LOCUS       NM_183001               3478 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens SHC adaptor protein 1 (SHC1), transcript variant 1,
            mRNA.
ACCESSION   NM_183001
VERSION     NM_183001.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3478)
  AUTHORS   Qiu,T., Kong,Y., Wei,G., Sun,K., Wang,R., Wang,Y., Chen,Y.,
            Wang,W., Zhang,Y., Jiang,C., Yang,P., Xie,T. and Chen,X.
  TITLE     CCDC6-RET fusion protein regulates Ras/MAPK signaling through the
            fusion- GRB2-SHC1 signal niche
  JOURNAL   Proc Natl Acad Sci U S A 121 (23), e2322359121 (2024)
   PUBMED   38805286
  REMARK    GeneRIF: CCDC6-RET fusion protein regulates Ras/MAPK signaling
            through the fusion- GRB2-SHC1 signal niche.
REFERENCE   2  (bases 1 to 3478)
  AUTHORS   Peng,G., Feng,Y., Wang,X., Huang,W. and Li,Y.
  TITLE     The mitochondria-related gene risk mode revealed p66Shc as a
            prognostic mitochondria-related gene of glioblastoma
  JOURNAL   Sci Rep 14 (1), 11418 (2024)
   PUBMED   38763954
  REMARK    GeneRIF: The mitochondria-related gene risk mode revealed p66Shc as
            a prognostic mitochondria-related gene of glioblastoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3478)
  AUTHORS   Mo,J.S., Lamichhane,S., Yun,K.J. and Chae,S.C.
  TITLE     MicroRNA 452 regulates SHC1 expression in human colorectal cancer
            and colitis
  JOURNAL   Genes Genomics 45 (10), 1295-1304 (2023)
   PUBMED   37523129
  REMARK    GeneRIF: MicroRNA 452 regulates SHC1 expression in human colorectal
            cancer and colitis.
REFERENCE   4  (bases 1 to 3478)
  AUTHORS   Barros,P., Matos,A.M., Matos,P. and Jordan,P.
  TITLE     YES1 Kinase Mediates the Membrane Removal of Rescued F508del-CFTR
            in Airway Cells by Promoting MAPK Pathway Activation via SHC1
  JOURNAL   Biomolecules 13 (6), 949 (2023)
   PUBMED   37371529
  REMARK    GeneRIF: YES1 Kinase Mediates the Membrane Removal of Rescued
            F508del-CFTR in Airway Cells by Promoting MAPK Pathway Activation
            via SHC1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3478)
  AUTHORS   Miller,D.R., Ingersoll,M.A., Chou,Y.W., Kosmacek,E.A.,
            Oberley-Deegan,R.E. and Lin,M.F.
  TITLE     Dynamics of antioxidant heme oxygenase-1 and pro-oxidant p66Shc in
            promoting advanced prostate cancer progression
  JOURNAL   Free Radic Biol Med 193 (Pt 1), 274-291 (2022)
   PUBMED   36265795
  REMARK    GeneRIF: Dynamics of antioxidant heme oxygenase-1 and pro-oxidant
            p66Shc in promoting advanced prostate cancer progression.
REFERENCE   6  (bases 1 to 3478)
  AUTHORS   Ventura,A., Maccarana,M., Raker,V.A. and Pelicci,P.G.
  TITLE     A cryptic targeting signal induces isoform-specific localization of
            p46Shc to mitochondria
  JOURNAL   J Biol Chem 279 (3), 2299-2306 (2004)
   PUBMED   14573619
REFERENCE   7  (bases 1 to 3478)
  AUTHORS   Wolf,G., Trub,T., Ottinger,E., Groninga,L., Lynch,A., White,M.F.,
            Miyazaki,M., Lee,J. and Shoelson,S.E.
  TITLE     PTB domains of IRS-1 and Shc have distinct but overlapping binding
            specificities
  JOURNAL   J Biol Chem 270 (46), 27407-27410 (1995)
   PUBMED   7499194
REFERENCE   8  (bases 1 to 3478)
  AUTHORS   Mikol,V., Baumann,G., Zurini,M.G. and Hommel,U.
  TITLE     Crystal structure of the SH2 domain from the adaptor protein SHC: a
            model for peptide binding based on X-ray and NMR data
  JOURNAL   J Mol Biol 254 (1), 86-95 (1995)
   PUBMED   7473762
REFERENCE   9  (bases 1 to 3478)
  AUTHORS   Spivak-Kroizman,T., Mohammadi,M., Hu,P., Jaye,M., Schlessinger,J.
            and Lax,I.
  TITLE     Point mutation in the fibroblast growth factor receptor eliminates
            phosphatidylinositol hydrolysis without affecting neuronal
            differentiation of PC12 cells
  JOURNAL   J Biol Chem 269 (20), 14419-14423 (1994)
   PUBMED   7514169
REFERENCE   10 (bases 1 to 3478)
  AUTHORS   Pelicci,G., Lanfrancone,L., Grignani,F., McGlade,J., Cavallo,F.,
            Forni,G., Nicoletti,I., Grignani,F., Pawson,T. and Pelicci,P.G.
  TITLE     A novel transforming protein (SHC) with an SH2 domain is implicated
            in mitogenic signal transduction
  JOURNAL   Cell 70 (1), 93-104 (1992)
   PUBMED   1623525
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX647149.1.
            
            On Jun 2, 2019 this sequence version replaced NM_183001.4.
            
            Summary: This gene encodes three main isoforms that differ in
            activities and subcellular location. While all three are adapter
            proteins in signal transduction pathways, the longest (p66Shc) may
            be involved in regulating life span and the effects of reactive
            oxygen species. The other two isoforms, p52Shc and p46Shc, link
            activated receptor tyrosine kinases to the Ras pathway by
            recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras
            activation. Unlike the other two isoforms, p46Shc is targeted to
            the mitochondrial matrix. Several transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Feb 2011].
            
            Transcript Variant: This variant (1) has an alternate splice site
            in the CDS, as compared to variant 3. The resulting isoform (1),
            also known as p66Shc, lacks an internal amino acid, as compared to
            isoform 3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U73377.1, SRR14038197.2119517.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1473              BX647149.1         1-1473
            1474-3350           BX647149.1         1477-3353
            3351-3478           BX647149.1         3355-3482
FEATURES             Location/Qualifiers
     source          1..3478
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..3478
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /note="SHC adaptor protein 1"
                     /db_xref="GeneID:6464"
                     /db_xref="HGNC:HGNC:10840"
                     /db_xref="MIM:600560"
     exon            1..716
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..1973
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /note="isoform 1 is encoded by transcript variant 1; SH2
                     domain protein C1; SHC (Src homology 2 domain containing)
                     transforming protein 1; SHC-transforming protein 3;
                     SHC-transforming protein A"
                     /codon_start=1
                     /product="SHC-transforming protein 1 isoform 1"
                     /protein_id="NP_892113.4"
                     /db_xref="CCDS:CCDS30881.1"
                     /db_xref="GeneID:6464"
                     /db_xref="HGNC:HGNC:10840"
                     /db_xref="MIM:600560"
                     /translation="MDLLPPKPKYNPLRNESLSSLEEGASGSTPPEELPSPSASSLGP
                     ILPPLPGDDSPTTLCSFFPRMSNLRLANPAGGRPGSKGEPGRAADDGEGIVGAAMPDS
                     GPLPLLQDMNKLSGGGGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGV
                     SYLVRYMGCVEVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPCSRPLSS
                     ILGRSNLKFAGMPITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAY
                     VAKDPVNQRACHILECPEGLAQDVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDG
                     SAWDEEEEEPPDHQYYNDFPGKEPPLGGVVDMRLREGAAPGAARPTAPNAQTPSHLGA
                     TLPVGQPVGGDPEVRKQMPPPPPCPGRELFDDPSYVNVQNLDKARQAVGGAGPPNPAI
                     NGSAPRDLFDMKPFEDALRVPPPPQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGDF
                     LVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKDHRFESVSHLISYHMDNHLPI
                     ISAGSELCLQQPVERKL"
     exon            717..787
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            788..851
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            852..971
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1025
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1077
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1204
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1403
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1473
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1605
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1844
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..3478
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3457..3462
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /note="hexamer: ATTAAA"
     polyA_site      3478
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /note="major polyA site"
ORIGIN      
        1 agagaagagg ctccacgttg ggcggggatg gggcctgaaa ctgtctgggt ctgagctggg
       61 gagcggaagc cacttgtccc tctccctccc caggacttct gtgactcctg ggccacagag
      121 gtccaaccag gctaagggcc tggggatacc ccctgcctgg cccccttgcc caaactggca
      181 ggggggccag gctgggcagc agcccctctt tcacctcaac tatggatctc ctgcccccca
      241 agcccaagta caatccactc cggaatgagt ctctgtcatc gctggaggaa ggggcttctg
      301 ggtccacccc cccggaggag ctgccttccc catcagcttc atccctgggg cccatcctgc
      361 ctcctctgcc tggggacgat agtcccacta ccctgtgctc cttcttcccc cggatgagca
      421 acctgaggct ggccaacccg gctggggggc gcccagggtc taagggggag ccaggaaggg
      481 cagctgatga tggggagggg atcgtagggg cagccatgcc agactcaggc cccctacccc
      541 tcctccagga catgaacaag ctgagtggag gcggcgggcg caggactcgg gtggaagggg
      601 gccagcttgg gggcgaggag tggacccgcc acgggagctt tgtcaataag cccacgcggg
      661 gctggctgca tcccaacgac aaagtcatgg gacccggggt ttcctacttg gttcggtaca
      721 tgggttgtgt ggaggtcctc cagtcaatgc gtgccctgga cttcaacacc cggactcagg
      781 tcaccaggga ggccatcagt ctggtgtgtg aggctgtgcc gggtgctaag ggggcgacaa
      841 ggaggagaaa gccctgtagc cgcccgctca gctctatcct ggggaggagt aacctgaaat
      901 ttgctggaat gccaatcact ctcaccgtct ccaccagcag cctcaacctc atggccgcag
      961 actgcaaaca gatcatcgcc aaccaccaca tgcaatctat ctcatttgca tccggcgggg
     1021 atccggacac agccgagtat gtcgcctatg ttgccaaaga ccctgtgaat cagagagcct
     1081 gccacattct ggagtgtccc gaagggcttg cccaggatgt catcagcacc attggccagg
     1141 ccttcgagtt gcgcttcaaa caatacctca ggaacccacc caaactggtc acccctcatg
     1201 acaggatggc tggctttgat ggctcagcat gggatgagga ggaggaagag ccacctgacc
     1261 atcagtacta taatgacttc ccggggaagg aacccccctt ggggggggtg gtagacatga
     1321 ggcttcggga aggagccgct ccaggggctg ctcgacccac tgcacccaat gcccagaccc
     1381 ccagccactt gggagctaca ttgcctgtag gacagcctgt tgggggagat ccagaagtcc
     1441 gcaaacagat gccacctcca ccaccctgtc caggcagaga gctttttgat gatccctcct
     1501 atgtcaacgt ccagaaccta gacaaggccc ggcaagcagt gggtggtgct gggcccccca
     1561 atcctgctat caatggcagt gcaccccggg acctgtttga catgaagccc ttcgaagatg
     1621 ctcttcgcgt gcctccacct ccccagtcgg tgtccatggc tgagcagctc cgaggggagc
     1681 cctggttcca tgggaagctg agccggcggg aggctgaggc actgctgcag ctcaatgggg
     1741 acttcctggt acgggagagc acgaccacac ctggccagta tgtgctcact ggcttgcaga
     1801 gtgggcagcc taagcatttg ctactggtgg accctgaggg tgtggttcgg actaaggatc
     1861 accgctttga aagtgtcagt caccttatca gctaccacat ggacaatcac ttgcccatca
     1921 tctctgcggg cagcgaactg tgtctacagc aacctgtgga gcggaaactg tgatctgccc
     1981 tagcgctctc ttccagaaga tgccctccaa tcctttccac cctattccct aactctcggg
     2041 acctcgtttg ggagtgttct gtgggcttgg ccttgtgtca gagctgggag tagcatggac
     2101 tctgggtttc atatccagct gagtgagagg gtttgagtca aaagcctggg tgagaatcct
     2161 gcctctcccc aaacattaat caccaaagta ttaatgtaca gagtggcccc tcacctgggc
     2221 ctttcctgtg ccaacctgat gccccttccc caagaaggtg agtgcttgtc atggaaaatg
     2281 tcctgtggtg acaggcccag tggaacagtc acccttctgg gcaaggggga acaaatcaca
     2341 cctctgggct tcagggtatc ccagacccct ctcaacaccc gcccccccca tgtttaaact
     2401 ttgtgccttt gaccatctct taggtctaat gatattttat gcaaacagtt cttggacccc
     2461 tgaattcaat gacagggatg ccaacacctt cttggcttct gggacctgtg ttcttgctga
     2521 gcaccctctc cggtttgggt tgggataaca gaggcaggag tggcagctgt cccctctccc
     2581 tggggatatg caacccttag agattgcccc agagccccac tcccggccag gcgggagatg
     2641 gacccctccc ttgctcagtg cctcctggcc ggggcccctc accccaaggg gtctgtatat
     2701 acatttcata aggcctgccc tcccatgttg catgcctatg tactctacgc caaagtgcag
     2761 cccttcctcc tgaagcctct gccctgcctc cctttctggg agggcggggt gggggtgact
     2821 gaatttgggc ctcttgtaca gttaactctc ccaggtggat tttgtggagg tgagaaaagg
     2881 ggcattgaga ctataaagca gtagacaatc cccacatacc atctgtagag ttggaactgc
     2941 attcttttaa agttttatat gcatatattt tagggctgta gacttacttt cctattttct
     3001 tttccattgc ttattcttga gcacaaaatg ataatcaatt attacattta tacatcacct
     3061 ttttgacttt tccaagccct tttacagctc ttggcatttt cctcgcctag gcctgtgagg
     3121 taactgggat cgcacctttt ataccagaga cctgaggcag atgaaattta tttccatcta
     3181 ggactagaaa aacttgggtc tcttaccgcg agactgagag gcagaagtca gcccgaatgc
     3241 ctgtcagttt catggagggg aaacgcaaaa cctgcagttc ctgagtacct tctacaggcc
     3301 cggcccagcc taggcccggg gtggccacac cacagcaagc cggccccccc tcttttggcc
     3361 ttgtggataa gggagagttg accgttttca tcctggcctc cttttgctgt ttggatgttt
     3421 ccacgggtct cacttatacc aaagggaaaa ctcttcatta aagtccgtat ttcttcta
//
