LOCUS       NM_001080505            2322 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens shisa family member 3 (SHISA3), mRNA.
ACCESSION   NM_001080505 XM_496688
VERSION     NM_001080505.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2322)
  AUTHORS   Shahzad,N., Munir,T., Javed,M., Tasneem,F., Aslam,B., Ali,M.,
            Mutahir,Z., Akhtar Ali,M., Umer,M., Ahmad,M., Farooq,K., Hassan,U.,
            Mustafa,T., Anjum,R.S. and Shakoori,A.R.
  TITLE     SHISA3, an antagonist of the Wnt/beta-catenin signaling, is
            epigenetically silenced and its ectopic expression suppresses
            growth in breast cancer
  JOURNAL   PLoS One 15 (7), e0236192 (2020)
   PUBMED   32692756
  REMARK    GeneRIF: SHISA3, an antagonist of the Wnt/beta-catenin signaling,
            is epigenetically silenced and its ectopic expression suppresses
            growth in breast cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2322)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2322)
  AUTHORS   Si,J., Ma,Y., Bi,J.W., Xiong,Y., Lv,C., Li,S., Wu,N. and Yang,Y.
  TITLE     Shisa3 brakes resistance to EGFR-TKIs in lung adenocarcinoma by
            suppressing cancer stem cell properties
  JOURNAL   J Exp Clin Cancer Res 38 (1), 481 (2019)
   PUBMED   31801598
  REMARK    GeneRIF: For TKI-resistant PC9/ER tumors in nod-scid mice,
            overexpressed shisa3 had a significant inhibitory effect. In
            addition, we verified that shisa3 inhibited EGFR-TKI resistance by
            interacting with FGFR1/3 to regulate AKT/mTOR signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2322)
  AUTHORS   Zhang,J., Li,Y.Q., Guo,R., Wang,Y.Q., Zhang,P.P., Tang,X.R.,
            Wen,X., Hong,X.H., Lei,Y., He,Q.M., Yang,X.J., Sun,Y., Ma,J. and
            Liu,N.
  TITLE     Hypermethylation of SHISA3 Promotes Nasopharyngeal Carcinoma
            Metastasis by Reducing SGSM1 Stability
  JOURNAL   Cancer Res 79 (4), 747-759 (2019)
   PUBMED   30573520
  REMARK    GeneRIF: Low Shisa3 expression is associated with Nasopharyngeal
            Carcinoma Metastasis.
REFERENCE   5  (bases 1 to 2322)
  AUTHORS   Shen,Z., Zhou,C., Li,J., Ye,D., Deng,H., Cao,B., Hao,W., Lin,L. and
            Zhang,Y.
  TITLE     SHISA3 Promoter Methylation Is a Potential Diagnostic and
            Prognostic Biomarker for Laryngeal Squamous Cell Carcinoma
  JOURNAL   Biomed Res Int 2017, 9058749 (2017)
   PUBMED   28299336
  REMARK    GeneRIF: SHISA3 promoter hypermethylation might increase the risk
            of LSCC through regulation of gene expression and is a potential
            diagnostic and prognostic biomarker for laryngeal squamous cell
            carcinoma
REFERENCE   6  (bases 1 to 2322)
  AUTHORS   Tsai,M.H., Chen,W.C., Yu,S.L., Chen,C.C., Jao,T.M., Huang,C.Y.,
            Tzeng,S.T., Yen,S.J. and Yang,Y.C.
  TITLE     DNA Hypermethylation of SHISA3 in Colorectal Cancer: An Independent
            Predictor of Poor Prognosis
  JOURNAL   Ann Surg Oncol 22 Suppl 3, S1481-S1489 (2015)
   PUBMED   25968618
  REMARK    GeneRIF: Down-regulation of SHISA3 expression was associated with
            colorectal cancer.
REFERENCE   7  (bases 1 to 2322)
  AUTHORS   Chen,C.C., Chen,H.Y., Su,K.Y., Hong,Q.S., Yan,B.S., Chen,C.H.,
            Pan,S.H., Chang,Y.L., Wang,C.J., Hung,P.F., Yuan,S., Chang,G.C.,
            Chen,J.J., Yang,P.C., Yang,Y.C. and Yu,S.L.
  TITLE     Shisa3 is associated with prolonged survival through promoting
            beta-catenin degradation in lung cancer
  JOURNAL   Am J Respir Crit Care Med 190 (4), 433-444 (2014)
   PUBMED   25036006
REFERENCE   8  (bases 1 to 2322)
  AUTHORS   Cruciat,C.M. and Niehrs,C.
  TITLE     Secreted and transmembrane wnt inhibitors and activators
  JOURNAL   Cold Spring Harb Perspect Biol 5 (3), a015081 (2013)
   PUBMED   23085770
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2322)
  AUTHORS   Pei,J. and Grishin,N.V.
  TITLE     Unexpected diversity in Shisa-like proteins suggests the importance
            of their roles as transmembrane adaptors
  JOURNAL   Cell Signal 24 (3), 758-769 (2012)
   PUBMED   22120523
REFERENCE   10 (bases 1 to 2322)
  AUTHORS   Furushima,K., Yamamoto,A., Nagano,T., Shibata,M., Miyachi,H.,
            Abe,T., Ohshima,N., Kiyonari,H. and Aizawa,S.
  TITLE     Mouse homologues of Shisa antagonistic to Wnt and Fgf signalings
  JOURNAL   Dev Biol 306 (2), 480-492 (2007)
   PUBMED   17481602
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC024022.6, AC084010.6 and
            AA131240.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001080505.2.
            
            Summary: This gene encodes a single-transmembrane protein which is
            one of nine members of a family of transmembrane adaptors that
            modulate both WNT and FGF signaling by blocking the maturation and
            transport of their receptors to the cell surface. Members of this
            family contain an N-terminal cysteine-rich domain with a distinct
            cysteine pattern, a single transmembrane domain, and a C-terminal
            proline-rich, low complexity region. The encoded protein acts as a
            tumor suppressor by accelerating beta-catenin degradation.
            [provided by RefSeq, Jul 2017].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.42257.1,
                                           SRR1163658.202574.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000319234.5/ ENSP00000326445.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-846               AC024022.6         180289-181134
            847-1789            AC024022.6         183813-184755
            1790-2321           AC084010.6         1-532
            2322-2322           AA131240.1         11-11               c
FEATURES             Location/Qualifiers
     source          1..2322
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p13"
     gene            1..2322
                     /gene="SHISA3"
                     /gene_synonym="hShisa3"
                     /note="shisa family member 3"
                     /db_xref="GeneID:152573"
                     /db_xref="HGNC:HGNC:25159"
                     /db_xref="MIM:617325"
     exon            1..846
                     /gene="SHISA3"
                     /gene_synonym="hShisa3"
                     /inference="alignment:Splign:2.1.0"
     CDS             570..1286
                     /gene="SHISA3"
                     /gene_synonym="hShisa3"
                     /note="protein shisa-3 homolog; shisa homolog 3"
                     /codon_start=1
                     /product="protein shisa-3 homolog precursor"
                     /protein_id="NP_001073974.1"
                     /db_xref="CCDS:CCDS33979.1"
                     /db_xref="GeneID:152573"
                     /db_xref="HGNC:HGNC:25159"
                     /db_xref="MIM:617325"
                     /translation="MRALLALCLLLGWLRWGPAGAQQSGEYCHGWVDVQGNYHEGFQC
                     PEDFDTLDATICCGSCALRYCCAAADARLEQGGCTNDRRELEHPGITAQPVYVPFLIV
                     GSIFIAFIILGSVVAIYCCTCLRPKEPSQQPIRFSLRSYQTETLPMILTSTSPRAPSR
                     QSSTATSSSSTGGSIRRFSFARAEPGCLVPSPPPPYTTSHSIHLAQPSGFLVSPQYFA
                     YPLQQEPPLPGKSCPDFSSS"
     exon            847..2322
                     /gene="SHISA3"
                     /gene_synonym="hShisa3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2292..2297
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SHISA3"
                     /gene_synonym="hShisa3"
                     /note="hexamer: AATAAA"
     polyA_site      2322
                     /gene="SHISA3"
                     /gene_synonym="hShisa3"
                     /note="major polyA site"
ORIGIN      
        1 agcaaccccg cggccgtttg tacttggccg cggcggagct gactcctgct cctgtgacag
       61 ataggggctg gggctgagcg gccgcctgtc tggggtactc gcacgtgggg aacaaattct
      121 tttcctccgg ctcctctcgg gacccggcga tcgccacagg ttgggactct gtgcggcgct
      181 ggagttggca gccccgggcg ctatggctcc cttgaggagt ggggagggag gtggccgggg
      241 ggttggcgcg cccctcgcgc ggggagcgct atgagccggg cgaagggcgg cagcgacagc
      301 cccagcaact gcctctgccg gcgcctcccg caggccctcg ccaactcgcc ccgcgcacca
      361 tgctgactcc cggcctgcgg aactcgtagt gcagcccctg tcgcctcccc ggcccctgct
      421 atcccacgca ggactggctt cggccgccgg ggccagcagc ttgcgacgtg tccctgggga
      481 ggcggaatcg ctgtgcgccc tgagcccggg ctcagccctt cgctttccag ctgcgtcctg
      541 ctcccggccg cccagggagc ccagtggcga tgagggcact gctggcgctt tgccttctcc
      601 ttggctggct gcgctggggc ccggcgggcg cccagcagtc cggagagtac tgccacggct
      661 gggtggacgt gcagggcaac taccacgagg gcttccagtg cccagaggac ttcgacacgc
      721 tggacgctac catctgctgc ggctcctgcg cgctccgcta ctgttgcgcc gcggccgacg
      781 ccaggctgga gcagggcggc tgcaccaacg accgccgcga actggagcac ccaggcatca
      841 ctgcgcagcc tgtctacgtc ccctttctca tcgtcggctc catcttcatt gcgttcatca
      901 tcctgggctc tgtagtggct atttattgtt gcacctgttt gagacccaag gagccctcgc
      961 agcagccaat ccgcttctca ctccgcagct atcagacaga gaccctgccc atgatcctga
     1021 cctccaccag ccccagggca ccctcccggc agtccagcac agccacgagc tccagctcca
     1081 caggcggctc catccgcagg ttctcctttg ccagggctga gccgggctgc ctggtgccct
     1141 caccgccccc gccatacacc accagccact caatccacct ggctcagcca tctggtttcc
     1201 tggtgtcacc ccagtatttc gcttaccccc tccagcagga gcccccactg cctgggaaga
     1261 gctgtccaga cttcagttcc agttgacacg cccaggccat gaatccacaa ctcagtcaga
     1321 tggcagacag gtggagccct gctcccattg ccacatgcaa ttctgagaaa atttcccttg
     1381 taactgatca gtgtcatgga ggagcatgct aggaaaacac agcaccttct aatttgaaag
     1441 ttcctgtctc caatcacaga aaggctaaac cagagaactg ttttctggtt ttgcaaacat
     1501 gtgatcatta catttcaatc tatgctactt ttattcaaaa tatgcagcag tttgacttta
     1561 aagttgcaaa ctggctaaaa acgttttact ggacattcag ctatattgct tagaaaaggg
     1621 ctacatgttt ctttttcata taagttgttc attgagttat gataggaata tattcataaa
     1681 taagcaaaga aaaataccta attgtaatta tcaaaggttc acttaaaaaa ttaactatta
     1741 ggtaaactta agggggcagt gaaaaatcta tttatgattt cgggagtaac ctaaccatga
     1801 ataatattag cataatgaga acatttactt tttaaataaa taactaaatt ttgtttacaa
     1861 tatgagtttt tccagaatac aaggtttcaa taatcacatg aggagtttaa agttttaaat
     1921 atatactcag acattcattg taacacagag tgtatgtaaa atcatttccc ccactcactg
     1981 gagggagtat ttattgcaga ctttttgttc agcaacattt agtgtttcag tgaaagttgg
     2041 acagttgggg cttaaaacat ttatttgtaa aatgagctat gttcaaatgt aaatatttgt
     2101 aatttaatgt atttaccaca ttgactgtac taattattta gtagtcatac tgtaattttt
     2161 atgttaataa taactggagt tcaaagtcta gctattggta taatcatcta atattatata
     2221 tatctccagt gcccctgaat tttatgtttg atgactatat atttgggcat atatcttgtt
     2281 ggattagaat aaataaaaca ctttatattt tcatgaactc ta
//
