgacaggca tcccagtgca gccagtatac ccataccccc aggaccccaa
      541 agctggccct gcacccccac agcctggctt catataccca cctagtggtc ctgctcccca
      601 atatccactc tacccagctg ggcccccagt ctacaaccct gcagctcctc ctccctatat
      661 gccaccacag ccctcttacc cgggagcctg aggaaccagc catgtctctg ctgccccttc
      721 agtgatgcca accttgggag atgccctcat cctgtacctg catctggtcc tgggggtggc
      781 aggagtcctc cagccaccag gccccagacc aagccaagcc ctgggcccta ctggggacag
      841 agccccaggg aagtggaaca ggagctgaac tagaactatg aggggttggg gggagggctt
      901 ggaattatgg gctattttta ctgggggcaa gggagggaga tgacagcctg ggtcacagtg
      961 cctgttttca aatagtccct ctgctcccaa gatcccagcc aggaaggctg gggccctact
     1021 gtttgtcccc tctgggctgg ggtgggggga gggaggaggt tccgtcagca gctggcagta
     1081 gccctcctct ctggctgccc cactggccac atctctggcc tgctagatta aagctgtaaa
     1141 gacataactc atatcagtcg catcattgga cccatccaca ccttccagga acaccgcctt
     1201 cagctgggcc cagactgttg cccactccat attccaaaag taggggaggg ccagcaccag
     1261 catcggagca cagcaccatc ctcaccccca tccacaagca gaccaaggcg gactgttcct
     1321 ggcttcctaa aggcttccta aagacaatga ggtgaatttt gccacagctc tgaagagatg
     1381 ctcgtttgca ctacagatat tccctgctag ggatcaacag ctctacaaca gc
//
