LOCUS       NM_001130041            3059 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens SHC adaptor protein 1 (SHC1), transcript variant 4,
            mRNA.
ACCESSION   NM_001130041
VERSION     NM_001130041.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3059)
  AUTHORS   Qiu,T., Kong,Y., Wei,G., Sun,K., Wang,R., Wang,Y., Chen,Y.,
            Wang,W., Zhang,Y., Jiang,C., Yang,P., Xie,T. and Chen,X.
  TITLE     CCDC6-RET fusion protein regulates Ras/MAPK signaling through the
            fusion- GRB2-SHC1 signal niche
  JOURNAL   Proc Natl Acad Sci U S A 121 (23), e2322359121 (2024)
   PUBMED   38805286
  REMARK    GeneRIF: CCDC6-RET fusion protein regulates Ras/MAPK signaling
            through the fusion- GRB2-SHC1 signal niche.
REFERENCE   2  (bases 1 to 3059)
  AUTHORS   Peng,G., Feng,Y., Wang,X., Huang,W. and Li,Y.
  TITLE     The mitochondria-related gene risk mode revealed p66Shc as a
            prognostic mitochondria-related gene of glioblastoma
  JOURNAL   Sci Rep 14 (1), 11418 (2024)
   PUBMED   38763954
  REMARK    GeneRIF: The mitochondria-related gene risk mode revealed p66Shc as
            a prognostic mitochondria-related gene of glioblastoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3059)
  AUTHORS   Mo,J.S., Lamichhane,S., Yun,K.J. and Chae,S.C.
  TITLE     MicroRNA 452 regulates SHC1 expression in human colorectal cancer
            and colitis
  JOURNAL   Genes Genomics 45 (10), 1295-1304 (2023)
   PUBMED   37523129
  REMARK    GeneRIF: MicroRNA 452 regulates SHC1 expression in human colorectal
            cancer and colitis.
REFERENCE   4  (bases 1 to 3059)
  AUTHORS   Barros,P., Matos,A.M., Matos,P. and Jordan,P.
  TITLE     YES1 Kinase Mediates the Membrane Removal of Rescued F508del-CFTR
            in Airway Cells by Promoting MAPK Pathway Activation via SHC1
  JOURNAL   Biomolecules 13 (6), 949 (2023)
   PUBMED   37371529
  REMARK    GeneRIF: YES1 Kinase Mediates the Membrane Removal of Rescued
            F508del-CFTR in Airway Cells by Promoting MAPK Pathway Activation
            via SHC1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3059)
  AUTHORS   Miller,D.R., Ingersoll,M.A., Chou,Y.W., Kosmacek,E.A.,
            Oberley-Deegan,R.E. and Lin,M.F.
  TITLE     Dynamics of antioxidant heme oxygenase-1 and pro-oxidant p66Shc in
            promoting advanced prostate cancer progression
  JOURNAL   Free Radic Biol Med 193 (Pt 1), 274-291 (2022)
   PUBMED   36265795
  REMARK    GeneRIF: Dynamics of antioxidant heme oxygenase-1 and pro-oxidant
            p66Shc in promoting advanced prostate cancer progression.
REFERENCE   6  (bases 1 to 3059)
  AUTHORS   Ventura,A., Maccarana,M., Raker,V.A. and Pelicci,P.G.
  TITLE     A cryptic targeting signal induces isoform-specific localization of
            p46Shc to mitochondria
  JOURNAL   J Biol Chem 279 (3), 2299-2306 (2004)
   PUBMED   14573619
REFERENCE   7  (bases 1 to 3059)
  AUTHORS   Wolf,G., Trub,T., Ottinger,E., Groninga,L., Lynch,A., White,M.F.,
            Miyazaki,M., Lee,J. and Shoelson,S.E.
  TITLE     PTB domains of IRS-1 and Shc have distinct but overlapping binding
            specificities
  JOURNAL   J Biol Chem 270 (46), 27407-27410 (1995)
   PUBMED   7499194
REFERENCE   8  (bases 1 to 3059)
  AUTHORS   Mikol,V., Baumann,G., Zurini,M.G. and Hommel,U.
  TITLE     Crystal structure of the SH2 domain from the adaptor protein SHC: a
            model for peptide binding based on X-ray and NMR data
  JOURNAL   J Mol Biol 254 (1), 86-95 (1995)
   PUBMED   7473762
REFERENCE   9  (bases 1 to 3059)
  AUTHORS   Spivak-Kroizman,T., Mohammadi,M., Hu,P., Jaye,M., Schlessinger,J.
            and Lax,I.
  TITLE     Point mutation in the fibroblast growth factor receptor eliminates
            phosphatidylinositol hydrolysis without affecting neuronal
            differentiation of PC12 cells
  JOURNAL   J Biol Chem 269 (20), 14419-14423 (1994)
   PUBMED   7514169
REFERENCE   10 (bases 1 to 3059)
  AUTHORS   Pelicci,G., Lanfrancone,L., Grignani,F., McGlade,J., Cavallo,F.,
            Forni,G., Nicoletti,I., Grignani,F., Pawson,T. and Pelicci,P.G.
  TITLE     A novel transforming protein (SHC) with an SH2 domain is implicated
            in mitogenic signal transduction
  JOURNAL   Cell 70 (1), 93-104 (1992)
   PUBMED   1623525
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK292143.1, X68148.1 and
            BC014158.2.
            
            On Jun 2, 2019 this sequence version replaced NM_001130041.1.
            
            Summary: This gene encodes three main isoforms that differ in
            activities and subcellular location. While all three are adapter
            proteins in signal transduction pathways, the longest (p66Shc) may
            be involved in regulating life span and the effects of reactive
            oxygen species. The other two isoforms, p52Shc and p46Shc, link
            activated receptor tyrosine kinases to the Ras pathway by
            recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras
            activation. Unlike the other two isoforms, p46Shc is targeted to
            the mitochondrial matrix. Several transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Feb 2011].
            
            Transcript Variant: This variant (4) has an alternate 5' sequence
            and an alternate splice site in the CDS, as compared to variant 3.
            The resulting isoform (4), also known as p52Shc, has a shorter
            N-terminus and lacks an internal amino acid, as compared to isoform
            3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X68148.1, SRR14038192.337052.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               AK292143.1         108-213
            107-1208            X68148.1           56-1157
            1209-3059           BC014158.2         1200-3050
FEATURES             Location/Qualifiers
     source          1..3059
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..3059
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /note="SHC adaptor protein 1"
                     /db_xref="GeneID:6464"
                     /db_xref="HGNC:HGNC:10840"
                     /db_xref="MIM:600560"
     exon            1..129
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            130..297
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..1554
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /note="isoform 4 is encoded by transcript variant 4; SH2
                     domain protein C1; SHC (Src homology 2 domain containing)
                     transforming protein 1; SHC-transforming protein 3;
                     SHC-transforming protein A"
                     /codon_start=1
                     /product="SHC-transforming protein 1 isoform 4"
                     /protein_id="NP_001123513.1"
                     /db_xref="CCDS:CCDS44234.1"
                     /db_xref="GeneID:6464"
                     /db_xref="HGNC:HGNC:10840"
                     /db_xref="MIM:600560"
                     /translation="MNKLSGGGGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDK
                     VMGPGVSYLVRYMGCVEVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGATRRRKPC
                     SRPLSSILGRSNLKFAGMPITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDPDT
                     AEYVAYVAKDPVNQRACHILECPEGLAQDVISTIGQAFELRFKQYLRNPPKLVTPHDR
                     MAGFDGSAWDEEEEEPPDHQYYNDFPGKEPPLGGVVDMRLREGAAPGAARPTAPNAQT
                     PSHLGATLPVGQPVGGDPEVRKQMPPPPPCPGRELFDDPSYVNVQNLDKARQAVGGAG
                     PPNPAINGSAPRDLFDMKPFEDALRVPPPPQSVSMAEQLRGEPWFHGKLSRREAEALL
                     QLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKDHRFESVSHLISYHM
                     DNHLPIISAGSELCLQQPVERKL"
     exon            298..368
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            369..432
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            433..552
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            553..606
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            607..658
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            659..785
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            786..984
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1054
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1186
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1425
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..3059
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3038..3043
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /note="hexamer: ATTAAA"
     polyA_site      3059
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /note="major polyA site"
ORIGIN      
        1 gagtgtaata aagtttctcc agggaggcag ggcccgggga gaaagttgga gcggtaacct
       61 aagctggcag tggcgtgatc cggcaccaaa tcggcccgcg gtgcggtgcg gagactccat
      121 gaggccctgg acatgaacaa gctgagtgga ggcggcgggc gcaggactcg ggtggaaggg
      181 ggccagcttg ggggcgagga gtggacccgc cacgggagct ttgtcaataa gcccacgcgg
      241 ggctggctgc atcccaacga caaagtcatg ggacccgggg tttcctactt ggttcggtac
      301 atgggttgtg tggaggtcct ccagtcaatg cgtgccctgg acttcaacac ccggactcag
      361 gtcaccaggg aggccatcag tctggtgtgt gaggctgtgc cgggtgctaa gggggcgaca
      421 aggaggagaa agccctgtag ccgcccgctc agctctatcc tggggaggag taacctgaaa
      481 tttgctggaa tgccaatcac tctcaccgtc tccaccagca gcctcaacct catggccgca
      541 gactgcaaac agatcatcgc caaccaccac atgcaatcta tctcatttgc atccggcggg
      601 gatccggaca cagccgagta tgtcgcctat gttgccaaag accctgtgaa tcagagagcc
      661 tgccacattc tggagtgtcc cgaagggctt gcccaggatg tcatcagcac cattggccag
      721 gccttcgagt tgcgcttcaa acaatacctc aggaacccac ccaaactggt cacccctcat
      781 gacaggatgg ctggctttga tggctcagca tgggatgagg aggaggaaga gccacctgac
      841 catcagtact ataatgactt cccggggaag gaacccccct tggggggggt ggtagacatg
      901 aggcttcggg aaggagccgc tccaggggct gctcgaccca ctgcacccaa tgcccagacc
      961 cccagccact tgggagctac attgcctgta ggacagcctg ttgggggaga tccagaagtc
     1021 cgcaaacaga tgccacctcc accaccctgt ccaggcagag agctttttga tgatccctcc
     1081 tatgtcaacg tccagaacct agacaaggcc cggcaagcag tgggtggtgc tgggcccccc
     1141 aatcctgcta tcaatggcag tgcaccccgg gacctgtttg acatgaagcc cttcgaagat
     1201 gctcttcgcg tgcctccacc tccccagtcg gtgtccatgg ctgagcagct ccgaggggag
     1261 ccctggttcc atgggaagct gagccggcgg gaggctgagg cactgctgca gctcaatggg
     1321 gacttcctgg tacgggagag cacgaccaca cctggccagt atgtgctcac tggcttgcag
     1381 agtgggcagc ctaagcattt gctactggtg gaccctgagg gtgtggttcg gactaaggat
     1441 caccgctttg aaagtgtcag tcaccttatc agctaccaca tggacaatca cttgcccatc
     1501 atctctgcgg gcagcgaact gtgtctacag caacctgtgg agcggaaact gtgatctgcc
     1561 ctagcgctct cttccagaag atgccctcca atcctttcca ccctattccc taactctcgg
     1621 gacctcgttt gggagtgttc tgtgggcttg gccttgtgtc agagctggga gtagcatgga
     1681 ctctgggttt catatccagc tgagtgagag ggtttgagtc aaaagcctgg gtgagaatcc
     1741 tgcctctccc caaacattaa tcaccaaagt attaatgtac agagtggccc ctcacctggg
     1801 cctttcctgt gccaacctga tgccccttcc ccaagaaggt gagtgcttgt catggaaaat
     1861 gtcctgtggt gacaggccca gtggaacagt cacccttctg ggcaaggggg aacaaatcac
     1921 acctctgggc ttcagggtat cccagacccc tctcaacacc cgcccccccc atgtttaaac
     1981 tttgtgcctt tgaccatctc ttaggtctaa tgatatttta tgcaaacagt tcttggaccc
     2041 ctgaattcaa tgacagggat gccaacacct tcttggcttc tgggacctgt gttcttgctg
     2101 agcaccctct ccggtttggg ttgggataac agaggcagga gtggcagctg tcccctctcc
     2161 ctggggatat gcaaccctta gagattgccc cagagcccca ctcccggcca ggcgggagat
     2221 ggacccctcc cttgctcagt gcctcctggc cggggcccct caccccaagg ggtctgtata
     2281 tacatttcat aaggcctgcc ctcccatgtt gcatgcctat gtactctacg ccaaagtgca
     2341 gcccttcctc ctgaagcctc tgccctgcct ccctttctgg gagggcgggg tgggggtgac
     2401 tgaatttggg cctcttgtac agttaactct cccaggtgga ttttgtggag gtgagaaaag
     2461 gggcattgag actataaagc agtagacaat ccccacatac catctgtaga gttggaactg
     2521 cattctttta aagttttata tgcatatatt ttagggctgt agacttactt tcctattttc
     2581 ttttccattg cttattcttg agcacaaaat gataatcaat tattacattt atacatcacc
     2641 tttttgactt ttccaagccc ttttacagct cttggcattt tcctcgccta ggcctgtgag
     2701 gtaactggga tcgcaccttt tataccagag acctgaggca gatgaaattt atttccatct
     2761 aggactagaa aaacttgggt ctcttaccgc gagactgaga ggcagaagtc agcccgaatg
     2821 cctgtcagtt tcatggaggg gaaacgcaaa acctgcagtt cctgagtacc ttctacaggc
     2881 ccggcccagc ctaggcccgg ggtggccaca ccacagcaag ccggcccccc ctcttttggc
     2941 cttgtggata agggagagtt gaccgttttc atcctggcct ccttttgctg tttggatgtt
     3001 tccacgggtc tcacttatac caaagggaaa actcttcatt aaagtccgta tttcttcta
//
