LOCUS       XM_011516480            4607 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens sonic hedgehog signaling molecule (SHH),
            transcript variant X1, mRNA.
ACCESSION   XM_011516480
VERSION     XM_011516480.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000007.14) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_011516480.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4607
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
     gene            1..4607
                     /gene="SHH"
                     /gene_synonym="HHG1; HLP3; HPE3; MCOPCB5; ShhNC; SMMCI;
                     TPT; TPTPS"
                     /note="sonic hedgehog signaling molecule; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 1 mRNA, 1 EST, 72 long SRA reads, 1 Protein, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 1 sample with support for all
                     annotated introns"
                     /db_xref="GeneID:6469"
                     /db_xref="HGNC:HGNC:10848"
                     /db_xref="MIM:600725"
     CDS             560..1687
                     /gene="SHH"
                     /gene_synonym="HHG1; HLP3; HPE3; MCOPCB5; ShhNC; SMMCI;
                     TPT; TPTPS"
                     /codon_start=1
                     /product="sonic hedgehog protein isoform X1"
                     /protein_id="XP_011514782.1"
                     /db_xref="GeneID:6469"
                     /db_xref="HGNC:HGNC:10848"
                     /db_xref="MIM:600725"
                     /translation="MLSLFPSPGPGSSRCKDKLNALAISVMNQWPGVKLRVTEGWDED
                     GHHSEESLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAHIHCSVKAEN
                     SVAAKSGGCFPGSATVHLEQGGTKLVKDLSPGDRVLAADDQGRLLYSDFLTFLDRDDG
                     AKKVFYVIETREPRERLLLTAAHLLFVAPHNDSATGEPEASSGSGPPSGGALGPRALF
                     ASRVRPGQRVYVVAERDGDRRLLPAAVHSVTLSEEAAGAYAPLTAQGTILINRVLASC
                     YAVIEEHSWAHRAFAPFRLAHALLAALAPARTDRGGDSGGGDRGGGGGRVALTAPGAA
                     DAPGAGATAGIHWYSQLLYQIGTWLLDSEALHPLGMAVKSS"
ORIGIN      
        1 agacacgctc tccccgcgcg ggcctaggtg ccaggcgagg gtgctggcgg ccagggggct
       61 cctaaggggc aggaggccag agggccggat ctgaagcctg gagtggggtc ccgagccgct
      121 acactaaata gatttaatgt gcgctctggg gccgccagga aagacgctca gtttgctctt
      181 caaacttgct ggacgccatt ctatgctggg gccaagaaca caagagcgga ggaagggaac
      241 aggttaaaga aaacaagaaa cacaatcaga ccacagaaaa gccaggcaga aaagggttcg
      301 acgggcaaaa agaatgtggc tgtccagata aagaatgtct gtcccggccc cggcctgtgc
      361 tgcaagtggc aactcaccta gccgcctgcc acccaggctc ccgcccaccg cgcagccccg
      421 ccagcggctt ctcgcctccc ctctgcctcg gatagggtta gggcctgagg cctcgctagg
      481 agcatcggct gtttcaggac ctggagaaag gcccccagct ctaccctgag aggacgtgct
      541 cctccacgct cctccgcaaa tgctgtccct cttccccagc ccagggcccg gctcttcgag
      601 gtgtaaggac aagttgaacg ctttggccat ctcggtgatg aaccagtggc caggagtgaa
      661 actgcgggtg accgagggct gggacgaaga tggccaccac tcagaggagt ctctgcacta
      721 cgagggccgc gcagtggaca tcaccacgtc tgaccgcgac cgcagcaagt acggcatgct
      781 ggcccgcctg gcggtggagg ccggcttcga ctgggtgtac tacgagtcca aggcacatat
      841 ccactgctcg gtgaaagcag agaactcggt ggcggccaaa tcgggaggct gcttcccggg
      901 ctcggccacg gtgcacctgg agcagggcgg caccaagctg gtgaaggacc tgagccccgg
      961 ggaccgcgtg ctggcggcgg acgaccaggg ccggctgctc tacagcgact tcctcacttt
     1021 cctggaccgc gacgacggcg ccaagaaggt cttctacgtg atcgagacgc gggagccgcg
     1081 cgagcgcctg ctgctcaccg ccgcgcacct gctctttgtg gcgccgcaca acgactcggc
     1141 caccggggag cccgaggcgt cctcgggctc ggggccgcct tccgggggcg cactggggcc
     1201 tcgggcgctg ttcgccagcc gcgtgcgccc gggccagcgc gtgtacgtgg tggccgagcg
     1261 tgacggggac cgccggctcc tgcccgccgc tgtgcacagc gtgaccctaa gcgaggaggc
     1321 cgcgggcgcc tacgcgccgc tcacggccca gggcaccatt ctcatcaacc gggtgctggc
     1381 ctcgtgctac gcggtcatcg aggagcacag ctgggcgcac cgggccttcg cgcccttccg
     1441 cctggcgcac gcgctcctgg ctgcactggc gcccgcgcgc acggaccgcg gcggggacag
     1501 cggcggcggg gaccgcgggg gcggcggcgg cagagtagcc ctaaccgctc caggtgctgc
     1561 cgacgctccg ggtgcggggg ccaccgcggg catccactgg tactcgcagc tgctctacca
     1621 aataggcacc tggctcctgg acagcgaggc cctgcacccg ctgggcatgg cggtcaagtc
     1681 cagctgaagc cggggggccg ggggaggggc gcgggagggg gcggggcggg gcagcaacag
     1741 caacgcaaag caaaaagaca ctcggaaaag gcgcacgaac cagactgagt tataataaga
     1801 ataagaataa taaagtagga cagtccaaag tagactctaa ggaaacaagg accccgggaa
     1861 gttttgttgt tgtgcttagt tgatatatat tttttgaatt tttttggtta ttgttttatt
     1921 ttggttattt tttcctcctc tcctggctat ttatttgttt ggtatgaata gatgttttaa
     1981 ataatatgaa ccggaccttc aagagcctta aatagtttgt ttcttggata atttattatg
     2041 atcatgtgaa ctgtactcac gggggaaaga ttattttgtg aggccaagca acctgctcag
     2101 agtctatttt tctacatgtc cctcgtcccg gctgtcagaa agcaaacctc tgtccccgcc
     2161 atccctccct tccatctcct gcttctcagc aagtgcaaac tcaaacgtgc ttcatggggg
     2221 tccacaaatt atatttttat acacagaatt gtaaattaga ttttttgaga gatcaatact
     2281 taactgaatt acatttcatt tttgaaatag tgtaaaatat gaaaatatat tattttaatt
     2341 taactagttt ccgatgtaac agccatctcc tctgttgtct ttatggtttc atattccctt
     2401 tgtattcacc attttgccac attcttggaa gccaagactg ttacacacac aacatacaca
     2461 cacacttttc tttttctttt cttttctttt tttttttttt tttttttttt ggacaaactg
     2521 gaagaactgt tatttttaac ttcaaagaat ttattagaaa ataatatttt ttaaaagcgc
     2581 acatagtgac gagcccacga ggatggagcc tgcagtttgt acagagaaaa caaaggatgt
     2641 ttttgcatta ataaattgag aaataacgct gtaaatttac taaaatgtat ttttgaatat
     2701 tttgtaatag ttttatagaa ataaaatgtg ccatgcacag aacgcttagt atctaataac
     2761 taagaattcc tgttgcagcc ctttttcttt tagtttttgg cttctttgtt tgggaaacct
     2821 agcgctgaca ggagctccca atattctatt tagatgtgtt gcttatactg tgaactcaga
     2881 ctgactgact taggtaacca aagtaggcac acaaaccaac ttgtttcttc tcatggctgg
     2941 agaaacctca gctctgtttg tatttattgt gtgaagctct ttctacactc ccaaaggttg
     3001 ggagtgccat tcgtggggac tgtgctgtcc ccctcacccc accccttaac tagcaaagcc
     3061 tgatgtgtaa gcccagagga ggtggcctgg ggatggccac caacaacctt ctcttaggac
     3121 tcctgtgtgt ggttgctggg cagacccctg gcctgaccct gtttgtgctt ctctgatctg
     3181 tagggaggag gctcattgct gctttctgag gtcctgttgt gtcccttcca gaaagcatcc
     3241 ttagaagaga ggacccggtt tgatcttctc tgaagctcct atcctctttt cttgagggtc
     3301 cccttaaatc tgagtggcaa gcccacagtg gcgagggcca gtcgctggaa tgtcggggct
     3361 gctgttgagg tcctcaggct acactggttg tctgtgtcac atggcggtcg ggcgtggact
     3421 ttgatccctg ttgagagagc atgctgctgt gggcgctggg ctggggaagg tccttccatg
     3481 cttcatgctg ccttggaggt ttggccaaga gggtctctgc ccttggcggt tgtcagggtc
     3541 ccaggtggag gactactccc agttctttgg cttacggaag gtgtctgcca tgctttgtgc
     3601 tttgggccga atcgtctgag caggctgggc cttggaagag ttgcgctgca tgagcttggg
     3661 gcctcccagc agctgcagcc tgtgtagaag gtggtccagg cttagggaac aggagtgaac
     3721 agacttcagc cccacctggc aggggctggc tcccgaggtt gggcccagtc cctgagggtc
     3781 tgctctgcta cgggtctgcc cttgagtggc cttccgtgga gggtgtgtga ccaggtggat
     3841 ggcgcagggc ctctggagcc ctctcctcag gagcagtcct cagccttttt ctgtaaaaga
     3901 cttttctttg gtgttctagg tggtcagcag gttccaggct ggtgtttaca atctcggagg
     3961 aagtgcgatg gtttctgttc ttttgacagt tcagtctgat ttcaagtcag tcgaaagcga
     4021 accagaagca ccgggcacag cagctcctct ggctgtgtag acagacctgg caatgtggcc
     4081 gtgcagccca gacgatcaga gagaagccag gcgttgacca agccccaagg tgcctgaggc
     4141 catggtgcaa ctctgctggt gactggggca ccttggagca gagcttcacc cggatgggaa
     4201 atcctcactc ctgggtggca ctccctcctg gacaggcccg gtggcagagt gtccgtgctg
     4261 ctgggtgctg tccccagccc tcctggtcca tcttcttaag atgcgtccac tgctttatat
     4321 ttaaaattct ctttttcaca ggcaaggaaa ggaaaccact gcttagagac actaggtaca
     4381 gggcatcaag agggtgcagc ccagccccgc caggacgagg cgccgacttc tcattcaggg
     4441 ttgacggagc caagagtttg tgcaaaatgt atgcatggtg gttgctgcca gcctccctca
     4501 tgactaaatg catatctatt cctgtcaaaa cgtgtatcac aatgtacttg aaactgttat
     4561 ctttgtgctc tattgtttga ataattaaag aaattacaga gactctc
//
