LOCUS       NM_030933               2113 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens SHC binding and spindle associated 1 like (SHCBP1L),
            transcript variant 1, mRNA.
ACCESSION   NM_030933 XM_001131391 XM_001132681
VERSION     NM_030933.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2113)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2113)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2113)
  AUTHORS   Liu,M., Shi,X., Bi,Y., Qi,L., Guo,X., Wang,L., Zhou,Z. and Sha,J.
  TITLE     SHCBP1L, a conserved protein in mammals, is predominantly expressed
            in male germ cells and maintains spindle stability during meiosis
            in testis
  JOURNAL   Mol Hum Reprod 20 (6), 463-475 (2014)
   PUBMED   24557841
  REMARK    GeneRIF: SHCBP1L is a conserved mammalian protein predominantly
            expressed in male germ cells and it maintains spindle stability
            during meiosis in testis.
REFERENCE   4  (bases 1 to 2113)
  AUTHORS   Sood,R., Bonner,T.I., Makalowska,I., Stephan,D.A., Robbins,C.M.,
            Connors,T.D., Morgenbesser,S.D., Su,K., Faruque,M.U., Pinkett,H.,
            Graham,C., Baxevanis,A.D., Klinger,K.W., Landes,G.M., Trent,J.M.
            and Carpten,J.D.
  TITLE     Cloning and characterization of 13 novel transcripts and the human
            RGS8 gene from the 1q25 region encompassing the hereditary prostate
            cancer (HPC1) locus
  JOURNAL   Genomics 73 (2), 211-222 (2001)
   PUBMED   11318611
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL450304.33, AF288398.1,
            BC050305.1 and AL662837.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_030933.3.
            
            Summary: This gene encodes a Src homology 2 domain-binding protein
            1-like protein. The encoded protein interacts with heat shock 70
            kDa protein 2 and may be involved in maintaining spindle integrity
            during meiosis. This gene is located in region of chromoso0me 1
            encompassing a prostate cancer susceptibility locus. [provided by
            RefSeq, Sep 2016].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF288398.1, BC050305.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367547.8/ ENSP00000356518.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                AL450304.33        29975-30025         c
            52-623              AF288398.1         303-874
            624-2107            BC050305.1         828-2311
            2108-2113           AL662837.2         16986-16991         c
FEATURES             Location/Qualifiers
     source          1..2113
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.3"
     gene            1..2113
                     /gene="SHCBP1L"
                     /gene_synonym="C1orf14; GE36"
                     /note="SHC binding and spindle associated 1 like"
                     /db_xref="GeneID:81626"
                     /db_xref="HGNC:HGNC:16788"
                     /db_xref="MIM:619514"
     exon            1..438
                     /gene="SHCBP1L"
                     /gene_synonym="C1orf14; GE36"
                     /inference="alignment:Splign:2.1.0"
     CDS             34..1995
                     /gene="SHCBP1L"
                     /gene_synonym="C1orf14; GE36"
                     /note="isoform 1 is encoded by transcript variant 1; SHC
                     SH2-domain binding protein 1-like; testicular
                     spindle-associated protein SHCBP1L; SHC SH2 domain-binding
                     protein 1-like protein"
                     /codon_start=1
                     /product="testicular spindle-associated protein SHCBP1L
                     isoform 1"
                     /protein_id="NP_112195.2"
                     /db_xref="CCDS:CCDS30955.1"
                     /db_xref="GeneID:81626"
                     /db_xref="HGNC:HGNC:16788"
                     /db_xref="MIM:619514"
                     /translation="MASGSKASVPADSFRTISPDRRGEKSASAVSGDTAAATTLKGTA
                     IPVRSVVASPRPVKGKAGRETARLRLQRLPAAQAEDTGEAAAAAAEEPLLPVPEDEEE
                     AQPLPPVCVSRMRGMWRDEKVSLYCDEVLQDCKAEDADEVMGKYLSEKLKLKDKWLGV
                     WKTNPSVFFVKYEEASIPFVGILVEVTCEPYQDSSSRFKVTVSVAEPFSSNIANIPRD
                     LVDEILEELEHSVPLLEVYPVEGQDTDIHVIALALEVVRFFYDFLWRDWDDEESCENY
                     TALIEERINLWCDIQDGTIPGPIAQRFKKTLEKYKNKRVELIEYQSNIKEDPSAAEAV
                     ECWKKYYEIVMLCGLLKMWEDLRLRVHGPFFPRILRRRKGKREFGKTITHIVAKMMTT
                     EMIKDLSSDTLLQQHGDLDLALDNCYSGDTVIIFPGEYQAANLALLTDDIIIKGVGKR
                     EEIMITSEPSRDSFVVSKADNVKLMHLSLIQQGTVDGIVVVESGHMTLENCILKCEGT
                     GVCVLTGAALTITDSEITGAQGAGVELYPGSIAILERNEIHHCNNLRTSNSSKSTLGG
                     VNMKVLPAPKLKMTNNHIYSNKGYGVSILQPMEQFFIVAEEALNKRASSGDKKDDKML
                     FKVMQNLNLEMNNNKIEANVKGDIRIVTS"
     exon            439..588
                     /gene="SHCBP1L"
                     /gene_synonym="C1orf14; GE36"
                     /inference="alignment:Splign:2.1.0"
     exon            589..803
                     /gene="SHCBP1L"
                     /gene_synonym="C1orf14; GE36"
                     /inference="alignment:Splign:2.1.0"
     exon            804..890
                     /gene="SHCBP1L"
                     /gene_synonym="C1orf14; GE36"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1109
                     /gene="SHCBP1L"
                     /gene_synonym="C1orf14; GE36"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1215
                     /gene="SHCBP1L"
                     /gene_synonym="C1orf14; GE36"
                     /inference="alignment:Splign:2.1.0"
     exon            1216..1369
                     /gene="SHCBP1L"
                     /gene_synonym="C1orf14; GE36"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1620
                     /gene="SHCBP1L"
                     /gene_synonym="C1orf14; GE36"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1743
                     /gene="SHCBP1L"
                     /gene_synonym="C1orf14; GE36"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..2113
                     /gene="SHCBP1L"
                     /gene_synonym="C1orf14; GE36"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2092..2097
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SHCBP1L"
                     /gene_synonym="C1orf14; GE36"
                     /note="hexamer: ATTAAA"
     polyA_site      2113
                     /gene="SHCBP1L"
                     /gene_synonym="C1orf14; GE36"
                     /note="major polyA site"
ORIGIN      
        1 aacggctgcc tcggccctcg ggctgctgag gagatggcgt cgggctccaa ggcctcggtg
       61 cccgcggact cattccgcac catcagcccg gacaggcgag gcgagaagtc cgcctccgct
      121 gtctccgggg acacggcggc cgcgaccacc ctgaagggca ccgcgatccc agtgcggtcg
      181 gtggtggcct cccctcgccc ggtgaagggg aaagcgggcc gggagacggc caggctgcgg
      241 ctccagcgcc tgcccgcggc tcaggccgag gacacgggag aggcggcggc ggcggcggcg
      301 gaggagcccc tgctgccagt gcctgaggat gaagaggagg cgcagcccct gcccccagtc
      361 tgcgtgtccc gtatgagggg gatgtggcgg gacgagaagg tgtcgctgta ttgcgacgaa
      421 gtgctgcagg actgtaaggc agaagatgct gatgaagtta tgggtaaata cctatcagaa
      481 aaattaaagt tgaaagacaa atggcttgga gtctggaaga ctaatcccag tgtattcttt
      541 gtgaaatatg aagaagcttc tatccctttt gttggtatat tggttgaggt aacttgtgaa
      601 ccataccaag actcatcatc tcgtttcaaa gttactgttt ctgttgctga gcccttttct
      661 tccaacattg caaatattcc aagagatttg gttgatgaga ttttggagga actggaacac
      721 agtgtgcctc ttttggaagt gtatcctgtt gagggacaag atactgatat acatgttatt
      781 gctttggcct tggaagttgt caggtttttt tatgactttc tttggagaga ctgggatgat
      841 gaagaaagtt gtgagaatta tactgcactt attgaagaaa gaattaattt gtggtgtgat
      901 atacaggatg gaacaatacc tggtcctatc gcacaacgtt ttaaaaaaac tttggagaaa
      961 tataaaaaca aacgtgtcga gctcattgag tatcagagca atattaaaga agatccatct
     1021 gcagcagagg ctgttgaatg ctggaaaaaa tactatgaga tagtcatgct ctgtggatta
     1081 ctgaaaatgt gggaagattt acgcctccga gttcatggac ctttctttcc aagaattctg
     1141 aggcgtagga aaggaaaaag agaatttgga aagactataa cacatattgt agcaaaaatg
     1201 atgactactg aaatgataaa ggatttatct tcagacacac ttctccaaca gcatggtgat
     1261 ttggatttgg ctttggataa ttgttatagt ggagatacag taataatttt tccaggagaa
     1321 tatcaagctg caaatcttgc tttgttgaca gatgacatca ttataaaggg agttggaaag
     1381 agagaggaaa ttatgattac ttctgaacct tctcgtgaca gttttgtggt gtccaaagct
     1441 gacaatgtga aactaatgca tctatctttg atacaacaag ggacggttga tggtatcgtg
     1501 gtggtggagt ctggtcacat gactctagaa aactgcatat taaaatgtga aggaacagga
     1561 gtgtgtgttc ttacaggggc tgctttgaca attacagaca gtgaaataac tggcgcccag
     1621 ggtgctggtg ttgaactgta tcctggaagc atagctattt tggaaagaaa tgaaattcat
     1681 cactgtaata acctcagaac cagtaacagt tcaaaaagca ccttaggtgg agttaatatg
     1741 aaggttcttc cagcacccaa attgaagatg actaataatc atatttatag caacaaaggc
     1801 tatggagtaa gcattcttca accaatggaa cagtttttta tcgtagcaga agaagctctc
     1861 aacaaaaggg cttcttcagg agataaaaaa gatgataaaa tgctcttcaa agtaatgcaa
     1921 aatctgaatc tggaaatgaa taataataag atagaagcaa acgtcaaggg ggatatcaga
     1981 atagtcacaa gttaaagcgt ctgaattgat gttaaagttt tatatttcac aaatttgttt
     2041 aatacatgat tctcataccc cactgaaatg gtagtttcaa ttcaaagctt aattaaaaaa
     2101 tatttaaata tca
//
