LOCUS       NM_203349               5027 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens SHC adaptor protein 4 (SHC4), mRNA.
ACCESSION   NM_203349
VERSION     NM_203349.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5027)
  AUTHORS   Zhong,W., Jian,Y., Zhang,C., Li,Y., Yuan,Z., Xiong,Z., Huang,W.,
            Ouyang,Y., Chen,X., Song,L., Liu,P. and Wang,X.
  TITLE     SHC4 orchestrates beta-catenin pathway-mediated metastasis in
            triple-negative breast cancer by promoting Src kinase
            autophosphorylation
  JOURNAL   Cancer Lett 582, 216516 (2024)
   PUBMED   38052369
  REMARK    GeneRIF: SHC4 orchestrates beta-catenin pathway-mediated metastasis
            in triple-negative breast cancer by promoting Src kinase
            autophosphorylation.
REFERENCE   2  (bases 1 to 5027)
  AUTHORS   Tilak,M., Alural,B., Wismer,S.E., Brasher,M.I., New,L.A.,
            Sheridan,S.D., Perlis,R.H., Coppolino,M.G., Lalonde,J. and Jones,N.
  TITLE     Adaptor Protein ShcD/SHC4 Interacts with Tie2 Receptor to
            Synergistically Promote Glioma Cell Invasion
  JOURNAL   Mol Cancer Res 19 (5), 757-770 (2021)
   PUBMED   33495401
  REMARK    GeneRIF: Adaptor Protein ShcD/SHC4 Interacts with Tie2 Receptor to
            Synergistically Promote Glioma Cell Invasion.
REFERENCE   3  (bases 1 to 5027)
  AUTHORS   Kennedy,S.A., Jarboui,M.A., Srihari,S., Raso,C., Bryan,K.,
            Dernayka,L., Charitou,T., Bernal-Llinares,M., Herrera-Montavez,C.,
            Krstic,A., Matallanas,D., Kotlyar,M., Jurisica,I., Curak,J.,
            Wong,V., Stagljar,I., LeBihan,T., Imrie,L., Pillai,P., Lynn,M.A.,
            Fasterius,E., Al-Khalili Szigyarto,C., Breen,J., Kiel,C.,
            Serrano,L., Rauch,N., Rukhlenko,O., Kholodenko,B.N.,
            Iglesias-Martinez,L.F., Ryan,C.J., Pilkington,R., Cammareri,P.,
            Sansom,O., Shave,S., Auer,M., Horn,N., Klose,F., Ueffing,M.,
            Boldt,K., Lynn,D.J. and Kolch,W.
  TITLE     Extensive rewiring of the EGFR network in colorectal cancer cells
            expressing transforming levels of KRASG13D
  JOURNAL   Nat Commun 11 (1), 499 (2020)
   PUBMED   31980649
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5027)
  AUTHORS   Wills,M.K.B., Lau,H.R. and Jones,N.
  TITLE     The ShcD phosphotyrosine adaptor subverts canonical EGF receptor
            trafficking
  JOURNAL   J Cell Sci 130 (17), 2808-2820 (2017)
   PUBMED   28724758
  REMARK    GeneRIF: ShcD appears to possess several molecular permutations
            that actively govern the EGFR, which may have implications in
            development and disease.
REFERENCE   5  (bases 1 to 5027)
  AUTHORS   Wills,M.K., Keyvani Chahi,A., Lau,H.R., Tilak,M., Guild,B.D.,
            New,L.A., Lu,P., Jacquet,K., Meakin,S.O., Bisson,N. and Jones,N.
  TITLE     Signaling adaptor ShcD suppresses extracellular signal-regulated
            kinase (Erk) phosphorylation distal to the Ret and Trk neurotrophic
            receptors
  JOURNAL   J Biol Chem 292 (14), 5748-5759 (2017)
   PUBMED   28213521
  REMARK    GeneRIF: ShcD binds to active Ret, TrkA, and TrkB neurotrophic
            factor receptors predominantly via its phosphotyrosine-binding
            (PTB) domain.
REFERENCE   6  (bases 1 to 5027)
  AUTHORS   You,Y., Li,W., Gong,Y., Yin,B., Qiang,B., Yuan,J. and Peng,X.
  TITLE     ShcD interacts with TrkB via its PTB and SH2 domains and regulates
            BDNF-induced MAPK activation
  JOURNAL   BMB Rep 43 (7), 485-490 (2010)
   PUBMED   20663410
  REMARK    GeneRIF: ShcD interacts with TrkB in a kinase-activity-dependent
            manner.
REFERENCE   7  (bases 1 to 5027)
  AUTHORS   You,Y.G., Li,W.Q., Yin,B. and Peng,X.Z.
  TITLE     [ShcD interacts with TrkC through its PTB and SH2 domains]
  JOURNAL   Zhongguo Yi Xue Ke Xue Yuan Xue Bao 31 (6), 720-723 (2009)
   PUBMED   20078941
  REMARK    GeneRIF: ShcD binds to TrkC in a kinase-activity-dependent manner
            through its PTB and SH2 domains.
REFERENCE   8  (bases 1 to 5027)
  AUTHORS   Jones,N., Hardy,W.R., Friese,M.B., Jorgensen,C., Smith,M.J.,
            Woody,N.M., Burden,S.J. and Pawson,T.
  TITLE     Analysis of a Shc family adaptor protein, ShcD/Shc4, that
            associates with muscle-specific kinase
  JOURNAL   Mol Cell Biol 27 (13), 4759-4773 (2007)
   PUBMED   17452444
  REMARK    GeneRIF: A new member of the Shc family of docking proteins is
            characterised, which may mediate a specific aspect of signaling
            downstream of the MuSK receptor.
REFERENCE   9  (bases 1 to 5027)
  AUTHORS   Fagiani,E., Giardina,G., Luzi,L., Cesaroni,M., Quarto,M., Capra,M.,
            Germano,G., Bono,M., Capillo,M., Pelicci,P. and Lanfrancone,L.
  TITLE     RaLP, a new member of the Src homology and collagen family,
            regulates cell migration and tumor growth of metastatic melanomas
  JOURNAL   Cancer Res 67 (7), 3064-3073 (2007)
   PUBMED   17409413
REFERENCE   10 (bases 1 to 5027)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091073.3, AY464565.1 and AC012379.7.
            
            On Nov 23, 2018 this sequence version replaced NM_203349.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.216458.1,
                                           SRR1803612.9473.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332408.9/ ENSP00000329668.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1058              AC091073.3         76336-77393         c
            1059-2808           AY464565.1         193-1942
            2809-5027           AC012379.7         66173-68391         c
FEATURES             Location/Qualifiers
     source          1..5027
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q21.1"
     gene            1..5027
                     /gene="SHC4"
                     /gene_synonym="RaLP; SHCD"
                     /note="SHC adaptor protein 4"
                     /db_xref="GeneID:399694"
                     /db_xref="HGNC:HGNC:16743"
                     /db_xref="MIM:617372"
     exon            1..1489
                     /gene="SHC4"
                     /gene_synonym="RaLP; SHCD"
                     /inference="alignment:Splign:2.1.0"
     CDS             905..2797
                     /gene="SHC4"
                     /gene_synonym="RaLP; SHCD"
                     /note="rai-like protein; hShcD; SH2 domain protein C4;
                     SHC-transforming protein D; src homology 2
                     domain-containing-transforming protein C4; SHC (Src
                     homology 2 domain containing) family, member 4"
                     /codon_start=1
                     /product="SHC-transforming protein 4"
                     /protein_id="NP_976224.3"
                     /db_xref="CCDS:CCDS10130.1"
                     /db_xref="GeneID:399694"
                     /db_xref="HGNC:HGNC:16743"
                     /db_xref="MIM:617372"
                     /translation="MRERGQDSLAGLVLYVGLFGHPGMLHRAKYSRFRNESITSLDEG
                     SSGGSVGNKGSPQPPHPALAPHLPTEDATLPSQESPTPLCTLIPRMASMKLANPATLL
                     SLKNFCLGTKEVPRLKLQESRDPGSSGPSSPETSLSRSGTAPPPQQDLVGHRATALTP
                     DSCPLPGPGEPTLRSRQDRHFLQHLLGMGMNYCVRYMGCVEVLQSMRSLDFGMRTQVT
                     REAISRLCEAVPGANGAIKKRKPPVKFLSTVLGKSNLQFSGMNIKLTISTCSLTLMNL
                     DNQQIIANHHMQSISFASGGDPDTTDYVAYVAKDPVNQRACHILECHNGMAQDVISTI
                     GQAFELRFKQYLKNPSLNTSCESEEVHIDSHAEEREDHEYYNEIPGKQPPVGGVSDMR
                     IKVQATEQMAYCPIQCEKLCYLPGNSKCSSVYENCLEQSRAIGNVHPRGVQSQRDTSL
                     LKHTCRVDLFDDPCYINTQALQSTPGSAGNQRSAQPLGSPWHCGKAPETVQPGATAQP
                     ASSHSLPHIKQQLWSEECYHGKLSRKAAESLLVKDGDFLVRESATSPGQYVLSGLQGG
                     QAKHLLLVDPEGKVRTKDHVFDNVGHLIRYHMDNSLPIISSGSEVSLKQPVRKDNNPA
                     LLHSNK"
     exon            1490..1560
                     /gene="SHC4"
                     /gene_synonym="RaLP; SHCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1624
                     /gene="SHC4"
                     /gene_synonym="RaLP; SHCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1744
                     /gene="SHC4"
                     /gene_synonym="RaLP; SHCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..1798
                     /gene="SHC4"
                     /gene_synonym="RaLP; SHCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..1850
                     /gene="SHC4"
                     /gene_synonym="RaLP; SHCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..1974
                     /gene="SHC4"
                     /gene_synonym="RaLP; SHCD"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2146
                     /gene="SHC4"
                     /gene_synonym="RaLP; SHCD"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..2207
                     /gene="SHC4"
                     /gene_synonym="RaLP; SHCD"
                     /inference="alignment:Splign:2.1.0"
     exon            2208..2387
                     /gene="SHC4"
                     /gene_synonym="RaLP; SHCD"
                     /inference="alignment:Splign:2.1.0"
     exon            2388..2641
                     /gene="SHC4"
                     /gene_synonym="RaLP; SHCD"
                     /inference="alignment:Splign:2.1.0"
     exon            2642..5027
                     /gene="SHC4"
                     /gene_synonym="RaLP; SHCD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3336..3341
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SHC4"
                     /gene_synonym="RaLP; SHCD"
                     /note="hexamer: AATAAA"
     polyA_site      3359
                     /gene="SHC4"
                     /gene_synonym="RaLP; SHCD"
                     /note="major polyA site"
     regulatory      5002..5007
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SHC4"
                     /gene_synonym="RaLP; SHCD"
                     /note="hexamer: AATAAA"
     polyA_site      5027
                     /gene="SHC4"
                     /gene_synonym="RaLP; SHCD"
                     /note="major polyA site"
ORIGIN      
        1 attcacagat ttattagctt gcacacacac agagaaattc attcggcaaa gttcattcat
       61 aaaaatttca acacgctgcg tatcatcctg cacatctcag ctttcggctg caaatgggct
      121 tctgaaaaaa gctccgagag gaatccagga gggagggaag ctctgagcga gggtaggcag
      181 gctgggaggg gatctgagga acacggaccc atcacaagtc agtgaaacaa tgcggagcag
      241 cgcccgtcag tagtactcct ggctggtggc ccagaacggg atgcaagaca agatcttcca
      301 agagagggca gcctttggaa tcaacgaacc caggcaaaag ggcctttggt tcatagatac
      361 attttttttt cctttttaaa tgaacaatca ctggaacaaa taaagggtta ataggccagt
      421 catttgcccc gccctgtgag agccgaaggg agcaggttcg aaagttcctg tgtgcagaac
      481 agaaggctgg ggtgagggtg ggagtcgggt gctaaatatt tctactaggc tcctgcaagg
      541 ctagtgatgc agcgggcccc ccgaccggcg ctcgcccggg ttctgcgcct aagagttggc
      601 cgtgagcgac ccgcgccgcc gggagcctgg gtctaggctc tcccgacaag gattccaagg
      661 cgagaacact ggtgcctctg cctgggccag ggagagactg aaatcagagc aggggaggcg
      721 tttcccccat gggctgtcac ccttaagggg ccgggagccg aggtgggcga gctcgagagc
      781 agagttggag aggtggctgc tgtgagttgc atcgggcgtt gaggtatctg atgtctgcac
      841 cgtttatcta ccagacgacg aggcgattta tgcaacagta tcctgtttca gcactgccaa
      901 ggctatgcga gaacgcggcc aggacagcct ggcaggactc gtgctgtatg taggactctt
      961 cgggcacccc gggatgctgc acagggccaa gtacagccgc tttcggaacg agtcgatcac
     1021 gtccttggac gaaggtagct ccggaggctc ggtcgggaac aagggctcgc cgcagcctcc
     1081 ccaccccgcc ctggcacctc acctgccgac tgaagatgcc accttgccgt cgcaggagag
     1141 ccccacccca ctgtgcacct tgatcccccg catggcaagc atgaagctgg ccaacccggc
     1201 cactttgctg agtctgaaaa acttttgcct gggtaccaaa gaggtgcctc ggctgaagct
     1261 ccaggaaagc cgggacccag gttccagcgg cccctcttcc ccagaaacca gtttaagtag
     1321 gtccgggact gcacctccac cgcagcagga cctggtggga cacagggcaa ccgccctaac
     1381 ccctgattcg tgcccgcttc ctggccctgg ggagccaaca cttaggagca ggcaggacag
     1441 gcactttcta cagcacctgt tggggatggg catgaactac tgtgtgaggt acatgggctg
     1501 tgttgaagtg ctgcaatcaa tgagatcact ggattttgga atgagaaccc aagttacaag
     1561 ggaagcaata agtcgcctgt gtgaagctgt ccccggggca aatggagcca ttaaaaagcg
     1621 aaagcctcca gttaagttcc tatcaacagt ccttggcaaa agtaatcttc agttttcagg
     1681 aatgaatata aaactgacca tctcaacatg cagtctcaca ttgatgaatc ttgacaacca
     1741 acagattatt gcaaatcatc atatgcagtc tatttcattt gcctctggag gggatcctga
     1801 tactacagac tatgttgcct acgtagctaa agatccagtt aatcaacgag cctgtcacat
     1861 attggaatgc cacaatggaa tggcccaaga cgtcataagt accatagggc aggcttttga
     1921 actccggttt aaacagtact tgaaaaatcc ttctttgaat acttcttgtg aaagtgagga
     1981 ggtgcatatt gatagccatg ccgaggagag agaagatcat gaatattaca atgaaattcc
     2041 agggaagcag ccaccagtag gtggtgtttc agatatgcgg atcaaagttc aagccacgga
     2101 acaaatggct tactgcccca tacagtgtga aaagttgtgc tatttgcctg gaaactccaa
     2161 gtgcagcagt gtatatgaga actgtttaga acaaagcagg gcaataggta atgtccatcc
     2221 aagaggggtg cagtcccagc gagatacctc attattgaag cacacgtgcc gagtggatct
     2281 ctttgatgac ccctgctaca ttaatacaca ggctcttcaa agtacacctg gctctgctgg
     2341 aaatcaaagg tcagcccaac cactggggag cccatggcac tgcggaaagg caccagaaac
     2401 tgttcagccg ggtgccacag cccagcctgc cagctcacat tctttgccac acattaagca
     2461 gcagctgtgg agcgaagaat gctatcatgg caagctgagc aggaaggcgg cagagagcct
     2521 cttggtaaag gatggggact ttttggttcg agagagtgca acatcccctg gccaatatgt
     2581 gctgagtgga ctacagggag gccaagcaaa acatcttctc ctggtggatc ctgaaggcaa
     2641 ggtgaggacc aaggatcatg tatttgataa tgtcggccac cttatcagat accatatgga
     2701 taacagtttg ccaatcatct cctctggaag cgaagtaagc cttaaacaac cagtgagaaa
     2761 agataataat ccagcacttt tgcattccaa caaatgacag tattgaagca ccatcacact
     2821 gatatttcaa gaaaccccat tttgtattag gacacaaaga taatttaaac tttgtttgta
     2881 gataaaatag agcacaaact gtgaagtgca tctttccaag accatcatgg accaggtcct
     2941 ctataaaatg aagaactaac aaaaattagt cttcagaaat gaaaatcaga aaagaggaag
     3001 agggttggtc attttaaaag aaattatatg tatgcacgga tgtcactttt taaggccata
     3061 ttgcattgat aacaagctaa aagcacaact aaaatttcac atgctaacga caacttgaat
     3121 gaactgctgg ggcagtggta tgtgcctttc aacttgataa tttgggggac attttcatat
     3181 tgggagatta attctaagta tcttcatgtt ctatgactat agaaccattt gccaaaaaaa
     3241 aaagcttttc ttgctacaaa aaataagcaa ttttcttgag ccttattgac tttattacat
     3301 tttctgttta gcagcatttt tcactgcaat gttaaaataa atatgacatt gaattcgaac
     3361 tgtgtgtatg tcagtggaat caaatcaaaa gccactaaca tggctgtctg tttcattgga
     3421 ctgtcccatt tgctggttaa aaggattggg gcccaaatcc tctggcctag catttctcag
     3481 tgtttgctat tcagactgtc taaatacagc atgtgacaag ctgaagaagc caaatctatc
     3541 agtcatttct gatttcatta tattctcccc ctcttcctgc taaaaagaca aaaaacaaaa
     3601 aacaaaaaaa acaaaaaaaa cctcatgagt gcatggattt aaaagagggc aaacaaaacc
     3661 agtattcttc atatttacta ttcaaattgg tttcattctt agtaaaagta cagaatctat
     3721 ttgaaattat agtaaaattt cttcttgatt ggctgacact gaatcatagt ttctcaccta
     3781 catatatcct tagcacctcg tatagatatg atcagacaaa atgcagaagg aaaaaaaaac
     3841 atattgaatg aagcacttgg aaagattttc cacatgtaga ccaactggta aactaacaga
     3901 gtgattaagc atggtgtaca gaaaagcatt acgctgagtc ttaccagtgt gaccttcagc
     3961 aagttgctga atctgtttgg gttccagttt ccttggcaat aaaatgagct aaatgggcta
     4021 ggtgaatttg gaggactact tcagtcctaa cttatagtat gagtctctaa aaagcaagtt
     4081 tttcatttgt tagaggtcgt tattgataac cagtctgtat agttaaggta aaaaattaag
     4141 cttttcttct atagtctgtg tccatactca cagaatgaat ggcacacctg agatcaacat
     4201 tcacatagtt tagactccaa accattcagt ctaaaatact gaaactttgg aatataggga
     4261 atgatgataa aagtggattt ggtttgagta gcagaaaact acttatgtcc ttttcttgcc
     4321 tttccaagaa aaatgttttt tgtttttttt tttaatcttg agttatctgg atattgcctt
     4381 gactccattt cattttggct atgtagatac aacttagtct ttgtgattgt gatatatttg
     4441 ctaagtttta aataaaactt cttttggata gaaatcatta gaaaccaagc atactgcact
     4501 ctaatatttt actgtaaagg cttatgattt ttatttctac tgccattaat tttttagatg
     4561 gatttgtttc ctcttacaca actagaatta atgtattttt caccagtttt ccatatacct
     4621 taggtcttga tcgtttgtcc ttaaaaaggg gatcagcatg agtatagaca gtagaaatgt
     4681 atgggtagtc taaccacttt tatcagagac agagcagggc tgtggtctca ctctagctga
     4741 gcagagtatt aacttggtag caagagttcc tgatacaaat agatgcaatg actgtaaatg
     4801 gtgtcagcag tacacatgga taatcagtat ttgactgtaa tagtatagta gttaaataca
     4861 gcacttaaaa ataccacaga cacagttaaa gcaaaaggaa acaataaaag gaatgtctgc
     4921 atgctatttt aatctcacat tctttatctg tcttaaagtg gaaatccatt tgcctataaa
     4981 tacctgtaaa cgactttaaa aaataaatga ttattgcttt gtgacaa
//
