LOCUS       NM_001007538            3845 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens shisa family member 2 (SHISA2), mRNA.
ACCESSION   NM_001007538 XM_370718
VERSION     NM_001007538.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3845)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3845)
  AUTHORS   Furushima,K., Yamamoto,A., Nagano,T., Shibata,M., Miyachi,H.,
            Abe,T., Ohshima,N., Kiyonari,H. and Aizawa,S.
  TITLE     Mouse homologues of Shisa antagonistic to Wnt and Fgf signalings
  JOURNAL   Dev Biol 306 (2), 480-492 (2007)
   PUBMED   17481602
REFERENCE   3  (bases 1 to 3845)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   4  (bases 1 to 3845)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL139004.11.
            
            On Dec 3, 2019 this sequence version replaced NM_001007538.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.1078198.1,
                                           SRR14038197.277066.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000319420.4/ ENSP00000313079.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1375              AL139004.11        28419-29793         c
            1376-3845           AL139004.11        22374-24843         c
FEATURES             Location/Qualifiers
     source          1..3845
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12.13"
     gene            1..3845
                     /gene="SHISA2"
                     /gene_synonym="bA398O19.2; C13orf13; hShisa; PRO28631;
                     TMEM46; WGAR9166"
                     /note="shisa family member 2"
                     /db_xref="GeneID:387914"
                     /db_xref="HGNC:HGNC:20366"
                     /db_xref="MIM:617324"
     exon            1..1375
                     /gene="SHISA2"
                     /gene_synonym="bA398O19.2; C13orf13; hShisa; PRO28631;
                     TMEM46; WGAR9166"
                     /inference="alignment:Splign:2.1.0"
     CDS             1042..1929
                     /gene="SHISA2"
                     /gene_synonym="bA398O19.2; C13orf13; hShisa; PRO28631;
                     TMEM46; WGAR9166"
                     /note="transmembrane protein 46; protein shisa-2 homolog;
                     shisa homolog 2"
                     /codon_start=1
                     /product="protein shisa-2 homolog precursor"
                     /protein_id="NP_001007539.1"
                     /db_xref="CCDS:CCDS31951.1"
                     /db_xref="GeneID:387914"
                     /db_xref="HGNC:HGNC:20366"
                     /db_xref="MIM:617324"
                     /translation="MWGARRSSVSSSWNAASLLQLLLAALLAAGARASGEYCHGWLDA
                     QGVWRIGFQCPERFDGGDATICCGSCALRYCCSSAEARLDQGGCDNDRQQGAGEPGRA
                     DKDGPDGSAVPIYVPFLIVGSVFVAFIILGSLVAACCCRCLRPKQDPQQSRAPGGNRL
                     METIPMIPSASTSRGSSSRQSSTAASSSSSANSGARAPPTRSQTNCCLPEGTMNNVYV
                     NMPTNFSVLNCQQATQIVPHQGQYLHPPYVGYTVQHDSVPMTAVPPFMDGLQPGYRQI
                     QSPFPHTNSEQKMYPAVTV"
     exon            1376..3845
                     /gene="SHISA2"
                     /gene_synonym="bA398O19.2; C13orf13; hShisa; PRO28631;
                     TMEM46; WGAR9166"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3824..3829
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SHISA2"
                     /gene_synonym="bA398O19.2; C13orf13; hShisa; PRO28631;
                     TMEM46; WGAR9166"
                     /note="hexamer: AATAAA"
     polyA_site      3845
                     /gene="SHISA2"
                     /gene_synonym="bA398O19.2; C13orf13; hShisa; PRO28631;
                     TMEM46; WGAR9166"
                     /note="major polyA site"
ORIGIN      
        1 ggagtcggag ctggtctggc gccgggcggg gcgaggcgag gctgtgggcg gctgctgcgc
       61 tcggcttctc ccgtagcccg gaggaaagaa acttccgtgg gaggcttcca tcggtgcgca
      121 cacctcccga gggcgaggca gcgaccggga gagggagagc cggccggagg ctgccgggct
      181 cctgtgggac cgcgctgcag ccggggaggc ggagaagggg aaccggggcg agccgcccgc
      241 ctggatccgc gcccagcagc agccgcggcc gccgccagct gggcaggctc ccgggactgc
      301 ggctgggggc gcgcaggacc ctcgcctgcg tcctggacgt tcccggggtc aggagcgctc
      361 cctcggcgac gtgctgggaa gattggccgt cggccccgcc gagtggagcg tcggggctgc
      421 acccccgtgg gctgcccggg cggcccggcc ggagccatgc ggaccaagtt cggggcagag
      481 gaggctgagc gcggccggct gcgtcacttg ctgcccagag ccttgcgtgc actgcccgcc
      541 ttcgcccctt ctacccgccc gaggagggaa taaaggaggg gagacgggcc ctgattcgcg
      601 cgcgggaccc tgaggcttaa accctgcgca gagccctggc tccaggtccg cggcggcgcg
      661 cccagcggtc attcggctcg agtgagcatc ccttcgggga tgctcaggga gggtccggtt
      721 gccagtgaaa cctccagagg cttccggacg acagccccgg gggccttctg actgcatccc
      781 gagatttcca tcagcgagtg caactcataa ggcagtccct aaggggaccg ggccaccggc
      841 tgaggacggg gatggcttag gagctcctgg acctagggcc cggcgtcgtc gcctcctggg
      901 cgtcgcggca gaggggagtg gcccgcgcgg aaagcgccgc gggacagtca gtgacgaggc
      961 ccgggggtcg ccggggccac gacttctcgg agaccgtcct gcgctctctg gagacgcgct
     1021 gtccgcgccc agggtggtgc catgtggggc gctcgccgct cgtccgtctc ctcatcctgg
     1081 aacgccgctt cgctcctgca gctgctgctg gctgcgctgc tggcggcggg ggcgagggcc
     1141 agcggcgagt actgccacgg ctggctggac gcgcagggcg tctggcgcat cggcttccag
     1201 tgtcccgagc gcttcgacgg cggcgacgcc accatctgct gcggcagctg cgcgttgcgc
     1261 tactgctgct ccagcgccga ggcgcgcctg gaccagggcg gctgcgacaa tgaccgccag
     1321 cagggcgctg gcgagcctgg ccgggcggac aaagacggcc ccgacggctc ggcagtgccc
     1381 atctacgtgc cgttcctcat tgttggctcc gtgtttgtcg cctttatcat cttggggtcc
     1441 ctggtggcag cctgttgctg cagatgtctc cggcctaagc aggatcccca gcagagccga
     1501 gccccagggg gtaaccgctt gatggagacc atccccatga tccccagtgc cagcacctcc
     1561 cgggggtcgt cctcacgcca gtccagcaca gctgccagtt ccagctccag cgccaactca
     1621 ggggcccggg cgcccccaac aaggtcacag accaactgtt gcttgccgga agggaccatg
     1681 aacaacgtgt atgtcaacat gcccacgaat ttctctgtgc tgaactgtca gcaggccacc
     1741 cagattgtgc cacatcaagg gcagtatctg catcccccat acgtggggta cacggtgcag
     1801 cacgactctg tgcccatgac agctgtgcca cctttcatgg acggcctgca gcctggctac
     1861 aggcagattc agtccccctt ccctcacacc aacagtgaac agaagatgta cccagcggtg
     1921 actgtataac cgagagtcac tggtgggttc ctttactgaa gggagacgaa ggcaggggtg
     1981 gattctcgag gtggaagtcc gcacatgtcg gtggtattta tggcacgatt cctttggatg
     2041 gcttcatttg cccccagact gtatgaaaac atctccgaat tagcatttct ggatatgttt
     2101 catccagggt atcattgatt tatgatggaa aaccggcctc agctggagat gactgtgatg
     2161 ttgctgatgg gtgtataaca aatgcttgag tccgaagtgc ccttgagata tggttgacga
     2221 aagaatttta taaactgata aattaaggat ttttattatg ttgttattat tatttctttt
     2281 ttgttgttga ctgcacagga tcaaaatgcc tgttatctcc cttttacctg ggactttttt
     2341 tttttttttt ttttttttta atcagacagg gtcttgctct gttgcccagg ctggagtgca
     2401 gtggtgcgat ctcggctcac tgcaacttca gcctcctgga ttcaggcaac actcctgcct
     2461 cagcctccca cgtggctggg attacaggtg cctgccccca tggctaattt tttgtatttt
     2521 ttgtagagat ggggtttcac catgttggct gggctggtct cactctcctg acctcaagca
     2581 atctgcctgt ctcagcctcc caaagtgctg ggattacagg cgtgagccac cgcccccagc
     2641 ctgagccttt ttttttttct aatgcatcca aggttaaggg gaagacgcaa ataacaggac
     2701 tattctaaaa ggaaacctgt ttgaactctg tgagatcagt catcagtctc agtattccac
     2761 aggcacacct taatttcatt gtaaaaagat atatatattt tgtctatttt tgtgcttttg
     2821 ggggcctatt ttgtgctttt ttaccttatg tagagatctt attacaaagt gattttctac
     2881 attaaaaaga gactgaaata aattgtatag ttacttaact aatgaagaca tttcagaact
     2941 ctgggatgat tttaatcttg aagtagtagg tggtatagtc ataaaaccat tcatcccctt
     3001 cttgattgta tcttaatttt ctggctttaa ggtgacatct gagaggtaat gcattctttt
     3061 ttatattgaa atcataaact atcacccgct gcttctctga gttactttta attttgcctt
     3121 gtggttatgg tttggcgttt ccttctgttt ggttttcaga gccccatgtc tatatagtcc
     3181 tgagtgcaag taattactat acttgtaaat gaagatcagt atttctgcct agatctgata
     3241 aaaaaatttt cttgtcttag ttataaaaat tcaaagaaat gtgttacaaa gatacttagt
     3301 atagctcctc agccataacc tgagacttgg gatgaaattt aaaccagata cgatttactt
     3361 tgcagatcat aaggcttttt atactcttgt tatcaaaatg gcttattttt caggcactaa
     3421 ggattgttaa gagaaaagct tttcaacgaa ggattgcctt tcttctccca cactgttctt
     3481 gatttcctct ctctttcagg cctcaacagg cactgtattc attgccaatg ttccaaatta
     3541 tcaaattcaa gtgaatttat ttgtgtgttc tttacttata taaaaaaaga taactttaag
     3601 gatgtgcaag tacatttcca actgctagca caaccagtat tttgtaatta aacaaatcgc
     3661 tgtatggtat ggtcttctac acatttatgt ctatagatat ctatcgatca tctttctatt
     3721 ctgtttcatg actgaataat gtaaaaccag tgttggcaat tggtatcatc aatgatactc
     3781 attttttaat aaccaaaggc aggggaaaat cattttactt attaataaat attttatgat
     3841 gtgaa
//
