LOCUS       NM_001010846            6542 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens Src homology 2 domain containing E (SHE), transcript
            variant 1, mRNA.
ACCESSION   NM_001010846 XM_375809
VERSION     NM_001010846.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6542)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 6542)
  AUTHORS   Kauwe,J.S., Bailey,M.H., Ridge,P.G., Perry,R., Wadsworth,M.E.,
            Hoyt,K.L., Staley,L.A., Karch,C.M., Harari,O., Cruchaga,C.,
            Ainscough,B.J., Bales,K., Pickering,E.H., Bertelsen,S., Fagan,A.M.,
            Holtzman,D.M., Morris,J.C. and Goate,A.M.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative
  TITLE     Genome-wide association study of CSF levels of 59 alzheimer's
            disease candidate proteins: significant associations with proteins
            involved in amyloid processing and inflammation
  JOURNAL   PLoS Genet 10 (10), e1004758 (2014)
   PUBMED   25340798
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6542)
  AUTHORS   Leung,K.K., Hause,R.J. Jr., Barkinge,J.L., Ciaccio,M.F., Chuu,C.P.
            and Jones,R.B.
  TITLE     Enhanced prediction of Src homology 2 (SH2) domain binding
            potentials using a fluorescence polarization-derived c-Met, c-Kit,
            ErbB, and androgen receptor interactome
  JOURNAL   Mol Cell Proteomics 13 (7), 1705-1723 (2014)
   PUBMED   24728074
REFERENCE   4  (bases 1 to 6542)
  AUTHORS   Jikuya,H., Takano,J., Kikuno,R., Hirosawa,M., Nagase,T., Nomura,N.
            and Ohara,O.
  TITLE     Characterization of long cDNA clones from human adult spleen. II.
            The complete sequences of 81 cDNA clones
  JOURNAL   DNA Res 10 (1), 49-57 (2003)
   PUBMED   12693554
REFERENCE   5  (bases 1 to 6542)
  AUTHORS   Oda,T., Kujovich,J., Reis,M., Newman,B. and Druker,B.J.
  TITLE     Identification and characterization of two novel SH2
            domain-containing proteins from a yeast two hybrid screen with the
            ABL tyrosine kinase
  JOURNAL   Oncogene 15 (11), 1255-1262 (1997)
   PUBMED   9315092
  REMARK    GeneRIF: Reports data for mouse She and not human.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL162591.16, BC117210.1 and AI797276.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001010846.2.
            
            Transcript Variant: This variant (1) encodes the supported protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK074067.1, SRR1660809.113045.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304760.3/ ENSP00000307369.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-362               AL162591.16        21474-21835
            363-757             BC117210.1         1-395
            758-758             AL162591.16        22231-22231
            759-1903            BC117210.1         397-1541
            1904-6399           AL162591.16        39767-44262
            6400-6542           AI797276.1         7-149               c
FEATURES             Location/Qualifiers
     source          1..6542
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..6542
                     /gene="SHE"
                     /note="Src homology 2 domain containing E"
                     /db_xref="GeneID:126669"
                     /db_xref="HGNC:HGNC:27004"
                     /db_xref="MIM:610482"
     exon            1..977
                     /gene="SHE"
                     /inference="alignment:Splign:2.1.0"
     CDS             387..1874
                     /gene="SHE"
                     /codon_start=1
                     /product="SH2 domain-containing adapter protein E"
                     /protein_id="NP_001010846.1"
                     /db_xref="CCDS:CCDS30877.1"
                     /db_xref="GeneID:126669"
                     /db_xref="HGNC:HGNC:27004"
                     /db_xref="MIM:610482"
                     /translation="MQWSPTPGASACLGWASSLACSTAPTLLGRAGRGPLMAAKWFKE
                     FPLNLKTVSERAKPGGGGGKLRKNSEAGGAGPGPGKGRKNSAAELGSGRAGVGPKDSR
                     LSRDSLQGLIQAAAGKGRKNSRATEEEPHRGATKSSGCSTYINRLIKVDTQEKNGKSN
                     YPSSSSSSSSSSSSASSSPSSLGPELDKGKIIKQQETVIILEDYADPYDAKRTKGQRD
                     AERVGENDGYMEPYDAQQMITEIRRRGSKDPLVKALQLLDSPCEPADGGLKSETLAKR
                     RSSKDLLGKPPQLYDTPYEPAEGGPRAEGKARPPDSRLPENDERPAAEYEQPWEWKKE
                     QIVRALSVQFEGAERPSFREETVRQHHRQKSWTQKILKPALSDHSEGEKVDPGLPLEK
                     QPWYHGAISRAEAESRLQPCKEAGYLVRNSESGNSRYSIALKTSQGCVHIIVAQTKDN
                     KYTLNQTSAVFDSIPEVVHYYSNEKLPFKGAEHMTLLYPVHSKLH"
     exon            978..1104
                     /gene="SHE"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1410
                     /gene="SHE"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1567
                     /gene="SHE"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1687
                     /gene="SHE"
                     /inference="alignment:Splign:2.1.0"
     exon            1688..6542
                     /gene="SHE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6521..6526
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SHE"
                     /note="hexamer: AATAAA"
     polyA_site      6542
                     /gene="SHE"
                     /note="major polyA site"
ORIGIN      
        1 gtctgtcgct gcgccgggga tactcccgcc gcctccgctc ggtcctctct ggtccctggg
       61 agcgtgggct gggccgcagg gggcttccgt gggcctggcc tctcccaccg caggaggaaa
      121 gagcaggggg aagcccccgg cgcccgccgc ctccgagagc cacggtgtcc tcgggccggg
      181 caggcgttga agacgagccc gggcggggcc ccccgcgcgt cgtgcctgtc gcctgccgtg
      241 tccggagcag aggctagcgc ccgcccgctc ggcgccccga gccgtgagaa ccccaccctg
      301 ccgggcgtgg gcgacggccg gccgggggcg cacggagcag ccgtcgcggg gcctcgccgc
      361 ggcctccagc gccccagtca cggggaatgc agtggtcccc gacccctggc gcctctgcgt
      421 gtctgggctg ggcttcctcg ctcgcctgct ccacggcccc gacgctcctg ggccgagccg
      481 gccggggccc cctcatggcg gccaagtggt tcaaggagtt ccccctgaac ctgaagaccg
      541 tgtcggagcg ggccaagccc gggggcggcg gcggcaaatt gcgcaagaac tcggaggcgg
      601 gcggcgctgg gccgggtcct ggcaagggcc gcaagaactc ggcggccgag ctggggagcg
      661 gcagggccgg cgtcggcccc aaggacagcc ggctgtcccg cgacagcctg cagggtctga
      721 ttcaggccgc cgcgggcaag ggccgcaaaa actcccgggc cacggaggag gagccccacc
      781 ggggtgcaac caagagctcg ggctgcagca cctacatcaa caggctcatc aaggtggaca
      841 ctcaggagaa gaacgggaag agcaactacc ccagcagcag tagctccagc tccagctcct
      901 cttcctccgc gtcctcttcc ccttcctccc tggggcccga gctggacaag ggcaagatta
      961 ttaagcagca agagacggtc atcattttag aagactatgc tgacccttat gatgccaaac
     1021 ggacaaaggg tcaaagggat gcagagagag tcggagagaa cgacggttac atggaaccat
     1081 atgatgcaca gcaaatgata acagaaatta gacgacgggg ttccaaagat cccctggtga
     1141 aggctctcca gctgcttgac agtccctgtg aacccgcaga cggtggcctg aaatcagaga
     1201 ccttggccaa aagacggagt tccaaggacc tcctggggaa gccgccacag ctatacgaca
     1261 ctccctacga gcctgcagaa ggggggccca gggcagaggg gaaggcgcgg cccccagaca
     1321 gccggctgcc cgagaacgac gagaggcccg cggcagagta cgagcagcca tgggagtgga
     1381 agaaggagca gatcgtgcgg gctctgtcag tccagtttga aggagctgag cgaccttcct
     1441 tcagggagga gacagtgagg cagcaccacc ggcagaagag ctggacccag aagatcctga
     1501 agccagccct ctcggaccac agtgagggag agaaagtgga cccgggcctg cccctggaga
     1561 agcagccctg gtatcatggt gccatcagcc gtgctgaggc tgagagtcga ctacagccct
     1621 gcaaagaagc tggttacctg gttcgaaata gtgagtcagg gaacagcagg tactccattg
     1681 ccctaaagac tagtcaagga tgtgtccaca tcatagtggc tcagaccaaa gacaacaaat
     1741 acacactgaa tcagacaagc gctgtgtttg acagcatccc tgaagtggta cactattatt
     1801 ccaatgaaaa gttgcctttc aaaggggcag aacacatgac tttactctac ccagtgcaca
     1861 gcaagcttca ctaagattca gccactgcaa gccctgggcc tctggcacct tcaagggcat
     1921 catcagcgca caaccagcat ctcagaggac aaggctggac tagcaactgc tagaaaatgg
     1981 gagtcttcct tgaaaagtca gagagtgatt tgttttgttt tgtttgagac gaagtctcgc
     2041 tgtgttgccc aggctggagt gcaatggcgc aatcttggct cactgcaaca tctgactcct
     2101 gggttcaagc agttcttccc catcagcctc ccaagtaggt gggactatag gttcgcacca
     2161 ccactcccag ctaatttttt tttttgtatt tttagtagag atggggtttc gccgtcttcg
     2221 tcaggctggt ctcaaactcc tgacctcaaa tgatccaccc acctcagtct ccccgagtgc
     2281 ctggattaca ggcatgagcc actgcacccg gccaagtctt tggtcttaaa gtgattccat
     2341 gacactttgt ttgtggcctg tcccttgttt ccttgctaag tagttctaca ataagaaatc
     2401 atgatttagc tgttgcctcc agctctgggg tagggtgttc tttttatggt gtgaccctca
     2461 ggaaggttaa gtcaggagtt caggagcatc agagttctct agaaatgtgc ctacttgtta
     2521 cctggaatac ctggtctcta aacaaaccaa caaaaaatcc acgtggcttt tccacatgat
     2581 ggtgcagact ggaagaggat gttatattgg actcgttatt ggggaaatga atgagcggga
     2641 gaaaatgtga atgacgggca agaaggtggt ctttctccct cagaagtcct aattcagctc
     2701 tggagttcat ggaaatccgc aacttcagag tgtggcctaa ggattatttt gttggtcagc
     2761 ctttccaaga aagtgtgtgt tctctcaatc tctgtggatt ttctcatttt ttagcaaatc
     2821 agtgagataa gcataaatag gaaggaagat accccaggtt taagaatcac caatatcatt
     2881 aggcattggc atcattatta gaattctgaa ttatagaata aaaggtacaa caaaaatttc
     2941 atttctgaat tttaaaattc tggaaatttg caaagctcca caactgtttt tttactgaat
     3001 taattacata gaacttcgat gtcttttgtt tcatcatcat tgggcatttt agttgctatg
     3061 gaataatttt taatttttgt ctctaaaatt agatttgctt tgtagtaaat tttttaaaaa
     3121 tgcaacccta agatctgatt atatgaactg ggtctctaaa gcctacaaag attctctcgt
     3181 tctgtaccaa gcagactgcc ttgtactata cagaagtgtt tgaaaagacc tagaggtttt
     3241 ctcttaaata ccattactta agattcatag tattaggatc tttatgattt atcatgagct
     3301 tatatcacca gtttatttac tgtgaaaaaa accatgggaa tggcatactg tgagaagagt
     3361 actatggtga atggctccag aattaaaatt cagcagatgt gtctgtattc tggggttggt
     3421 catttgggtc tcaaaactgc cccatatgca aatgtactga ctgtcatcaa tgaaaagtta
     3481 acctttgtag cttataaata cacacaaaat gttgatttgg ttaatttttt aggaaagtat
     3541 acctttgtag ttactagtta catttgactg taagatttag aggttagtaa atttttgctt
     3601 ctttattcag ataagatctc agccaaaagg ttgtgtgatc tttgatttta aaaatttaag
     3661 aggaactttt cctcactgga acacaatgat tttattaata aagaatgtag gctgggtgcg
     3721 gtggctcatg cacgtaatcc caacaatttg ggaggctgag gcaggcagat cacgtgaggt
     3781 caggagtttg agaccagcct ggccaacatg gtgaaaccct gtctgtagta aaaatacaaa
     3841 aattagctgg gcacggtggc gggcacctgt agttccagct gcttgggagg ctgaggcacg
     3901 agaatcactt gagcccagga ggtggaggtt gcagtgagcc aagattatgt cactgcactc
     3961 catcctgggt gacaagagcg aaactccatc tcaaaaaaaa aaaaaaaaaa aagcctggcc
     4021 tggtggtgga tgcctgtggt tccagctatt cgggaggctg aggtaggtgg atcacctctg
     4081 ctcaggtcaa ggctgcagcg agccatgatc gcaccattgc actccagcct gagtgacaga
     4141 gtgagaccct gtctcaacaa gcaagcaaac aaaaaaccaa aaggaatgtt tttttcagat
     4201 actgatagaa tgttttcagt gtgtattggt tcatttacta tatctttagt gtaagatttt
     4261 aaaaggtttt ttcagcatcc attcaacaaa tatttattat ctttatacaa attattcatt
     4321 gtgttaaact tatttttagt ttaacattct agaaatgaaa cgtttttact taaccttatt
     4381 ctacaaaggg aatacagcag ttattctaat tttaataaat gctaaaagct ttatacaatt
     4441 tttctttgtg cactaaatga tttttggccc atacccagca actgtgatga atgtataatg
     4501 aaataacatc ttgaaaacag gccagataca ttaagtattt attgagcttc tgtcatatgc
     4561 ccagtattat gcttcttcta tactgtttct ctgtgacaag tcatactata ttctttatag
     4621 aattaaaagt agaggagagg cagagtttac atattgtcca gttgctttac agttgtacag
     4681 gaggttataa gaagaaatat agtaaattag tgggaagtca gaggtggggg cgttagtgag
     4741 ctattttctt cttgaggttg tgacacaagc tgacaaaagc cagggagttc acagctgtgt
     4801 ggtggcacaa agttccatat gttctaaaaa caattaggcc cagcagggtg tccctaatgg
     4861 cttccttgtt aaacctccat ggccagctga tctgaagctc tgtgacatgt tctctgagct
     4921 ctgaatgctc tggctttttg tcattttgtc ttgagacaag tattttcctg tagtcctcat
     4981 tccttcgagt tattccatct cccaggatat tctctggtga gaagaatgtc tttcagtgaa
     5041 tttgccttga atttagcatc catagagctg tgtcagtgtt cttcttgatc acaccttctt
     5101 taaaaaaaat acttgcttgc gatgactgga caagttcagt tggttagttt caggcctata
     5161 agaagagaga gtaaaggacc ttgctattta ctttgatacc atagttgtat ctcaggatgg
     5221 cctgcaaacc actggccttg tgtgtattta agctaggaat aaaataatgg agaagtgtta
     5281 atatgtatac aaaaaggtaa atattgatat atctactctc tgttgggggc agaagtgtca
     5341 ttttaagtta ttcaaagcac tttcttaagc attttagaaa gcctttattc tttgctgttg
     5401 gaagtctccg tactttgcag aattggtatt tgtgtactag cctctgccgc aggatgggga
     5461 ggtgggcagg tagctgatag gggcagccag gagtttttga ggcaggtggt gggaaattgt
     5521 cctaatttgt taattggatt atgtaactct gttactagtc tgttattggc tgttgttact
     5581 ggatgcatct tgatattcag aagaataact gtgaggcatt cttcagttgc gggttaagtg
     5641 gggttagttt ctgttctgtc agatgccctt tttcagtcaa aggttagccc cttgtttctc
     5701 cctccttcca gggtttaggg agtgcagtga tgtcgatttc atttcccttc cccgcacccc
     5761 ttgacactca gcaggattgc actgaaaccc ttcacagatc tctcgttcac tagttgtctc
     5821 ctatttttcc ataactagca ctagtttggc cttatgacct ggttagaatc actcttctgt
     5881 attctcattt ccaatttttg tgccccacta acgtggacta gagaaacttg gcctgctgtg
     5941 cagtgggcct tctgttcaac ttaccctcca ccgctgaccc tgtgtgaaga gagatggtgc
     6001 gttactgcca tctaatggga aaagagaaaa ctgcagttgg gaaaagcagc tgtgcattta
     6061 agggtagggc tttctgaagg atttctgata cagtccagaa aagggaaaat gatgacacag
     6121 cagttgccat cttgaaaaat gccctttcct gcggaaaggg tgttttgaag tctaatacaa
     6181 ctatcatcac aaggtccctg gactaaggct ggatcgtgta atttagaatc tcaaattgta
     6241 ttttaattaa tatgctggca acagaatcat tgaaacaggc gtctcatttt gtcaagttct
     6301 tagccgttca gtttgtcagg ggctttaata ttttagatat caactaatac atagtttcaa
     6361 cttttaaaaa tgtttgaaga ttgtatgtaa tataggtgtc tatctatagt gccttagtaa
     6421 tttaaatcag aaatatttta taaaacttct ggttgttttg cagtagccaa tataggcttc
     6481 atgccctcct gaagatagtt tcctctgaaa tgtaacttta aataaacatt attccaagaa
     6541 aa
//
