LOCUS       NM_001289114            1164 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens sex hormone binding globulin (SHBG), transcript
            variant 6, mRNA.
ACCESSION   NM_001289114 NR_027463 XM_005256760
VERSION     NM_001289114.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1164)
  AUTHORS   Ma,H. and Chen,Y.
  TITLE     Examining the causal relationship between sex hormone-binding
            globulin (SHBG) and infertility: A Mendelian randomization study
  JOURNAL   PLoS One 19 (6), e0304216 (2024)
   PUBMED   38848344
  REMARK    GeneRIF: Examining the causal relationship between sex
            hormone-binding globulin (SHBG) and infertility: A Mendelian
            randomization study.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1164)
  AUTHORS   Yang,J., Zhou,J., Liu,H., Hao,J., Hu,S., Zhang,P., Wu,H., Gao,Y.
            and Tang,W.
  TITLE     Blood lipid levels mediating the effects of sex hormone-binding
            globulin on coronary heart disease: Mendelian randomization and
            mediation analysis
  JOURNAL   Sci Rep 14 (1), 11993 (2024)
   PUBMED   38796576
  REMARK    GeneRIF: Blood lipid levels mediating the effects of sex
            hormone-binding globulin on coronary heart disease: Mendelian
            randomization and mediation analysis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1164)
  AUTHORS   Li,M.J., Jiang,C.Q., Jin,Y.L., Zhu,T., Zhu,F., Zhang,W.S. and Xu,L.
  TITLE     Association of Testosterone and Sex Hormone-Binding Globulin With
            All-Cause and Cardiovascular Disease Mortality in Older Chinese Men
  JOURNAL   J Gerontol A Biol Sci Med Sci 79 (4) (2024)
   PUBMED   38394359
  REMARK    GeneRIF: Association of Testosterone and Sex Hormone-Binding
            Globulin With All-Cause and Cardiovascular Disease Mortality in
            Older Chinese Men.
REFERENCE   4  (bases 1 to 1164)
  AUTHORS   Hedderson,M.M., Capra,A., Lee,C., Habel,L.A., Lee,J., Gold,E.B.,
            Badon,S.E., Mitro,S.D. and El Khoudary,S.R.
  TITLE     Longitudinal Changes in Sex Hormone Binding Globulin (SHBG) and
            Risk of Incident Diabetes: The Study of Women's Health Across the
            Nation (SWAN)
  JOURNAL   Diabetes Care 47 (4), 676-682 (2024)
   PUBMED   38320264
  REMARK    GeneRIF: Longitudinal Changes in Sex Hormone Binding Globulin
            (SHBG) and Risk of Incident Diabetes: The Study of Women's Health
            Across the Nation (SWAN).
REFERENCE   5  (bases 1 to 1164)
  AUTHORS   Ponomarenko,I., Pasenov,K., Churnosova,M., Sorokina,I.,
            Aristova,I., Churnosov,V., Ponomarenko,M., Reshetnikov,E. and
            Churnosov,M.
  TITLE     Sex-Hormone-Binding Globulin Gene Polymorphisms and Breast Cancer
            Risk in Caucasian Women of Russia
  JOURNAL   Int J Mol Sci 25 (4), 2182 (2024)
   PUBMED   38396861
  REMARK    GeneRIF: Sex-Hormone-Binding Globulin Gene Polymorphisms and Breast
            Cancer Risk in Caucasian Women of Russia.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1164)
  AUTHORS   Power,S.G., Bocchinfuso,W.P., Pallesen,M., Warmels-Rodenhiser,S.,
            Van Baelen,H. and Hammond,G.L.
  TITLE     Molecular analyses of a human sex hormone-binding globulin variant:
            evidence for an additional carbohydrate chain
  JOURNAL   J Clin Endocrinol Metab 75 (4), 1066-1070 (1992)
   PUBMED   1400872
REFERENCE   7  (bases 1 to 1164)
  AUTHORS   Berube,D., Seralini,G.E., Gagne,R. and Hammond,G.L.
  TITLE     Localization of the human sex hormone-binding globulin gene (SHBG)
            to the short arm of chromosome 17 (17p12----p13)
  JOURNAL   Cytogenet Cell Genet 54 (1-2), 65-67 (1990)
   PUBMED   2249477
REFERENCE   8  (bases 1 to 1164)
  AUTHORS   Gershagen,S., Lundwall,A. and Fernlund,P.
  TITLE     Characterization of the human sex hormone binding globulin (SHBG)
            gene and demonstration of two transcripts in both liver and testis
  JOURNAL   Nucleic Acids Res 17 (22), 9245-9258 (1989)
   PUBMED   2587256
REFERENCE   9  (bases 1 to 1164)
  AUTHORS   Hammond,G.L., Underhill,D.A., Rykse,H.M. and Smith,C.L.
  TITLE     The human sex hormone-binding globulin gene contains exons for
            androgen-binding protein and two other testicular messenger RNAs
  JOURNAL   Mol Endocrinol 3 (11), 1869-1876 (1989)
   PUBMED   2608061
REFERENCE   10 (bases 1 to 1164)
  AUTHORS   Que,B.G. and Petra,P.H.
  TITLE     Characterization of a cDNA coding for sex steroid-binding protein
            of human plasma
  JOURNAL   FEBS Lett 219 (2), 405-409 (1987)
   PUBMED   2956125
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from EU352670.1 and X05403.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001289114.1.
            
            Summary: This gene encodes a steroid binding protein that was first
            described as a plasma protein secreted by the liver but is now
            thought to participate in the regulation of steroid responses. The
            encoded protein transports androgens and estrogens in the blood,
            binding each steroid molecule as a dimer formed from identical or
            nearly identical monomers. Polymorphisms in this gene have been
            associated with polycystic ovary syndrome and type 2 diabetes
            mellitus. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Jan 2014].
            
            Transcript Variant: This variant (6) differs in the 5' UTR, lacks
            part of the 5' coding region, and uses a downstream start codon,
            compared to variant 1. The encoded isoform (5) has a shorter
            N-terminus, compared to isoform 1. Both variants 5 and 6 encode the
            same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU352670.1 [ECO:0000332]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1146              EU352670.1         1-1146
            1147-1164           X05403.1           1149-1166
FEATURES             Location/Qualifiers
     source          1..1164
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..1164
                     /gene="SHBG"
                     /gene_synonym="ABP; SBP; TEBG"
                     /note="sex hormone binding globulin"
                     /db_xref="GeneID:6462"
                     /db_xref="HGNC:HGNC:10839"
                     /db_xref="MIM:182205"
     exon            1..48
                     /gene="SHBG"
                     /gene_synonym="ABP; SBP; TEBG"
                     /inference="alignment:Splign:2.1.0"
     exon            49..138
                     /gene="SHBG"
                     /gene_synonym="ABP; SBP; TEBG"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..1144
                     /gene="SHBG"
                     /gene_synonym="ABP; SBP; TEBG"
                     /note="isoform 5 is encoded by transcript variant 6;
                     testosterone-binding beta-globulin; sex steroid-binding
                     protein; testis-specific androgen-binding protein;
                     testosterone-estrogen-binding globulin;
                     testosterone-estradiol-binding globulin"
                     /codon_start=1
                     /product="sex hormone-binding globulin isoform 5"
                     /protein_id="NP_001276043.1"
                     /db_xref="CCDS:CCDS73961.1"
                     /db_xref="GeneID:6462"
                     /db_xref="HGNC:HGNC:10839"
                     /db_xref="MIM:182205"
                     /translation="MTFDLTKITKTSSSFEVRTWDPEGVIFYGDTNPKDDWFMLGLRD
                     GRPEIQLHNHWAQLTVGAGPRLDDGRWHQVEVKMEGDSVLLEVDGEEVLRLRQVSGPL
                     TSKRHPIMRIALGGLLFPASNLRLPLVPALDGCLRRDSWLDKQAEISASAPTSLRSCD
                     VESNPGIFLPPGTQAEFNLRDIPQPHAEPWAFSLDLGLKQAAGSGHLLALGTPENPSW
                     LSLHLQDQKVVLSSGSGPGLDLPLVLGLPLQLKLSMSRVVLSQGSKMKALALPPLGLA
                     PLLNLWAKPQGRLFLGALPGEDSSTSFCLNGLWAQGQRLDVDQALNRSHEIWTHSCPQ
                     SPGNGTDASH"
     exon            139..328
                     /gene="SHBG"
                     /gene_synonym="ABP; SBP; TEBG"
                     /inference="alignment:Splign:2.1.0"
     exon            329..490
                     /gene="SHBG"
                     /gene_synonym="ABP; SBP; TEBG"
                     /inference="alignment:Splign:2.1.0"
     exon            491..650
                     /gene="SHBG"
                     /gene_synonym="ABP; SBP; TEBG"
                     /inference="alignment:Splign:2.1.0"
     exon            651..787
                     /gene="SHBG"
                     /gene_synonym="ABP; SBP; TEBG"
                     /inference="alignment:Splign:2.1.0"
     exon            788..995
                     /gene="SHBG"
                     /gene_synonym="ABP; SBP; TEBG"
                     /inference="alignment:Splign:2.1.0"
     exon            996..1164
                     /gene="SHBG"
                     /gene_synonym="ABP; SBP; TEBG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1140..1145
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SHBG"
                     /gene_synonym="ABP; SBP; TEBG"
                     /note="hexamer: ATTAAA"
     polyA_site      1164
                     /gene="SHBG"
                     /gene_synonym="ABP; SBP; TEBG"
                     /note="major polyA site"
ORIGIN      
        1 aattctccat gtgcttggat cgtggggaag atgtgattaa ggtctaagtg cccacgaccc
       61 tccggctgtc cacctcagca atggcccagg acaagagcct atcgctgtca tgacctttga
      121 cctcaccaag atcacaaaaa cctcctcctc ctttgaggtt cgaacctggg acccagaggg
      181 agtgattttt tatggggata ccaaccctaa ggatgactgg tttatgctgg gacttcgaga
      241 cggcaggcct gagatccaac tgcacaatca ctgggcccag cttacggtgg gtgctggacc
      301 acggctggat gatgggagat ggcaccaggt ggaagtcaag atggaggggg actctgtgct
      361 gctggaggtg gatggggagg aggtgctgcg cctgagacag gtctctgggc ccctgaccag
      421 caaacgccat cccatcatga ggattgcgct tggggggctg ctcttccccg cttccaacct
      481 tcggttgccg ctggttcctg ccctggatgg ctgcctgcgc cgggattcct ggctggacaa
      541 acaggccgag atctcagcat ctgcccccac tagcctcaga agctgtgatg tagaatcaaa
      601 tcccgggata tttctccctc cagggactca ggcagaattc aatctccgag acattcccca
      661 gcctcatgca gagccctggg ccttctcttt ggacctggga ctcaagcagg cagcaggctc
      721 aggccacctc cttgctcttg ggacaccaga gaacccatct tggctcagtc tccacctcca
      781 agatcaaaag gtggtgttgt cttctgggtc ggggccaggg ctggatctgc ccctggtctt
      841 gggactccct cttcagctga agctgagtat gtccagggtg gtcttgagcc aagggtcgaa
      901 gatgaaggcc cttgccctgc ctcccttagg cctggctccc ctccttaacc tctgggccaa
      961 gcctcaaggg cgtctcttcc tgggggcttt accaggagaa gactcttcca cctctttttg
     1021 cctgaatggc ctttgggcac aaggtcagag gctggatgtg gaccaggccc tgaacagaag
     1081 ccatgagatc tggactcaca gctgccccca gagcccaggc aatggcactg acgcttccca
     1141 ttaaagctcc acctaagaac cccc
//
