LOCUS       NM_016848               9819 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens SHC adaptor protein 3 (SHC3), mRNA.
ACCESSION   NM_016848
VERSION     NM_016848.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9819)
  AUTHORS   Liu,Y., Cao,F., Xia,F., Li,J., Dong,X., Guo,Y., Zhang,J., Zhao,Q.
            and Liu,Y.
  TITLE     Shc3 facilitates breast cancer drug resistance by interacting with
            ErbB2 to initiate ErbB2/COX2/MDR1 axis
  JOURNAL   Cancer Med 12 (9), 10768-10780 (2023)
   PUBMED   36880347
  REMARK    GeneRIF: Shc3 facilitates breast cancer drug resistance by
            interacting with ErbB2 to initiate ErbB2/COX2/MDR1 axis.
REFERENCE   2  (bases 1 to 9819)
  AUTHORS   Criscuoli,M., Ulivieri,C., Filippi,I., Monaci,S., Guerrini,G.,
            Crifo,B., De Tommaso,D., Pelicci,G., Baldari,C.T., Taylor,C.T.,
            Carraro,F. and Naldini,A.
  TITLE     The Shc protein Rai enhances T-cell survival under hypoxia
  JOURNAL   J Cell Physiol 235 (11), 8058-8070 (2020)
   PUBMED   31944299
  REMARK    GeneRIF: The Shc protein Rai enhances T-cell survival under
            hypoxia.
REFERENCE   3  (bases 1 to 9819)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 9819)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 9819)
  AUTHORS   Liu,Y., Zhang,X., Yang,B., Zhuang,H., Guo,H., Wei,W., Li,Y.,
            Chen,R., Li,Y. and Zhang,N.
  TITLE     Demethylation-Induced Overexpression of Shc3 Drives
            c-Raf-Independent Activation of MEK/ERK in HCC
  JOURNAL   Cancer Res 78 (9), 2219-2232 (2018)
   PUBMED   29330146
  REMARK    GeneRIF: our results indicate the importance of Shc3 in HCC
            progression and identify Shc3 as a novel biomarker and potential
            therapeutic target in HCC.Significance: Ectopic expression of Shc3
            forms a complex with MVP/MEK/ERK to potentiate ERK activation and
            plays an important role in sorafinib resistance in HCC.
REFERENCE   6  (bases 1 to 9819)
  AUTHORS   Wang,J.F., Ganju,R.K., Liu,Z.Y., Avraham,H., Avraham,S. and
            Groopman,J.E.
  TITLE     Signal transduction in human hematopoietic cells by vascular
            endothelial growth factor related protein, a novel ligand for the
            FLT4 receptor
  JOURNAL   Blood 90 (9), 3507-3515 (1997)
   PUBMED   9345034
REFERENCE   7  (bases 1 to 9819)
  AUTHORS   Nakamura,T., Sanokawa,R., Sasaki,Y., Ayusawa,D., Oishi,M. and
            Mori,N.
  TITLE     N-Shc: a neural-specific adapter molecule that mediates signaling
            from neurotrophin/Trk to Ras/MAPK pathway
  JOURNAL   Oncogene 13 (6), 1111-1121 (1996)
   PUBMED   8808684
REFERENCE   8  (bases 1 to 9819)
  AUTHORS   Pelicci,G., Dente,L., De Giuseppe,A., Verducci-Galletti,B.,
            Giuli,S., Mele,S., Vetriani,C., Giorgio,M., Pandolfi,P.P.,
            Cesareni,G. and Pelicci,P.G.
  TITLE     A family of Shc related proteins with conserved PTB, CH1 and SH2
            regions
  JOURNAL   Oncogene 13 (3), 633-641 (1996)
   PUBMED   8760305
REFERENCE   9  (bases 1 to 9819)
  AUTHORS   O'Bryan,J.P., Songyang,Z., Cantley,L., Der,C.J. and Pawson,T.
  TITLE     A mammalian adaptor protein with conserved Src homology 2 and
            phosphotyrosine-binding domains is related to Shc and is
            specifically expressed in the brain
  JOURNAL   Proc Natl Acad Sci U S A 93 (7), 2729-2734 (1996)
   PUBMED   8610109
REFERENCE   10 (bases 1 to 9819)
  AUTHORS   Waters,S.B., Yamauchi,K. and Pessin,J.E.
  TITLE     Insulin-stimulated disassociation of the SOS-Grb2 complex
  JOURNAL   Mol Cell Biol 15 (5), 2791-2799 (1995)
   PUBMED   7739560
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL160054.14, BC026314.1, D84361.1, AL353150.25 and AL772202.14.
            
            On Nov 23, 2018 this sequence version replaced NM_016848.5.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026314.1, D84361.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375835.9/ ENSP00000364995.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                AL160054.14        145367-145417
            52-530              BC026314.1         2-480
            531-1695            D84361.1           353-1517
            1696-2018           BC026314.1         1646-1968
            2019-6656           AL353150.25        2001-6638           c
            6657-9819           AL772202.14        52794-55956         c
FEATURES             Location/Qualifiers
     source          1..9819
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.1"
     gene            1..9819
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /note="SHC adaptor protein 3"
                     /db_xref="GeneID:53358"
                     /db_xref="HGNC:HGNC:18181"
                     /db_xref="MIM:605263"
     exon            1..832
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /inference="alignment:Splign:2.1.0"
     CDS             359..2143
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /note="neuronal Shc; SHC (Src homology 2 domain
                     containing) transforming protein 3; src homology 2
                     domain-containing transforming protein C3; protein Rai;
                     SH2 domain protein C3; SHC-transforming protein C; Shc3
                     p51"
                     /codon_start=1
                     /product="SHC-transforming protein 3"
                     /protein_id="NP_058544.3"
                     /db_xref="CCDS:CCDS6681.1"
                     /db_xref="GeneID:53358"
                     /db_xref="HGNC:HGNC:18181"
                     /db_xref="MIM:605263"
                     /translation="MLPRTKYNRFRNDSVTSVDDLLHSLSVSGGGGKVSAARATPAAA
                     PYLVSGEALRKAPDDGPGSLGHLLHKVSHLKLSSSGLRGLSSAARERAGARLSGSCSA
                     PSLAAPDGSAPSAPRAPAMSAARKGRPGDEPLPRPPRGAPHASDQVLGPGVTYVVKYL
                     GCIEVLRSMRSLDFSTRTQITREAISRVCEAVPGAKGAFKKRKPPSKMLSSILGKSNL
                     QFAGMSISLTISTASLNLRTPDSKQIIANHHMRSISFASGGDPDTTDYVAYVAKDPVN
                     RRACHILECCDGLAQDVIGSIGQAFELRFKQYLQCPTKIPALHDRMQSLDEPWTEEEG
                     DGSDHPYYNSIPSKMPPPGGFLDTRLKPRPHAPDTAQFAGKEQTYYQGRHLGDTFGED
                     WQQTPLRQGSSDIYSTPEGKLHVAPTGEAPTYVNTQQIPPQAWPAAVSSAESSPRKDL
                     FDMKPFEDALKNQPLGPVLSKAASVECISPVSPRAPDAKMLEELQAETWYQGEMSRKE
                     AEGLLEKDGDFLVRKSTTNPGSFVLTGMHNGQAKHLLLVDPEGTIRTKDRVFDSISHL
                     INHHLESSLPIVSAGSELCLQQPVERKQ"
     exon            833..903
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /inference="alignment:Splign:2.1.0"
     exon            904..967
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1087
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1141
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1193
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..1320
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1471
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1559
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1718
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /inference="alignment:Splign:2.1.0"
     exon            1719..2014
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /inference="alignment:Splign:2.1.0"
     exon            2015..9819
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9797..9802
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /note="hexamer: AATAAA"
     polyA_site      9819
                     /gene="SHC3"
                     /gene_synonym="N-Shc; NSHC; RAI; SHCC"
                     /note="major polyA site"
ORIGIN      
        1 gcagtgctca ccgagccttt gttgagaagg gtctcctctc agagtgagtc atgcttttgc
       61 tgtgagcagc cccaagcagc tgggcgctcc atcagaggca actatgactt ttgcaaagca
      121 aacgtgcaac cccaagcagc ggtctcccgg gccggggctg cgcggccgcc gctgtgctgg
      181 cttttaacgg tgggagggca ccatcctctt gctctgctct cgttctccag aaggctgtcc
      241 cggggccccc actctccgtc ccgctccggg gacagtggct cgcctgctat gcgcggcagc
      301 ccgcgccggg gccggcacca gcagcgcccg ggcggatgca gcgagcccac ggaggggcat
      361 gcttccacgc accaagtata accgcttcag gaatgactcg gtgacatcgg tcgatgacct
      421 tctccacagc ctgtcggtga gcggcggcgg aggcaaggtt tcggcggcgc gcgcgacccc
      481 ggcggcggct ccctacttgg tgtccggcga ggcgctgcgc aaggcgcccg acgatgggcc
      541 cggcagcctg ggccacctgc tccacaaggt gtcccacctg aaactctcca gctcgggcct
      601 ccgcggcctg tcgtcggccg cccgggagcg ggcgggcgcg cggctctcgg gcagctgcag
      661 cgcgcccagc ctggccgccc cggacggcag tgcgccctcg gcgccccgcg ccccggccat
      721 gagcgccgcc aggaagggcc ggcccggcga cgagccgctg cccaggcccc ctcggggggc
      781 gccgcacgcc agcgaccagg tgctggggcc cggagtcacc tacgtggtca agtacttggg
      841 gtgcattgaa gttctgcgct caatgaggtc tcttgacttc agtacaagaa cacaaattac
      901 cagggaagcc atcagccgcg tctgtgaagc tgtgcctggt gcgaagggag ccttcaagaa
      961 gagaaagcct ccaagcaaaa tgctgtccag catcttggga aagagcaacc tccagtttgc
     1021 gggaatgagc atctctctga ccatctccac ggccagtctg aacctgcgaa ctccggactc
     1081 caaacagatc atagcgaatc accacatgcg gtccatctcc ttcgcctctg ggggagaccc
     1141 ggacacaact gactatgttg catatgtggc taaggaccct gttaatcgca gagcttgtca
     1201 cattttggaa tgctgtgatg ggctggccca ggatgtcatc ggctccatcg gacaagcctt
     1261 tgagctccgg tttaagcaat atttacagtg tcctaccaag attcccgctc tccatgatcg
     1321 aatgcagagt ctggatgagc catggacgga agaggaggga gatggctcag accacccata
     1381 ctacaacagc atcccaagca agatgcctcc tccagggggc tttcttgata ctagactgaa
     1441 acccagaccc catgctcctg acacagccca gtttgcagga aaagagcaga cttattacca
     1501 gggaagacac ttaggagaca cttttggcga agactggcag caaacacctt taaggcaagg
     1561 gtcctcggac atctacagca cgccagaagg gaaactgcac gtggccccca cgggagaagc
     1621 acccacctac gtcaacactc agcagatccc accacaggcc tggccggctg cggtcagcag
     1681 tgctgagagc agcccaagga aagacctctt tgacatgaaa ccttttgaag atgctctcaa
     1741 gaaccagccc ttggggcccg tgttaagcaa ggcagcctcc gtggagtgca tcagccctgt
     1801 gtcacctaga gccccagatg ccaagatgct ggaggaactg caagccgaga cttggtacca
     1861 aggagagatg agcaggaagg aggcagaggg gctgctggag aaagacggag acttcctggt
     1921 caggaagagc accaccaacc cgggctcctt tgtcctcacg ggcatgcaca atggccaggc
     1981 caagcacctg ctgctcgtgg acccagaagg cacgatccgg acaaaggaca gagtctttga
     2041 cagtatcagc cacctcatca accaccacct agaaagcagc ctgcccattg tctctgcagg
     2101 gagtgagctg tgtctccagc agccagtgga gaggaagcag tgacctggcc agcactgctc
     2161 ccagcactgc gcaccaggtc aggaggacct ggagtggact agaatcgggg ctgctggaac
     2221 tgggacagct gcctgtggct cagagccttc ttcaaaagct tcaaaaggaa ggcttccttt
     2281 aaggtcaagt ttcataaact tggttctgaa tttctcatat gcatattaaa ggtgtacata
     2341 cctatacatc ctgtacaaat tatccctcta tatttatatt ttttaagact aagaaagatg
     2401 taagactaat gttctgtgct gtatgttttt aatgaaaaaa aaaaataagt ttaactgtag
     2461 ttgtccaggc aaaaatttaa ttcaactgac ccatcccacc gggaaatgcc actaggaagg
     2521 tgtagcctgc agttttacct aataagcaca actggagggg aatagaaaca cagaattgtg
     2581 agggaatcgc aaggcatgct gctcagagca tgcctagccc tgcactgaaa gctatgagat
     2641 actggttctg aggcatggct gtgcttgctg gtgggagcgg gcatcctccc ttggcctccc
     2701 tgggacacct cctgtgctcc ctgcactgca ctccacgtgc ctggggtgtc tacacaactc
     2761 gctgcagctt cactaaagaa caggtggcac tccagcttct ccgggtcctg ctgagcacag
     2821 ggccccgcca cccttgaccc cagttgtgcg aggagtactt gggaattcat ttcatgccaa
     2881 aatggcacaa aataagcttc accaaccaag attttgattg acaagtgctt ccctgttctc
     2941 atgtatctaa tgctaaaatg ggtatttgta gaagggtggt cggggcaaat tcctggtttg
     3001 tgtctccctc tagtcagcgg ttgactacag gctgcttatg gtaattgcta gtaaagtccc
     3061 ccgcccgcct tatacaatag gggagaagcc tgtgtgacag caagagcagg cacccatccc
     3121 agagctcagt cccgaagact caggtattga ggcttctggg gctgcatgtg ccagaaaccc
     3181 aggagtcact ggaatccatt tgaggtactg cctctggcat gagggatggg ggaaaggcct
     3241 gctgtcccaa caacaaggtt tctccgttgc tgcagggaag agcatgtgcc tgcccccact
     3301 ctttgtcttg actccctttc ttccaggtaa aatactgtca tttcctgagg agtcatttgg
     3361 tgttagaaag ctggcaatgt ttataccttt caaatactat ctgggctgag attgccctgt
     3421 gattttcaca gatgcccttt aaagaataga tggatccatt tgcttgctgg cagcgtggct
     3481 cttgttctgg tgagacccca cagggtacag caccctgtag ggtatgggtc agcagaacag
     3541 aaagacacac taaacacgct tagagttgga tagtgataaa tctgatcctg taaggagagt
     3601 tatgaggaga ctgaaaaatc tggcagataa taatactgct aagttctaat gccaatggta
     3661 tgagccccat ttctgccttg gggtgtgcgt gtggccagat ggaaggacag gttagagcta
     3721 accagtgagg atgagtcagg gcaggcccca gccttcatac atggccttct agggagtctt
     3781 tgcctttgag ggtccagtga atttgagatg acagtgaagt cagtgttcta gaatgttctg
     3841 cagtggattg aaactctgga gagtctgaca ctactgtaga ctgcactgct gttttctgaa
     3901 atggttttgg cttcaggcat catgtggata ctctgcttag tgatccagaa gcagacggct
     3961 ccacggggtt gctggcagca gctgcatcag gctcctgccc caagacagca tagacttggg
     4021 tgctctgaga gctgccctgc acatctgtcc tctgggaggc tgggagccct ggagagacac
     4081 acacagctct gacccacctg tgcatgaatg tgcaccacat agaaaaatgt gcgaaatgac
     4141 cttctttcta cattcatgca ttccccactt gtgaaaggtc aaaatgctat tataacattc
     4201 agggacaata gcaaagtagg aaatgcaagt taggagctgt gaatgctgta acatttgatt
     4261 tactttattt ttctcttggg gggacttgaa tggtaacctg cagctttagt agctcttgct
     4321 gtgaagtcag tgtctagttc gatggtgata gaaaatatat atattttttg catgagaatc
     4381 aatttagaaa atttaaagta ttggagtcga attttttctt tttaatatta attcaaaata
     4441 tacattttta agctcagatt atatattggt tacactagaa tagtgccagt gaagtgagca
     4501 ggcttcagac atagcagatg gcagcgattt tctaatcttt gttccctccc atttgtaaag
     4561 tgggttagag cacacattag ttatcccaac tcttccctcc agcactgtgt ggtgggccat
     4621 tcctgtgagc ctcacagaca catggggaaa gtgaggctgg ggctggtgcc acaccttcct
     4681 ggaggccatg ttgtcatctg gctgcagagc tcttctgctc actcagcatt tcgtgagccc
     4741 tgctgtgtgc cagcctgtgc tttgagctca ggattccaag gcaaaagcaa tggaggctcc
     4801 tccctgtcta gcctgggccc ctcttcccca cactttctca ggccacatct ctgcctgggc
     4861 agggcaggga agctgaacaa tgaacgcagc gggaatggca ttaggccttg cgttccaggg
     4921 cctcaggctt ccagggcaca gtcgctgctg ctgtgctggg ccaccctggt cctgcagagt
     4981 gcacctgggc cctgctgtcc ctccaatggg cacccccaac acttaacccc aaactctatg
     5041 tcttctggga gtacaaggtg ggggccagca gtcctaaaac ggcccctctg cccttaccga
     5101 gtggccctag agacccccac ccacctcccc taaccccacg aatgaatcag ctgtgcttca
     5161 aatgacatct ctgtcccacg gaggccggct gggcctctca tgggggtgct cattgtggtt
     5221 taagtcagct ttgattcttg acctccaagg ctgcctctga gtagctaacc ggagaatcgg
     5281 gtggggaggt gaaaaacacc gcagtcaaat gactcaatct ttaatcctgt gcttaagaca
     5341 ccactgttgc tgttttttat atttgaagca cccaaagact gggcgtccgc tcagccttga
     5401 tgagcgagca gctattttgt caggccatct atgatgttgg gataatggac aaaggcctga
     5461 ttgggccata tatggccttc tttagggcct cctggaggtg gaggaagttg tgggtaattt
     5521 ctaataaaga cgggaaatga caagccgtgt gtgtaggtaa agtcctaact taaaaggaag
     5581 gacaggccta gggaagggtg gaccctaaag ggcccatgtg ccaggggaac agtggacatg
     5641 tgtgtccagc ccaacctcca tgtctggtgc tgggattctg aaggtggccc ccagctccca
     5701 aaataaagct ttccttttca gtagcgtccg acacttgggt agcttctttc tataagcaat
     5761 gcttgaagat ggacgtctgg gtcctcattt cctccaaact ggctgctacc tgaaggcagt
     5821 cacacatttc ttttctgttg ggctgagctg ggcagaagcc tcggactata ggcctttcca
     5881 gggcagaggc aatgcgggcc acgagtagat acctccatcc agcctccacc ctggcacacc
     5941 cagaacggcg tggactcagg cgggttgctg gatttctctg agccttggcg tgctctacac
     6001 tgcagggcta tacatgttcc cagcttgagg gcgtgctggg gattgacaaa tatatgaaac
     6061 atataagcgc aatgattttc taaaattgtg cattcccagc gtgcccattg gttctctctc
     6121 gctggcccaa ctttgtgtgc tgtccataaa tccctttctg tggacggtga cagtaggatt
     6181 gggagtgagt gggaagattg tggaaagatt gcaaagaggt cattgcagga ctcagacaga
     6241 ccttgcagtg ggtttcagag taatactcag gttctcccat ggaactttca aagctggctc
     6301 taagaaagat gaagaggaca aacccactcc tggacatagt gccaacctag aactgtcagc
     6361 tccacacagg atcacaggga agggagcttg gtaagacagc ccagtagggg gccctgcttt
     6421 tcagaagagg aaactggagc catgcaaggg cctggggatc aacttagaaa agagcacagg
     6481 actcacagtc ctgggcctgc acgtaaagct agccccctgc cccacggaaa tggcaagcag
     6541 tgcttccctc caggggttct acatctgtgc tccatctcaa aatgcataaa agcctgagtc
     6601 attcagatgg gagagacagt gtttctactt cctcttagtt ggggttcctc cagaaggaga
     6661 ccctgagaga ggacttgagg ttatgtagtt tatttgagtg aagatcccgg aagtagggag
     6721 agaaggaagc tgacggggaa ggcgtgcatt atcaagtaag ttaccgtcat gtgcacaact
     6781 ggagctgaat cccaccgggg aaccccgaga gacagagctg acaccccaga gttcacccag
     6841 caaggcgggg agacagctgg ggtatttatt caccaagtct atcacttatg aaaggctgtt
     6901 tctggaaaca atttctgact ggccctgcac acacctgagc atacttccta agccggggat
     6961 gtccctgagc tgagacaggc gttcgtgaca agcagacttc gagtggaagg caggcatcag
     7021 aaccaccctg tgagctggtt cagacaaaga ttgcaggccc ttccaccccc ctggccccgc
     7081 caagttcctg actccctagg tctggagtgg ggcccgggaa tttgcatttc aaaaaatctc
     7141 gaggtgatgc tggtgcagct gctctgaagt cttgactttg agaaccactc actagtgaga
     7201 gtttccagcc cttacctgtc tcttattgat ggctttcccc cctctaattt ataattatgc
     7261 tttcacacca cttcatgtca cagatcccag ggtccgtgct gtgaatttaa aagtggagaa
     7321 ttaataagca tttataactc catgcaacca ttgctggcag cttaaatgcc atctgccagc
     7381 cataatttat ttataatggg gtttatacat atttataagt ttgcaagcaa caaatgcaca
     7441 gttttaaaac tggcacattt tatagcagcc agaaaaattg caactttata ccaggacttg
     7501 tgaatgtgaa ttgcatatgt atatacatat acgcatatac ttacattgat taaaaacgga
     7561 tctgcatctc tgtacacacg cagattggct ctgtgttgtg caccttggga ctcctccctg
     7621 ggctttggtt ttacagctaa gtaggaagtc aaacaaacgt gaagaatttg ggaattggca
     7681 ggctgtggca tcagccatgg aggatggtcc tggatgctgt aggatgtgag atccagcaca
     7741 aagagaacaa gaacaggaca tgaggaccac agggattggg ggaacccact gtgggaaatg
     7801 acagagaagc cagtggggga agacaaagaa agaagaaggt ggaggcagaa taaaggtgag
     7861 aagaagggaa ggggaggata aaacaagtcc agatttagat cttccttcat gcagccatgc
     7921 atagctgtct gaggccagca gggaaggagg agaaagggaa ggtgtggtgg aggaggctgt
     7981 gctcgtgatg tcatgctttc gtgtattccc aggtgcagct gcatatactt ggcacagttt
     8041 cttgggattt ctagccagtt tcttggcctc atttgtgcat tagttaatat gtggctggcc
     8101 ctgtactggg atggtgggat agagaagtga atgtatgagg cctctgcctg agtttataac
     8161 ctagaaagaa ataaagacac acacacacaa aggtgttgga gtgtgacaag ccttaaggta
     8221 cccgtgtgtc caagtaaagt agaaccagca agggtggagt gcccaggtca gtctggggac
     8281 tctggaggct tcgcactgca ggcgtcagat actgagtgtt agtggcacgg agaagagtgt
     8341 ggaaggctca ggatgggggt ggacagcctg gagttgtcac tctcagtaga gatgctagaa
     8401 ggggcgggag gtgatcccag cctcccttct ttcctcctcc tggctgtcac agatgctctg
     8461 aattgatgaa tccttcaggc caaaaacaca caggctcctt ccctaggtct ggaaaaatgg
     8521 ttctcgctga aaaagcacca ggaataaaat ctcatacaat tttaggtgtc tattttgttg
     8581 tctcaccttg aaatactgca gacagaaaaa catgcacatg gggagctgtg gtcctgagct
     8641 ttgaggtaat gaattcccac tcatgtgatc atttttacca taaccaaagt ttctaaccat
     8701 caaaatcaag tgacaattaa aacaggcatt aatggataaa tccgtcttta aatattaatg
     8761 gggttaattt tgttaacagc tatgtgttgg ttgcaagtgg aatgttctct gttcatttga
     8821 cttttgaata taacttgttc cagaatattg taaaattaag tatgtgaatg tttctttgta
     8881 ttcagaatta aacatttggt gttaaaatcc caggattagg agacaactcc atgtaaattt
     8941 aatgtgtaat aataagataa taacttttta aaaagcattt ggatggcaaa ttatacatac
     9001 tgacaaatga atattatctg aaagttgttt tgtttccatt aacttttgtg aaacaaaaag
     9061 aattactgta acagtctatg tcttggcgta ttgccaattc accactttct actttgtgct
     9121 ggaacagaac tggctttttt gacatccctg aggagtggaa atgcaaaacg aatttcaagt
     9181 tctctaatct ttgttctatg acaaatgaaa aaacctaagt tatctggtgt tttggagatt
     9241 tgagaataca gcaggtgaag agaattagct taaattccct cctccctttt gataaatcca
     9301 cagggattcc ttcactctgt caggaaatgg tgtggtttcc aagcattagc ccttcatgat
     9361 ctgtctggtg catttctgtg ctcctgggat cgccaagtgc aggcacggca tcgcatcccc
     9421 aggtgtcatc ctgtgaccca ggaggggaag atgacacacc caatttaggt aatgctgcac
     9481 ttcttgttat aattggttat tggaaaatgt gcctttatta tcagaacagt ggtgtgcgca
     9541 tttctgatta tggagctaac ttttggatat ctgacttaga tactaaaaac atttgggtgt
     9601 tgcagttttg cacttgtaga tacaacttaa aagcatgaaa ctggtgattt aattagatgt
     9661 tttctataaa atgcaccttg ttacatttct gtgaaagggt cttaccagcg tggaataact
     9721 ggctcaaggg ttgagagaaa caaccatttt ctaaacagtt aattgtttaa aggactatac
     9781 atgtaagtct gcaggcaata aaggctgttg tgaaaagta
//
