LOCUS       NM_001289115            1501 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens sex hormone binding globulin (SHBG), transcript
            variant 7, mRNA.
ACCESSION   NM_001289115 XM_005256763
VERSION     NM_001289115.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1501)
  AUTHORS   Ma,H. and Chen,Y.
  TITLE     Examining the causal relationship between sex hormone-binding
            globulin (SHBG) and infertility: A Mendelian randomization study
  JOURNAL   PLoS One 19 (6), e0304216 (2024)
   PUBMED   38848344
  REMARK    GeneRIF: Examining the causal relationship between sex
            hormone-binding globulin (SHBG) and infertility: A Mendelian
            randomization study.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1501)
  AUTHORS   Yang,J., Zhou,J., Liu,H., Hao,J., Hu,S., Zhang,P., Wu,H., Gao,Y.
            and Tang,W.
  TITLE     Blood lipid levels mediating the effects of sex hormone-binding
            globulin on coronary heart disease: Mendelian randomization and
            mediation analysis
  JOURNAL   Sci Rep 14 (1), 11993 (2024)
   PUBMED   38796576
  REMARK    GeneRIF: Blood lipid levels mediating the effects of sex
            hormone-binding globulin on coronary heart disease: Mendelian
            randomization and mediation analysis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1501)
  AUTHORS   Li,M.J., Jiang,C.Q., Jin,Y.L., Zhu,T., Zhu,F., Zhang,W.S. and Xu,L.
  TITLE     Association of Testosterone and Sex Hormone-Binding Globulin With
            All-Cause and Cardiovascular Disease Mortality in Older Chinese Men
  JOURNAL   J Gerontol A Biol Sci Med Sci 79 (4) (2024)
   PUBMED   38394359
  REMARK    GeneRIF: Association of Testosterone and Sex Hormone-Binding
            Globulin With All-Cause and Cardiovascular Disease Mortality in
            Older Chinese Men.
REFERENCE   4  (bases 1 to 1501)
  AUTHORS   Hedderson,M.M., Capra,A., Lee,C., Habel,L.A., Lee,J., Gold,E.B.,
            Badon,S.E., Mitro,S.D. and El Khoudary,S.R.
  TITLE     Longitudinal Changes in Sex Hormone Binding Globulin (SHBG) and
            Risk of Incident Diabetes: The Study of Women's Health Across the
            Nation (SWAN)
  JOURNAL   Diabetes Care 47 (4), 676-682 (2024)
   PUBMED   38320264
  REMARK    GeneRIF: Longitudinal Changes in Sex Hormone Binding Globulin
            (SHBG) and Risk of Incident Diabetes: The Study of Women's Health
            Across the Nation (SWAN).
REFERENCE   5  (bases 1 to 1501)
  AUTHORS   Ponomarenko,I., Pasenov,K., Churnosova,M., Sorokina,I.,
            Aristova,I., Churnosov,V., Ponomarenko,M., Reshetnikov,E. and
            Churnosov,M.
  TITLE     Sex-Hormone-Binding Globulin Gene Polymorphisms and Breast Cancer
            Risk in Caucasian Women of Russia
  JOURNAL   Int J Mol Sci 25 (4), 2182 (2024)
   PUBMED   38396861
  REMARK    GeneRIF: Sex-Hormone-Binding Globulin Gene Polymorphisms and Breast
            Cancer Risk in Caucasian Women of Russia.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1501)
  AUTHORS   Power,S.G., Bocchinfuso,W.P., Pallesen,M., Warmels-Rodenhiser,S.,
            Van Baelen,H. and Hammond,G.L.
  TITLE     Molecular analyses of a human sex hormone-binding globulin variant:
            evidence for an additional carbohydrate chain
  JOURNAL   J Clin Endocrinol Metab 75 (4), 1066-1070 (1992)
   PUBMED   1400872
REFERENCE   7  (bases 1 to 1501)
  AUTHORS   Berube,D., Seralini,G.E., Gagne,R. and Hammond,G.L.
  TITLE     Localization of the human sex hormone-binding globulin gene (SHBG)
            to the short arm of chromosome 17 (17p12----p13)
  JOURNAL   Cytogenet Cell Genet 54 (1-2), 65-67 (1990)
   PUBMED   2249477
REFERENCE   8  (bases 1 to 1501)
  AUTHORS   Gershagen,S., Lundwall,A. and Fernlund,P.
  TITLE     Characterization of the human sex hormone binding globulin (SHBG)
            gene and demonstration of two transcripts in both liver and testis
  JOURNAL   Nucleic Acids Res 17 (22), 9245-9258 (1989)
   PUBMED   2587256
REFERENCE   9  (bases 1 to 1501)
  AUTHORS   Hammond,G.L., Underhill,D.A., Rykse,H.M. and Smith,C.L.
  TITLE     The human sex hormone-binding globulin gene contains exons for
            androgen-binding protein and two other testicular messenger RNAs
  JOURNAL   Mol Endocrinol 3 (11), 1869-1876 (1989)
   PUBMED   2608061
REFERENCE   10 (bases 1 to 1501)
  AUTHORS   Que,B.G. and Petra,P.H.
  TITLE     Characterization of a cDNA coding for sex steroid-binding protein
            of human plasma
  JOURNAL   FEBS Lett 219 (2), 405-409 (1987)
   PUBMED   2956125
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007421.13, AK302603.1 and
            X05403.1.
            
            On Aug 14, 2020 this sequence version replaced NM_001289115.1.
            
            Summary: This gene encodes a steroid binding protein that was first
            described as a plasma protein secreted by the liver but is now
            thought to participate in the regulation of steroid responses. The
            encoded protein transports androgens and estrogens in the blood,
            binding each steroid molecule as a dimer formed from identical or
            nearly identical monomers. Polymorphisms in this gene have been
            associated with polycystic ovary syndrome and type 2 diabetes
            mellitus. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Jan 2014].
            
            Transcript Variant: This variant (7) differs in the 5' UTR, lacks
            part of the 5' coding region, uses a downstream start codon, and
            lacks an exon in the 3' coding region, which results in a
            frameshift, compared to variant 1. The encoded isoform (6) is
            shorter, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK302603.1, X16351.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145122
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-408               AC007421.13        44204-44611         c
            409-1439            AK302603.1         1-1031
            1440-1501           X05403.1           1105-1166
FEATURES             Location/Qualifiers
     source          1..1501
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..1501
                     /gene="SHBG"
                     /gene_synonym="ABP; SBP; TEBG"
                     /note="sex hormone binding globulin"
                     /db_xref="GeneID:6462"
                     /db_xref="HGNC:HGNC:10839"
                     /db_xref="MIM:182205"
     exon            1..591
                     /gene="SHBG"
                     /gene_synonym="ABP; SBP; TEBG"
                     /inference="alignment:Splign:2.1.0"
     exon            592..683
                     /gene="SHBG"
                     /gene_synonym="ABP; SBP; TEBG"
                     /inference="alignment:Splign:2.1.0"
     CDS             655..1362
                     /gene="SHBG"
                     /gene_synonym="ABP; SBP; TEBG"
                     /note="isoform 6 is encoded by transcript variant 7;
                     testosterone-binding beta-globulin; sex steroid-binding
                     protein; testis-specific androgen-binding protein;
                     testosterone-estrogen-binding globulin;
                     testosterone-estradiol-binding globulin"
                     /codon_start=1
                     /product="sex hormone-binding globulin isoform 6"
                     /protein_id="NP_001276044.1"
                     /db_xref="CCDS:CCDS73962.1"
                     /db_xref="GeneID:6462"
                     /db_xref="HGNC:HGNC:10839"
                     /db_xref="MIM:182205"
                     /translation="MTFDLTKITKTSSSFEVRTWDPEGVIFYGDTNPKDDWFMLGLRD
                     GRPEIQLHNHWAQLTVGAGPRLDDGRWHQVEVKMEGDSVLLEVDGEEVLRLRQVSGPL
                     TSKRHPIMRIALGGLLFPASNLRLPLVPALDGCLRRDSWLDKQAEISASAPTSLRSCD
                     VESNPGIFLPPGTQAEFNLRDIPQPHAEPWAFSLDLGLKQAAGSGHLLALGTPENPSW
                     LSLHLQDQEKTLPPLFA"
     exon            684..873
                     /gene="SHBG"
                     /gene_synonym="ABP; SBP; TEBG"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1035
                     /gene="SHBG"
                     /gene_synonym="ABP; SBP; TEBG"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1195
                     /gene="SHBG"
                     /gene_synonym="ABP; SBP; TEBG"
                     /inference="alignment:Splign:2.1.0"
     exon            1196..1332
                     /gene="SHBG"
                     /gene_synonym="ABP; SBP; TEBG"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1501
                     /gene="SHBG"
                     /gene_synonym="ABP; SBP; TEBG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1477..1482
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SHBG"
                     /gene_synonym="ABP; SBP; TEBG"
                     /note="hexamer: ATTAAA"
     polyA_site      1501
                     /gene="SHBG"
                     /gene_synonym="ABP; SBP; TEBG"
                     /note="major polyA site"
ORIGIN      
        1 agtcttcacc cgaatcagcc tcaggatatc tccacagtct ccctccttgg cctctcggat
       61 ccgcacggaa gccatccgga tccccgctgt ctgggaccaa agtcccaggg cctcgcaaac
      121 ggcaactaga ccccttaaag ggcctacgga cttggatcct gaagagcctg agagagcggg
      181 gtggcgggag tcggggggga cggcggggta gccgcggcct ggtaagtgga gctgggattc
      241 cggcgccgta cgggaggaga gagtaggcca gcgaggcgat cctctgtccg ggcatagccc
      301 caccccctcg aattctgtcg cagcaggggg cacaactgtc agccaatcag cttggagaac
      361 aggcacggcc gcgtcccccc caagccccac ccccgacagc tggatcttgt gactgggctc
      421 ctgggtagag ttcaaggttg gagtgaagcg gcttccttgc ggttgtgtgg gtgtcccaac
      481 ctgggtcgag ataccccgcg gttcaaaggc tcccccgcag tgctttttaa attgacatat
      541 gcagtgataa cctgctttag cctcaggctc actcacccgc ccagaccctg gagtgcccac
      601 gaccctccgg ctgtccacct cagcaatggc ccaggacaag agcctatcgc tgtcatgacc
      661 tttgacctca ccaagatcac aaaaacctcc tcctcctttg aggttcgaac ctgggaccca
      721 gagggagtga ttttttatgg ggataccaac cctaaggatg actggtttat gctgggactt
      781 cgagacggca ggcctgagat ccaactgcac aatcactggg cccagcttac ggtgggtgct
      841 ggaccacggc tggatgatgg gagatggcac caggtggaag tcaagatgga gggggactct
      901 gtgctgctgg aggtggatgg ggaggaggtg ctgcgcctga gacaggtctc tgggcccctg
      961 accagcaaac gccatcccat catgaggatt gcgcttgggg ggctgctctt ccccgcttcc
     1021 aaccttcggt tgccgctggt tcctgccctg gatggctgcc tgcgccggga ttcctggctg
     1081 gacaaacagg ccgagatctc agcatctgcc cccactagcc tcagaagctg tgatgtagaa
     1141 tcaaatcccg ggatatttct ccctccaggg actcaggcag aattcaatct ccgagacatt
     1201 ccccagcctc atgcagagcc ctgggccttc tctttggacc tgggactcaa gcaggcagca
     1261 ggctcaggcc acctccttgc tcttgggaca ccagagaacc catcttggct cagtctccac
     1321 ctccaagatc aagagaagac tcttccacct ctttttgcct gaatggcctt tgggcacaag
     1381 gtcagaggct ggatgtggac caggccctga acagaagcca tgagatctgg actcacagct
     1441 gcccccagag cccaggcaat ggcactgacg cttcccatta aagctccacc taagaacccc
     1501 c
//
