LOCUS       NM_001130040            3481 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens SHC adaptor protein 1 (SHC1), transcript variant 3,
            mRNA.
ACCESSION   NM_001130040
VERSION     NM_001130040.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3481)
  AUTHORS   Qiu,T., Kong,Y., Wei,G., Sun,K., Wang,R., Wang,Y., Chen,Y.,
            Wang,W., Zhang,Y., Jiang,C., Yang,P., Xie,T. and Chen,X.
  TITLE     CCDC6-RET fusion protein regulates Ras/MAPK signaling through the
            fusion- GRB2-SHC1 signal niche
  JOURNAL   Proc Natl Acad Sci U S A 121 (23), e2322359121 (2024)
   PUBMED   38805286
  REMARK    GeneRIF: CCDC6-RET fusion protein regulates Ras/MAPK signaling
            through the fusion- GRB2-SHC1 signal niche.
REFERENCE   2  (bases 1 to 3481)
  AUTHORS   Peng,G., Feng,Y., Wang,X., Huang,W. and Li,Y.
  TITLE     The mitochondria-related gene risk mode revealed p66Shc as a
            prognostic mitochondria-related gene of glioblastoma
  JOURNAL   Sci Rep 14 (1), 11418 (2024)
   PUBMED   38763954
  REMARK    GeneRIF: The mitochondria-related gene risk mode revealed p66Shc as
            a prognostic mitochondria-related gene of glioblastoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3481)
  AUTHORS   Mo,J.S., Lamichhane,S., Yun,K.J. and Chae,S.C.
  TITLE     MicroRNA 452 regulates SHC1 expression in human colorectal cancer
            and colitis
  JOURNAL   Genes Genomics 45 (10), 1295-1304 (2023)
   PUBMED   37523129
  REMARK    GeneRIF: MicroRNA 452 regulates SHC1 expression in human colorectal
            cancer and colitis.
REFERENCE   4  (bases 1 to 3481)
  AUTHORS   Barros,P., Matos,A.M., Matos,P. and Jordan,P.
  TITLE     YES1 Kinase Mediates the Membrane Removal of Rescued F508del-CFTR
            in Airway Cells by Promoting MAPK Pathway Activation via SHC1
  JOURNAL   Biomolecules 13 (6), 949 (2023)
   PUBMED   37371529
  REMARK    GeneRIF: YES1 Kinase Mediates the Membrane Removal of Rescued
            F508del-CFTR in Airway Cells by Promoting MAPK Pathway Activation
            via SHC1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3481)
  AUTHORS   Miller,D.R., Ingersoll,M.A., Chou,Y.W., Kosmacek,E.A.,
            Oberley-Deegan,R.E. and Lin,M.F.
  TITLE     Dynamics of antioxidant heme oxygenase-1 and pro-oxidant p66Shc in
            promoting advanced prostate cancer progression
  JOURNAL   Free Radic Biol Med 193 (Pt 1), 274-291 (2022)
   PUBMED   36265795
  REMARK    GeneRIF: Dynamics of antioxidant heme oxygenase-1 and pro-oxidant
            p66Shc in promoting advanced prostate cancer progression.
REFERENCE   6  (bases 1 to 3481)
  AUTHORS   Ventura,A., Maccarana,M., Raker,V.A. and Pelicci,P.G.
  TITLE     A cryptic targeting signal induces isoform-specific localization of
            p46Shc to mitochondria
  JOURNAL   J Biol Chem 279 (3), 2299-2306 (2004)
   PUBMED   14573619
REFERENCE   7  (bases 1 to 3481)
  AUTHORS   Wolf,G., Trub,T., Ottinger,E., Groninga,L., Lynch,A., White,M.F.,
            Miyazaki,M., Lee,J. and Shoelson,S.E.
  TITLE     PTB domains of IRS-1 and Shc have distinct but overlapping binding
            specificities
  JOURNAL   J Biol Chem 270 (46), 27407-27410 (1995)
   PUBMED   7499194
REFERENCE   8  (bases 1 to 3481)
  AUTHORS   Mikol,V., Baumann,G., Zurini,M.G. and Hommel,U.
  TITLE     Crystal structure of the SH2 domain from the adaptor protein SHC: a
            model for peptide binding based on X-ray and NMR data
  JOURNAL   J Mol Biol 254 (1), 86-95 (1995)
   PUBMED   7473762
REFERENCE   9  (bases 1 to 3481)
  AUTHORS   Spivak-Kroizman,T., Mohammadi,M., Hu,P., Jaye,M., Schlessinger,J.
            and Lax,I.
  TITLE     Point mutation in the fibroblast growth factor receptor eliminates
            phosphatidylinositol hydrolysis without affecting neuronal
            differentiation of PC12 cells
  JOURNAL   J Biol Chem 269 (20), 14419-14423 (1994)
   PUBMED   7514169
REFERENCE   10 (bases 1 to 3481)
  AUTHORS   Pelicci,G., Lanfrancone,L., Grignani,F., McGlade,J., Cavallo,F.,
            Forni,G., Nicoletti,I., Grignani,F., Pawson,T. and Pelicci,P.G.
  TITLE     A novel transforming protein (SHC) with an SH2 domain is implicated
            in mitogenic signal transduction
  JOURNAL   Cell 70 (1), 93-104 (1992)
   PUBMED   1623525
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX647149.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001130040.1.
            
            Summary: This gene encodes three main isoforms that differ in
            activities and subcellular location. While all three are adapter
            proteins in signal transduction pathways, the longest (p66Shc) may
            be involved in regulating life span and the effects of reactive
            oxygen species. The other two isoforms, p52Shc and p46Shc, link
            activated receptor tyrosine kinases to the Ras pathway by
            recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras
            activation. Unlike the other two isoforms, p46Shc is targeted to
            the mitochondrial matrix. Several transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Feb 2011].
            
            Transcript Variant: This variant (3) encodes the longest isoform
            (3).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX647149.1, AK096169.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000448116.7/
                                                  ENSP00000401303.3
            RefSeq Select criteria             :: based on manual assertion,
                                                  conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3353              BX647149.1         1-3353
            3354-3481           BX647149.1         3355-3482
FEATURES             Location/Qualifiers
     source          1..3481
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..3481
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /note="SHC adaptor protein 1"
                     /db_xref="GeneID:6464"
                     /db_xref="HGNC:HGNC:10840"
                     /db_xref="MIM:600560"
     exon            1..716
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            717..787
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            788..851
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            852..971
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1025
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1077
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1204
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1403
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1473
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1474..1608
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1847
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..3481
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3460..3465
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /note="hexamer: ATTAAA"
     polyA_site      3481
                     /gene="SHC1"
                     /gene_synonym="SHC; SHCA"
                     /note="major polyA site"
ORIGIN      
        1 agagaagagg ctccacgttg ggcggggatg gggcctgaaa ctgtctgggt ctgagctggg
       61 gagcggaagc cacttgtccc tctccctccc caggacttct gtgactcctg ggccacagag
      121 gtccaaccag gctaagggcc tggggatacc ccctgcctgg cccccttgcc caaactggca
      181 ggggggccag gctgggcagc agcccctctt tcacctcaac tatggatctc ctgcccccca
      241 agcccaagta caatccactc cggaatgagt ctctgtcatc gctggaggaa ggggcttctg
      301 ggtccacccc cccggaggag ctgccttccc catcagcttc atccctgggg cccatcctgc
      361 ctcctctgcc tggggacgat agtcccacta ccctgtgctc cttcttcccc cggatgagca
      421 acctgaggct ggccaacccg gctggggggc gcccagggtc taagggggag ccaggaaggg
      481 cagctgatga tggggagggg atcgtagggg cagccatgcc agactcaggc cccctacccc
      541 tcctccagga catgaacaag ctgagtggag gcggcgggcg caggactcgg gtggaagggg
      601 gccagcttgg gggcgaggag tggacccgcc acgggagctt tgtcaataag cccacgcggg
      661 gctggctgca tcccaacgac aaagtcatgg gacccggggt ttcctacttg gttcggtaca
      721 tgggttgtgt ggaggtcctc cagtcaatgc gtgccctgga cttcaacacc cggactcagg
      781 tcaccaggga ggccatcagt ctggtgtgtg aggctgtgcc gggtgctaag ggggcgacaa
      841 ggaggagaaa gccctgtagc cgcccgctca gctctatcct ggggaggagt aacctgaaat
      901 ttgctggaat gccaatcact ctcaccgtct ccaccagcag cctcaacctc atggccgcag
      961 actgcaaaca gatcatcgcc aaccaccaca tgcaatctat ctcatttgca tccggcgggg
     1021 atccggacac agccgagtat gtcgcctatg ttgccaaaga ccctgtgaat cagagagcct
     1081 gccacattct ggagtgtccc gaagggcttg cccaggatgt catcagcacc attggccagg
     1141 ccttcgagtt gcgcttcaaa caatacctca ggaacccacc caaactggtc acccctcatg
     1201 acaggatggc tggctttgat ggctcagcat gggatgagga ggaggaagag ccacctgacc
     1261 atcagtacta taatgacttc ccggggaagg aacccccctt ggggggggtg gtagacatga
     1321 ggcttcggga aggagccgct ccaggggctg ctcgacccac tgcacccaat gcccagaccc
     1381 ccagccactt gggagctaca ttgcctgtag gacagcctgt tgggggagat ccagaagtcc
     1441 gcaaacagat gccacctcca ccaccctgtc cagcaggcag agagcttttt gatgatccct
     1501 cctatgtcaa cgtccagaac ctagacaagg cccggcaagc agtgggtggt gctgggcccc
     1561 ccaatcctgc tatcaatggc agtgcacccc gggacctgtt tgacatgaag cccttcgaag
     1621 atgctcttcg cgtgcctcca cctccccagt cggtgtccat ggctgagcag ctccgagggg
     1681 agccctggtt ccatgggaag ctgagccggc gggaggctga ggcactgctg cagctcaatg
     1741 gggacttcct ggtacgggag agcacgacca cacctggcca gtatgtgctc actggcttgc
     1801 agagtgggca gcctaagcat ttgctactgg tggaccctga gggtgtggtt cggactaagg
     1861 atcaccgctt tgaaagtgtc agtcacctta tcagctacca catggacaat cacttgccca
     1921 tcatctctgc gggcagcgaa ctgtgtctac agcaacctgt ggagcggaaa ctgtgatctg
     1981 ccctagcgct ctcttccaga agatgccctc caatcctttc caccctattc cctaactctc
     2041 gggacctcgt ttgggagtgt tctgtgggct tggccttgtg tcagagctgg gagtagcatg
     2101 gactctgggt ttcatatcca gctgagtgag agggtttgag tcaaaagcct gggtgagaat
     2161 cctgcctctc cccaaacatt aatcaccaaa gtattaatgt acagagtggc ccctcacctg
     2221 ggcctttcct gtgccaacct gatgcccctt ccccaagaag gtgagtgctt gtcatggaaa
     2281 atgtcctgtg gtgacaggcc cagtggaaca gtcacccttc tgggcaaggg ggaacaaatc
     2341 acacctctgg gcttcagggt atcccagacc cctctcaaca cccgcccccc ccatgtttaa
     2401 actttgtgcc tttgaccatc tcttaggtct aatgatattt tatgcaaaca gttcttggac
     2461 ccctgaattc aatgacaggg atgccaacac cttcttggct tctgggacct gtgttcttgc
     2521 tgagcaccct ctccggtttg ggttgggata acagaggcag gagtggcagc tgtcccctct
     2581 ccctggggat atgcaaccct tagagattgc cccagagccc cactcccggc caggcgggag
     2641 atggacccct cccttgctca gtgcctcctg gccggggccc ctcaccccaa ggggtctgta
     2701 tatacatttc ataaggcctg ccctcccatg ttgcatgcct atgtactcta cgccaaagtg
     2761 cagcccttcc tcctgaagcc tctgccctgc ctccctttct gggagggcgg ggtgggggtg
     2821 actgaatttg ggcctcttgt acagttaact ctcccaggtg gattttgtgg aggtgagaaa
     2881 aggggcattg agactataaa gcagtagaca atccccacat accatctgta gagttggaac
     2941 tgcattcttt taaagtttta tatgcatata ttttagggct gtagacttac tttcctattt
     3001 tcttttccat tgcttattct tgagcacaaa atgataatca attattacat ttatacatca
     3061 cctttttgac ttttccaagc ccttttacag ctcttggcat tttcctcgcc taggcctgtg
     3121 aggtaactgg gatcgcacct tttataccag agacctgagg cagatgaaat ttatttccat
     3181 ctaggactag aaaaacttgg gtctcttacc gcgagactga gaggcagaag tcagcccgaa
     3241 tgcctgtcag tttcatggag gggaaacgca aaacctgcag ttcctgagta ccttctacag
     3301 gcccggccca gcctaggccc ggggtggcca caccacagca agccggcccc ccctcttttg
     3361 gccttgtgga taagggagag ttgaccgttt tcatcctggc ctccttttgc tgtttggatg
     3421 tttccacggg tctcacttat accaaaggga aaactcttca ttaaagtccg tatttcttct
     3481 a
//
