LOCUS       NM_012435               2525 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens SHC adaptor protein 2 (SHC2), transcript variant 1,
            mRNA.
ACCESSION   NM_012435 XM_001129272 XM_939572
VERSION     NM_012435.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2525)
  AUTHORS   Teodorczyk,M., Kleber,S., Wollny,D., Sefrin,J.P., Aykut,B.,
            Mateos,A., Herhaus,P., Sancho-Martinez,I., Hill,O., Gieffers,C.,
            Sykora,J., Weichert,W., Eisen,C., Trumpp,A., Sprick,M.R.,
            Bergmann,F., Welsch,T. and Martin-Villalba,A.
  TITLE     CD95 promotes metastatic spread via Sck in pancreatic ductal
            adenocarcinoma
  JOURNAL   Cell Death Differ 22 (7), 1192-1202 (2015)
   PUBMED   25613377
  REMARK    GeneRIF: Sck was identified as a novel molecule indispensable for
            CD95's activation of the PI3K and MAPK pathways and induction of
            cell cycle progression in pancreatic ductal adenocarcinoma.
REFERENCE   2  (bases 1 to 2525)
  AUTHORS   Leung,K.K., Hause,R.J. Jr., Barkinge,J.L., Ciaccio,M.F., Chuu,C.P.
            and Jones,R.B.
  TITLE     Enhanced prediction of Src homology 2 (SH2) domain binding
            potentials using a fluorescence polarization-derived c-Met, c-Kit,
            ErbB, and androgen receptor interactome
  JOURNAL   Mol Cell Proteomics 13 (7), 1705-1723 (2014)
   PUBMED   24728074
REFERENCE   3  (bases 1 to 2525)
  AUTHORS   Ferguson,M.C., Garland,E.M., Hedges,L., Womack-Nunley,B., Hamid,R.,
            Phillips,J.A. 3rd, Shibao,C.A., Raj,S.R., Biaggioni,I. and
            Robertson,D.
  TITLE     SHC2 gene copy number in multiple system atrophy (MSA)
  JOURNAL   Clin Auton Res 24 (1), 25-30 (2014)
   PUBMED   24170347
  REMARK    GeneRIF: SHC2 gene deletions underlie few, if any, cases of
            well-characterized multiple system atrophy in the US population.
REFERENCE   4  (bases 1 to 2525)
  AUTHORS   Sasaki,H., Emi,M., Iijima,H., Ito,N., Sato,H., Yabe,I., Kato,T.,
            Utsumi,J. and Matsubara,K.
  TITLE     Copy number loss of (src homology 2 domain containing)-transforming
            protein 2 (SHC2) gene: discordant loss in monozygotic twins and
            frequent loss in patients with multiple system atrophy
  JOURNAL   Mol Brain 4, 24 (2011)
   PUBMED   21658278
  REMARK    GeneRIF: Data show that copy number loss of SHC2 strongly indicates
            a causal link to multiple system atrophy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2525)
  AUTHORS   Choy,K.W., Wang,C.C., Ogura,A., Lau,T.K., Rogers,M.S., Ikeo,K.,
            Gojobori,T., Lam,D.S. and Pang,C.P.
  TITLE     Genomic annotation of 15,809 ESTs identified from pooled early
            gestation human eyes
  JOURNAL   Physiol Genomics 25 (1), 9-15 (2006)
   PUBMED   16368877
REFERENCE   6  (bases 1 to 2525)
  AUTHORS   Sofroniew,M.V., Howe,C.L. and Mobley,W.C.
  TITLE     Nerve growth factor signaling, neuroprotection, and neural repair
  JOURNAL   Annu Rev Neurosci 24, 1217-1281 (2001)
   PUBMED   11520933
  REMARK    Review article
REFERENCE   7  (bases 1 to 2525)
  AUTHORS   Nakamura,T., Muraoka,S., Sanokawa,R. and Mori,N.
  TITLE     N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their
            differential regional expression in the brain and roles in
            neurotrophin and Src signaling
  JOURNAL   J Biol Chem 273 (12), 6960-6967 (1998)
   PUBMED   9507002
REFERENCE   8  (bases 1 to 2525)
  AUTHORS   Pelicci,G., Dente,L., De Giuseppe,A., Verducci-Galletti,B.,
            Giuli,S., Mele,S., Vetriani,C., Giorgio,M., Pandolfi,P.P.,
            Cesareni,G. and Pelicci,P.G.
  TITLE     A family of Shc related proteins with conserved PTB, CH1 and SH2
            regions
  JOURNAL   Oncogene 13 (3), 633-641 (1996)
   PUBMED   8760305
REFERENCE   9  (bases 1 to 2525)
  AUTHORS   Waters,S.B., Yamauchi,K. and Pessin,J.E.
  TITLE     Insulin-stimulated disassociation of the SOS-Grb2 complex
  JOURNAL   Mol Cell Biol 15 (5), 2791-2799 (1995)
   PUBMED   7739560
REFERENCE   10 (bases 1 to 2525)
  AUTHORS   Kavanaugh,W.M. and Williams,L.T.
  TITLE     An alternative to SH2 domains for binding tyrosine-phosphorylated
            proteins
  JOURNAL   Science 266 (5192), 1862-1865 (1994)
   PUBMED   7527937
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC006124.2, AC138433.2 and AC008988.13.
            
            On Sep 23, 2020 this sequence version replaced NM_012435.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB001451.1, ERR4352444.340483.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264554.11/ ENSP00000264554.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-505               AC006124.2         25737-26241         c
            506-576             AC138433.2         25889-25959         c
            577-637             AC138433.2         23997-24057         c
            638-757             AC138433.2         23745-23864         c
            758-811             AC138433.2         21657-21710         c
            812-863             AC138433.2         21407-21458         c
            864-990             AC138433.2         21192-21318         c
            991-1147            AC138433.2         19736-19892         c
            1148-1211           AC138433.2         15711-15774         c
            1212-1346           AC138433.2         10124-10258         c
            1347-1657           AC008988.13        33226-33536         c
            1658-1791           AC008988.13        30003-30136         c
            1792-2525           AC008988.13        27669-28402         c
FEATURES             Location/Qualifiers
     source          1..2525
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..2525
                     /gene="SHC2"
                     /gene_synonym="SCK; SHCB; SLI"
                     /note="SHC adaptor protein 2"
                     /db_xref="GeneID:25759"
                     /db_xref="HGNC:HGNC:29869"
                     /db_xref="MIM:605217"
     exon            1..505
                     /gene="SHC2"
                     /gene_synonym="SCK; SHCB; SLI"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..1786
                     /gene="SHC2"
                     /gene_synonym="SCK; SHCB; SLI"
                     /note="isoform 1 is encoded by transcript variant 1;
                     neuronal Shc adaptor homolog; SHC-transforming protein 2;
                     protein Sck; SH2 domain protein C2; SHC-transforming
                     protein B; src homology 2 domain-containing-transforming
                     protein C2; SHC (Src homology 2 domain containing)
                     transforming protein 2"
                     /codon_start=1
                     /product="SHC-transforming protein 2 isoform 1"
                     /protein_id="NP_036567.2"
                     /db_xref="CCDS:CCDS45891.1"
                     /db_xref="GeneID:25759"
                     /db_xref="HGNC:HGNC:29869"
                     /db_xref="MIM:605217"
                     /translation="MTQGPGGRAPPAPPAPPEPEAPTTFCALLPRMPQWKFAAPGGFL
                     GRGPAAARAAGASGGADPQPEPAGPGGVPALAAAVLGACEPRCAAPCPLPALSRCRGA
                     GSRGSRGGRGAAGSGDAAAAAEWIRKGSFIHKPAHGWLHPDARVLGPGVSYVVRYMGC
                     IEVLRSMRSLDFNTRTQVTREAINRLHEAVPGVRGSWKKKAPNKALASVLGKSNLRFA
                     GMSISIHISTDGLSLSVPATRQVIANHHMPSISFASGGDTDMTDYVAYVAKDPINQRA
                     CHILECCEGLAQSIISTVGQAFELRFKQYLHSPPKVALPPERLAGPEESAWGDEEDSL
                     EHNYYNSIPGKEPPLGGLVDSRLALTQPCALTALDQGPSPSLRDACSLPWDVGSTGTA
                     PPGDGYVQADARGPPDHEEHLYVNTQGLDAPEPEDSPKKDLFDMRPFEDALKLHECSV
                     AAGVTAAPLPLEDQWPSPPTRRAPVAPTEEQLRQEPWYHGRMSRRAAERMLRADGDFL
                     VRDSVTNPGQYVLTGMHAGQPKHLLLVDPEGVVRTKDVLFESISHLIDHHLQNGQPIV
                     AAESELHLRGVVSREP"
     exon            506..576
                     /gene="SHC2"
                     /gene_synonym="SCK; SHCB; SLI"
                     /inference="alignment:Splign:2.1.0"
     exon            577..637
                     /gene="SHC2"
                     /gene_synonym="SCK; SHCB; SLI"
                     /inference="alignment:Splign:2.1.0"
     exon            638..757
                     /gene="SHC2"
                     /gene_synonym="SCK; SHCB; SLI"
                     /inference="alignment:Splign:2.1.0"
     exon            758..811
                     /gene="SHC2"
                     /gene_synonym="SCK; SHCB; SLI"
                     /inference="alignment:Splign:2.1.0"
     exon            812..863
                     /gene="SHC2"
                     /gene_synonym="SCK; SHCB; SLI"
                     /inference="alignment:Splign:2.1.0"
     exon            864..990
                     /gene="SHC2"
                     /gene_synonym="SCK; SHCB; SLI"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1147
                     /gene="SHC2"
                     /gene_synonym="SCK; SHCB; SLI"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1211
                     /gene="SHC2"
                     /gene_synonym="SCK; SHCB; SLI"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1346
                     /gene="SHC2"
                     /gene_synonym="SCK; SHCB; SLI"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1657
                     /gene="SHC2"
                     /gene_synonym="SCK; SHCB; SLI"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1791
                     /gene="SHC2"
                     /gene_synonym="SCK; SHCB; SLI"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..2525
                     /gene="SHC2"
                     /gene_synonym="SCK; SHCB; SLI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2501..2506
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SHC2"
                     /gene_synonym="SCK; SHCB; SLI"
                     /note="hexamer: ATTAAA"
     polyA_site      2525
                     /gene="SHC2"
                     /gene_synonym="SCK; SHCB; SLI"
                     /note="major polyA site"
ORIGIN      
        1 gcagcgcccg gtcgggctcc gtcgggcggc cgcggccatg acgcagggtc cgggcgggcg
       61 cgcgcccccg gcgccccccg cgccccccga gcccgaggcg cccaccacct tctgcgcgtt
      121 gctgccccga atgccgcagt ggaagttcgc ggccccgggc ggcttcctgg gccgcggccc
      181 ggcggcggcg cgggcggctg gggcctcggg gggcgcggac ccccaacccg agccggcggg
      241 cccggggggc gtcccggcgc tggcggccgc cgtcctgggc gcctgcgagc cccgctgcgc
      301 cgcgccctgt cccctgcccg cgctcagccg ctgtcggggc gcggggtcgc gggggtcgcg
      361 gggcgggcgg ggggcggcgg ggtccgggga cgccgccgcc gccgccgagt ggatccggaa
      421 gggcagcttc atccacaaac ccgcgcacgg ctggctacac cccgacgcca gggtcctggg
      481 gcccggggtc tcctacgtcg tgcggtacat gggctgcatc gaggttctcc gctctatgcg
      541 ctccctggac tttaacacgc gcacgcaggt gaccagggaa gccatcaacc ggctccatga
      601 ggccgtgcct ggcgtccggg gatcctggaa gaaaaaggcc cccaacaagg ccctggcgtc
      661 cgtcctgggc aagagcaacc ttcgctttgc cggcatgagc atctccatcc acatctccac
      721 tgatggcctc agcctctccg tgcctgccac gcgccaggtc atcgccaacc accacatgcc
      781 gtccatctcc ttcgcgtcag gcggagacac ggacatgacg gattacgtgg cctacgtcgc
      841 caaggacccc atcaaccaga gagcctgcca catcctggag tgctgtgagg gcctggcaca
      901 gagcatcatc agcaccgtgg gccaagcttt cgagctgcgc ttcaagcagt acctgcacag
      961 cccgcccaag gtggcgctgc ccccagaaag gctggcaggg ccggaggagt cggcctgggg
     1021 ggacgaggag gactctttgg agcacaatta ctacaacagc atcccgggga aggagccgcc
     1081 gctgggcggg ctagtggact ccaggctggc cctgacacag ccctgcgccc tcacggccct
     1141 cgaccagggc ccatctcctt ctctaagaga tgcctgcagc ctgccatggg acgtggggtc
     1201 caccggtaca gctccaccgg gggacggcta cgtgcaggcg gacgcccggg gccccccgga
     1261 ccacgaggag cacctgtatg tcaacaccca gggtctggac gcccccgagc cggaggacag
     1321 ccccaaaaag gatctgtttg acatgcgacc ctttgaggat gccctgaagt tgcatgagtg
     1381 ctcagtggcg gcaggcgtga cagcagcccc tcttcccttg gaggaccagt ggcccagccc
     1441 ccctacccgc cgggcccctg tggcccccac ggaggaacag ctgcgtcagg agccctggta
     1501 ccacggccgg atgagccgcc gggcggcaga gaggatgctt cgagctgacg gggacttcct
     1561 tgtgcgagac agcgtcacca accccgggca gtatgtcctc accggcatgc acgccgggca
     1621 gcccaagcac ctgctgctcg tggaccccga gggcgtggta cggacgaagg acgtgctgtt
     1681 tgagagcatc agccacctga tcgaccacca cctgcagaac gggcagccca tcgtggccgc
     1741 cgagagtgag ctgcacctgc gtggcgtggt ctcacgggag ccctgagcca ggtgaccgtt
     1801 ctcagccctg gctcctgcct gttctcagcc ccggctcctg cctgtcatgg ccttggggct
     1861 ctcagccctc ctcctggatc ctggtcaggc cgaaccaccg ctgcctctcc ttcctccgca
     1921 tgagcctctg gcatggtcct tcctccagct ggccccgggc tgggcagagc ctcctcctgc
     1981 cggggcccct gcccaccccc tcctttgcct ggagtgaggg tgttcatacc aaagacggaa
     2041 ccatttcgcc tttaaagaaa atatatccag aagcagccgc tgcctcggag ccctggccct
     2101 tgggtccccc tctcgcctgg ctggttcggt ctaacgcccc ggagagtcag ggctcccagg
     2161 accctgggga ggaggcggat tccgggcctg gctgggcttc ctcttcccac ctgaggactg
     2221 ggtgcacagt tgtctttgag gggggacgct taaggtgctt tggggttctc aggccaggat
     2281 acatgctggc gctgaagtgc aggcagcctt gaggtcacct gggatctcgg ggtagccagg
     2341 ctgctccaag acagtggata tcgaggcagt cgtgaggccc ctactccacc tgggagcagg
     2401 ggaaggacgt ggttgcctgg cctgggctgc gcccagcagc ttccccccag tcctgccctc
     2461 ccagctgtcg acccagatgg gatgttcgga tcggtttgta attaaacctg ggaatggcca
     2521 caaga
//
