LOCUS       NM_001040               1267 bp    mRNA    linear   PRI 27-APR-2025
DEFINITION  Homo sapiens sex hormone binding globulin (SHBG), transcript
            variant 1, mRNA.
ACCESSION   NM_001040
VERSION     NM_001040.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1267)
  AUTHORS   Ma,H. and Chen,Y.
  TITLE     Examining the causal relationship between sex hormone-binding
            globulin (SHBG) and infertility: A Mendelian randomization study
  JOURNAL   PLoS One 19 (6), e0304216 (2024)
   PUBMED   38848344
  REMARK    GeneRIF: Examining the causal relationship between sex
            hormone-binding globulin (SHBG) and infertility: A Mendelian
            randomization study.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1267)
  AUTHORS   Yang,J., Zhou,J., Liu,H., Hao,J., Hu,S., Zhang,P., Wu,H., Gao,Y.
            and Tang,W.
  TITLE     Blood lipid levels mediating the effects of sex hormone-binding
            globulin on coronary heart disease: Mendelian randomization and
            mediation analysis
  JOURNAL   Sci Rep 14 (1), 11993 (2024)
   PUBMED   38796576
  REMARK    GeneRIF: Blood lipid levels mediating the effects of sex
            hormone-binding globulin on coronary heart disease: Mendelian
            randomization and mediation analysis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1267)
  AUTHORS   Li,M.J., Jiang,C.Q., Jin,Y.L., Zhu,T., Zhu,F., Zhang,W.S. and Xu,L.
  TITLE     Association of Testosterone and Sex Hormone-Binding Globulin With
            All-Cause and Cardiovascular Disease Mortality in Older Chinese Men
  JOURNAL   J Gerontol A Biol Sci Med Sci 79 (4) (2024)
   PUBMED   38394359
  REMARK    GeneRIF: Association of Testosterone and Sex Hormone-Binding
            Globulin With All-Cause and Cardiovascular Disease Mortality in
            Older Chinese Men.
REFERENCE   4  (bases 1 to 1267)
  AUTHORS   Hedderson,M.M., Capra,A., Lee,C., Habel,L.A., Lee,J., Gold,E.B.,
            Badon,S.E., Mitro,S.D. and El Khoudary,S.R.
  TITLE     Longitudinal Changes in Sex Hormone Binding Globulin (SHBG) and
            Risk of Incident Diabetes: The Study of Women's Health Across the
            Nation (SWAN)
  JOURNAL   Diabetes Care 47 (4), 676-682 (2024)
   PUBMED   38320264
  REMARK    GeneRIF: Longitudinal Changes in Sex Hormone Binding Globulin
            (SHBG) and Risk of Incident Diabetes: The Study of Women's Health
            Across the Nation (SWAN).
REFERENCE   5  (bases 1 to 1267)
  AUTHORS   Ponomarenko,I., Pasenov,K., Churnosova,M., Sorokina,I.,
            Aristova,I., Churnosov,V., Ponomarenko,M., Reshetnikov,E. and
            Churnosov,M.
  TITLE     Sex-Hormone-Binding Globulin Gene Polymorphisms and Breast Cancer
            Risk in Caucasian Women of Russia
  JOURNAL   Int J Mol Sci 25 (4), 2182 (2024)
   PUBMED   38396861
  REMARK    GeneRIF: Sex-Hormone-Binding Globulin Gene Polymorphisms and Breast
            Cancer Risk in Caucasian Women of Russia.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1267)
  AUTHORS   Power,S.G., Bocchinfuso,W.P., Pallesen,M., Warmels-Rodenhiser,S.,
            Van Baelen,H. and Hammond,G.L.
  TITLE     Molecular analyses of a human sex hormone-binding globulin variant:
            evidence for an additional carbohydrate chain
  JOURNAL   J Clin Endocrinol Metab 75 (4), 1066-1070 (1992)
   PUBMED   1400872
REFERENCE   7  (bases 1 to 1267)
  AUTHORS   Berube,D., Seralini,G.E., Gagne,R. and Hammond,G.L.
  TITLE     Localization of the human sex hormone-binding globulin gene (SHBG)
            to the short arm of chromosome 17 (17p12----p13)
  JOURNAL   Cytogenet Cell Genet 54 (1-2), 65-67 (1990)
   PUBMED   2249477
REFERENCE   8  (bases 1 to 1267)
  AUTHORS   Gershagen,S., Lundwall,A. and Fernlund,P.
  TITLE     Characterization of the human sex hormone binding globulin (SHBG)
            gene and demonstration of two transcripts in both liver and testis
  JOURNAL   Nucleic Acids Res 17 (22), 9245-9258 (1989)
   PUBMED   2587256
REFERENCE   9  (bases 1 to 1267)
  AUTHORS   Hammond,G.L., Underhill,D.A., Rykse,H.M. and Smith,C.L.
  TITLE     The human sex hormone-binding globulin gene contains exons for
            androgen-binding protein and two other testicular messenger RNAs
  JOURNAL   Mol Endocrinol 3 (11), 1869-1876 (1989)
   PUBMED   2608061
REFERENCE   10 (bases 1 to 1267)
  AUTHORS   Que,B.G. and Petra,P.H.
  TITLE     Characterization of a cDNA coding for sex steroid-binding protein
            of human plasma
  JOURNAL   FEBS Lett 219 (2), 405-409 (1987)
   PUBMED   2956125
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from EU352659.1 and BC101785.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001040.4.
            
            Summary: This gene encodes a steroid binding protein that was first
            described as a plasma protein secreted by the liver but is now
            thought to participate in the regulation of steroid responses. The
            encoded protein transports androgens and estrogens in the blood,
            binding each steroid molecule as a dimer formed from identical or
            nearly identical monomers. Polymorphisms in this gene have been
            associated with polycystic ovary syndrome and type 2 diabetes
            mellitus. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Jan 2014].
            
            Transcript Variant: This variant (1), which has also been referred
            to as SHBG-L, encodes the longest protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189664.21847.1, BC101785.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2144835
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380450.9/ ENSP00000369816.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 EU352659.1         42-48
            8-1267              BC101785.1         1-1260
FEATURES             Location/Qualifiers
     source          1..1267
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..1267
                     /gene="SHBG"
                     /gene_synonym="ABP; SBP; TEBG"
                     /note="sex hormone binding globulin"
                     /db_xref="GeneID:6462"
                     /db_xref="HGNC:HGNC:10839"
                     /db_xref="MIM:182205"
     exon            1..149
                     /gene="SHBG"
                     /gene_synonym="ABP; SBP; TEBG"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..1247
                     /gene="SHBG"
                     /gene_synonym="ABP; SBP; TEBG"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; testosterone-binding beta-globulin; sex
                     steroid-binding protein; testis-specific androgen-binding
                     protein; testosterone-estrogen-binding globulin;
                     testosterone-estradiol-binding globulin"
                     /codon_start=1
                     /product="sex hormone-binding globulin isoform 1
                     precursor"
                     /protein_id="NP_001031.2"
                     /db_xref="CCDS:CCDS11117.1"
                     /db_xref="GeneID:6462"
                     /db_xref="HGNC:HGNC:10839"
                     /db_xref="MIM:182205"
                     /translation="MESRGPLATSRLLLLLLLLLLRHTRQGWALRPVLPTQSAHDPPA
                     VHLSNGPGQEPIAVMTFDLTKITKTSSSFEVRTWDPEGVIFYGDTNPKDDWFMLGLRD
                     GRPEIQLHNHWAQLTVGAGPRLDDGRWHQVEVKMEGDSVLLEVDGEEVLRLRQVSGPL
                     TSKRHPIMRIALGGLLFPASNLRLPLVPALDGCLRRDSWLDKQAEISASAPTSLRSCD
                     VESNPGIFLPPGTQAEFNLRDIPQPHAEPWAFSLDLGLKQAAGSGHLLALGTPENPSW
                     LSLHLQDQKVVLSSGSGPGLDLPLVLGLPLQLKLSMSRVVLSQGSKMKALALPPLGLA
                     PLLNLWAKPQGRLFLGALPGEDSSTSFCLNGLWAQGQRLDVDQALNRSHEIWTHSCPQ
                     SPGNGTDASH"
     exon            150..241
                     /gene="SHBG"
                     /gene_synonym="ABP; SBP; TEBG"
                     /inference="alignment:Splign:2.1.0"
     exon            242..431
                     /gene="SHBG"
                     /gene_synonym="ABP; SBP; TEBG"
                     /inference="alignment:Splign:2.1.0"
     exon            432..593
                     /gene="SHBG"
                     /gene_synonym="ABP; SBP; TEBG"
                     /inference="alignment:Splign:2.1.0"
     exon            594..753
                     /gene="SHBG"
                     /gene_synonym="ABP; SBP; TEBG"
                     /inference="alignment:Splign:2.1.0"
     exon            754..890
                     /gene="SHBG"
                     /gene_synonym="ABP; SBP; TEBG"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1098
                     /gene="SHBG"
                     /gene_synonym="ABP; SBP; TEBG"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1267
                     /gene="SHBG"
                     /gene_synonym="ABP; SBP; TEBG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1243..1248
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SHBG"
                     /gene_synonym="ABP; SBP; TEBG"
                     /note="hexamer: ATTAAA"
     polyA_site      1267
                     /gene="SHBG"
                     /gene_synonym="ABP; SBP; TEBG"
                     /note="major polyA site"
ORIGIN      
        1 aagagttgtc tgagccgccg agtggacagt ggctgattat ggagagcaga ggcccactgg
       61 ctacctcgcg cctgctgctg ttgctgctgt tgctactact gcgtcacacc cgccagggat
      121 gggccctgag acctgttctc cccacccaga gtgcccacga ccctccggct gtccacctca
      181 gcaatggccc aggacaagag cctatcgctg tcatgacctt tgacctcacc aagatcacaa
      241 aaacctcctc ctcctttgag gttcgaacct gggacccaga gggagtgatt ttttatgggg
      301 ataccaaccc taaggatgac tggtttatgc tgggacttcg agacggcagg cctgagatcc
      361 aactgcacaa tcactgggcc cagcttacgg tgggtgctgg accacggctg gatgatggga
      421 gatggcacca ggtggaagtc aagatggagg gggactctgt gctgctggag gtggatgggg
      481 aggaggtgct gcgcctgaga caggtctctg ggcccctgac cagcaaacgc catcccatca
      541 tgaggattgc gcttgggggg ctgctcttcc ccgcttccaa ccttcggttg ccgctggttc
      601 ctgccctgga tggctgcctg cgccgggatt cctggctgga caaacaggcc gagatctcag
      661 catctgcccc cactagcctc agaagctgtg atgtagaatc aaatcccggg atatttctcc
      721 ctccagggac tcaggcagaa ttcaatctcc gagacattcc ccagcctcat gcagagccct
      781 gggccttctc tttggacctg ggactcaagc aggcagcagg ctcaggccac ctccttgctc
      841 ttgggacacc agagaaccca tcttggctca gtctccacct ccaagatcaa aaggtggtgt
      901 tgtcttctgg gtcggggcca gggctggatc tgcccctggt cttgggactc cctcttcagc
      961 tgaagctgag tatgtccagg gtggtcttga gccaagggtc gaagatgaag gcccttgccc
     1021 tgcctccctt aggcctggct cccctcctta acctctgggc caagcctcaa gggcgtctct
     1081 tcctgggggc tttaccagga gaagactctt ccacctcttt ttgcctgaat ggcctttggg
     1141 cacaaggtca gaggctggat gtggaccagg ccctgaacag aagccatgag atctggactc
     1201 acagctgccc ccagagccca ggcaatggca ctgacgcttc ccattaaagc tccacctaag
     1261 aaccccc
//
