LOCUS       NM_024745               5177 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens SHC binding and spindle associated 1 (SHCBP1),
            transcript variant 1, mRNA.
ACCESSION   NM_024745
VERSION     NM_024745.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5177)
  AUTHORS   Zhou,M., Duan,L., Chen,J., Li,Y., Yin,Z., Song,S., Cao,Y., Luo,P.,
            Hu,F., Yang,G., Xu,J., Liao,T. and Jin,Y.
  TITLE     The dynamic role of nucleoprotein SHCBP1 in the cancer cell cycle
            and its potential as a synergistic target for DNA-damaging agents
            in cancer therapy
  JOURNAL   Cell Commun Signal 22 (1), 131 (2024)
   PUBMED   38365687
  REMARK    GeneRIF: The dynamic role of nucleoprotein SHCBP1 in the cancer
            cell cycle and its potential as a synergistic target for
            DNA-damaging agents in cancer therapy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5177)
  AUTHORS   Lin,Y. and Cai,H.
  TITLE     Biological functions and therapeutic potential of SHCBP1 in human
            cancer
  JOURNAL   Biomed Pharmacother 160, 114362 (2023)
   PUBMED   36739763
  REMARK    GeneRIF: Biological functions and therapeutic potential of SHCBP1
            in human cancer.
            Review article
REFERENCE   3  (bases 1 to 5177)
  AUTHORS   Huang,Y., You,M., Wu,Q., Zhu,W., Guo,F. and Lin,W.
  TITLE     SHCBP1 Is a Prognostic Biomarker Related to the Tumour Immune
            Microenvironment in Pan-Cancer
  JOURNAL   Ann Clin Lab Sci 52 (6), 904-917 (2022)
   PUBMED   36564070
  REMARK    GeneRIF: SHCBP1 Is a Prognostic Biomarker Related to the Tumour
            Immune Microenvironment in Pan-Cancer.
REFERENCE   4  (bases 1 to 5177)
  AUTHORS   Yin,H., Zhang,C., Wei,Z., He,W., Xu,N., Xu,Y., Li,T., Ren,K.,
            Kuang,Y., Zhu,X., Yuan,F., Yu,H. and Gou,X.
  TITLE     EGF-induced nuclear translocation of SHCBP1 promotes bladder cancer
            progression through inhibiting RACGAP1-mediated RAC1 inactivation
  JOURNAL   Cell Death Dis 13 (1), 39 (2022)
   PUBMED   35013128
  REMARK    GeneRIF: EGF-induced nuclear translocation of SHCBP1 promotes
            bladder cancer progression through inhibiting RACGAP1-mediated RAC1
            inactivation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5177)
  AUTHORS   Wang,H., Zhang,Z., Zhang,Y., Liu,S. and Li,L.
  TITLE     Long Non-Coding RNA TP53TG1 Upregulates SHCBP1 to Promote
            Retinoblastoma Progression by Sponging miR-33b
  JOURNAL   Cell Transplant 30, 9636897211025223 (2021)
   PUBMED   34247545
  REMARK    GeneRIF: Long Non-Coding RNA TP53TG1 Upregulates SHCBP1 to Promote
            Retinoblastoma Progression by Sponging miR-33b.
REFERENCE   6  (bases 1 to 5177)
  AUTHORS   Jin,J., Smith,F.D., Stark,C., Wells,C.D., Fawcett,J.P.,
            Kulkarni,S., Metalnikov,P., O'Donnell,P., Taylor,P., Taylor,L.,
            Zougman,A., Woodgett,J.R., Langeberg,L.K., Scott,J.D. and Pawson,T.
  TITLE     Proteomic, functional, and domain-based analysis of in vivo 14-3-3
            binding proteins involved in cytoskeletal regulation and cellular
            organization
  JOURNAL   Curr Biol 14 (16), 1436-1450 (2004)
   PUBMED   15324660
REFERENCE   7  (bases 1 to 5177)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   8  (bases 1 to 5177)
  AUTHORS   Obuse,C., Yang,H., Nozaki,N., Goto,S., Okazaki,T. and Yoda,K.
  TITLE     Proteomics analysis of the centromere complex from HeLa interphase
            cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of
            the CEN-complex, while BMI-1 is transiently co-localized with the
            centromeric region in interphase
  JOURNAL   Genes Cells 9 (2), 105-120 (2004)
   PUBMED   15009096
REFERENCE   9  (bases 1 to 5177)
  AUTHORS   Schmandt,R., Liu,S.K. and McGlade,C.J.
  TITLE     Cloning and characterization of mPAL, a novel Shc SH2
            domain-binding protein expressed in proliferating cells
  JOURNAL   Oncogene 18 (10), 1867-1879 (1999)
   PUBMED   10086341
REFERENCE   10 (bases 1 to 5177)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092368.3.
            
            On Nov 23, 2018 this sequence version replaced NM_024745.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030699.1, AK055931.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000303383.8/ ENSP00000306473.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-123               AC092368.3         153872-153994       c
            124-291             AC092368.3         150820-150987       c
            292-407             AC092368.3         150249-150364       c
            408-616             AC092368.3         148561-148769       c
            617-709             AC092368.3         140912-141004       c
            710-943             AC092368.3         136843-137076       c
            944-1112            AC092368.3         136590-136758       c
            1113-1233           AC092368.3         136154-136274       c
            1234-1365           AC092368.3         132446-132577       c
            1366-1484           AC092368.3         128167-128285       c
            1485-1571           AC092368.3         116618-116704       c
            1572-1713           AC092368.3         116131-116272       c
            1714-5177           AC092368.3         111206-114669       c
FEATURES             Location/Qualifiers
     source          1..5177
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q11.2"
     gene            1..5177
                     /gene="SHCBP1"
                     /gene_synonym="PAL"
                     /note="SHC binding and spindle associated 1"
                     /db_xref="GeneID:79801"
                     /db_xref="HGNC:HGNC:29547"
                     /db_xref="MIM:611027"
     exon            1..123
                     /gene="SHCBP1"
                     /gene_synonym="PAL"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..2039
                     /gene="SHCBP1"
                     /gene_synonym="PAL"
                     /note="isoform 1 is encoded by transcript variant 1; SHC
                     SH2 domain-binding protein 1; Protein expressed in
                     Activated Lymphocytes"
                     /codon_start=1
                     /product="SHC SH2 domain-binding protein 1 isoform 1"
                     /protein_id="NP_079021.4"
                     /db_xref="CCDS:CCDS10720.1"
                     /db_xref="GeneID:79801"
                     /db_xref="HGNC:HGNC:29547"
                     /db_xref="MIM:611027"
                     /translation="MADGSLTGGGLEAAAMAPERMGWAVEQELASLEKGLFQDEDSCS
                     DCSYRDKPGSSLQSFMPEGKTFFPEIFQTNQLLFYERFRAYQDYILADCKASEVQEFT
                     AEFLEKVLEPSGWRAVWHTNVFKVLVEITDVDFAALKAVVRLAEPYLCDSQVSTFTME
                     CMKELLDLKEHRLPLQELWVVFDDSGVFDQTALAIEHVRFFYQNIWRSWDEEEEDEYD
                     YFVRCVEPRLRLHYDILEDRVPSGLIVDYHNLLSQCEESYRKFLNLRSSLSNCNSDSE
                     QENISMVEGLKLYSEMEQLKQKLKLIENPLLRYVFGYQKNSNIQAKGVRSSGQKITHV
                     VSSTMMAGLLRSLLTDRLCQEPGEEEREIQFHSDPLSAINACFEGDTVIVCPGHYVVH
                     GTFSIADSIELEGYGLPDDIVIEKRGKGDTFVDCTGADIKISGIKFVQHDAVEGILIV
                     HRGKTTLENCVLQCETTGVTVRTSAEFLMKNSDLYGAKGAGIEIYPGSQCTLSDNGIH
                     HCKEGILIKDFLDEHYDIPKISMVNNIIHNNEGYGVVLVKPTIFSDLQENAEDGTEEN
                     KALKIQTSGEPDVAERVDLEELIECATGKMELCARTDPSEQVEGNCEIVNELIAASTQ
                     KGQIKKKRLSELGITQADDNLMSQEMFVGIVGNQFKWNGKGSFGTFLF"
     exon            124..291
                     /gene="SHCBP1"
                     /gene_synonym="PAL"
                     /inference="alignment:Splign:2.1.0"
     exon            292..407
                     /gene="SHCBP1"
                     /gene_synonym="PAL"
                     /inference="alignment:Splign:2.1.0"
     exon            408..616
                     /gene="SHCBP1"
                     /gene_synonym="PAL"
                     /inference="alignment:Splign:2.1.0"
     exon            617..709
                     /gene="SHCBP1"
                     /gene_synonym="PAL"
                     /inference="alignment:Splign:2.1.0"
     exon            710..943
                     /gene="SHCBP1"
                     /gene_synonym="PAL"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1112
                     /gene="SHCBP1"
                     /gene_synonym="PAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1233
                     /gene="SHCBP1"
                     /gene_synonym="PAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1365
                     /gene="SHCBP1"
                     /gene_synonym="PAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1484
                     /gene="SHCBP1"
                     /gene_synonym="PAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1485..1571
                     /gene="SHCBP1"
                     /gene_synonym="PAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1713
                     /gene="SHCBP1"
                     /gene_synonym="PAL"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..5177
                     /gene="SHCBP1"
                     /gene_synonym="PAL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2501..2506
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SHCBP1"
                     /gene_synonym="PAL"
                     /note="hexamer: AATAAA"
     polyA_site      2524
                     /gene="SHCBP1"
                     /gene_synonym="PAL"
                     /note="major polyA site"
     regulatory      3192..3197
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SHCBP1"
                     /gene_synonym="PAL"
                     /note="hexamer: ATTATA"
     polyA_site      3214
                     /gene="SHCBP1"
                     /gene_synonym="PAL"
                     /note="major polyA site"
     regulatory      5074..5079
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SHCBP1"
                     /gene_synonym="PAL"
                     /note="hexamer: AATATA"
     polyA_site      5104
                     /gene="SHCBP1"
                     /gene_synonym="PAL"
     regulatory      5156..5161
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SHCBP1"
                     /gene_synonym="PAL"
                     /note="hexamer: AATATA"
     polyA_site      5177
                     /gene="SHCBP1"
                     /gene_synonym="PAL"
ORIGIN      
        1 gccgtccgcg gaaatttgaa atggctgacg ggtcgctgac gggcggcggt ctggaggcag
       61 cggccatggc gccggagcgc atgggctggg cggtggagca ggagctggcg tctctggaga
      121 aaggtttgtt ccaagatgaa gattcatgca gtgattgtag ctaccgtgat aaaccaggtt
      181 ctagtttaca aagttttatg ccagaaggaa aaaccttttt cccagaaatt ttccaaacaa
      241 atcaactttt gttctatgag cgattcagag cctatcaaga ttacatttta gctgactgca
      301 aggcctctga ggtacaggaa ttcacagctg agttcttgga gaaggtcctt gagccatctg
      361 gatggcgggc agtctggcac actaatgtgt tcaaggtgct ggttgagatc acagatgtgg
      421 actttgcagc cttgaaggca gtggtgaggc ttgctgaacc atacctctgt gactctcaag
      481 tgagcacttt taccatggag tgcatgaagg agctccttga tctgaaggag catcggttgc
      541 ccctgcagga gctgtgggtg gtgtttgatg attcaggagt gtttgaccag acagcccttg
      601 caattgagca tgtcagattt ttctaccaaa acatttggag gagttgggat gaagaagagg
      661 aggatgaata cgattatttt gtcagatgtg ttgaacctcg attaagattg cattatgaca
      721 ttcttgaaga ccgagttcca tcaggactta ttgttgacta ccacaatctg ttgtctcaat
      781 gtgaggagag ttacaggaaa tttttaaatc tgagaagcag tttgtcaaat tgtaactctg
      841 attccgagca ggaaaatatc tccatggtgg aagggttaaa attgtattcg gagatggaac
      901 agttgaaaca aaagctgaaa ctcattgaga atcctttgtt gaggtatgtg tttggttatc
      961 agaagaattc taacatccaa gcaaagggtg tccgttccag cggtcagaag atcactcatg
     1021 tggtctcctc caccatgatg gctggtctcc tgcggtccct gcttacggac aggctttgcc
     1081 aggagcctgg tgaggaagaa agagaaattc agttccatag tgatccattg tctgctataa
     1141 atgcctgctt cgaaggtgac actgttattg tttgtcctgg ccattatgtg gtacatggca
     1201 ctttctccat tgctgactcc attgagttgg aaggatatgg cctaccagat gacattgtga
     1261 tagaaaagag gggcaaaggc gacacttttg tggactgcac tggtgctgat attaaaatct
     1321 caggcataaa atttgttcag catgatgctg tagagggaat cttaattgtt caccgtggta
     1381 agactacgct ggaaaactgt gtgctgcagt gtgagacgac cggagtcaca gtgcggacat
     1441 cagcagagtt tctaatgaag aactcggatt tatatggcgc caagggtgct ggtatagaaa
     1501 tctaccctgg gagtcagtgc accctgagtg acaatgggat ccatcactgc aaggaaggga
     1561 tcctcattaa ggacttctta gatgaacatt atgacattcc caagatatcc atggtgaata
     1621 atataataca taataatgaa ggttatggtg ttgtcttggt gaaacctaca atcttctctg
     1681 acctgcaaga aaatgctgaa gatggaactg aagaaaataa agcgcttaaa attcagacaa
     1741 gtggagagcc agatgtggct gaaagagtgg atctagaaga gctgattgag tgtgcaactg
     1801 gtaaaatgga gctttgtgca agaactgacc cttctgagca agtcgaggga aattgtgaaa
     1861 ttgtaaatga actaattgct gcctccacac agaaaggcca gataaagaag aaaaggttga
     1921 gtgaactggg gatcacgcaa gctgatgaca acttaatgtc acaggagatg tttgttggga
     1981 ttgtggggaa ccagttcaag tggaatggga aaggtagttt tggcacattt cttttctgac
     2041 tacagtgatg taagtagata gcaaaatact ggattttgca catgctgccc taagaatcac
     2101 tgctgccatt gtagtttgct gtattgtctg tattttatat ttgattattt gggcttgagt
     2161 gaaaggtaga tttatttcca tttgcaggtg ttgcacataa aacactccct ctttataaga
     2221 aaaatcataa atgcatataa aatagaaaat atttggagat tgcttatctg aaagtcttgc
     2281 tttcttatac acatggttct ctcatattaa gcctggtagt aactttttag tgtaattacc
     2341 tttagcactt caaagacgag gaagtaagga agggaatgca agactagtgc ataaaaatgc
     2401 aataggtgtc atatgtacag cattcttctt agagttgcct tttcatccca attacagtga
     2461 gtctgatttc catcctgtat ttgcataata cttgtcttaa aataaaagct tttatgattg
     2521 ggaatttatc tgcctaatca gacttattat tgagacgtca atgggacgca tttttctgtt
     2581 gagctatgca gtcgtcaaaa cagcgataga cagcatagga ggtttgaagc agaaatgaaa
     2641 tgtgttattc agagccaatg ttgtacatag agcattttca ctattgctga atgggaatga
     2701 ttaaaaacaa ggtatttttc gggccaggcg gtggctcacg cttgtaatcg cagcactttg
     2761 ggaggctgag gcaggaggat cacttgagcc caggagttca agactagcct aggcaacata
     2821 gtgagaccct gtctctacta aaaataaatt taaaaaaaat tagctgagtg tggtggtgca
     2881 tgcatgtagt tccagctact caggaggctg aggctagagg atccttgagc ccaggaggtt
     2941 gaggctgcag tgaggtgtga ttgcgccact gcattccagc ttgggcgaca gagcgagacc
     3001 cagtctcaaa aaaaaaaaaa agtatttttc tcttaccgtt acagtattct gattatatta
     3061 ctgacacagt caaaatgatt aactgtacaa cctgtatctg ctgggtgttc ttgttatcat
     3121 attgtaaaac agctttaaaa atatttatat tttaaaaact gtatgtgaca ttaatatgcc
     3181 taatgattaa aattatagtg atgaaataac aaaattgaat cttgttatat cttttcaaac
     3241 tcactgtggg ccatagtgtc agtgtagcat atgtggtcat ttaagaatac atggtatttt
     3301 ggtatctgtt ttcatgcttt agaaagagta ttacattttt tcccattaag tgtggttatg
     3361 tttgtttttt aaatttgagt aaaaaataat tcttattttt tggatgctac taaatgtagg
     3421 atttatgtta gatttattat ttgatcattg aaaggtattt ttacttttaa aaaatcttgt
     3481 tgcaaggagg tttaaaaagt aatgttcatt tctgcatcag tttcagccaa atgttgatat
     3541 taaaaccttt tattcttttt tttaattttt gcctctagat gtgatgcctt aagataaaaa
     3601 ccatttattc aacttaaaaa aaaatcactt tttttttttt tttgagatgg agtcttgctc
     3661 tgtcacccag gctggagtgc agtggcacta tctcggctta ctgtaacctc cacctcctga
     3721 attcaagcaa ttctcctgcc tcagtcgcct gagtagctgg gattataggt gcccgccacc
     3781 atgcccagct aatttttttt ttgtatttat tttattttta ttttattttg ttttgttttt
     3841 gagatggagc ttcactttgt cacccaggct ggagtgcagt ggcatgatct cggctcattg
     3901 caacctcagt ctcctgggtt caagtgattc tcatgcctca gcctcccaag tagctggtat
     3961 gacagccacc atgcctggct aatttttgta tttttagtag agacagggtt taaccatgtt
     4021 ggccaggctg gtctcaaact cctgacctca agtgatccac ccaccttggc ctcccaaagt
     4081 gctgggatta caggcatgag ccacgtgcct ggcctttttt ttgtattttt agtagatatg
     4141 gggtttcacc atgttgccca ggctgttctc aaactcctga cctcaagtga tccacccacc
     4201 tcagcctccc aaatcacatt gatttttcaa ttgaatttct actttatctt ggtttagatt
     4261 ttgtagataa gttagtaaca tttatacctt ccttgtttct ttttataaca tggagttttt
     4321 cagatttcat gtctatttta gcttaaatct aagcttatat taatttttat tcacatgatt
     4381 cattataatg agtaggccta ctttgttctt atttaagtta tatgcagtac attttgcctc
     4441 aatcatggag agttaaacat ctcaaatggt atagcatagg gaatttaggg agtgccctag
     4501 aggggtatgg gtttgatatt tgagatgaaa acactgatgt ggagaaagga tagccttctg
     4561 tgttgactaa ttgtgtgtcc tgtccttatg gtccactctt agtgtgacct tgaatttatg
     4621 gcaggtagca aaattctatt ttgctgattt gagtatttta ttttagcttc tttagatgta
     4681 tttcccttct tcagtttctt gttgtattat tgcaccatag atattaacac gaatatattt
     4741 ttaaaaactg cccagagatc atttgatctc aagtgtatat acacttcact tttctggagt
     4801 tacagaagga tggtgaaata atcattttct ggattttgct tttcagaggg agattgaaga
     4861 aagttcaata gaacactgat gagctcataa gaaccgtgtc gttcatgttt ctttgtaatt
     4921 cagtttgctg tttttattct tattcctttc taggaagtac attccacagg cttctatgga
     4981 aattaagttg aaataaattt tgataattgg cctttgatgc aaaatttatg catagcattt
     5041 aattttataa cattttgttt tattctgtga ttaaatatat atatgtatat gttttaaagt
     5101 cttatatgtg gtgaacattc tcctcttttt ttagttctca ctattaatag aaaaaaatat
     5161 atattttaaa aacaaaa
//
