LOCUS       NM_020209               1910 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens Src homology 2 domain containing transforming protein
            D (SHD), transcript variant 1, mRNA.
ACCESSION   NM_020209 XM_031857
VERSION     NM_020209.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1910)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1910)
  AUTHORS   Leung,K.K., Hause,R.J. Jr., Barkinge,J.L., Ciaccio,M.F., Chuu,C.P.
            and Jones,R.B.
  TITLE     Enhanced prediction of Src homology 2 (SH2) domain binding
            potentials using a fluorescence polarization-derived c-Met, c-Kit,
            ErbB, and androgen receptor interactome
  JOURNAL   Mol Cell Proteomics 13 (7), 1705-1723 (2014)
   PUBMED   24728074
REFERENCE   3  (bases 1 to 1910)
  AUTHORS   Oda,T., Kujovich,J., Reis,M., Newman,B. and Druker,B.J.
  TITLE     Identification and characterization of two novel SH2
            domain-containing proteins from a yeast two hybrid screen with the
            ABL tyrosine kinase
  JOURNAL   Oncogene 15 (11), 1255-1262 (1997)
   PUBMED   9315092
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008616.6 and BC007206.1.
            
            On Jul 31, 2019 this sequence version replaced NM_020209.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK056268.1, AK055673.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000543264.7/ ENSP00000446058.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-573               AC008616.6         45412-45984         c
            574-1910            BC007206.1         1-1337
FEATURES             Location/Qualifiers
     source          1..1910
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..1910
                     /gene="SHD"
                     /note="Src homology 2 domain containing transforming
                     protein D"
                     /db_xref="GeneID:56961"
                     /db_xref="HGNC:HGNC:30633"
                     /db_xref="MIM:610481"
     exon            1..1095
                     /gene="SHD"
                     /inference="alignment:Splign:2.1.0"
     CDS             799..1821
                     /gene="SHD"
                     /note="src homology 2 domain-containing transforming
                     protein D"
                     /codon_start=1
                     /product="SH2 domain-containing adapter protein D"
                     /protein_id="NP_064594.3"
                     /db_xref="CCDS:CCDS12125.1"
                     /db_xref="GeneID:56961"
                     /db_xref="HGNC:HGNC:30633"
                     /db_xref="MIM:610481"
                     /translation="MAKWLRDYLSFGGRRPPPQPPTPDYTESDILRAYRAQKNLDFED
                     PYEDAESRLEPDPAGPGDSKNPGDAKYGSPKHRLIKVEAADMARAKALLGGPGEELEA
                     DTEYLDPFDAQPHPAPPDDGYMEPYDAQWVMSELPGRGVQLYDTPYEEQDPETADGPP
                     SGQKPRQSRMPQEDERPADEYDQPWEWKKDHISRAFAVQFDSPEWERTPGSAKELRRP
                     PPRSPQPAERVDPALPLEKQPWFHGPLNRADAESLLSLCKEGSYLVRLSETNPQDCSL
                     SLRSSQGFLHLKFARTRENQVVLGQHSGPFPSVPELVLHYSSRPLPVQGAEHLALLYP
                     VVTQTP"
     exon            1096..1201
                     /gene="SHD"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1390
                     /gene="SHD"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1514
                     /gene="SHD"
                     /inference="alignment:Splign:2.1.0"
     exon            1515..1634
                     /gene="SHD"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..1910
                     /gene="SHD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1893..1898
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SHD"
                     /note="hexamer: AATAAA"
     polyA_site      1910
                     /gene="SHD"
                     /note="major polyA site"
ORIGIN      
        1 gctgctgccc gggacgcggc ccggggctgg tgggaacagg ggcgtcctcc tgcgcgcccc
       61 cctccccagc gtcccacctc ccggcggcgg cggggaaagt ctctccgaaa gcgtgaaggg
      121 ggattggagg aggtttttat ttccctttgt gcgggtggct ggggccggat cgaggcggcg
      181 ggggccgcgg gactgggggc tccccgctga gccgagagga gcgcgacaaa ggatgcgtcc
      241 cgccggggtc acagtctccg cggcccaact ttgcgcgcgg cgcccgcgcc cctggggagc
      301 ccgcccgctg cgctgagaac ccaggcgtcc gggctgggag aggggccggg agcgtccgca
      361 ggtggcgctg gcccggatct cccgacccca ggaagggatc ccggagcttc ctggaggcgg
      421 cgggcggccg tgtcgctcca gggaaccgcg ctgcccgcgg aaactccgcg cgcctccgcg
      481 gatgcccctc gccctagccc ccagcgcgcg gggttcgggg ccctgcgagg tccccccttc
      541 ccccgcggtg cttcccaagc tgggctaagg cgggcttctc ttcctccctc ctctgtcgcc
      601 tccttttcct ccccctcgtt caccttttcc ttccctctat ccatccagag ccccgccaaa
      661 gggcgcacct gatctttctc atccttccct gctcttccct tcctctccac ctcctcctcc
      721 tccttgggga aaggggcccg gagaagggca tgtgggggcc cctctgacag tggcccgatt
      781 ggggtgacag gcgcccaaat ggccaagtgg ctacgggact acctgagctt tgggggtcgg
      841 aggccccctc cgcagccgcc caccccggac tacaccgaga gcgacatcct gagggcctac
      901 cgcgcgcaga agaacctgga cttcgaggac ccctatgagg acgcggagag ccgcttggag
      961 ccggaccccg cgggccctgg ggactccaag aaccccggag atgccaagta tggttctccc
     1021 aagcaccggc tcatcaaggt ggaggctgcg gatatggcca gagccaaggc ccttctgggc
     1081 ggccccgggg aggagctgga agccgacact gagtatttag acccctttga tgctcagcct
     1141 catcctgcac ccccggatga tgggtacatg gagccctacg atgcccaatg ggtcatgagt
     1201 gaacttcccg gcagaggggt gcagctctat gacacccctt atgaggaaca ggacccagag
     1261 acagcagatg gacccccttc tgggcagaag cctcggcaga gccggatgcc ccaggaagat
     1321 gaacggccag cagatgagta tgatcagccc tgggagtgga agaaagacca catctccagg
     1381 gcgtttgcag tgcagtttga cagtccagag tgggagagga ctccaggctc agccaaggag
     1441 ctccggagac ctccgcccag aagcccccag cctgcggagc gtgtggaccc agccctgccc
     1501 ctggagaaac agccgtggtt tcatggcccc ctgaacaggg cggatgcaga gagcctcctg
     1561 tccctctgca aggaaggcag ctacctagtg cggctcagtg agaccaaccc ccaggactgc
     1621 tccttgtctc tcaggagcag ccagggcttc ctgcatctga agttcgcgcg gacccgtgag
     1681 aaccaggtgg tgctgggcca acacagcggg cccttcccca gcgtgcccga gctcgtcctc
     1741 cactacagtt cacgcccact gccggtgcag ggtgccgagc atctggctct gctgtacccc
     1801 gtggtcacgc agaccccctg acagtgaccc tcggccccct tttgagtcct cgggcccaga
     1861 atcgtatccc aaagccctcc catggcctag aaaataaata agttattgtt
//
