LOCUS       NM_001394037            2215 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens Src homology 2 domain containing F (SHF), transcript
            variant 6, mRNA.
ACCESSION   NM_001394037
VERSION     NM_001394037.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2215)
  AUTHORS   Zhu,Z., Gong,M., Gong,W., Wang,B., Li,C., Hou,Q., Guo,H., Chai,J.,
            Guan,J. and Jia,Y.
  TITLE     SHF confers radioresistance in colorectal cancer by the regulation
            of mitochondrial DNA copy number
  JOURNAL   Clin Exp Med 23 (6), 2457-2471 (2023)
   PUBMED   36527512
  REMARK    GeneRIF: SHF confers radioresistance in colorectal cancer by the
            regulation of mitochondrial DNA copy number.
REFERENCE   2  (bases 1 to 2215)
  AUTHORS   Wang,J., Huang,Z., Ji,L., Chen,C., Wan,Q., Xin,Y., Pu,Z., Li,K.,
            Jiao,J., Yin,Y., Hu,Y., Gong,L., Zhang,R., Yang,X., Fang,X.,
            Wang,M., Zhang,B., Shao,J. and Zou,J.
  TITLE     SHF Acts as a Novel Tumor Suppressor in Glioblastoma Multiforme by
            Disrupting STAT3 Dimerization
  JOURNAL   Adv Sci (Weinh) 9 (26), e2200169 (2022)
   PUBMED   35843865
  REMARK    GeneRIF: SHF Acts as a Novel Tumor Suppressor in Glioblastoma
            Multiforme by Disrupting STAT3 Dimerization.
REFERENCE   3  (bases 1 to 2215)
  AUTHORS   Takagi,D., Tatsumi,Y., Yokochi,T., Takatori,A., Ohira,M.,
            Kamijo,T., Kondo,S., Fujii,Y. and Nakagawara,A.
  TITLE     Novel adaptor protein Shf interacts with ALK receptor and
            negatively regulates its downstream signals in neuroblastoma
  JOURNAL   Cancer Sci 104 (5), 563-572 (2013)
   PUBMED   23360421
  REMARK    GeneRIF: Patients showing high ALK and low Shf mRNA expressions
            showed poor prognosis.
REFERENCE   4  (bases 1 to 2215)
  AUTHORS   Lindholm,C.K., Frantz,J.D., Shoelson,S.E. and Welsh,M.
  TITLE     Shf, a Shb-like adapter protein, is involved in PDGF-alpha-receptor
            regulation of apoptosis
  JOURNAL   Biochem Biophys Res Commun 278 (3), 537-543 (2000)
   PUBMED   11095946
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC051619.7.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7410570.567158.1,
                                           SRR14327317.350868.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000690270.1/ ENSP00000508579.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-513               AC051619.7         58750-59262         c
            514-655             AC051619.7         49461-49602         c
            656-862             AC051619.7         46515-46721         c
            863-1003            AC051619.7         44872-45012         c
            1004-1175           AC051619.7         43443-43614         c
            1176-1295           AC051619.7         43179-43298         c
            1296-2215           AC051619.7         38510-39429         c
FEATURES             Location/Qualifiers
     source          1..2215
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.1"
     gene            1..2215
                     /gene="SHF"
                     /note="Src homology 2 domain containing F"
                     /db_xref="GeneID:90525"
                     /db_xref="HGNC:HGNC:25116"
                     /db_xref="MIM:617313"
     exon            1..513
                     /gene="SHF"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1482
                     /gene="SHF"
                     /note="isoform f is encoded by transcript variant 6; SH2
                     domain-containing adapter protein F; CTD-2651B20.7"
                     /codon_start=1
                     /product="SH2 domain-containing adapter protein F isoform
                     f"
                     /protein_id="NP_001380966.1"
                     /db_xref="CCDS:CCDS91993.1"
                     /db_xref="GeneID:90525"
                     /db_xref="HGNC:HGNC:25116"
                     /db_xref="MIM:617313"
                     /translation="MLLSGAPPAGSRPGPRTQGSAGGGPGGSRRGAGGAGAGPGGGGS
                     GGVAKWLREHLGFRGGGGGGGGSKPAPPEPDYRPPAPSPAAPPAPPPDILAAYRLQRE
                     RDFEDPYSGGSSGSAALATPVAPGPTPPPRHGSPPHRLIRVETPGPPAPPADERISGP
                     PASSDRLAILEDYADPFDVQETGEGSAGASGAPEKVPENDGYMEPYEAQKMMAEIRGS
                     KETATQPLPLYDTPYEPEEDGATAEGEGAPWPRESRLPEDDERPPEEYDQPWEWKKER
                     ISKAFAVDIKVIKDLPWPPPVGQLDSSPSLPDGDRDISGPASPLPEPSLEDSSAQFEG
                     PEKSCLSPGREEKGRLPPRLSAGNPKSAKPLSMEPSSPLGEWTDPALPLENQVWYHGA
                     ISRTDAENLLRLCKEASYLVRNSETSKNDFSLSLKSSQGFMHMKLSRTKEHKYVLGQN
                     SPPFSSVPEIVHHYASRKLPIKGAEHMSLLYPVAIRTL"
     exon            514..655
                     /gene="SHF"
                     /inference="alignment:Splign:2.1.0"
     exon            656..862
                     /gene="SHF"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1003
                     /gene="SHF"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1175
                     /gene="SHF"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1295
                     /gene="SHF"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..2215
                     /gene="SHF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2172..2177
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SHF"
                     /note="hexamer: TATAAA"
     polyA_site      2215
                     /gene="SHF"
                     /note="major polyA site"
ORIGIN      
        1 agtctggctg gccccatgtt actgagcgga gctcctccgg ctggctcccg cccggggccg
       61 cgaacgcagg ggagcgctgg gggcggcccg ggggggtccc gccggggcgc cgggggtgcg
      121 ggagccggcc caggaggggg cggcagcggc ggagtagcca agtggctccg ggagcacctg
      181 ggcttccgcg gggggggcgg cggcggaggg ggcagcaagc cggcgccccc cgagcccgac
      241 taccgccccc ctgcgccctc tccggccgcg ccccccgcgc cgcccccgga catcctggcc
      301 gcctacaggc tgcagcggga gcgcgacttc gaagacccct actccggggg gtcgtccggc
      361 tccgccgccc tcgccacccc tgtcgccccc ggacccacgc cgcccccgcg ccacggctct
      421 cccccacacc gccttattcg ggtcgagacc ccggggcccc cggcgccgcc tgctgatgag
      481 cggatctccg gaccccccgc cagcagcgat aggctagcta tcctagaaga ctatgcggac
      541 ccgtttgatg ttcaggagac tggcgaaggc tcagcaggag cttcaggagc cccagagaag
      601 gtccctgaaa atgatggcta catggagccc tatgaggctc aaaagatgat ggccgagatc
      661 cggggctcca aggagacagc aactcagccc ttgcctctgt atgacacacc ctatgagcca
      721 gaggaggatg gggccaccgc ggaaggtgag ggggccccct ggccccggga gtcccgcctg
      781 ccagaggatg atgagaggcc ccctgaggag tatgaccagc cctgggagtg gaagaaggag
      841 cggatttcca aagcctttgc agttgacatt aaggtcatca aagacctacc ttggcctcca
      901 cctgtgggac agctggacag cagcccctcc ctgcctgatg gggacaggga catctccggt
      961 ccagcctcgc ccctccctga gcccagcctg gaggacagca gcgcccagtt tgaaggaccg
     1021 gagaagagct gcctgtcacc tggccgggag gagaaggggc ggctacctcc ccgactctct
     1081 gcagggaacc ccaagtcagc caaaccccta agcatggagc ccagcagccc cctgggggag
     1141 tggacagatc cagcactgcc tctggaaaac caggtctggt atcacggggc catcagccga
     1201 accgacgccg agaacctgct ccggctgtgc aaagaggcca gctacctggt gcgcaacagt
     1261 gagaccagca agaatgactt ctccctctcc ctcaagagca gccagggatt catgcacatg
     1321 aagctgtccc gaaccaagga acacaaatat gtgctgggcc agaacagccc gcccttcagc
     1381 agcgtccctg aaattgtgca ccactatgcc agccgcaagc tacccattaa gggagccgaa
     1441 cacatgtccc tgctctaccc tgtggccatc cggactcttt agatgtgaag ccagggcact
     1501 gtgatagacc tgtacccagc cctgtgccca tcacctggct gagggctgtg gctcttgcca
     1561 gggacgtgat ctttcaaacc tttcttctcc tgggatccag tagaagctgg agattcctta
     1621 atttattcta aagggaaagg gctcctgggg ccttggagta aggggttgtc tggagctggg
     1681 gaaagaggaa tccctggaga gaaaggatag cccctggagg aagggggttc cagagctact
     1741 gggatggtag ggagtttcag actggcagct ccggctcctt tccgacctta gggcagaggt
     1801 ggtgacctcc accaccacca ccctctcccc actgggtccg tgcgaggtag tgcagaattc
     1861 ggccccttgg ggcgccttac cacctctctg cctccgtccc cgacttccac cccagaccgt
     1921 cggagggctc cgcccagagt ctggtaagag gtttggggaa gacaggcccc tgggaagcag
     1981 ccggctttgg ggggtgggga gagaagggga ggggctcggg cagagggaac tgtgcagtcc
     2041 ccaggccgcc ccggctccgg gccagaggca ataaataaac ccgatcctgc cgggcacagc
     2101 cgcgcccgcg cctccggcgc cgtccccggg ctgacggggg agggagcgga gaagcgagcg
     2161 cagattctgc gtataaatca gctctggagc agacacagcc cggctgtgaa aagca
//
